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Cited by 271Axon Guidance and Neuronal SignalingNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Ontogenetic changes in the projections of neocortical neurons

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Ivy, GO, Killackey, HP·1982·The Journal of Neuroscience
DOI 10.1523/jneurosci.02-06-00735.1982PMC PMC6564341
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Abstract

Development changes in the origins of contra- and ipsilateral projections from the rat parietal cortex were examined using the retrograde transport of horseradish peroxidase and of the fluorescent dyes fast blue and nuclear yellow. The aim of the study was to determine the fate of the neurons which send axons through the corpus callosum in the neonatal, but not the young adult, rat. 1. Neurons which project across the corpus callosum at postnatal day 8 (PND 8), but not at PND 20 or later, do not die; they merely lose their contralateral processes. 2. At PND 8, many of these neurons--in particular, those in lamina Va of the barrel field area--project simultaneously across the corpus callosum and to the ipsilateral motor cortex. 3. By PND 20 and later, many neurons in lamina Va of the barrel field area still project to the ipsilateral motor cortex but not across the corpus callosum. We conclude that at least some neocortical neurons initially elaborate more axonal processes than they will maintain and that they selectively eliminate major projections during development.

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  • A second pervasive form of degeneration in the developing brain is degeneration limited to axonal connections leaving the neurons of origin intact.

    “A second, pervasive form of degeneration in the developing brain is degeneration limited to axonal connections leaving the neurons of origin intact.”

    From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [28]

    The Abstract and Discussion report that some developing rat parietal-cortex neurons lose callosal axons while the neurons survive and retain other projections. The paper does not establish that this form of degeneration is pervasive throughout the developing brain; the Discussion also notes that other cells may die. Page numbers were not available in our copy. (LLM, conf=0.87)

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Research works printed but not linked: 1

  1. Kihackey, H. P. (1973) Anatomical evidence for cortical subdi- The Journal of Neuroscience Ontogenetic Changes in Neocortical Projections 743 visions based on vertically discrete thalamic projections from the ventral posterior nucleus to cortical barrels in the rat. Brain Res. 51: 326-331.

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Authors
Ivy, G., & Killackey, H.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
1982-06-01
Volume
2
Issue
6
Pages
735-743
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.02-06-00735.1982
PMC
PMC6564341
OpenAlex
W1679865271
Cited by
271
References
15
Citations by year
2026: 2 · 2025: 3 · 2023: 1 · 2021: 3 · 2019: 2 · 2018: 1 · 2015: 1 · 2014: 1 · 2013: 3
FWCI
9.82
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Axon Guidance and Neuronal Signaling
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
barrel cortex, postnatal development, retrograde tracing, neuronal fate
MeSH terms
Age Factors, Animals, Axons, Corpus Callosum, Motor Cortex, Muridae, Neural Pathways, Neurons, Parietal Lobe, Staining and Labeling

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