Muscarinic control of long-range GABAergic inhibition within the rhinal cortices

Apergis-Schoute, John; Pinto, Aline; Paré, Denis

doi:10.1523/jneurosci.0068-07.2007

Cited by 46Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Muscarinic control of long-range GABAergic inhibition within the rhinal cortices

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Apergis-Schoute, John, Pinto, Aline, Paré, Denis·2007·The Journal of Neuroscience

DOI 10.1523/jneurosci.0068-07.2007PMC PMC6672538

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Abstract

The perirhinal cortex plays a critical role in memory formation, in part because it forms reciprocal connections with the neocortex and entorhinal cortex and is thus in a position to integrate and transfer higher-order information to and from the hippocampus. However, for reasons that remain unclear, perirhinal transfer of neocortical inputs to the entorhinal cortex occurs with a low probability. Using patch recordings in vitro and tract-tracing combined with GAD-67 immunohistochemistry, we show that the perirhinal cortex contains GABAergic neurons with long-range projections to superficial entorhinal cells. This finding challenges the traditional model of cortical inhibition in which all trans-areal inhibition is thought to be disynaptic because the axons of GABAergic interneurons are assumed to be confined within the area in which their somata are located. Moreover, consistent with recent studies indicating that the formation of perirhinal-dependent memories requires activation of muscarinic receptors, long-range IPSPs were presynaptically inhibited by M2 receptor activation. Overall, these results suggest that long-range feedforward inhibition regulates perirhinal transfer of neocortical inputs to the entorhinal cortex, but that cholinergic inputs can presynaptically adjust the impact of this control mechanism as a function of environmental contingencies.

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Projections from the perirhinal cortex to LEC and those from the postrhinal cortex to MEC are functionally different, with the former primarily sending inhibitory signals and the latter primarily sending excitatory ones.
“Projections from the perirhinal cortex to LEC and those from the postrhinal cortex to MEC are functionally different, with the former primarily sending inhibitory signals (Apergis-Schoute et al., 2007; Pinto et al., 2006; Willems et al., 2018) and the latter primarily sending excitatory ones (Koganezawa et al., 2015).”
From The medial prefrontal cortex - hippocampus circuit that integrates information of object, place and time to construct episodic memory in rodents: Behavioral, anatomical and neurochemical properties (2020) · cites this paper as Apergis-Schoute et al., 2007

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Fashena, D. (1999) · doi:10.1002/(sici)1096-9861(19990412)406:3

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Alonso A (2002) Electrophysiology of neurones in the perirhinal and ento- rhinal cortices and neuromodulatory changes in firing patterns. In: The parahippocampal region (Witter MP, Wouterlood F, eds), pp 89 -105. Oxford: Oxford UP.

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Authors: Apergis-Schoute, J., Pinto, A., & Paré, D.
Affiliations: Rutgers, The State University of New Jersey (US)
ORCID: Paré, Denis
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2007-04-11
Volume: 27
Issue: 15
Pages: 4061-4071
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0068-07.2007
PMC: PMC6672538
OpenAlex: W2010288797
Cited by: 46
References: 86
Citations by year: 2026: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 3 · 2015: 6 · 2013: 5 · 2012: 4
FWCI: 1.32
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation (0208712)
National Institute of Mental Health (R01MH073610, MH073610)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: muscarinic receptors, M2 muscarinic receptor, perirhinal cortex, entorhinal cortex, GABAergic interneurons, long-range inhibition, feedforward inhibition, presynaptic inhibition, inhibitory postsynaptic potentials, cholinergic modulation, memory formation, hippocampus
MeSH terms: Animals, gamma-Aminobutyric Acid, Glutamate Decarboxylase, Guinea Pigs, Isoenzymes, Nerve Net, Neural Inhibition, Entorhinal Cortex, 6-Cyano-7-nitroquinoxaline-2,3-dione, Excitatory Postsynaptic Potentials, Receptor, Muscarinic M2, Inhibitory Postsynaptic Potentials

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Muscarinic control of long-range GABAergic inhibition within the rhinal cortices

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