Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

Srinivasan, Mythily; Lahiri, Debomoy K

doi:10.1517/14728222.2014.989834

Cited by 164NF-κB Signaling PathwaysNeuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

Open access

Srinivasan, Mythily, Lahiri, Debomoy K·2015·Expert Opinion on Therapeutic Targets

DOI 10.1517/14728222.2014.989834PMC PMC5873291

Open this paper in CoChat — free account

Abstract

INTRODUCTION: Advances in molecular pathogenesis suggest that the chronic inflammation is a shared mechanism in the initiation and progression of multiple neurodegenerative diseases with diverse clinical manifestations such as Alzheimer's disease (AD) and Multiple sclerosis (MS). Restricted cell renewal and regenerative capacity make the neural tissues extremely vulnerable to the uncontrolled inflammatory process leading to irreversible tissue damage. AREAS COVERED: A predominant consequence of increased inflammatory signaling is the upregulation of the transcription factor, NF-κB with subsequent neuroprotective or deleterious effects depending on the strength of the signal and the type of NF-κB dimers activated. We discuss the interplay between neuroinflammation and neurodegeneration keeping in focus NF-κB signaling as the point of convergence of multiple pathways associated with the development of the neurodegenerative pathologies, AD and MS. EXPERT OPINION: Considerable interest exists in developing efficient NF-κB inhibitors for neurodegenerative diseases. The review includes an overview of natural compounds and rationally designed agents that inhibit NF-κB and mediate neuroprotection in AD and MS. The key chemical moieties of the natural and the synthetic compounds provide efficient leads for the development of effective small molecule inhibitors that selectively target NF-κB activation; this would result in the desired benefit to risk therapeutic effects.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1517/14728222.2014.989834

Cites

107 of 107 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Neuroinflammation can be attenuated by reducing expression of NF-κB-p65 via NLRP3 pathways.
“Neuroinflammation is one of the major factors of AD and other disorders related to cholinergic transmission. It can be attenuated by reducing the expression of NF-κB-p65 via NLRP3 pathways.”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [142]
Targeting transcription factor NF-κβp65 could be a novel approach for treatment of AD.
“Thus targeting the transcription factor (NF-κβp65) could be the novel approach for the treatment of AD.”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [142]

