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Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel: This paper is also published in parallel in Archives of Medical Science [Banach M, Rizzo M, Toth PP, et al. Statin intolerance – an attempt at a unified definition. Position paper from an International Lipid Expert Panel. Arch Med Sci 2015; 11(1): 1–23]
Open accessAbstract
Statins are one of the most commonly prescribed drugs in clinical practice. They are usually well tolerated and effectively prevent cardiovascular events. Most adverse effects associated with statin therapy are muscle-related. The recent statement of the European Atherosclerosis Society (EAS) has focused on statin-associated muscle symptoms (SAMS), and avoided the use of the term 'statin intolerance'. Although muscle syndromes are the most common adverse effects observed after statin therapy, excluding other side effects might underestimate the number of patients with statin intolerance, which might be observed in 10 - 15% of patients. In clinical practice, statin intolerance limits effective treatment of patients at risk of, or with, cardiovascular disease. Knowledge of the most common adverse effects of statin therapy that might cause statin intolerance and the clear definition of this phenomenon is crucial to effectively treat patients with lipid disorders. Therefore, the aim of this position paper was to suggest a unified definition of statin intolerance, and to complement the recent EAS statement on SAMS, where the pathophysiology, diagnosis and the management were comprehensively presented.
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Cerivastatin, genetic variants, and the risk of rhabdomyolysis
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Statin use and musculoskeletal pain among adults with and without arthritis
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Association of Statin Use With Cataracts
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Statin‐associated myopathy and its exacerbation with exercise
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Self-citationEffect of Statins on Creatine Kinase Levels Before and After a Marathon Run
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Statins and Interstitial Lung Disease
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Lipids, blood pressure and kidney update 2014
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Self-citationSevere irritability associated with statin cholesterol-lowering drugs
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Muscle mitochondrial metabolism and calcium signaling impairment in patients treated with statins
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FDA drug safety communications: a narrative review and clinical considerations for older adults
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The Effect of Statins on Erectile Dysfunction: A Meta‐Analysis of Randomized Trials
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Self-citationStatins and primary liver cancer
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Lipid, blood pressure and kidney update 2013
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Self-citationStatin use and risk of hepatocellular carcinoma
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Statin Therapy and New-onset Diabetes: Molecular Mechanisms and Clinical Relevance
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Self-citationStatin therapy in the elderly: A review
Szadkowska, I., Stańczyk, A., Aronow, W. S., Kowalski, J., Pawlicki, L., Ahmed, A., & Banach, M. (2009) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2008.12.012 · Cited by 67
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High-dose Atorvastatin After Stroke or Transient Ischemic Attack
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State of the art papers Lipids, blood pressure, kidney – what was new in 2011?
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Can Statins Cause Chronic Low-Grade Myopathy?
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Contrasting Cholesterol Management Guidelines for Adults with CKD
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Proprotein Convertase Subtilisin/Kexin 9 Inhibitors
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Self-citationRhabdomyolysis and Satin Therapy: Relevance to the Elderly
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Use of statins is associated with an increased risk of rheumatoid arthritis
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Lipids, blood pressure and kidney update 2015
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Self-citationHow to use statins in patients with chronic liver disease.
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Randomized controlled trial assessing the effect of simvastatin in primary biliary cirrhosis
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The creatine kinase response to eccentric exercise with atorvastatin 10 mg or 80 mg
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Generalized Eczematous Skin Rash Possibly due to HMG-CoA Reductase Inhibitors
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Statin-Associated Psychiatric Adverse Events
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Thrombotic thrombocytopenic purpura and simvastatin
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Subclinical hypothyroidism and vascular risk: An update
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Self-citationNephroprotective and clinical potential of statins in dialyzed patients
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Self-citationLiver tests are irrelevant when prescribing statins
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Statin discontinuation: an underestimated risk?
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Self-citationManagement of statin intolerance
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Toxic Epidermal Necrolysis From Atorvastatin
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Self-citationScreening Stress Myocardial Perfusion Imaging and Eligibility for Liver Transplantation
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Yes! Statins can be given to liver patients
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Is decreased libido associated with the use of HMG‐CoA‐reductase inhibitors?
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Simvastatin‐induced thrombocytopenia
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Statins in Primary Biliary Cirrhosis: Are They Safe?
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Role and significance of statins in the treatment of hypertensive patients
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Asymptomatic hypothyroidism and statin-induced myopathy.
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Statin use and risk of diabetes mellitus in postmenopausal women
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Self-citationDermographism: an adverse effect of atorvastatin.
