Effects of Nine Weeks of β-Hydroxy-β- Methylbutyrate Supplementation on Strength and Body Composition in Resistance Trained Men

Thomson, Jasmine S; Watson, Patricia E; Rowlands, David S

doi:10.1519/jsc.0b013e3181a00d47

Cited by 72Muscle metabolism and nutritionSports Performance and TrainingBiochemical effects in animals

Effects of Nine Weeks of β-Hydroxy-β- Methylbutyrate Supplementation on Strength and Body Composition in Resistance Trained Men

Thomson, Jasmine S, Watson, Patricia E, Rowlands, David S·2009·Journal of Strength and Conditioning Research

DOI 10.1519/jsc.0b013e3181a00d47

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Abstract

The dietary supplement beta-hydroxy-beta-methylbutyrate (HMB) is claimed to increase strength, lean body mass, and decrease fat mass when used in conjunction with resistance training. Although there is some support for these claims, the evidence is not conclusive, and it is even less so for resistance trained individuals. Therefore, we aimed to further elucidate the effects of HMB supplementation in trained men. A randomized, double-blind, controlled study design was used to investigate the effects of supplementing 22 resistance trained men with 3 g.d of HMB or corn starch placebo for 9 weeks with resistance training. The effect of HMB on strength was determined using the 1-repetition maximum (1RM) method for the lower body (leg extension) and upper body (bench press, bicep preacher curl) at baseline and after the supplementation period. Body composition was assessed by skinfolds and bioelectrical impedance analysis (BIA). Overall, 9 weeks' HMB supplementation resulted in a clear-cut, trivial increase in combined averaged strength measures of 1.6% (90% confidence limits: +/-4.3%). When considered in isolation, however, leg extension 1RM increased by a substantial 9.1% (90% confidence limits: +/-7.5%), but the effect on upper-body strength was inconclusive (bench press: -1.9 +/- 9.3%; bicep curl: -1.7 +/- 4.7%). Based on BIA estimates, HMB had a decreasing (although inconclusive) influence on fat mass of -9 +/- 14%, but it had a clear, trivial effect on fat-free mass of 0.2 +/- 2.2%. The magnitude of change in body mass was trivial, but the probability of substantial reductions in skinfold thicknesses ranged from negligible to likely. In previously trained men, supplementation of HMB in conjunction with resistance training provides a substantial benefit to lower-body strength, but it has negligible effects on body composition.

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There are divergent results showing no such effects of resistance training with HMB supplementation on muscle mass, strength, and body fat.
“However, there are divergent results showing no such effects [28] and the efficiency of this combination appears to be population-specific [27].”
From β-hydroxy-β -methylbutyrate supplementation benefits the effects of resistance training on body fat reduction via increased irisin expression in white adipose tissue (2021) · cites this paper as [28]