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

1 retracted

<i>Retracted:</i> Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice
Wang, P., Su, C., Li, R., Wang, H., Ren, Y., Sun, H., Yang, J., Sun, J., Shi, J., Tian, J., et al. (2014) · Journal of Neuroscience Research · doi:10.1002/jnr.23322 · Cited by 65 · see citing works
Retracted
Mechanisms underlying inflammation in neurodegeneration
Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works
Curcumin Inhibits Formation of Amyloid β Oligomers and Fibrils, Binds Plaques, and Reduces Amyloid in Vivo
Yang, F., Lim, G. P., Begum, A. N., Ubeda, O. J., Simmons, M. R., Ambegaokar, S. S., Chen, P. P., Kayed, R., Glabe, C. G., Frautschy, S. A., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m404751200 · Cited by 2,336 · see citing works
MAP Kinases in the Immune Response
Dong, C., Davis, R. J., & Flavell, R. A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.091301.131133 · Cited by 1,660 · see citing works
Antagonistic crosstalk between NF-κB and SIRT1 in the regulation of inflammation and metabolic disorders
Kauppinen, A., Suuronen, T., Ojala, J. O., Kaarniranta, K., & Salminen, A. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.06.007 · Cited by 1,001 · see citing works
Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression
Gao, H., & Hong, J. (2008) · Trends in Immunology · doi:10.1016/j.it.2008.05.002 · Cited by 822 · see citing works
Inhibiting NF-κB activation by small molecules as a therapeutic strategy
Gupta, S. C., Sundaram, C., Reuter, S., & Aggarwal, B. B. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2010.05.004 · Cited by 762 · see citing works
SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling
Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509329200 · Cited by 740 · see citing works
Glucocorticoids increase amyloid-β and tau pathology in a mouse model of alzheimer’s disease
Green, K. N., Billings, L. M., Roozendaal, B., McGaugh, J. L., & LaFerla, F. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2797-06.2006 · Cited by 623 · see citing works
Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease
Kaltschmidt, B., Uherek, M., Volk, B., Baeuerle, P. A., & Kaltschmidt, C. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2642 · Cited by 611 · see citing works
Roles for NF-κB in nerve cell survival, plasticity, and disease
Mattson, M. P., & Meffert, M. K. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401837 · Cited by 597 · see citing works
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
Sierra, A., Abiega, O., Shahraz, A., & Neumann, H. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00006 · Cited by 574 · see citing works
Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons
Brown, G. C., & Neher, J. J. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8105-9 · Cited by 526 · see citing works
A Cell Surface Receptor Complex for Fibrillar β-Amyloid Mediates Microglial Activation
Bamberger, M. E., Harris, M. E., McDonald, D. R., Husemann, J., & Landreth, G. E. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02665.2003 · Cited by 501 · see citing works
Constitutive NF-kB Activity in Neurons
Kaltschmidt, C., Kaltschmidt, B., Neumann, H., Wekerle, H., & Baeuerle, P. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3981-3992.1994 · Cited by 398 · see citing works
Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis
Cohen, J. A., & Chun, J. J. M. (2011) · Annals of Neurology · doi:10.1002/ana.22426 · Cited by 394 · see citing works
Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death
Jang, J.-H. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00062-5 · Cited by 391 · see citing works
Highly Stabilized Curcumin Nanoparticles Tested in an In Vitro Blood–Brain Barrier Model and in Alzheimer’s Disease Tg2576 Mice
Cheng, K. K., Yeung, C. F., Ho, S. W., Chow, S. F., Chow, A. H. L., & Baum, L. (2012) · The AAPS Journal · doi:10.1208/s12248-012-9444-4 · Cited by 315 · see citing works
Fingolimod: Direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy
Groves, A., Kihara, Y., & Chun, J. J. M. (2013) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2013.02.011 · Cited by 314 · see citing works
Amyloid-β peptide activates cultured astrocytes: morphological alterations, cytokine induction and nitric oxide release
Hu, J., Akama, K. T., Krafft, G. A., Chromy, B. A., & Eldik, L. J. V. (1998) · Brain Research · doi:10.1016/s0006-8993(97)01318-8 · Cited by 313 · see citing works
Constitutive NF-kappa B activity in neurons.
Kaltschmidt, C., Kaltschmidt, B., Neumann, H., Wekerle, H., & Baeuerle, P. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3981 · Cited by 304 · see citing works
Curcumin Inhibits Experimental Allergic Encephalomyelitis by Blocking IL-12 Signaling Through Janus Kinase-STAT Pathway in T Lymphocytes
Natarajan, C., & Bright, J. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6506 · Cited by 290 · see citing works
Natural polyphenols against neurodegenerative disorders: Potentials and pitfalls
Ebrahimi, A., & Schluesener, H. J. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.006 · Cited by 276 · see citing works
Green Tea (-)-Epigallocatechin-3-Gallate Inhibits β-Amyloid-Induced Cognitive Dysfunction through Modification of Secretase Activity via Inhibition of ERK and NF-κB Pathways in Mice ,
Lee, J. W., Lee, Y. K., Ban, J. O., Ha, T. Y., Yun, Y. P., Han, S., Oh, K. W., & Hong, J. T. (2009) · Journal of Nutrition · doi:10.3945/jn.109.109785 · Cited by 269 · see citing works
Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease
Cui, J. G., Li, Y. Y., Zhao, Y., Bhattacharjee, S., & Lukiw, W. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.178848 · Cited by 240 · see citing works
NF-κB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling
Kaltschmidt, B., Ndiaye‐Lobry, D., Körte, M., Pothion, S., Arbibe, L., Prüllage, M., Pfeiffer, J., Lindecke, A., Staiger, V., Israël, A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2936-2946.2006 · Cited by 229 · see citing works
A novel p38α MAPK inhibitor suppresses brain proinflammatory cytokine up-regulation and attenuates synaptic dysfunction and behavioral deficits in an Alzheimer's disease mouse model
Munoz, L., Ranaivo, H. R., Roy, S. M., Hu, W., Craft, J. M., McNamara, L. K., Chico, L. W., Van Eldik, L. J., & Watterson, D. M. (2007) · Journal of Neuroinflammation · doi:10.1186/1742-2094-4-21 · Cited by 224 · see citing works
Resveratrol Protects Rats from Aβ-induced Neurotoxicity by the Reduction of iNOS Expression and Lipid Peroxidation
Huang, T.-C., Lu, K., Wo, Y.-Y. P., Wu, Y.-J., & Yang, Y.-L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029102 · Cited by 217 · see citing works
Enhancement of immunoreactivity for NF-κB in the hippocampal formation and cerebral cortex of Alzheimer's disease
Terai, K., Matsuo, A., & McGeer, P. L. (1996) · Brain Research · doi:10.1016/0006-8993(96)00310-1 · Cited by 215 · see citing works
Oral Resveratrol Reduces Neuronal Damage in a Model of Multiple Sclerosis
Shindler, K. S., Ventura, E. S., Dutt, M., Elliott, P. J., Fitzgerald, D. C., & Rostami, A. M. (2010) · Journal of Neuro-Ophthalmology · doi:10.1097/wno.0b013e3181f7f833 · Cited by 203 · see citing works
Inhibition of transcription factor NF-κB in the central nervous system ameliorates autoimmune encephalomyelitis in mice
Loo, G., Lorenzi, R. D., Schmidt, H., Huth, M., Mildner, A., Schmidt‐Supprian, M., Lassmann, H., Prinz, M., & Pasparakis, M. (2006) · Nature Immunology · doi:10.1038/ni1372 · Cited by 196 · see citing works
Activation of Extrasynaptic, But Not Synaptic, NMDA Receptors Modifies Amyloid Precursor Protein Expression Pattern and Increases Amyloid-β Production
Bordji, K., Becerril-Ortega, J., Nicole, O., & Buisson, A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3021-10.2010 · Cited by 195 · see citing works
The NF-κB/Rel family of proteins mediates Aβ-induced neurotoxicity and glial activation
Bales, K. R., Du, Y., Dodel, R. C., Yan, G.-M., Hamilton‐Byrd, E., & Paul, S. M. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00066-7 · Cited by 186 · see citing works
NF-κB as a therapeutic target in neurodegenerative diseases
Camandola, S., & Mattson, M. P. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.2.123 · Cited by 184 · see citing works
Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production
Xie, L., Li, X., Funeshima, N., Kimura, H., Matsumoto, Y., Isaka, Y., & Takahara, S. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.01.025 · Cited by 180 · see citing works
Identification of a p65 Peptide That Selectively Inhibits NF-κ B Activation Induced by Various Inflammatory Stimuli and Its Role in Down-regulation of NF-κB-mediated Gene Expression and Up-regulation of Apoptosis
Takada, Y., Singh, S., & Aggarwal, B. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311192200 · Cited by 179 · see citing works
Gene structure and organization of the human β‐secretase ( BACE ) promoter
Sambamurti, K., Kinsey, R., Maloney, B., Ge, Y., & Lahiri, D. K. (2004) · The FASEB Journal · doi:10.1096/fj.03-1378fje · Cited by 179 · see citing works
Molecular Basis of the Anti-Inflammatory Effects of Terpenoids
Heras, B. D. L., & Hortelano, S. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152809787582534 · Cited by 171 · see citing works
Resveratrol Neuroprotection in a Chronic Mouse Model of Multiple Sclerosis
Fonseca-Kelly, Z., Nassrallah, M., Uribe, J., Khan, R. S., Dine, K. E., Dutt, M., & Shindler, K. S. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00084 · Cited by 168 · see citing works
