Conservation of Glutamate Receptor 2-Containing AMPA Receptors during Long-Term Potentiation
Open accessAbstract
Long-term potentiation (LTP) at hippocampal synapses is thought to involve the insertion of AMPA receptors into the postsynaptic membrane. Conflicting evidence exists as to whether calcium-permeable receptors are inserted during LTP and whether synaptic activity mediated by the newly inserted AMPA receptors is required to maintain the increase in synaptic strength. Here, we rigorously test these hypotheses and conclude that calcium-permeable AMPA receptors are not inserted during LTP nor does potentiation require ongoing activity to be maintained.
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Heteromeric GluA1/GluA2 receptors seem to be the primary subtype of AMPAR that is inserted into synapses during LTP.
“Heteromeric GluA1/GluA2 receptors seem to be the primary subtype of AMPAR that is inserted into synapses during LTP (Adesnik and Nicoll 2007).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Adesnik and Nicoll 2007
The Discussion concludes that LTP in CA1 does not involve insertion of calcium-permeable AMPARs, supporting a role for GluA2-containing receptors. But the paper does not identify the inserted receptors specifically as GluA1/GluA2 heteromers or establish that they are the primary subtype across synapses generally. (LLM, conf=0.87)
Experimental — accuracy not yet measuredLTP in the mature hippocampus is mediated by GluA2-containing receptors.
“LTP in the mature hippocampus is mediated by GluA2-containing receptors (Adesnik and Nicoll, 2007).”
From The AMPA Receptor Code of Synaptic Plasticity (2018) · cites this paper as Adesnik and Nicoll, 2007
The Introduction says synaptic AMPA receptors in CA1 pyramidal cells generally contain GluR2 (GluA2), and the Discussion concludes that CA1 LTP does not involve inserting calcium-permeable receptors. But the Methods describe slices from 2–3-week-old animals, so the experiments do not establish the claim specifically for the mature hippocampus or for hippocampal regions beyond CA1. (LLM, conf=0.88)
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- Authors
- Adesnik, H., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Nicoll, Roger A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-04-25
- Volume
- 27
- Issue
- 17
- Pages
- 4598-4602
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672988
- OpenAlex
- W2058877455
- Cited by
- 213
- References
- 2
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 14 · 2023: 8 · 2022: 3 · 2021: 12 · 2020: 6 · 2019: 8 · 2018: 14 · 2017: 4 · 2016: 6 · 2015: 6 · 2014: 9 · 2013: 18 · 2012: 18
- FWCI
- 8.76
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- long-term potentiation, AMPA receptors, GluR2 subunit, hippocampal synapses, synaptic plasticity, postsynaptic membrane
- MeSH terms
- Animals, Calcium, Hippocampus, Memory, Neuronal Plasticity, Organ Culture Techniques, Synapses, Rats, Sprague-Dawley, Long-Term Potentiation, Receptors, AMPA, Mice, Knockout, Mice, Rats
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