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The Acquisition of Goal-Directed Actions Generates Opposing Plasticity in Direct and Indirect Pathways in Dorsomedial Striatum
Open accessAbstract
A cortical-basal ganglia network involving, particularly, the posterior region of dorsomedial striatum (DMS) has been implicated in the acquisition of goal-directed actions; however, no direct evidence of learning-related plasticity in this striatal region has been reported, nor is it known whether, or which, specific cell types are involved in this learning process. The striatum is primarily composed of two classes of spiny projection neurons (SPNs): the striatonigral and striatopallidal SPNs, which express dopamine D1 and D2 receptors, respectively. Here we establish that, in mice, the acquisition of goal-directed actions induced plasticity in both D1- and D2-SPNs specifically in the DMS and, importantly, that these changes were in opposing directions; after learning, AMPA/NMDA ratios were increased in D1-SPNs and reduced in the D2-SPNs in the DMS. Such opposing plasticity could provide the basis for rapidly rebiasing the control of task-specific actions, and its dysregulation could underlie disorders associated with striatal function.
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“DMS neuronal activity, especially plasticity in dopamine D1 receptor-expressing neurons72, is critical for the action-outcome learning that supports goal-directed decision making and when suppressed promotes inflexible habits26–28.”
From A dual-pathway architecture for stress to disrupt agency and promote habit (2025) · cites this paper as [72]
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Metadata
- Authors
- Shan, Q., Ge, M., Christie, M. J., & Balleine, B. W.
- Affiliations
- The University of Sydney (AU)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-07-09
- Volume
- 34
- Issue
- 28
- Pages
- 9196-9201
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6608360
- OpenAlex
- W2049375392
- Cited by
- 122
- References
- 38
- Citations by year
- 2026: 8 · 2025: 9 · 2024: 4 · 2023: 11 · 2022: 11 · 2021: 8 · 2020: 10 · 2019: 17 · 2018: 15 · 2017: 8 · 2016: 9 · 2015: 10 · 2014: 2
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Medical Research Council
- Australian Research Council (DP110105636)
- National Health and Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- goal-directed action, dorsomedial striatum, striatal plasticity, striatonigral neurons, striatopallidal neurons, medium spiny neurons, dopamine D1 receptor, dopamine D2 receptor, AMPA/NMDA ratio, learning
- MeSH terms
- Animals, Conditioning, Operant, Corpus Striatum, Goals, Male, Mice, Inbred C57BL, Mice, Transgenic, Neural Pathways, Neuronal Plasticity, Task Performance and Analysis, Mice
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