Reduced astrocytic NF-κB activation by laquinimod protects from cuprizone-induced demyelination
Brück, W., Pförtner, R., Pham, T., Zhang, J., Hayardeny, L., Piryatinsky, V., Hanisch, U., Regen, T., van Rossum, D., Brakelmann, L., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-1009-1 · Cited by 168 · see citing works
Micro RNA-125b (miRNA-125b) function in astrogliosis and glial cell proliferation
Pogue, A. I., Cui, J. G., Li, Y. Y., Zhao, Y., Culicchia, F., & Lukiw, W. J. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.03.054 · Cited by 165 · see citing works
Activation of NF-κB and c-jun Transcription Factors in Multiple Sclerosis Lesions
Bonetti, B., Stegagno, C., Cannella, B., Rizzuto, N., Moretto, G., & Raine, C. S. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65456-9 · Cited by 163 · see citing works
Experimental autoimmune encephalomyelitis in NF-kappa B-deficient mice:roles of NF-kappa B in the activation and differentiation of autoreactive T cells.
Hilliard, B. A., Samoilova, E. B., Liu, T. S., Rostami, A. M., & Chen, Y. (1999) · PubMed · Cited by 160 · see citing works
Opposing Roles for NF-κB/Rel Factors p65 and c-Rel in the Modulation of Neuron Survival Elicited by Glutamate and Interleukin-1β
Pizzi, M., Goffi, F., Boroni, F., Benarese, M., Perkins, S. E., Liou, H., & Spano, P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201014200 · Cited by 156 · see citing works
Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology
Guire, C. M., Prinz, M., Beyaert, R., & Loo, G. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.08.001 · Cited by 154 · see citing works
Nuclear translocation of NF-κB in cholinergic neurons of patients with Alzheimerʼs disease
Boissière‐Michot, F., Hunot, S., Faucheux, B. A., Duyckaerts, C. J., Hauw, J., Agid, Y., & Hirsch, É. C. (1997) · Neuroreport · doi:10.1097/00001756-199709080-00009 · Cited by 152 · see citing works
Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin
Ray, B., & Lahiri, D. K. (2009) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2009.06.012 · Cited by 152 · see citing works
NF‐κB pathway: a target for preventing β‐amyloid (Aβ)‐induced neuronal damage and Aβ42 production
Valerio, A., Boroni, F., Benarese, M., Sarnico, I., Ghisi, V., Bresciani, L. G., Ferrario, M., Borsani, G., Spano, P., & Pizzi, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04722.x · Cited by 148 · see citing works
Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappaB modulation in MES23.5 cells
Wang, J., Du, X., Jiang, H. F., & Xie, J. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.03.031 · Cited by 146 · see citing works
Neuroinflammation and Alzheimer's disease: critical roles for cytokine/Aβ-induced glial activation, NF-κB, and apolipoprotein E
Bales, K. (2000) · Neurobiology of Aging · doi:10.1016/s0197-4580(00)00143-3 · Cited by 143 · see citing works
TH17 cytokines in autoimmune neuro-inflammation
Becher, B., & Segal, B. M. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.08.005 · Cited by 142 · see citing works
Experimental Autoimmune Encephalomyelitis in NF-κB- Deficient Mice: Roles of NF-κB in the Activation and Differentiation of Autoreactive T Cells
Hilliard, B. A., Samoilova, E. B., Liu, T.-S. T., Rostami, A. M., & Chen, Y. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.5.2937 · Cited by 142 · see citing works
Antineuroinflammatory Effect of NF-κB Essential Modifier-Binding Domain Peptides in the Adoptive Transfer Model of Experimental Allergic Encephalomyelitis
Dasgupta, S., Jana, M., Zhou, Y., Fung, Y. K., Ghosh, S., & Pahan, K. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.2.1344 · Cited by 125 · see citing works
NFκB-dependent Control of BACE1 Promoter Transactivation by Aβ42
Buggia-Prévot, V., Sévalle, J., Roßner, S., & Checler, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706579200 · Cited by 125 · see citing works
Nuclear Factor-κB Regulates βAPP and β- and γ-Secretases Differently at Physiological and Supraphysiological Aβ Concentrations
Chami, L., Buggia-Prévot, V., Duplan, E., Delprete, D., Chami, M., Peyron, J., & Checler, F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.333054 · Cited by 120 · see citing works
Transcription Factor NF-kB and Inhibitor kBα are Localized in Macrophages in Active Multiple Sclerosis Lesions
Gveric, D. O., Kaltschmidt, C., Cuzner, M. L., & Newcombe, J. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199802000-00008 · Cited by 117 · see citing works
Epigallocatechin-3-gallate suppresses NF-κB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells
Kim, S.-J., Jeong, H.-J., Lee, K.-M., Myung, N.-Y., An, N.-H., Mo Yang, W., Kyu Park, S., Lee, H.-J., Hong, S.-H., Kim, H.-M., et al. (2007) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2006.11.001 · Cited by 116 · cited 11× · see citing works
“The localized increase in free radical generation promotes increased APP processing, Ab deposition, and tau phosphorylation.”
BackgroundInfluential
Regulation of Neurotropic Signaling by the Inducible, NF-kB-Sensitive miRNA-125b in Alzheimer's Disease (AD) and in Primary Human Neuronal-Glial (HNG) Cells
Zhao, Y., Bhattacharjee, S., Jones, B. M., Hill, J. M., Dua, P., & Lukiw, W. J. (2013) · Molecular Neurobiology · doi:10.1007/s12035-013-8595-3 · Cited by 115 · see citing works
Decreased severity of experimental autoimmune encephalomyelitis during resveratrol administration is associated with increased IL-17+IL-10+ T cells, CD4− IFN-γ+ cells, and decreased macrophage IL-6 expression
Imler, T. J., & Petro, T. M. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.10.015 · Cited by 100 · see citing works
NF-κB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid β-peptide toxicity
Pizzi, M., Sarnico, I., Boroni, F., Benarese, M., Steimberg, N., Mazzoleni, G., Dietz, G. P. H., Bähr, M., Liou, H.-C., & Spano, P. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401598 · Cited by 100 · see citing works
Neuroprotective Effect of Combination Therapy of Glatiramer Acetate and Epigallocatechin-3-Gallate in Neuroinflammation
Herges, K., Millward, J. M., Hentschel, N., Infante‐Duarte, C., Aktaş, O., & Zipp, F. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025456 · Cited by 100 · see citing works
Demethoxycurcumin, a natural derivative of curcumin attenuates LPS-induced pro-inflammatory responses through down-regulation of intracellular ROS-related MAPK/NF-κB signaling pathways in N9 microglia induced by lipopolysaccharide
Zhang, L., Wu, C., Zhao, S., Yuan, D., Lian, G., Wang, X., Wang, L., & Yang, J. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.12.004 · Cited by 99 · see citing works
Inhibitory effect of green tea extract on β-amyloid-induced PC12 cell death by inhibition of the activation of NF-κB and ERK/p38 MAP kinase pathway through antioxidant mechanisms
Lee, S. Y., Lee, J. W., Lee, H., Yoo, H. S., Yun, Y. P., Oh, K. W., Ha, T. Y., & Hong, J. T. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.07.009 · Cited by 98 · see citing works
Chapter 24 NF‐KappaB Dimers in the Regulation of Neuronal Survival
Sarnico, I., Lanzillotta, A., Benarese, M., Alghisi, M., Baiguera, C., Battistin, L., Spano, P., & Pizzi, M. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85024-1 · Cited by 97 · see citing works
Beneficial actions of oleanolic acid in an experimental model of multiple sclerosis: A potential therapeutic role
Martín, R., Tavares, J. C., Hernández, M., Arnés, M., Ruíz-Gutiérrez, V., & Nieto, M. L. (2009) · Biochemical Pharmacology · doi:10.1016/j.bcp.2009.08.002 · Cited by 97 · see citing works
Minimal NF-κB activity in neurons
LISTWAK, S. J., Rathore, P., & Herkenham, M. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.013 · Cited by 95 · see citing works
The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection
Tran, T. A. T., McCoy, M. K., Sporn, M. B., & Tansey, M. G. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-14 · Cited by 95 · see citing works
Molecular targets of non-steroidal anti-inflammatory drugs in neurodegenerative diseases
Lleo, A., Galea, E., & Sastre, M. (2007) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-007-6516-1 · Cited by 93 · see citing works
Dual roles of NF-κB in cell survival and implications of NF-κB inhibitors in neuroprotective therapy
Qin, Z., Tao, L., & Chen, X. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00741.x · Cited by 92 · see citing works
Expression and Genetic Analysis of MicroRNAs Involved in Multiple Sclerosis
Ridolfi, E., Fenoglio, C., Cantoni, C., Calvi, A., Riz, M. A. D., Pietroboni, A. M., Villa, C., Serpente, M., Bonsi, R., Vercellino, M., et al. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14034375 · Cited by 89 · see citing works
Vasoactive intestinal peptide protects against β‐amyloid‐induced neurodegeneration by inhibiting microglia activation at multiple levels
Delgado, M., Varela, N., & González‐Rey, E. (2008) · Glia · doi:10.1002/glia.20681 · Cited by 85 · see citing works
Inhibitors in the NFκB cascade comprise prime candidate genes predisposing to multiple sclerosis, especially in selected combinations
Miterski, B., Böhringer, S., Klein, W., Sindern, E., Haupts, M. R., Schimrigk, S., & Epplen, J. T. (2002) · Genes and Immunity · doi:10.1038/sj.gene.6363846 · Cited by 82 · see citing works
The increasing burden of mental and neurological disorders
Catalá-López, F., Gènova-Maleras, R., Vieta, E., & Tabarés‐Seisdedos, R. (2013) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.04.001 · Cited by 79 · see citing works
Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis
Pahan, K., & Schmid, M. J. (2000) · Neuroscience Letters · doi:10.1016/s0304-3940(00)01167-8 · Cited by 77 · see citing works
Interferon‐β activates multiple signaling cascades in primary human microglia
Kim, M., Si, Q., Zhou, J., Pestell, R. G., Brosnan, C. F., Locker, J. D., & Lee, S. C. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00949.x · Cited by 75 · see citing works
Resveratrol Exacerbates Both Autoimmune and Viral Models of Multiple Sclerosis
Sato, F., Martinez, N. E., Shahid, M., ROSE, J. W., Carlson, N. G., & Tsunoda, I. (2013) · American Journal Of Pathology · doi:10.1016/j.ajpath.2013.07.006 · Cited by 75 · see citing works
Diammonium Glycyrrhizinate Attenuates Aβ1–42‐Induced Neuroinflammation and Regulates MAPK and NF‐κB Pathways In Vitro and In Vivo
Zhao, H., Wang, S., Qian, L., Jin, J., Li, H., Xu, Y., & Zhu, X. (2012) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12043 · Cited by 71 · see citing works
Tripchlorolide protects neuronal cells from microglia‐mediated β‐amyloid neurotoxicity through inhibiting NF‐κB and JNK signaling
Pan, X., Chen, X., Zhu, Y., Chen, L., Zhang, J., Huang, T., Ye, Q., & Huang, H. (2009) · Glia · doi:10.1002/glia.20844 · Cited by 70 · see citing works
Triptolide inhibits amyloid-β1-42-induced TNF-α and IL-1β production in cultured rat microglia
Jiao, J., Xue, B., Zhang, L., Gong, Y., Li, K., Wang, H., Jing, L., Xie, J., & Wang, X. (2008) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2008.08.006 · Cited by 69 · see citing works
Salubrinal attenuates β-amyloid-induced neuronal death and microglial activation by inhibition of the NF-κB pathway
Huang, X., Chen, Y., Zhang, H., Ma, Q., Zhang, Y., & Xu, H. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.10.007 · Cited by 68 · see citing works
Kinase Inhibitors as Potential Therapeutics for Acute and Chronic Neurodegenerative Conditions
Cuny, G. D. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209789649330 · Cited by 65 · see citing works
Novel p65 Binding Glucocorticoid-induced Leucine Zipper Peptide Suppresses Experimental Autoimmune Encephalomyelitis
Srinivasan, M., & Janardhanam, S. B. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.279257 · Cited by 65 · see citing works
Corticosteroids Impair Remyelination in the Corpus Callosum of Cuprizone-Treated Mice
Clarner, T., Parabucki, A., Beyer, C., & Kipp, M. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02140.x · Cited by 60 · see citing works
Analysis of compound heterozygous mice reveals that the Trembler mutation can behave as a gain‐of‐function allele
Adlkofer, K., Naef, R., & Suter, U. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970915)49:6 · Cited by 59 · see citing works
A comparative study of curcuminoids to measure their effect on inflammatory and apoptotic gene expression in an Aβ plus ibotenic acid-infused rat model of Alzheimer's disease
Ahmed, T., & Gilani, A. H. (2011) · Brain Research · doi:10.1016/j.brainres.2011.05.022 · Cited by 58 · see citing works
Optical and SPION-Enhanced MR Imaging Shows that trans-Stilbene Inhibitors of NF-κB Concomitantly Lower Alzheimer's Disease Plaque Formation and Microglial Activation in AβPP/PS-1 Transgenic Mouse Brain
Solberg, N. O., Chamberlin, R., Vigil, J. R., Deck, L. M., Heidrich, J. E., Brown, D. C., Brady, C. I., Jagt, T. A. V., Garwood, M., Bisoffi, M., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131031 · Cited by 56 · see citing works
A pilot study on the use of interferon beta-1a in early Alzheimer’s disease subjects
Grimaldi, L. M. E., Zappalà, G., Iemolo, F., Castellano, A. E., Ruggieri, S. A., Bruno, G., & Paolillo, A. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-30 · Cited by 54 · see citing works
Dual effects of daily FTY720 on human astrocytes in vitro: relevance for neuroinflammation
Wu, C., Leong, S. Y., Moore, C. S., Cui, Q., Gris, P., Bernier, L., Johnson, T., Séguéla, P., Kennedy, T. E., Bar‐Or, A., et al. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-41 · Cited by 51 · see citing works
Targeting VIP and PACAP Receptor Signalling: New Therapeutic Strategies in Multiple Sclerosis
Tan, Y., & Waschek, J. A. (2011) · ASN NEURO · doi:10.1042/an20110024 · Cited by 47 · see citing works
Oral administration of triptolide ameliorates the clinical signs of experimental autoimmune encephalomyelitis (EAE) by induction of HSP70 and stabilization of NF-κB/IκBα transcriptional complex
Kizelsztein, P., Komarnytsky, S., & Raskin, I. (2009) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2009.08.017 · Cited by 46 · see citing works
Molecular Network Analysis of T‐Cell Transcriptome Suggests Aberrant Regulation of Gene Expression by NF‐κB As a Biomarker for Relapse of Multiple Sclerosis
Satoh, J., Misawa, T., Tabunoki, H., & Yamamura, T. (2008) · Disease Markers · doi:10.1155/2008/824640 · Cited by 46 · see citing works
Xanthoceraside Inhibits Pro-inflammatory Cytokine Expression in Aβ25–35/IFN-γ–Stimulated Microglia Through the TLR2 Receptor, MyD88, Nuclear Factor-κB, and Mitogen-Activated Protein Kinase Signaling Pathways
Qi, Y. A., Zou, L., Wang, L., Jin, G., Pan, J., Chi, T., & Ji, X. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.13031fp · Cited by 45 · see citing works
Dose-dependent and sequence-sensitive effects of amyloid-β peptide on neurosteroidogenesis in human neuroblastoma cells
Schaeffer, V., Meyer, L., Patte‐Mensah, C., Eckert, A., & Mensah‐Nyagan, A. G. (2008) · Neurochemistry International · doi:10.1016/j.neuint.2008.01.010 · Cited by 44 · see citing works
Functional characterization of three single‐nucleotide polymorphisms present in the human APOE promoter sequence: Differential effects in neuronal cells and on DNA–protein interactions
Maloney, B., Ge, Y., Petersen, R. C., Hardy, J., Rogers, J. T., Pérez‐Tur, J., & Lahiri, D. K. (2009) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30973 · Cited by 44 · see citing works
Dual roles of NF-KB in cell survival and implications of NF-KB inhibitors in neuroprotective therapy
Zhenghong, Qin, L., Luyang, Tao, T., Xin, & Chen (2007) · 中国药理学报：英文版 · Cited by 41 · see citing works
Inhibition of IκBα phosphorylation prevents glutamate-induced NF-κB activation and neuronal cell death
Pizzi, M., Sarnico, I., Boroni, F., Benetti, A., Benarese, M., & Spano, P. (2005) · Acta neurochirurgica. Supplementum · doi:10.1007/3-211-27577-0_8 · Cited by 36 · see citing works
Effects of Resveratrol and trans-3,5,4'-Trimethoxystilbene on Glutamate-Induced Cytotoxicity, Heme Oxygenase-1, and Sirtuin 1 in HT22 Neuronal Cells
Kim, D. W., Kim, Y., Kang, S. D., Han, Y., & Pae, H. (2012) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2012.20.3.306 · Cited by 30 · see citing works
NF-κB mediates amyloid β peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells
Du, Y.-S., Chen, X., Wei, X.-L., Bales, K., Berg, D., Paul, S., Farlow, M., Maloney, B., Ge, Y.-W., & Lahiri, D. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2005.02.001 · Cited by 28 · see citing works
The influence of donepezil and EGb 761 on the innate immunity of human leukocytes
Sochocka, M., Zaczyńska, E., Taboł, A., Czarny, A., Leszek, J., & Sobczyński, M. (2010) · International Immunopharmacology · doi:10.1016/j.intimp.2010.08.024 · Cited by 27 · see citing works
Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-κB Signaling
Yin, Q.-Q., Liu, C., Wu, Y., Wu, S.-F., Wang, Y., Zhang, X., Hu, X.-J., Pu, J., Lu, Y., Zhou, H.-C., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203546 · Cited by 25 · see citing works
A Role for Neuronal NF-κB in Suppressing Neuroinflammation and Promoting Neuroprotection in the CNS
Emmanouil, M., Taoufik, E., Tseveleki, V., Vamvakas, S. M., & Probert, L. (2010) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-6612-4_60 · Cited by 23 · see citing works
The inhibitor of IkappaBalpha phosphorylation BAY 11-7082 prevents NMDA neurotoxicity in mouse hippocampal slices
Goffi, F., Boroni, F., Benarese, M., Sarnico, I., Benetti, A., Spano, P., & Pizzi, M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.11.088 · Cited by 21 · see citing works
Targeting cytokine expression in glial cells by cellular delivery of an NF-κB decoy
Fisher, L., Samuelsson, M., Jiang, Y., Ramberg, V., Figueroa, R., Hallberg, E., Langel, Ü., & Iverfeldt, K. (2007) · Journal of Molecular Neuroscience · doi:10.1385/jmn:31:03:209 · Cited by 19 · see citing works
Intrathecal corticosteroids might slow Alzheimer’s disease progression
Alisky, J. M. (2008) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s3685 · Cited by 18 · see citing works
Amyloid β peptide-mediated neurotoxicity is attenuated by the proliferating microglia more potently than by the quiescent phenotype
Tsay, H.-J., Huang, Y., Huang, F.-L., Chen, C.-P., Tsai, Y.-C., Wang, Y.-H., Wu, M.-F., Chiang, F.-Y., & Shiao, Y. (2013) · Journal of Biomedical Science · doi:10.1186/1423-0127-20-78 · Cited by 16 · see citing works
High-dose methylprednisolone infusions in relapsing and in chronic progressive multiple sclerosis patients. One year follow-up.
Bergamaschi, R., Versino, M., Raiola, E., Citterio, A., & Cosi, V. (1993) · PubMed · Cited by 12 · see citing works
Functional characterization of a competitive peptide antagonist of p65 in human macrophage-like cells suggests therapeutic potential for chronic inflammation
Srinivasan, M., Lahiri, D. K., & Blackburn, C. (2014) · Drug Design Development and Therapy · doi:10.2147/dddt.s59722 · Cited by 10 · see citing works

