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Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel: This paper is also published in parallel in Archives of Medical Science [Banach M, Rizzo M, Toth PP, et al. Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel. Arch Med Sci 2015; 11(1): 1–23]
Open accessAbstract
Statins are one of the most commonly prescribed drugs in clinical practice. They are usually well tolerated and effectively prevent cardiovascular events. Most adverse effects associated with statin therapy are muscle-related. The recent statement of the European Atherosclerosis Society (EAS) has focused on statin-associated muscle symptoms (SAMS), and avoided the use of the term 'statin intolerance'. Although muscle syndromes are the most common adverse effects observed after statin therapy, excluding other side effects might underestimate the number of patients with statin intolerance, which might be observed in 10 - 15% of patients. In clinical practice, statin intolerance limits effective treatment of patients at risk of, or with, cardiovascular disease. Knowledge of the most common adverse effects of statin therapy that might cause statin intolerance and the clear definition of this phenomenon is crucial to effectively treat patients with lipid disorders. Therefore, the aim of this position paper was to suggest a unified definition of statin intolerance, and to complement the recent EAS statement on SAMS, where the pathophysiology, diagnosis and the management were comprehensively presented.
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Metadata
- Authors
- Banach, M., Rizzo, M., Toth, P. P., Farnier, M., Davidson, M. H., Al-Rasadi, K., Aronow, W. S., Athyros, V., Djuric, D. M., Ezhov, M. V., Greenfield, R. S., Hovingh, G. K., Kostner, K., Serban, C., Lighezan, D., Fras, Z., Moriarty, P. M., Muntner, P., Goudev, A., Ceska, R., Nicholls, S. J., Broncel, M., Nikolic, D., Pella, D., Puri, R., Rysz, J., Wong, N. D., Bajnok, L., Jones, S. R., Ray, K. K., & Mikhailidis, D. P.
- Affiliations
- Medical University of Lodz (PL)
- University of Palermo (IT)
- University of Chicago (US)
- Westchester Medical Center (US)
- University of Belgrade (RS)
- Amsterdam UMC Location University of Amsterdam (NL)
- The University of Queensland (AU)
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
- University of Ljubljana (SI)
- University of Kansas Medical Center (US)
- University of Alabama (US)
- Queen Giovanna Hospital (BG)
- South Australian Health and Medical Research Institute (AU)
- University of Pavol Jozef Šafárik (SK)
- Indraprastha Apollo Hospitals (IN)
- University of California, Irvine (US)
- Johns Hopkins Medicine (US)
- Imperial College London (GB)
- The Royal Free Hospital (GB)
- ORCID
- Banach, Maciej
- Rizzo, Manfredi
- Toth, Peter P
- Farnier, Michel
- Davidson, Michael H
- Aronow, Wilbert S
- Djuric, Dragan M
- Hovingh, G Kees
- Lighezan, Daniel
- Fras, Zlatko
- Moriarty, Patrick M
- Muntner, Paul
- Goudev, Assen
- Nicholls, Stephen J
- Broncel, Marlena
- Pella, Daniel
- Puri, Raman
- Rysz, Jacek
- Wong, Nathan D
- Jones, Steven R
- Ray, Kausik K
- Mikhailidis, Dimitri P
- Venue
- Expert Opinion on Drug Safety
- Publisher
- Informa UK Limited
- Published
- 2015-04-24
- Volume
- 14
- Issue
- 6
- Pages
- 935-955
- ISSN
- 1474-0338 (ISSN-L)
- 1744-764X
- OpenAlex
- W2105307761
- Cited by
- 162
- References
- 205
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 13 · 2022: 13 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 21 · 2017: 25 · 2016: 24 · 2015: 10
- FWCI
- 26.88
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- Expert Opinion on Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- statin intolerance, statin-associated muscle symptoms, statin adverse effects, lipid metabolism disorders, cardiovascular disease prevention, statin therapy
- MeSH terms
- Cardiovascular Diseases, Humans, Muscular Diseases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Dyslipidemias
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