Cited by 144Parkinson's Disease Mechanisms and TreatmentsAutophagy in Disease and TherapyNuclear Receptors and Signaling

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Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

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Ahmed, Ishrat, Liang, Yideng, Schools, Sabitha, Dawson, Valina L., Dawson, Ted M., Savitt, Joseph M.·2012·The Journal of Neuroscience

DOI 10.1523/jneurosci.0209-12.2012PMC PMC3508432

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Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disease caused by the interaction of genetic and environmental factors. However, the etiology of PD remains largely unknown. Macroautophagy is known to play an essential role in the degradation of abnormal proteins and organelles. Furthermore, the loss of autophagy-related (Atg) genes results in neurodegeneration and abnormal protein accumulation. Since these are also pathologic features of Parkinson's disease, the conditional impairment of autophagy may lead to improved animal models for the study of PD. Using transgenic mice expressing Cre recombinase under the control of either the dopamine transporter or the engrailed-1 promoters, we generated mice with the conditional deletion of Atg7 in the dopamine neurons of the substantia nigra pars compacta, other regions of the midbrain, and also the hindbrain. This conditional impairment of autophagy results in the age-related loss of dopaminergic neurons and corresponding loss of striatal dopamine, the accumulation of low-molecular-weight α-synuclein, and the presence of ubiquitinated protein aggregates, recapitulating many of the pathologic features of PD. These conditional knock-out animals provide insight into the process of autophagy in Parkinson's disease pathology.

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Authors: Ahmed, I., Liang, Y., Schools, S., Dawson, V. L., Dawson, T. M., & Savitt, J. M.
Affiliations: Johns Hopkins University (US)
ORCID: Ahmed, Ishrat
Liang, Yideng
Dawson, Valina L.
Dawson, Ted M.
Savitt, Joseph M.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2012-11-14
Volume: 32
Issue: 46
Pages: 16503-16509
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0209-12.2012
PMC: PMC3508432
OpenAlex: W2026969412
Cited by: 144
References: 23
Citations by year: 2026: 1 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 19 · 2020: 10 · 2019: 13 · 2018: 10 · 2017: 8 · 2016: 16 · 2015: 12 · 2014: 16 · 2013: 12
FWCI: 8.36
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
Funders: Parkinson's Disease Foundation
Adrienne Helis Malvin Medical Research Foundation
JPB Foundation
Johns Hopkins University
National Institutes of Health
National Institute of Neurological Disorders and Stroke (P50NS38377, K08NS052624, P50NS038377)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Keywords: Parkinson's disease, autophagy, ATG7, conditional knockout mice, dopaminergic neurons, substantia nigra pars compacta, alpha-synuclein aggregation, ubiquitinated protein aggregates, striatal dopamine, neurodegeneration, transgenic mice
MeSH terms: Autophagy-Related Protein 7, Dynactin Complex, Animals, Autophagy, Cell Count, Chromatography, High Pressure Liquid, Disease Models, Animal, Dopamine, Electrochemistry, Immunohistochemistry, Microtubule-Associated Proteins, Parkinson Disease, Blotting, Western, Neostriatum, Gene Deletion, Mice, Knockout, Neurotransmitter Agents, Ubiquitin, Polyubiquitin, Mice, alpha-Synuclein, Dopaminergic Neurons

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Development and Characterization of a New Parkinson's Disease Model Resulting from Impaired Autophagy

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