Flagged first, then by citations

1 of the 108 references couldn’t be matched to a known paper.

Sorted by citations

Mechanisms of NF-&kappa;B p65 and strategies for therapeutic manipulation
Giridharan, S., & Srinivasan, M. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s140188 · Cited by 686 · see citing works
microRNA dysregulation in neurodegenerative diseases: A systematic review
Juźwik, C. A., Drake, S., Zhang, Y., Paradis-Isler, N., Sylvester, A., Amar‐Zifkin, A., Douglas, C., Morquette, B., Moore, C. S., & Fournier, A. E. (2019) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2019.101664 · Cited by 436 · see citing works
The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease
Sun, E., Motolani, A., Campos, L., & Lu, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168972 · Cited by 369 · see citing works
Targeting Transcription Factors for Cancer Treatment
Lambert, M., Jambon, S., Depauw, S., & David‐Cordonnier, M. (2018) · Molecules · doi:10.3390/molecules23061479 · Cited by 351 · see citing works
Nanotechnology-based drug delivery systems for the treatment of Alzheimer’s disease
Fonseca‐Santos, B., Chorilli, M., & Gremião, M. P. D. (2015) · International Journal of Nanomedicine · doi:10.2147/ijn.s87148 · Cited by 313 · see citing works
Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach
Singh, S., & Singh, T. G. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200207120949 · Cited by 299 · see citing works
Shaping the Nrf2-ARE-related pathways in Alzheimer’s and Parkinson’s diseases
Fão, L., Mota, S. I., & Rego, A. C. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100942 · Cited by 270 · see citing works
Green tea polyphenols and their potential role in health and disease
Afzal, M., Safer, A.-M., & Menon, M. (2015) · Inflammopharmacology · doi:10.1007/s10787-015-0236-1 · Cited by 207 · see citing works
Putative Role of Red Wine Polyphenols against Brain Pathology in Alzheimer’s and Parkinson’s Disease
Caruana, M., Cauchi, R. J., & Vassallo, N. (2016) · Frontiers in Nutrition · doi:10.3389/fnut.2016.00031 · Cited by 162 · see citing works
Nuclear factor‐kappa β as a therapeutic target for Alzheimer's disease
Jha, N. K., Jha, S. K., Kar, R., Nand, P., Swati, K., & Goswami, V. K. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14687 · Cited by 160 · see citing works
microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration
Bhattacharjee, S., Zhao, Y., Dua, P., Rogaev, E. I., & Lukiw, W. J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0150211 · Cited by 147 · see citing works
Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti-inflammatory capacity in a cellular model of Alzheimer's disease
Zhao, F., Zhang, J., & Chang, N. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.01.046 · Cited by 128 · see citing works
Polyphenols Targeting NF-κB Pathway in Neurological Disorders: What We Know So Far?
Mamun, A. A., Shao, C., Geng, P., Wang, S., & Xiao, J. (2024) · International Journal of Biological Sciences · doi:10.7150/ijbs.90982 · Cited by 134 · see citing works
NF-κB Pathway and Its Inhibitors: A Promising Frontier in the Management of Alzheimer’s Disease
Sivamaruthi, B. S., Raghani, N. R., Chorawala, M. R., Bhattacharya, S., Prajapati, B. G., Elossaily, G. M., & Chaiyasut, C. (2023) · Biomedicines · doi:10.3390/biomedicines11092587 · Cited by 124 · see citing works
New insights into the role and mechanisms of ginsenoside Rg1 in the management of Alzheimer’s disease
Wu, J., Yu, Y., Wan, Y., Xia, J., Xu, J., Zhang, L., Liu, D., Chen, L., Tang, F., Ao, H., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113207 · Cited by 116 · see citing works
Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy
Arya, A., Chahal, R., Rao, R., Rahman, M. H., Kaushik, D., Akhtar, M. F., Saleem, A., Khalifa, S. M. A., El-Seedi, H. R., Kamel, M., et al. (2021) · Biomolecules · doi:10.3390/biom11030350 · Cited by 111 · see citing works
Treatment of Sjögren’s syndrome: current therapy and future directions
Fox, R. I., Fox, C. M., Gottenberg, J., & Dörner, T. (2019) · Lara D. Veeken · doi:10.1093/rheumatology/kez142 · Cited by 109 · see citing works
On the antioxidant, neuroprotective and anti-inflammatory properties of S-allyl cysteine: An update
Colín-González, A. L., Ali, S. F., Túnez, I., & Santamarı́a, A. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.06.011 · Cited by 106 · see citing works
Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances
Deng, Q., Wu, C., Parker, E., Liu, T. C.-Y., Duan, R., & Yang, L. (2023) · Aging and disease · doi:10.14336/ad.2023.0907 · Cited by 102 · see citing works
An overview of the relationship between inflammation and cognitive function in humans, molecular pathways and the impact of nutraceuticals
Mekhora, C., Lamport, D. J., & Spencer, J. P. E. (2024) · Neurochemistry International · doi:10.1016/j.neuint.2024.105900 · Cited by 103 · see citing works
Neurotoxicity of Polycyclic Aromatic Hydrocarbons: A Systematic Mapping and Review of Neuropathological Mechanisms
Olasehinde, T. A., & Olaniran, A. O. (2022) · Toxics · doi:10.3390/toxics10080417 · Cited by 101 · see citing works
Formononetin inhibits neuroinflammation and increases estrogen receptor beta (ERβ) protein expression in BV2 microglia
El-Bakoush, A., & Olajide, O. A. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.06.016 · Cited by 92 · see citing works
Nuclear factor‐kappa B (NF‐κB) in pathophysiology of Parkinson disease: Diverse patterns and mechanisms contributing to neurodegeneration
Dolatshahi, M., Hameghavandi, M. H. R., Sabahi, M., & Rostamkhani, S. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15242 · Cited by 85 · see citing works
The Influence of Gut Microbiota on Neurogenesis: Evidence and Hopes
Sarubbo, F., Cavallucci, V., & Pani, G. (2022) · Cells · doi:10.3390/cells11030382 · Cited by 82 · see citing works
Molecular Mechanisms of Lithium Action: Switching the Light on Multiple Targets for Dementia Using Animal Models
Kerr, F., Bjedov, I., & Sofola-Adesakin, O. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00297 · Cited by 78 · see citing works
Melatonin prevents diabetes‐associated cognitive dysfunction from microglia‐mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway
Cui, Y., Yang, M., Wang, Y., Ren, J., Lin, P., Cui, C., Song, J., He, Q., Hu, H., Wang, K., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002247rr · Cited by 73 · see citing works
α-Cyperone inhibits LPS-induced inflammation in BV-2 cells through activation of Akt/Nrf2/HO-1 and suppression of the NF-κB pathway
Huang, B., He, D., Chen, G., Ran, X., Guo, W., Kan, X., Wang, W., Liu, D., Fu, S., & Liu, J. (2018) · Food & Function · doi:10.1039/c8fo00057c · Cited by 71 · see citing works
Down-regulated expression of microRNA-338-5p contributes to neuropathology in Alzheimer’s disease.
Qian, Q., Zhang, J., He, F.-P., Bao, W.-X., Zheng, T.-T., Zhou, D.-M., Pan, H.-Y., Zhang, H., Zhang, X.-Q., He, X., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201801846r · Cited by 70 · see citing works
Transcriptional regulation of homeostatic and disease‐associated‐microglial genes by IRF1, LXRβ, and CEBPα
Gao, T., Jernigan, J. E., Raza, S. A., Dammer, E. B., Xiao, H., Seyfried, N. T., Levey, A. I., & Rangaraju, S. (2019) · Glia · doi:10.1002/glia.23678 · Cited by 64 · see citing works
SIRT1 Promotes Neuronal Fortification in Neurodegenerative Diseases through Attenuation of Pathological Hallmarks and Enhancement of Cellular Lifespan
Mishra, P., Mittal, A. K., Kalonia, H., Madan, S., Ghosh, S., Sinha, J. K., & Rajput, S. K. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200729111744 · Cited by 68 · see citing works
Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages
Jin, Y., Zhang, Q., Qin, X., Liu, Z., Li, Z., Zhong, X.-T., Xia, L., He, J., & Fang, B. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01681-6 · Cited by 57 · see citing works
Glial cell response to Epstein-Barr Virus infection: A plausible contribution to virus-associated inflammatory reactions in the brain
Jakhmola, S., & Jha, H. C. (2021) · Virology · doi:10.1016/j.virol.2021.04.005 · Cited by 63 · see citing works
Modulation of nuclear factor-kappa B activation by the endoplasmic reticulum stress sensor PERK to mediate estrogen-induced apoptosis in breast cancer cells
Fan, P., Tyagi, A. K., Agboke, F. A., Mathur, R., Pokharel, N., & Jordan, V. C. (2018) · Cell Death Discovery · doi:10.1038/s41420-017-0012-7 · Cited by 62 · see citing works
Impact of aging immune system on neurodegeneration and potential immunotherapies
Liang, Z., Zhao, Y., Ruan, L., Zhu, L., Jin, K., Zhuge, Q., Su, D., & Zhao, Y. L. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.07.006 · Cited by 61 · see citing works
Metformin Therapy Attenuates Pro-inflammatory Microglia by Inhibiting NF-κB in Cuprizone Demyelinating Mouse Model of Multiple Sclerosis
Abdi, M., Pasbakhsh, P., Shabani, M., Nekoonam, S., Sadeghi, A., Fathi, F., Abouzaripour, M., Mohamed, W. M. Y., Zibara, K., Kashani, I. R., et al. (2021) · Neurotoxicity Research · doi:10.1007/s12640-021-00417-y · Cited by 56 · see citing works
MicroRNA (miRNA) Signaling in the Human CNS in Sporadic Alzheimer’s Disease (AD)-Novel and Unique Pathological Features
