The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Eudragit®: a technology evaluation
Abstract
INTRODUCTION: Eudragit is the brand name for a diverse range of polymethacrylate-based copolymers. It includes anionic, cationic, and neutral copolymers based on methacrylic acid and methacrylic/acrylic esters or their derivatives. AREAS COVERED: In this review, the physicochemical characteristics and applications of different grades of Eudragit in colon-specific/enteric-coated/sustained release drug delivery and taste masking have been addressed. EXPERT OPINION: Eudragits are amorphous polymers having glass transition temperatures between 9 to > 150(o)C. Eudragits are non-biodegradable, nonabsorbable, and nontoxic. Anionic Eudragit L dissolves at pH > 6 and is used for enteric coating, while Eudragit S, soluble at pH > 7 is used for colon targeting. Studies in human volunteers have confirmed that pH drops from 7.0 at terminal ileum to 6.0 at ascending colon, and Eudragit S based systems sometimes fail to release the drug. To overcome the shortcoming, combination of Eudragit S and Eudragit L which ensures drug release at pH < 7 has been advocated. Eudragit RL and RS, having quaternary ammonium groups, are water insoluble, but swellable/permeable polymers which are suitable for the sustained release film coating applications. Cationic Eudragit E, insoluble at pH ≥ 5, can prevent drug release in saliva and finds application in taste masking.
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Azad, M. A., Olawuni, D., Kimbell, G., Badruddoza, A. Z. M., Hossain, M. S., & Sultana, T. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12020124 · Cited by 356
Electrospun Fibrous Architectures for Drug Delivery, Tissue Engineering and Cancer Therapy
Ding, Y., Li, W., Zhang, F., Liu, Z., Zanjanizadeh Ezazi, N., Liu, D., & Santos, H. A. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201802852 · Cited by 312
Novel nano-encapsulated probiotic agents: Encapsulate materials, delivery, and encapsulation systems
Xu, C., Ban, Q., Wang, W., Hou, J., & Jiang, Z. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.06.061 · Cited by 225
Enteric coating of oral solid dosage forms as a tool to improve drug bioavailability
Maderuelo, C., Lanao, J. M., & Zarzuelo, A. (2019) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2019.105019 · Cited by 147
Metadata
- Authors
- Thakral, S., Thakral, N. K., & Majumdar, D. K.
- Venue
- Expert Opinion on Drug Delivery
- Publisher
- Informa Healthcare
- Published
- 2012-10-26
- Volume
- 10
- Issue
- 1
- Pages
- 131-149
- ISSN
- 1742-5247 (ISSN-L)
- 1744-7593
- OpenAlex
- W2081056194
- Cited by
- 458
- References
- 54
- FWCI
- 4.31
- Type
- journal article
- Language
- en
- Open access
- closed
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- Thakral, S., Thakral, N. K., & Majumdar, D. K. (2013). Eudragit®: a technology evaluation. Expert Opinion on Drug Delivery. https://doi.org/10.1517/17425247.2013.736962
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