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Simvastatin induced rhabdomyolysis and an important clinical link with hypothyroidism
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Statin-induced lupus: a case/non-case study in a nationwide pharmacovigilance database
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Statin use increases the risk of depressive disorder in stroke patients: A population-based study
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Statins and New-Onset Diabetes
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Statins in patients with chronic kidney disease: why, who and when?
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Self-citationNightmares and Sleep Disturbances with Simvastatin and Metoprolol
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Tresch and Aronow’s Cardiovascular Disease in the Elderly
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Thrombotic Thrombocytopenic Purpura: Yesterday, Today, Tomorrow
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Updates on Cytochrome P450-Mediated Cardiovascular Drug Interactions
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Simvastatın improves endothelial function in patents with subclinical hypothyroidism
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Alopecia associated with atorvastatin
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Atorvastatin-Induced Diaphragmatic Muscle Impairment
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Effects of Alcohol and Fluvastatin on Lipid Metabolism and Hepatic Function
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Self-citation
Metadata
- Authors
- Banach, M., Rizzo, M., Toth, P. P., Farnier, M., Davidson, M. H., Al-Rasadi, K., Aronow, W. S., Athyros, V., Djuric, D. M., Ezhov, M. V., Greenfield, R. S., Hovingh, G. K., Kostner, K., Serban, C., Lighezan, D., Fras, Z., Moriarty, P. M., Muntner, P., Goudev, A., Ceska, R., Nicholls, S. J., Broncel, M., Nikolic, D., Pella, D., Puri, R., Rysz, J., Wong, N. D., Bajnok, L., Jones, S. R., Ray, K. K., & Mikhailidis, D. P.
- Affiliations
- Medical University of Lodz (PL)
- University of Palermo (IT)
- University of Chicago (US)
- Westchester Medical Center (US)
- University of Belgrade (RS)
- Amsterdam UMC Location University of Amsterdam (NL)
- The University of Queensland (AU)
- Victor Babeș University of Medicine and Pharmacy Timișoara (RO)
- University of Ljubljana (SI)
- University of Kansas Medical Center (US)
- University of Alabama (US)
- Queen Giovanna Hospital (BG)
- South Australian Health and Medical Research Institute (AU)
- University of Pavol Jozef Šafárik (SK)
- Indraprastha Apollo Hospitals (IN)
- University of California, Irvine (US)
- Johns Hopkins Medicine (US)
- Imperial College London (GB)
- The Royal Free Hospital (GB)
- ORCID
- Banach, Maciej
- Rizzo, Manfredi
- Toth, Peter P
- Farnier, Michel
- Davidson, Michael H
- Aronow, Wilbert S
- Djuric, Dragan M
- Hovingh, G Kees
- Lighezan, Daniel
- Fras, Zlatko
- Moriarty, Patrick M
- Muntner, Paul
- Goudev, Assen
- Nicholls, Stephen J
- Broncel, Marlena
- Pella, Daniel
- Puri, Raman
- Rysz, Jacek
- Wong, Nathan D
- Jones, Steven R
- Ray, Kausik K
- Mikhailidis, Dimitri P
- Venue
- Expert Opinion on Drug Safety
- Publisher
- Informa UK Limited
- Published
- 2015-04-24
- Volume
- 14
- Issue
- 6
- Pages
- 935-955
- ISSN
- 1474-0338 (ISSN-L)
- 1744-764X
- OpenAlex
- W2105307761
- Cited by
- 162
- References
- 205
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 6 · 2023: 13 · 2022: 13 · 2021: 10 · 2020: 14 · 2019: 12 · 2018: 21 · 2017: 25 · 2016: 24 · 2015: 10
- FWCI
- 26.88
- Type
- journal article
- Language
- en
- Open access
- green
- pure.amsterdamumc.nl
- Licence
- other-oa
- Locations
- Expert Opinion on Drug Safety (publishedVersion)
- PubMed (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Nova Science Publishers (Nova Science Publishers, Inc.) (submittedVersion)
- Pure Amsterdam UMC (submittedVersion, other-oa)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pharmacovigilance and Adverse Drug Reactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Lipids, and Metabolism
- Keywords
- statin intolerance, statin-associated muscle symptoms, statin adverse effects, lipid metabolism disorders, cardiovascular disease prevention, statin therapy
- MeSH terms
- Cardiovascular Diseases, Humans, Muscular Diseases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Dyslipidemias
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