Zhao, Y., Pogue, A. I., & Lukiw, W. J. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms161226223 · Cited by 57 · see citing works
Enteric Glia at the Crossroads between Intestinal Immune System and Epithelial Barrier: Implications for Parkinson Disease
Benvenuti, L., D’Antongiovanni, V., Pellegrini, C., Antonioli, L., Bernardini, N., Blandizzi, C., & Fornai, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21239199 · Cited by 56 · see citing works
Hsp70 and NF-kB Mediated Control of Innate Inflammatory Responses in a Canine Macrophage Cell Line
Lyu, Q., Wawrzyniuk, M., Rutten, V. P. M. G., van Eden, W., Sijts, A. J. A. M., & Broere, F. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186464 · Cited by 55 · see citing works
Inhibitors of Src Family Kinases, Inducible Nitric Oxide Synthase, and NADPH Oxidase as Potential CNS Drug Targets for Neurological Diseases
Gage, M., & Thippeswamy, T. (2021) · CNS Drugs · doi:10.1007/s40263-020-00787-5 · Cited by 54 · see citing works
Methylglyoxal Formation—Metabolic Routes and Consequences
Vašková, J., Sabolová, G., Pudelský, J., Palenčár, D., & Mičková, H. (2025) · Antioxidants · doi:10.3390/antiox14020212 · Cited by 54 · see citing works
Apigetrin from Scutellaria baicalensis Georgi Inhibits Neuroinflammation in BV-2 Microglia and Exerts Neuroprotective Effect in HT22 Hippocampal Cells
Lim, H.-S., Kim, O. S., Kim, B., & Jeong, S. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2016.0074 · Cited by 50 · see citing works
Caniferolide A, a Macrolide from Streptomyces caniferus, Attenuates Neuroinflammation, Oxidative Stress, Amyloid-Beta, and Tau Pathology in Vitro
Alvariño, R., Alonso, E., Lacret, R., Oves‐Costales, D., Genilloud, O., Reyes, F., Alfonso, A., & Botana, L. M. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01090 · Cited by 48 · see citing works
Regulation of Human Brain Microvascular Endothelial Cell Adhesion and Barrier Functions by Memantine
Wang, F., Zou, Z., Gong, Y., Yuan, D., Chen, X., & Sun, T. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0917-x · Cited by 47 · see citing works
Toxoplasma gondii: A possible etiologic agent for Alzheimer's disease
Nayeri, T., Sarvi, S., Sharif, M., & Daryani, A. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e07151 · Cited by 44 · see citing works
A Mechanistic Evaluation of Antioxidant Nutraceuticals on Their Potential against Age-Associated Neurodegenerative Diseases
Ramli, N. Z., Yahaya, M. F., Tooyama, I., & Damanhuri, H. A. (2020) · Antioxidants · doi:10.3390/antiox9101019 · Cited by 42 · see citing works
ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking
Xie, M.-X., Cao, X., Zeng, W., Lai, R.-C., Guo, L., Wang, J., Xiao, Y.-B., Zhang, X., Chen, D., Liu, X., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21731-1 · Cited by 38 · see citing works
Rhinacanthin C Alleviates Amyloid‐β Fibrils’ Toxicity on Neurons and Attenuates Neuroinflammation Triggered by LPS, Amyloid‐β, and Interferon‐γ in Glial Cells
Chuang, K., Li, M., Lin, N., Chang, C.-H., Lu, I.-H., Pan, I.-H., Takahashi, T., Perng, M., & Wen, S. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/5414297 · Cited by 39 · see citing works
Modulation of inflammation by toll-like receptor 4/nuclear factor-kappa B in diarrhea-predominant irritable bowel syndrome
He, X., Cui, L., Wang, X., Yan, Z., Li, C., Gong, S.-D., Zheng, Y., Luo, Z., & Wang, Y. (2017) · Oncotarget · doi:10.18632/oncotarget.23045 · Cited by 37 · see citing works
Interaction of NF-κB and Wnt/β-catenin Signaling Pathways in Alzheimer’s Disease and Potential Active Drug Treatments
Liu, X., Wang, K., Wei, X., Xie, T., Lv, B., Zhou, Q., & Wang, X. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03227-y · Cited by 37 · see citing works
The DEAD-Box RNA Helicase DDX3 Interacts with NF-κB Subunit p65 and Suppresses p65-Mediated Transcription
Xiang, N., He, M., Ishaq, M., Gao, Y., Song, F., Guo, L., Ma, L., Sun, G., Liu, D., Guo, D., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0164471 · Cited by 36 · see citing works
Betulin Alleviates the Inflammatory Response in Mouse Chondrocytes and Ameliorates Osteoarthritis via AKT/Nrf2/HO-1/NF-κB Axis
Ren, C., Jin, J., Hu, W. M., Chen, Q., Yang, J., Wu, Y., Zhou, Y., Sun, L., Gao, W., Zhang, X., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.754038 · Cited by 35 · see citing works
Mechanisms of microRNA-132 in central neurodegenerative diseases: A comprehensive review
Mu, C., Gao, M., Xu, W., Sun, X., Chen, T., Xu, H., & Qiu, H. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116029 · Cited by 35 · see citing works
Stem Cells as Potential Targets of Polyphenols in Multiple Sclerosis and Alzheimer’s Disease
Tandon, A., Singh, S. J., & Chaturvedi, R. K. (2018) · BioMed Research International · doi:10.1155/2018/1483791 · Cited by 35 · see citing works
Nuclear Factor-kappaB Gates Nav1.7 Channels in DRG Neurons via Protein-Protein Interaction
Xie, M.-X., Zhang, X., Xu, J., Zeng, W., Li, D., Xu, T., Pang, R., Ma, K., & Liu, X. (2019) · iScience · doi:10.1016/j.isci.2019.08.017 · Cited by 34 · see citing works
Beta-naphthoflavone inhibits LPS-induced inflammation in BV-2 cells via AKT/Nrf-2/HO-1-NF-κB signaling axis
Gao, X., He, D., Liu, D., Hu, G., Zhang, Y., Meng, T., Su, Y., Zhou, A., Huang, B., Du, J., et al. (2020) · Immunobiology · doi:10.1016/j.imbio.2020.151965 · Cited by 33 · see citing works
Differential DNA methylation in the brain as potential mediator of the association between traffic‐related PM2.5 and neuropathology markers of Alzheimer's disease
Li, Z., Liang, D., Ebelt, S., Gearing, M., Kobor, M. S., Konwar, C., Maclsaac, J. L., Dever, K., Wingo, A. P., Levey, A. I., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13650 · Cited by 32 · see citing works
Pathogenic microRNAs Common to Brain and Retinal Degeneration; Recent Observations in Alzheimer’s Disease and Age-Related Macular Degeneration
Hill, J. M., Pogue, A. I., & Lukiw, W. J. (2015) · Frontiers in Neurology · doi:10.3389/fneur.2015.00232 · Cited by 31 · see citing works
Play in advance against neurodegeneration: exploring enteric glial cells in gut-brain axis during neurodegenerative diseases
Seguella, L., Capuano, R., Sarnelli, G., & Esposito, G. (2019) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2019.1612744 · Cited by 31 · see citing works
A mechanistic review of pharmacological activities of homeopathic medicine licorice against neural diseases
Zulfugarova, P., Zivari‐Ghader, T., Maharramova, S., Ahmadian, E., Eftekhari, A., Khalilov, R. I., Türksoy, V. A., Rosic, G. L., & Selaković, D. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1148258 · Cited by 30 · see citing works
Anti-microRNAs as Novel Therapeutic Agents in the Clinical Management of Alzheimer's Disease
Zhao, Y., Alexandrov, P. N., & Lukiw, W. J. (2016) · Frontiers in Neuroscience · doi:10.3389/fnins.2016.00059 · Cited by 30 · see citing works
Dl-3-n-Butylphthalide Exerts Dopaminergic Neuroprotection Through Inhibition of Neuroinflammation
Chen, Y., Wu, T., Li, H., Li, X., Li, Q., Zhu, X., Yu, M., Kuo, S., Huang, F., & Wu, Y. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00044 · Cited by 30 · see citing works
Neuroprotective effects of glucomoringin-isothiocyanate against H2O2-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells
Mohammed, J. S., Nordin, N., Rosli, R., Shaari, K., Bako, H. Y., Saad, N., Noor, N. M., & Razis, A. F. A. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.09.008 · Cited by 30 · see citing works
Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunctions in a Mouse Model of Alzheimer’s Disease
D’Antongiovanni, V., Pellegrini, C., Antonioli, L., Benvenuti, L., Salvo, C. D., Flori, L., Piccarducci, R., Daniele, S., Martelli, A., Calderone, V., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.748021 · Cited by 30 · see citing works
Fucoxanthin attenuates behavior deficits and neuroinflammatory response in 1-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine-induced parkinson's disease in mice
Pang, Q., Sun, G., Xin, T., Zhang, R., & Liu, C. (2020) · Pharmacognosy Magazine · doi:10.4103/pm.pm_318_19 · Cited by 28 · see citing works
Normalization of Neuroinflammation: A New Strategy for Treatment of Persistent Pain and Memory/Emotional Deficits in Chronic Pain
Liu, X. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s379093 · Cited by 28 · see citing works
ICAM-1 protects neurons against Amyloid-β and improves cognitive behaviors in 5xFAD mice by inhibiting NF-Κb
Guha, S., Paidi, R. K., Goswami, S., Saha, P., & Biswas, S. C. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.11.021 · Cited by 26 · see citing works
RKIP-Mediated NF-κB Signaling is involved in ELF-MF-mediated improvement in AD rat
Zuo, H., Liu, X., Wang, D., Li, Y., Xu, X., Peng, R., & Song, T. (2018) · International Journal of Medical Sciences · doi:10.7150/ijms.28411 · Cited by 26 · see citing works
[Retracted] Oral Administration of Gintonin Protects the Brains of Mice against Aβ‐Induced Alzheimer Disease Pathology: Antioxidant and Anti‐Inflammatory Effects
Ikram, M. A., Jo, M. G., Park, T. J., Kim, M. W., Khan, I., Jo, M. H., & Kim, M. O. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/6635552 · Cited by 26 · see citing works
Retracted
