The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
HDAC1 Regulates Fear Extinction in Mice
Open accessAbstract
Histone acetylation has been implicated with the pathogenesis of neuropsychiatric disorders and targeting histone deacetylases (HDACs) using HDAC inhibitors was shown to be neuroprotective and to initiate neuroregenerative processes. However, little is known about the role of individual HDAC proteins during the pathogenesis of brain diseases. HDAC1 was found to be upregulated in patients suffering from neuropsychiatric diseases. Here, we show that virus-mediated overexpression of neuronal HDAC1 in the adult mouse hippocampus specifically affects the extinction of contextual fear memories, while other cognitive abilities were unaffected. In subsequent experiments we show that under physiological conditions, hippocampal HDAC1 is required for extinction learning via a mechanism that involves H3K9 deacetylation and subsequent trimethylation of target genes. In conclusion, our data show that hippocampal HDAC1 has a specific role in memory function.
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Cites
Chromatin modifications and their function
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HDAC2 negatively regulates memory formation and synaptic plasticity
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Self-citationRegulation of histone acetylation during memory formation in the hippocampus
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Altered Histone Acetylation Is Associated with Age-Dependent Memory Impairment in Mice
Peleg, S., Sananbenesi, F., Zovoilis, A., Burkhardt, S., Bahari-Javan, S., Agis-Balboa, R. C., Cota, P., Wittnam, J. L., Gogol-Doering, A., Opitz, L., et al. (2010) · Science · doi:10.1126/science.1186088 · Cited by 951
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Regulation of the GABA cell phenotype in hippocampus of schizophrenics and bipolars
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Cited by
Histone acetylation: molecular mnemonics on the chromatin
Gräff, J., & Tsai, L.-H. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3427 · Cited by 680
Tet1 Is Critical for Neuronal Activity-Regulated Gene Expression and Memory Extinction
Rudenko, A., Dawlaty, M. M., Seo, J., Cheng, A. W., Meng, J., Le, T., Faull, K. F., Jaenisch, R., & Tsai, L.-H. (2013) · Neuron · doi:10.1016/j.neuron.2013.08.003 · Cited by 441
Singewald, N., Schmuckermair, C., Whittle, N., Holmes, A., & Ressler, K. J. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.12.004 · Cited by 390
HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner
Malvaez, M., McQuown, S. C., Rogge, G. A., Astarabadi, M., Jacques, V., Carreiro, S., Rusche, J. R., & Wood, M. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213364110 · Cited by 395
The Role of Histone Acetylation in Memory Formation and Cognitive Impairments
Peixoto, L., & Abel, T. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.86 · Cited by 338
Metadata
- Authors
- Bahari-Javan, S., Maddalena, A., Kerimoglu, C., Wittnam, J., Held, T., Bähr, M., Burkhardt, S., Delalle, I., Kügler, S., Fischer, A., & Sananbenesi, F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-04-11
- Volume
- 32
- Issue
- 15
- Pages
- 5062-5073
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2035871717
- Cited by
- 185
- References
- 14
- FWCI
- 12.13
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bahari-Javan, S., Maddalena, A., Kerimoglu, C., Wittnam, J., Held, T., Bähr, M., Burkhardt, S., Delalle, I., Kügler, S., Fischer, A., & Sananbenesi, F. (2012). HDAC1 Regulates Fear Extinction in Mice. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0079-12.2012
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