Bioelectrical impedance analysis?part I: review of principles and methods
KYLE, U. (2004) · Clinical Nutrition · doi:10.1016/j.clnu.2004.06.004 · Cited by 3,200 · see citing works
Making Meaningful Inferences About Magnitudes
Batterham, A. M., & Hopkins, W. G. (2006) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.1.1.50 · Cited by 2,186 · see citing works
Design and analysis of research on sport performance enhancement
HOPKINS, W. G., HAWLEY, J. A., & BURKE, L. M. (1999) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199903000-00018 · Cited by 708 · see citing works
A Meta-analysis to Determine the Dose Response for Strength Development
RHEA, M. R., ALVAR, B. A., BURKETT, L. N., & BALL, S. D. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000053727.63505.d4 · Cited by 666 · see citing works
The role of learning and coordination in strength training
RUTHERFORD, O. M., & Jones, D. A. (1986) · European Journal of Applied Physiology · doi:10.1007/bf00422902 · Cited by 479 · see citing works
Muscle hypertrophy, hormonal adaptations and strength development during strength training in strength-trained and untrained men
Ahtiainen, J. P., Pakarinen, A., Alén, M., Kraemer, W. J., & H�kkinen, K. (2003) · European Journal of Applied Physiology · doi:10.1007/s00421-003-0833-3 · Cited by 469 · see citing works
Silencing of Epidermal Growth Factor Receptor Suppresses Hypoxia-Inducible Factor-2–Driven VHL −/− Renal Cancer
Smith, K., Gunaratnam, L., Morley, M., Franovic, A., Mekhail, K., & Lee, S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0169 · Cited by 456 · see citing works
Effect of leucine metabolite β-hydroxy-β-methylbutyrate on muscle metabolism during resistance-exercise training
Nissen, S., Sharp, R., Ray, M., Rathmacher, J. A., Rice, D., Fuller, J. C., Connelly, A. S., & Abumrad, N. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.81.5.2095 · Cited by 393 · see citing works
Nutritional role of the leucine metabolite β-hydroxy β-methylbutyrate (HMB)
Nissen, S., & Abumrad, N. N. (1997) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(97)00048-x · Cited by 269 · see citing works
Maximum Strength-Power-Performance Relationships in Collegiate Throwers
STONE, M. H., SANBORN, K., OʼBRYANT, H. S., HARTMAN, M., STONE, M. E., PROULX, C., WARD, B., & HRUBY, J. (2003) · Journal of Strength and Conditioning Research · doi:10.1519/00124278-200311000-00019 · Cited by 254 · see citing works
Body Composition in 70-Year-Old Adults Responds to Dietary β-Hydroxy-β-Methylbutyrate Similarly to That of Young Adults
Vukovich, M. D., Stubbs, N. B., & Bohlken, R. M. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.7.2049 · Cited by 222 · see citing works
Fatty acid composition of skeletal muscle reflects dietary fat composition in humans
Andersson, A., Nälsén, C., Tengblad, S., & Vessby, B. (2002) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/76.6.1222 · Cited by 221 · see citing works
Nutritional supplementation of the leucine metabolite β-hydroxy-β-methylbutyrate (hmb) during resistance training
Panton, L. B., Rathmacher, J. A., Baier, S., & Nissen, S. (2000) · Nutrition · doi:10.1016/s0899-9007(00)00376-2 · Cited by 204 · see citing works
Creatine and β-hydroxy-β-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program
Jówko, E., Ostaszewski, P., Jank, M., Sacharuk, J., Zieniewicz, A., Wilczak, J., & Nissen, S. (2001) · Nutrition · doi:10.1016/s0899-9007(01)00540-8 · Cited by 189 · see citing works
β-Hydroxy-β-Methylbutyrate (HMB) Supplementation in Humans Is Safe and May Decrease Cardiovascular Risk Factors
Nissen, S., Sharp, R. L., Panton, L. B., Vukovich, M. D., Trappe, S. W., & Fuller, J. C. (2000) · Journal of Nutrition · doi:10.1093/jn/130.8.1937 · Cited by 172 · see citing works
??-hydroxy-??-methylbutyrate ingestion, Part I: effects on strength and fat free mass
GALLAGHER, P. M., CARRITHERS, J. A., GODARD, M. P., SCHULZE, K. E., & TRAPPE, A. S. W. (2000) · Medicine and Science in Sports and Exercise · doi:10.1097/00005768-200012000-00022 · Cited by 171 · see citing works
Attenuation of Proteasome-Induced Proteolysis in Skeletal Muscle by β-Hydroxy-β-Methylbutyrate in Cancer-Induced Muscle Loss