Beneficial and Sexually Dimorphic Response to Combined HDAC Inhibitor Valproate and AMPK/SIRT1 Pathway Activator Resveratrol in the Treatment of ALS Mice
Bankole, O. O., Scambi, I., Parrella, E., Muccilli, M., Bonafede, R., Turano, E., Pizzi, M., & Mariotti, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031047 · Cited by 25 · see citing works
History in Perspective: The prime pathological players and role of phytochemicals in Alzheimer’s disease
Sajad, M., Kumar, R., & Thakur, S. C. (2022) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2022.04.009 · Cited by 25 · see citing works
Ambrosin, a potent NF-κβ inhibitor, ameliorates lipopolysaccharide induced memory impairment, comparison to curcumin
Khalil, M. N. A., Choucry, M. A., El Senousy, A. S., Hassan, A., El-Marasy, S. A., El Awdan, S. A., & Omar, F. A. (2019) · PLOS ONE · doi:10.1371/journal.pone.0219378 · Cited by 25 · see citing works
Targeting Autophagy, Ferroptosis, and Neuroinflammation: Polyphenol-Mediated Modulation of Emerging Signaling Pathways in Neurodegeneration
Jindal, A., & Nand, S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05760-9 · Cited by 25 · see citing works
Paricalcitol improves experimental autoimmune encephalomyelitis (EAE) by suppressing inflammation via NF-κB signaling
Zhang, D., Qiao, L., & Fu, T. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109528 · Cited by 24 · see citing works
A nuclear factor-kappa B inhibiting peptide suppresses innate immune receptors and gliosis in a transgenic mouse model of Alzheimer’s disease
Lindsay, A. K., Hickman, D., & Srinivasan, M. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111405 · Cited by 23 · see citing works
Glucocorticoid-Induced Leucine Zipper in Central Nervous System Health and Disease
Srinivasan, M., & Lahiri, D. K. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0277-5 · Cited by 23 · see citing works
The COP9 signalosome reduces neuroinflammation and attenuates ischemic neuronal stress in organotypic brain slice culture model
Tian, Y., Milić, J., Monasor, L. S., Chakraborty, R., Wang, S., Yuan, Y., Asare, Y., Behrends, C., Tahirovic, S., & Bernhagen, J. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04911-8 · Cited by 21 · see citing works
An insight into the concept of neuroinflammation and neurodegeneration in Alzheimer’s disease: targeting molecular approach Nrf2, NF-κB, and CREB
Bhardwaj, S., Grewal, A. K., Singh, S., Dhankar, V., & Jindal, A. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01502-2 · Cited by 24 · see citing works
Synergistic association of resveratrol and histone deacetylase inhibitors as treatment in amyotrophic lateral sclerosis
Parrella, E., Porrini, V., Scambi, I., Gennari, M. M., Gussago, C., Bankole, O. O., Benarese, M., Mariotti, R., & Pizzi, M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1017364 · Cited by 23 · see citing works
Streptocyclinones A and B ameliorate Alzheimer's disease pathological processes in vitro
Alvariño, R., Alonso, E., Lacret, R., Oves‐Costales, D., Genilloud, O., Reyes, F., Alfonso, A., & Botana, L. M. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.09.008 · Cited by 21 · see citing works
Resatorvid Relieves Breast Cancer Complicated with Depression by Inactivating Hippocampal Microglia Through TLR4/NF-κB/NLRP3 Signaling Pathway
Luo, W., Han, Y.-S., Meng, P., Yang, Q., Zhao, H.-Q., Ling, J., & Wang, Y. (2020) · Cancer Management and Research · doi:10.2147/cmar.s279800 · Cited by 18 · see citing works
The Neuroprotective Effects of Spray-Dried Porcine Plasma Supplementation Involve the Microbiota−Gut−Brain Axis
Rosell‐Cardona, C., Amat, C., Griñán‐Ferré, C., Polo, J., Pallàs, M., Pérez‐Bosque, A., Moretó, M., & Miró, L. (2022) · Nutrients · doi:10.3390/nu14112211 · Cited by 21 · see citing works
The role of MAPK/NF-κB-associated microglial activation in T-2 toxin-induced mouse learning and memory impairment
Li, N., Yao, C., Diao, J., Liu, X., Tang, E., Huang, Q.-S., Zhou, Y., Hu, Y.-G., Li, X.-K., Long, J., et al. (2023) · Food and Chemical Toxicology · doi:10.1016/j.fct.2023.113663 · Cited by 21 · see citing works
Ginsenoside Rg1, lights up the way for the potential prevention of Alzheimer's disease due to its therapeutic effects on the drug-controllable risk factors of Alzheimer's disease
Wu, J., Zhang, L., Liu, D., Xia, J., Yang, Y., Tang, F., Chen, L., Ao, H., & Peng, C. Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116955 · Cited by 19 · see citing works
Identification of gene expression predictors of occupational benzene exposure
Schiffman, C., McHale, C. M., Hubbard, A., Zhang, L., Thomas, R., Vermeulen, R. C. H., Li, G., Shen, M., Rappaport, S. M., Yin, S., et al. (2018) · PLoS ONE · doi:10.1371/journal.pone.0205427 · Cited by 19 · see citing works
Retracted: Palmitate‐induced C/EBP homologous protein activation leads to NF‐κB‐mediated increase in BACE1 activity and amyloid beta genesis
Marwarha, G., Schommer, J., Lund, J., Schommer, T., & Ghribi, O. (2018) · Journal of Neurochemistry · doi:10.1111/jnc.14292 · Cited by 19 · see citing works
Retracted
CHIP promotes the activation of NF-κB signaling through enhancing the K63-linked ubiquitination of TAK1
Liu, Y., Sun, Y., Han, S., Guo, Y., Tian, Q., Ma, Q., & Zhang, S. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00637-3 · Cited by 18 · see citing works
Novel Nuclear Factor-KappaB Targeting Peptide Suppresses β-Amyloid Induced Inflammatory and Apoptotic Responses in Neuronal Cells
Srinivasan, M., Bayon, B. L., Chopra, N., & Lahiri, D. K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0160314 · Cited by 17 · see citing works
Aquilariae Lignum Methylene Chloride Fraction Attenuates IL-1β-Driven Neuroinflammation in BV2 Microglial Cells
Lee, J., Jeon, Y.-J., Kang, J.-Y., Lee, S.-K., Lee, H.-D., & Son, C. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155465 · Cited by 18 · see citing works
Role of Butylphthalide in Immunity and Inflammation: Butylphthalide May Be a Potential Therapy for Anti‐Inflammation and Immunoregulation
Zhang, Y., Ren, Y., Chen, X., Deng, S., & Lü, W. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/7232457 · Cited by 18 · see citing works
Reduction of NF-κB (p65) in Scrapie-Infected Cultured Cells and in the Brains of Scrapie-Infected Rodents
Ma, Y., Shi, Q., Wang, J., Xiao, K., Sun, J. F., Lv, Y., Guo, M., Zhou, W., Chen, C., Chen, G., et al. (2017) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00273 · Cited by 18 · see citing works
Hypoxia and its Emerging Therapeutics in Neurodegenerative, Inflammatory and Renal Diseases
Bhatia, D., Ardekani, M. S., Shi, Q., & Movafagh, S. (2017) · Hypoxia and Human Diseases · doi:10.5772/66089 · Cited by 17 · see citing works
Phytochemical allylguaiacol exerts a neuroprotective effect on hippocampal cells and ameliorates scopolamine-induced memory impairment in mice
Lim, H.-S., Kim, B., Kim, Y. J., & Jeong, S. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.11.003 · Cited by 17 · see citing works
Molecular mechanism and the main signaling pathways in the development and progression of multiple sclerosis
Naserpour, L., Jalise, S. Z., Khoshandam, M., & Hosseinzadeh, F. (2025) · Experimental Cell Research · doi:10.1016/j.yexcr.2025.114769 · Cited by 17 · see citing works
Alzheimer’s disease and infectious agents: a comprehensive review of pathogenic mechanisms and microRNA roles
Hosseininasab, S.-S.-M., Ebrahimi, R., Yaghoobpoor, S., Kazemi, K., Khakpour, Y., Hajibeygi, R., Mohamadkhani, A., Fathi, M., Vakili, K., Tavasol, A., et al. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1513095 · Cited by 18 · see citing works
Intrathecal Delivery of ssAAV9-DAO Extends Survival in SOD1G93A ALS Mice
Wang, W., Duan, W., Wang, Y., Wen, D., Liu, Y., Li, Z., Hu, H., Cui, H., Cui, C., Lin, H., et al. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2131-6 · Cited by 16 · see citing works
Genetic Association and Altered Gene Expression of CYBB in Multiple Sclerosis Patients
Cardamone, G., Paraboschi, E. M., Soldà, G., Duga, S., Saarela, J., & Asselta, R. (2018) · Biomedicines · doi:10.3390/biomedicines6040117 · Cited by 16 · see citing works
Combining UPLC/Q-TOF-MS/MS With Biological Evaluation for NF-κB Inhibitors in Uyghur Medicine Althaea rosea Flowers
Ma, F., Cui, Q., & Bai, G. (2019) · Frontiers in Plant Science · doi:10.3389/fpls.2018.01975 · Cited by 16 · see citing works
Stroke and Amyloid-β Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response
Guglielmotto, M., Repetto, I. E., Monteleone, D., Vasciaveo, V., Franchino, C., Rinaldi, S., Tabaton, M., & Tamagno, E. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190494 · Cited by 15 · see citing works
A Nitroalkene Benzoic Acid Derivative Targets Reactive Microglia and Prolongs Survival in an Inherited Model of ALS via NF-κB Inhibition
Ibarburu, S., Kovacs, M., Varela, V., Rodriguez‐Duarte, J., Ingold, M., Invernizzi, P., Porcal, W., Arévalo, A. P., Perelmuter, K., Bollati‐Fogolín, M., et al. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00953-z · Cited by 15 · see citing works
Characterization of Inflammatory Signals in BV-2 Microglia in Response to Wnt3a
Li, C., Wu, Y., Huang, M., & Song, X. (2023) · Biomedicines · doi:10.3390/biomedicines11041121 · Cited by 17 · see citing works

