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The Acquisition of Goal-Directed Actions Generates Opposing Plasticity in Direct and Indirect Pathways in Dorsomedial Striatum

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Shan, Q., Ge, M., Christie, M. J., Balleine, B. W.·2014·Journal of Neuroscience

DOI 10.1523/jneurosci.0313-14.2014PMC PMC6608360

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Abstract

A cortical-basal ganglia network involving, particularly, the posterior region of dorsomedial striatum (DMS) has been implicated in the acquisition of goal-directed actions; however, no direct evidence of learning-related plasticity in this striatal region has been reported, nor is it known whether, or which, specific cell types are involved in this learning process. The striatum is primarily composed of two classes of spiny projection neurons (SPNs): the striatonigral and striatopallidal SPNs, which express dopamine D1 and D2 receptors, respectively. Here we establish that, in mice, the acquisition of goal-directed actions induced plasticity in both D1- and D2-SPNs specifically in the DMS and, importantly, that these changes were in opposing directions; after learning, AMPA/NMDA ratios were increased in D1-SPNs and reduced in the D2-SPNs in the DMS. Such opposing plasticity could provide the basis for rapidly rebiasing the control of task-specific actions, and its dysregulation could underlie disorders associated with striatal function.

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Authors: Shan, Q., Ge, M., Christie, M. J., & Balleine, B. W.
Affiliations: The University of Sydney (AU)
ORCID: Shan, Q.
Christie, M. J.
Balleine, B. W.
Venue: Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2014-07-09
Volume: 34
Issue: 28
Pages: 9196-9201
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.0313-14.2014
PMC: PMC6608360
OpenAlex: W2049375392
Cited by: 122
References: 38
Citations by year: 2026: 8 · 2025: 9 · 2024: 4 · 2023: 11 · 2022: 11 · 2021: 8 · 2020: 10 · 2019: 17 · 2018: 15 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 2
FWCI: 4.42
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Medical Research Council
Australian Research Council (DP110105636)
National Health and Medical Research Council
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: goal-directed action, dorsomedial striatum, striatal plasticity, striatonigral neurons, striatopallidal neurons, medium spiny neurons, dopamine D1 receptor, dopamine D2 receptor, AMPA/NMDA ratio, learning
MeSH terms: Animals, Conditioning, Operant, Corpus Striatum, Goals, Male, Mice, Inbred C57BL, Mice, Transgenic, Neural Pathways, Neuronal Plasticity, Task Performance and Analysis, Mice

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The Acquisition of Goal-Directed Actions Generates Opposing Plasticity in Direct and Indirect Pathways in Dorsomedial Striatum

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