GluA2-lacking, calcium-permeable AMPA receptors--inducers of plasticity?
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AMPA receptors (AMPARs) are heterotetromeric complexes composed of GluA1-4 subunits. They are glutamate-gated channels traditionally considered solely as ion carriers for postsynaptic depolarization. However, the existence and dynamic regulation of GluA2-lacking, calcium-permeable AMPARs (Cp-AMPARs) enable these special receptors to serve also as signaling molecules presumably via calcium influx. Recent studies have implicated Cp-AMPARs in several types of synaptic plasticity, including homeostatic synaptic regulation and Hebbian synaptic plasticity. Cp-AMPARs are usually expressed transiently at an early stage of synaptic plasticity, but are then replaced with normal GluA2-containing receptors, indicating a role for Cp-AMPARs in induction, rather than the maintenance, of synaptic plasticity.
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GluA2-lacking AMPARs are CP ionotropic receptors with larger single-channel conductance and can undergo voltage-dependent blockade by polyamines.
“GluA2-lacking AMPARs are CP ionotropic receptors with larger single-channel conductance and can undergo voltage-dependent blockade by polyamines (Twomey et al., 2018; Man, 2011).”
From Oxytocin neurons mediate the effect of social isolation via the VTA circuits (2022) · cites this paper as Man, 2011
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- Authors
- Man, H.-Y.
- Affiliations
- Boston University (US)
- Corresponding author
- Man, Heng-Ye
- ORCID
- Man, Heng-Ye
- Venue
- Current Opinion in Neurobiology
- Publisher
- Elsevier BV
- Published
- 2011-04
- Volume
- 21
- Issue
- 2
- Pages
- 291-298
- ISSN
- 0959-4388 (ISSN-L)
- PMC
- PMC3092818
- OpenAlex
- W2076942850
- Cited by
- 142
- References
- 67
- Citations by year
- 2026: 10 · 2025: 11 · 2024: 8 · 2023: 13 · 2022: 10 · 2021: 11 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 6 · 2015: 4 · 2014: 10 · 2013: 15 · 2012: 13
- FWCI
- 1.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (MH079407, R01MH079407)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- calcium-permeable AMPA receptors, GluA2, synaptic plasticity, Hebbian plasticity, calcium signaling
- MeSH terms
- Animals, Calcium, Humans, Neuronal Plasticity, Synapses, Receptors, AMPA, Calcium Signaling
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