Smith, H. J., Mukerji, P., & Tisdale, M. J. (2005) · Cancer Research · doi:10.1158/0008-5472.277.65.1 · Cited by 170 · see citing works
Methodology, Correlational Analysis, and Interpretation of Diet Diary Records of the Food and Fluid Intake of Free-living Humans
de Castro, J. M. (1994) · Appetite · doi:10.1006/appe.1994.1045 · Cited by 124 · see citing works
Effects of Calcium â-Hydroxy-â-methylbutyrate (HMB) Supplementation During Resistance-Training on Markers of Catabolism, Body Composition and Strength
Kreider, Ferreira, Wilson, & Almada (1999) · International Journal of Sports Medicine · doi:10.1055/s-1999-8835 · Cited by 122 · see citing works
β-Hydroxy-β-Methylbutyrate (HMB) Supplementation Does Not Affect Changes in Strength or Body Composition during Resistance Training in Trained Men
Slater, G., Jenkins, D., Logan, P., Lee, H., Vukovich, M., Rathmacher, J. A., & Hahn, A. G. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.3.384 · Cited by 122 · see citing works
??-Hydroxy-F128b-Methylbutyrate (HMB) Supplementation and the Promotion of Muscle Growth and Strength
Slater, G. J., & Jenkins, D. (2000) · Sports Medicine · doi:10.2165/00007256-200030020-00004 · Cited by 120 · see citing works
Protein synthesis rates in human muscles: neither anatomical location nor fibre‐type composition are major determinants
Mittendorfer, B., Andersen, J. L., Plomgaard, P., Saltin, B., Babraj, J., Smith, K., & Rennie, M. J. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.077180 · Cited by 117 · see citing works
Effects of β-Hydroxy-β-Methylbutyrate Supplementation During Resistance Training on Strength, Body Composition, and Muscle Damage in Trained and Untrained Young Men: A Meta-Analysis
Rowlands, D. S., & Thomson, J. S. (2009) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181a00c80 · Cited by 76 · see citing works
Self-citation
β-hydroxy-β-methylbutyrate (HMB) kinetics and the influence of glucose ingestion in humans
Vukovich, M. D., Slater, G., Macchi, M. B., Turner, M. J., Fallon, K., Boston, T., & Rathmacher, J. (2001) · The Journal of Nutritional Biochemistry · doi:10.1016/s0955-2863(01)00182-6 · Cited by 66 · see citing works
Effects of Six Weeks of β-Hydroxy-β-Methylbutyrate (HMB) and HMB/Creatine Supplementation on Strength, Power, and Anthropometry of Highly Trained Athletes
O’Connor, D., & Crowe, M. (2007) · The Journal of Strength and Conditioning Research · doi:10.1519/r-15974.1 · Cited by 57 · see citing works
Regional fat placement in physically fit males and changes with weight loss
Nindl, B. C., Friedl, K. E., Marchitelli, L. J., Shippee, R. L., Thomas, C., & Patton, J. F. (1996) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-199607000-00003 · Cited by 48 · see citing works
Effects of β-hydroxy-β-methyl butyrate on performance and carcass quality of feedlot steers
Koevering, M. T. V., Dolezal, H. G., Gill, D. R., Owens, F. N., Strasia, C. A., Buchanan, D. S., Lake, R., & Nissen, S. (1994) · Journal of Animal Science · doi:10.2527/1994.7281927x · Cited by 46 · see citing works
The leucine metabolite 3‐hydroxy‐3‐methylbutyrate (HMB) modifies protein turnover in muscles of laboratory rats and domestic chickensin vitro
Ostaszewski, P., Костюк, С. С., Bałasińska, B., Jank, M., Papet, I., & Glomot, F. (2000) · Journal of Animal Physiology and Animal Nutrition · doi:10.1046/j.1439-0396.2000.00272.x · Cited by 44 · see citing works
Reliability of Performance of Elite Olympic Weightlifters
McGuigan, M. R., & Kane, M. K. (2004) · The Journal of Strength and Conditioning Research · doi:10.1519/00124278-200408000-00046 · Cited by 40 · see citing works
Is There a Physiologic Basis for Creatine Use in Children and Adolescents?
UNNITHAN, V. B., VEEHOF, S. H. E., VELLA, C. A., & KERN, M. (2001) · Journal of Strength and Conditioning Research · doi:10.1519/00124278-200111000-00021 · Cited by 18 · see citing works
HMB meta-analysis and the clustering of data sources
Décombaz, J., Bury, A., & Hager, C. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00563.2003 · Cited by 7 · see citing works

