The DOI matches its Crossref record; 47 of the 47 references it cites were found in a registry or an index.
Identification of Glyoxalase-I as a Protein Marker in a Mouse Model of Extremes in Trait Anxiety
Open accessAbstract
For >15 generations, CD1 mice have been selectively and bidirectionally bred for either high-anxiety-related behavior (HAB-M) or low-anxiety-related behavior (LAB-M) on the elevated plus-maze. Independent of gender, HAB-M were more anxious than LAB-M animals in a variety of additional tests, including those reflecting risk assessment behaviors and ultrasound vocalization, with unselected CD1 “normal” control (NAB-M) and cross-mated (CM-M) mice displaying intermediate behavioral scores in most cases. Furthermore, in both the forced-swim and tail-suspension tests, LAB-M animals showed lower scores of immobility than did HAB-M and NAB-M animals, indicative of a reduced depression-like behavior. Using proteomic and microarray analyses, glyoxalase-I was identified as a protein marker, which is consistently expressed to a higher extent in LAB-M than in HAB-M mice in several brain areas. The same phenotype-dependent difference was found in red blood cells with NAB-M and CM-M animals showing intermediate expression profiles of glyoxalase-I. Additional studies will examine whether glyoxalase-I has an impact beyond that of a biomarker to predict the genetic predisposition to anxiety- and depression-like behavior.
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“Although risk assessment behavior confirmed the marked difference in trait anxiety between HAB-M and LAB-M animals, the forced swim and tail-suspension tests rather reflect depression-like behavior (Cryan et al., 2002; Yoshikawa et al., 2002; Cryan and Mombereau, 2004).”
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Cited by
The ascent of mouse: advances in modelling human depression and anxiety
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Oxidative Stress and Anxiety: Relationship and Cellular Pathways
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Brain Oxytocin Correlates with Maternal Aggression: link to Anxiety
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50 years of hurdles and hope in anxiolytic drug discovery
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Metadata
- Authors
- Krömer, S. A., Keßler, M. S., Milfay, D., Birg, I. N., Bunck, M., Czibere, L., Panhuysen, M., Pütz, B., Deussing, J. M., Holsboer, F., Landgraf, R., & Turck, C. W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-04-27
- Volume
- 25
- Issue
- 17
- Pages
- 4375-4384
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2146653873
- Cited by
- 263
- References
- 47
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Krömer, S. A., Keßler, M. S., Milfay, D., Birg, I. N., Bunck, M., Czibere, L., Panhuysen, M., Pütz, B., Deussing, J. M., Holsboer, F., Landgraf, R., & Turck, C. W. (2005). Identification of Glyoxalase-I as a Protein Marker in a Mouse Model of Extremes in Trait Anxiety. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0115-05.2005
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