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Cited by 40Exercise and Physiological ResponsesMuscle metabolism and nutritionBiochemical effects in animals

A Review of the Effects of Leucine Metabolite (β-Hydroxy-β-methylbutyrate) Supplementation and Resistance Training on Inflammatory Markers: A New Approach to Oxidative Stress and Cardiovascular Risk Factors

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Arazi, Hamid, Taati, Behzad, Suzuki, Katsuhiko·2018·Antioxidants
DOI 10.3390/antiox7100148PMC PMC6210682

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Abstract

β-hydroxy β-methylbutyrate (HMB) is a bioactive metabolite formed from the breakdown of the branched-chain amino acid, leucine. Given the popularity of HMB supplements among different athletes, specifically, those who participate in regular resistance training, this review was performed to summarize current literature on some aspects of HMB supplementation that have received less attention. Because of the small number of published studies, it has not been possible to conclude the exact effects of HMB on cardiovascular parameters, oxidative stress, and inflammatory markers. Thus, the interpretation of outcomes should be taken cautiously. However, the data presented here suggest that acute HMB supplementation may attenuate the pro-inflammatory response following an intense bout of resistance exercise in athletes. Also, the available findings collectively indicate that chronic HMB consumption with resistance training does not improve cardiovascular risk factors and oxidative stress markers greater than resistance training alone. Taken together, there is clearly a need for further well-designed, long-term studies to support these findings and determine whether HMB supplementation affects the adaptations induced by resistance training associated with the body’s inflammatory condition, antioxidative defense system, and cardiovascular risk factors in humans.

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Cited by

Sorted by citations

Authors
Arazi, H., Taati, B., & Suzuki, K.
Affiliations
  • University of Guilan (IR)
  • Waseda University (JP)
Corresponding author
Arazi, Hamid
ORCID
Venue
Antioxidants
Publisher
MDPI AG
Published
2018-10-20
Volume
7
Issue
10
Pages
148
ISSN
2076-3921 (ISSN-L)
DOI
10.3390/antiox7100148
PMC
PMC6210682
OpenAlex
W2896506790
Cited by
40
References
6
Citations by year
2026: 3 · 2025: 10 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 3 · 2020: 7 · 2019: 4 · 2018: 1
FWCI
0.47
Type
journal article
Language
en
Open access
Licence
Locations
  • Antioxidants (publishedVersion, cc-by)
  • Preprints.org (acceptedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology › Biochemical effects in animals
Keywords
beta-hydroxy-beta-methylbutyrate, HMB supplementation, leucine metabolites, resistance training, inflammatory markers, oxidative stress, cardiovascular risk factors, athletes, branched-chain amino acids, antioxidant defense

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