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ISSN exercise & sports nutrition review update: research & recommendations
Kerksick, C. M., Wilborn, C. D., Roberts, M. D., Smith-Ryan, A., Kleiner, S. M., Jäger, R., Collins, R., Cooke, M., Davis, J. N., Galvan, E., et al. (2018) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-018-0242-y · Cited by 945 · see citing works
“In agreement, Thomson and researchers [572] had 22 resistance trained men supplement, in a double-blind fashion, with either HMB or placebo for 9 weeks and concluded that HMB was responsible for a significant increase in lower-body strength.”
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Kreider, R. B., Wilborn, C. D., Taylor, L., Campbell, B., Almada, A. L., Collins, R., Cooke, M., Earnest, C. P., Greenwood, M., Kalman, D. S., et al. (2010) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-7-7 · Cited by 428 · see citing works
Beta‐hydroxy‐beta‐methylbutyrate supplementation and skeletal muscle in healthy and muscle‐wasting conditions
Holeček, M. (2017) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12208 · Cited by 287 · see citing works
International Society of Sports Nutrition Position Stand: beta-hydroxy-beta-methylbutyrate (HMB)
Wilson, J. M., Fitschen, P. J., Campbell, B., Wilson, G. J., Zanchi, N., Taylor, L., Wilborn, C., Kalman, D. S., Stout, J. R., Hoffman, J. R., et al. (2013) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-10-6 · Cited by 196 · see citing works
HMB supplementation: clinical and athletic performance-related effects and mechanisms of action
Zanchi, N. E., Gerlinger‐Romero, F., Guimarães‐Ferreira, L., Filho, M. A. D. S., Felitti, V., Lira, F. S., Seelaender, M. C. L., & Lancha, A. H. (2010) · Amino Acids · doi:10.1007/s00726-010-0678-0 · Cited by 151 · see citing works
The effects of 12 weeks of beta-hydroxy-beta-methylbutyrate free acid supplementation on muscle mass, strength, and power in resistance-trained individuals: a randomized, double-blind, placebo-controlled study
Wilson, J. M., Lowery, R. P., Joy, J. M., Andersen, J. C., Wilson, S. M. C., Stout, J. R., Duncan, N., Fuller, J. C., Baier, S. M., Naimo, M. A., et al. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2854-5 · Cited by 123 · see citing works
Beta-hydroxy-beta-methylbutyrate supplementation in health and disease: a systematic review of randomized trials
Molfino, A., Gioia, G., Fanelli, F. R., & Muscaritoli, M. (2013) · Amino Acids · doi:10.1007/s00726-013-1592-z · Cited by 99 · see citing works
The effect of HMB supplementation on body composition, fitness, hormonal and inflammatory mediators in elite adolescent volleyball players: a prospective randomized, double-blind, placebo-controlled study
Portal, S., Zadik, Z., Rabinowitz, J., Pilz-Burstein, R., Adler-Portal, D., Meckel, Y., Cooper, D. M., Eliakim, A., & Nemet, D. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1855-x · Cited by 90 · see citing works
The Effect of a 12-Week Beta-hydroxy-beta-methylbutyrate (HMB) Supplementation on Highly-Trained Combat Sports Athletes: A Randomised, Double-Blind, Placebo-Controlled Crossover Study
Durkalec-Michalski, K., Jeszka, J., & Podgórski, T. (2017) · Nutrients · doi:10.3390/nu9070753 · Cited by 78 · see citing works
Metabolic and functional effects of beta-hydroxy-beta-methylbutyrate (HMB) supplementation in skeletal muscle
Pinheiro, C. H. D. J., Gerlinger-Romero, F., Guimarães-Ferreira, L., de Souza-Jr, A. L., Vitzel, K. F., Nachbar, R. T., Nunes, M. T., & Curi, R. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-011-2224-5 · Cited by 77 · see citing works
Mechanism of Action and the Effect of Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Different Types of Physical Performance - A Systematic Review
Kaczka, P., Michalczyk, M. M., Jastrząb, R., Gawełczyk, M., & Kubicka, K. (2019) · Journal of Human Kinetics · doi:10.2478/hukin-2019-0070 · Cited by 76 · see citing works
A Systematic Review with Meta-Analysis of the Effect of Resistance Training on Whole-Body Muscle Growth in Healthy Adult Males
Benito, P. J., Cupeiro, R., Ramos-Campo, D. J., Alcaraz, P. E., & Rubio-Arias, J. Á. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17041285 · Cited by 71 · see citing works
β-Hydroxy-β-methylbutyrate (HMB)-free acid attenuates circulating TNF-α and TNFR1 expression postresistance exercise
Townsend, J. R., Fragala, M. S., Jajtner, A. R., Gonzalez, A. M., Wells, A. J., Mangine, G. T., Robinson, E. H., McCormack, W. P., Beyer, K. S., Pruna, G. J., et al. (2013) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00738.2013 · Cited by 63 · see citing works
Interaction of Beta-Hydroxy-Beta-Methylbutyrate Free Acid and Adenosine Triphosphate on Muscle Mass, Strength, and Power in Resistance Trained Individuals
Lowery, R. P., Joy, J. M., Rathmacher, J. A., Baier, S. M., Fuller, J. C., Shelley, M. C., Jäger, R., Purpura, M., Wilson, S. M. C., & Wilson, J. M. (2016) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000000482 · Cited by 62 · see citing works
Impact of β−hydroxy-β−methylbutyrate (HMB) on muscle loss and protein metabolism in critically ill patients: A RCT
Viana, M. V., Becce, F., Pantet, O., Schmidt, S., Bagnoud, G., Thaden, J. J., Have, G. A. M. T., ENGELEN, M. P. K. J., Voidey, A., Deutz, N. E. P., et al. (2021) · Clinical Nutrition · doi:10.1016/j.clnu.2021.07.018 · Cited by 60 · see citing works
Effect of HMB Supplementation on Body Composition, Fitness, Hormonal Profile and Muscle Damage Indices
Portal, S., Eliakim, A. R., Nemet, D., Halevy, O., & Zadik, Z. (2010) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2010.23.7.641 · Cited by 45 · see citing works
Effects of beta-hydroxy-beta-methylbutyrate supplementation on strength and body composition in trained and competitive athletes: A meta-analysis of randomized controlled trials
Sanchez‐Martinez, J., Santos‐Lozano, A., García‐Hermoso, A., Sadarangani, K. P., & Cristi‐Montero, C. (2017) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2017.11.003 · Cited by 45 · see citing works
A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors
Arazi, H., Taati, B., & Suzuki, K. (2018) · Antioxidants · doi:10.3390/antiox7100148 · Cited by 40 · see citing works
Effect of the Combination of Creatine Monohydrate Plus HMB Supplementation on Sports Performance, Body Composition, Markers of Muscle Damage and Hormone Status: A Systematic Review
Fernández-Landa, J., Calleja-González, J., León-Guereño, P., Caballero-García, A., Córdova, A., & Mielgo‐Ayuso, J. (2019) · Nutrients · doi:10.3390/nu11102528 · Cited by 41 · see citing works
Effects of Amino Acid Derivativeson Physical, Mental, and Physiological Activities
Luckose, F., Pandey, M. C., & Radhakrishna, K. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2012.708368 · Cited by 38 · see citing works
Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls
Weihrauch, M., & Handschin, C. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2017.10.006 · Cited by 37 · see citing works
Leucine Metabolites Do Not Enhance Training-induced Performance or Muscle Thickness
TEIXEIRA, F. J., MATIAS, C. N., MONTEIRO, C. P., VALAMATOS, M. J., REIS, J. F., TAVARES, F., BATISTA, A., DOMINGOS, C., ALVES, F., SARDINHA, L. B., et al. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001754 · Cited by 35 · see citing works
Equivalent Hypertrophy and Strength Gains in β-Hydroxy-β-Methylbutyrate- or Leucine-supplemented Men
JAKUBOWSKI, J. S., WONG, E. P. T., NUNES, E. A., NOGUCHI, K. S., VANDEWEERD, J. K., MURPHY, K. T., MORTON, R. W., MCGLORY, C., & PHILLIPS, S. M. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001752 · Cited by 34 · see citing works
International society of sports nutrition position stand: β-hydroxy-β-methylbutyrate (HMB)
Rathmacher, J. A., Pitchford, L. M., Stout, J. R., Townsend, J. R., Jäger, R., Kreider, R. B., Campbell, B. I., Kerksick, C. M., Harty, P. S., Candow, D. G., et al. (2024) · Journal of the International Society of Sports Nutrition · doi:10.1080/15502783.2024.2434734 · Cited by 37 · see citing works
The effects of phosphatidic acid supplementation on strength, body composition, muscular endurance, power, agility, and vertical jump in resistance trained men
Escalante, G., Alencar, M., Haddock, B., & Harvey, P. (2016) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-016-0135-x · Cited by 32 · see citing works
The Effect of β-Hydroxy-β-Methylbutyrate on Aerobic Capacity and Body Composition in Trained Athletes
Durkalec-Michalski, K., & Jeszka, J. (2016) · Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000001361 · Cited by 31 · see citing works
Supplementation with the Leucine Metabolite β-hydroxy-β-methylbutyrate (HMB) does not Improve Resistance Exercise-Induced Changes in Body Composition or Strength in Young Subjects: A Systematic Review and Meta-Analysis
Jakubowski, J., Nunes, E. A., Teixeira, F. J., Vescio, V., Morton, R. W., Banfield, L. E., & Phillips, S. M. (2020) · Nutrients · doi:10.3390/nu12051523 · Cited by 31 · see citing works
Does HMB Enhance Body Composition in Athletes? A Systematic Review and Meta-analysis
Holland, B. M., Roberts, B. M., Krieger, J. W., & Schoenfeld, B. J. (2019) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000003461 · Cited by 26 · see citing works
Regular exercise modulates obesity factors and body composition in sturdy men
Ko, I., & Choi, P.-B. (2013) · Journal of Exercise Rehabilitation · doi:10.12965/jer.130008 · Cited by 23 · see citing works
USEFULNESS OF Β-HYDROXY-Β-METHYLBUTYRATE (HMB) SUPPLEMENTATION IN DIFFERENT SPORTS: AN UPDATE AND PRACTICAL IMPLICATIONS.
Albert, F. J., Morente-Sánchez, J., Ortega, F. B., Castillo, M. J., & Gutiérrez, Á. (2015) · PubMed · doi:10.3305/nh.2015.32.1.9101 · Cited by 23 · see citing works
Effect of Resistance Training Combined with Beta‐Hydroxy‐Beta‐Methylbutyric Acid Supplements in Elderly Patients with Sarcopenia after Hip Replacement
Han, Z., Ji, N., Ma, J., Dong, Q., & Ma, X. (2022) · Orthopaedic Surgery · doi:10.1111/os.13208 · Cited by 17 · see citing works
Determination of β-hydroxy-β-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry
Walker, D. K., Thaden, J. J., Wierzchowska-McNew, R. A., ENGELEN, M. P. K. J., & Deutz, N. E. P. (2016) · Journal of Chromatography B · doi:10.1016/j.jchromb.2016.11.010 · Cited by 16 · see citing works
The Effects of Beta-Hydroxy-Beta-Methylbutyrate-Free Acid Supplementation and Resistance Training on Oxidative Stress Markers: A Randomized, Double-Blind, Placebo-Controlled Study
Arazi, H., Asadi, A., & Suzuki, K. (2018) · Antioxidants · doi:10.3390/antiox7060076 · Cited by 16 · see citing works
Sarcopenia and Ageing
Cheng, K. Y.-K., Bao, Z., Long, Y., Liu, C., Huang, T., Cui, C., Chow, S. K.-H., Wong, R. M. Y., & Cheung, W.-H. (2023) · Subcellular Biochemistry · doi:10.1007/978-3-031-26576-1_6 · Cited by 14 · see citing works
Negligible Effects of β-Hydroxy-β-Methylbutyrate Free Acid and Calcium Salt on Strength and Hypertrophic Responses to Resistance Training: A Randomized, Placebo-Controlled Study
Tritto, A. C., Bueno, S., Rodrigues, R. M. P., Gualano, B., Roschel, H., & Artioli, G. G. (2019) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2018-0337 · Cited by 14 · see citing works
Dietary Supplements Used in Combat Sports
Campbell, B. I., Bounty, P. M. L., & Wilborn, C. (2011) · Strength and conditioning journal · doi:10.1519/ssc.0b013e31823a4e90 · Cited by 11 · see citing works
The addition of β-Hydroxy β-Methylbutyrate (HMB) to creatine monohydrate supplementation does not improve anthropometric and performance maintenance across a collegiate rugby season
Mangine, G. T., VanDusseldorp, T. A., Hester, G. M., Julian, J. M., & Feito, Y. (2020) · Journal of the International Society of Sports Nutrition · doi:10.1186/s12970-020-00359-4 · Cited by 10 · see citing works
Effects of oral supplementation of β -hydroxy-β -methylbutyrate on muscle mass and strength in individuals over the age of 50: a meta-analysis
Li, N., Chen, S., He, Y., Chen, Y., Duan, X., He, W., Wang, Q., Liu, S., Liu, T., & Fang, H. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1522287 · Cited by 8 · see citing works
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Zhou, S., Liu, G., Wang, Z., Lei, Z., Chen, W., & Wang, C. (2025) · Foods · doi:10.3390/foods14081294 · Cited by 8 · see citing works
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[Beta]-hydroxy-[beta]-methylbutyrate (HMB) supplementation of resistance trained men : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Science in Nutritional Science at Massey University
Thomson, J. S. (2004) · Massey Research Online (Massey University)
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Slater, G., Jenkins, D., Logan, P., Lee, H., Vukovich, M., Rathmacher, J. A., & Hahn, A. G. (2001) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.11.3.384 · Cited by 122 · see citing works
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Authors: Thomson, J. S., Watson, P. E., & Rowlands, D. S.
Affiliations: Massey University (NZ)
Corresponding author: Thomson, Jasmine S
ORCID: Thomson, Jasmine S
Rowlands, David S
Venue: Journal of Strength and Conditioning Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2009-05
Volume: 23
Issue: 3
Pages: 827-835
ISSN: 1064-8011 (ISSN-L)
DOI: 10.1519/jsc.0b013e3181a00d47
OpenAlex: W2082243216
Cited by: 72
References: 31
Citations by year: 2026: 2 · 2025: 4 · 2024: 2 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 6 · 2019: 4 · 2018: 10 · 2017: 5 · 2016: 3 · 2015: 4 · 2014: 4 · 2013: 8 · 2012: 5
FWCI: 1.92
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Strength and Conditioning Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
Health Sciences › Medicine › Physiology › Biochemical effects in animals
Keywords: beta-hydroxy-beta-methylbutyrate, HMB supplementation, resistance training, muscle strength, body composition, fat mass, fat-free mass, trained men, leg extension, bench press, biceps curl, skinfold thickness, bioelectrical impedance analysis
MeSH terms: Body Composition, Capsules, Diet, Double-Blind Method, Energy Metabolism, Humans, Male, Placebos, Valerates, Dietary Supplements, Muscle Strength, Resistance Training, Young Adult

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Effects of Nine Weeks of β-Hydroxy-β- Methylbutyrate Supplementation on Strength and Body Composition in Resistance Trained Men

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