The Pivotal Role of NF-kB in the Pathogenesis and Therapeutics of Alzheimer’s Disease
Sun, E., Motolani, A., Campos, L., & Lu, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23168972 · Cited by 369 · see citing works
UNVEILING THE COMPLEX ROLE OF NF-ΚB IN ALZHEIMER'S DISEASE: INSIGHTS INTO BRAIN INFLAMMATION AND POTENTIAL THERAPEUTIC TARGETS.
Verma, Y., Sachdeva, H., Kalra, S., Kumar, P., & Singh, G. (2023) · PubMed · Cited by 4 · see citing works
Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach
Singh, S., & Singh, T. G. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200207120949 · Cited by 299 · see citing works
NF-κB as a therapeutic target in neurodegenerative diseases
Camandola, S., & Mattson, M. P. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.2.123 · Cited by 184 · see citing works
An insight into the concept of neuroinflammation and neurodegeneration in Alzheimer’s disease: targeting molecular approach Nrf2, NF-κB, and CREB
Bhardwaj, S., Grewal, A. K., Singh, S., Dhankar, V., & Jindal, A. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01502-2 · Cited by 24 · see citing works

Authors: Srinivasan, M., & Lahiri, D. K.
Affiliations: Indiana University (US)
Indiana University School of Medicine (US)
ORCID: Srinivasan, Mythily
Lahiri, Debomoy K
Venue: Expert Opinion on Therapeutic Targets
Publisher: Informa UK Limited
Published: 2015-02-04
Volume: 19
Issue: 4
Pages: 471-487
ISSN: 1472-8222 (ISSN-L)
1744-7631
DOI: 10.1517/14728222.2014.989834
PMC: PMC5873291
OpenAlex: W1973257468
Cited by: 164
References: 108
Citations by year: 2026: 10 · 2025: 12 · 2024: 11 · 2023: 13 · 2022: 16 · 2021: 21 · 2020: 19 · 2019: 16 · 2018: 19 · 2017: 10 · 2016: 10 · 2015: 6
FWCI: 4.96
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Expert Opinion on Therapeutic Targets (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
IUScholarWorks (Indiana University) (submittedVersion)
Purdue University Indianapolis (Indiana University) (submittedVersion)
Author eBooks
Funders: National Institutes of Health (5r21ag042804-02)
National Institute on Aging (R21-AG042804, 5R21AG042804, 1R21AG047)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords: NF-κB signaling, Alzheimer's disease, multiple sclerosis, neuroinflammation, neurodegeneration, NF-κB inhibitors, neuroprotection, natural compounds, small molecule inhibitors, chronic inflammation
MeSH terms: Alzheimer Disease, Animals, Humans, Multiple Sclerosis, Drug Design, Signal Transduction, Up-Regulation, NF-kappa B, Neuroprotective Agents

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Significance of NF-κB as a pivotal therapeutic target in the neurodegenerative pathologies of Alzheimer’s disease and multiple sclerosis

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks