Neural precursor lineages specify distinct neocortical pyramidal neuron types.
Open accessAbstract
Several neural precursor populations contemporaneously generate neurons in the developing neocortex. Specifically, radial glial stem cells of the dorsal telencephalon divide asymmetrically to produce excitatory neurons, but also indirectly to produce neurons via three types of intermediate progenitor cells. Why so many precursor types are needed to produce neurons has not been established; whether different intermediate progenitor cells merely expand the output of radial glia or instead generate distinct types of neurons is unknown. Here we use a novel genetic fate mapping technique to simultaneously track multiple precursor streams in the developing mouse brain and show that layer 2 and 3 pyramidal neurons exhibit distinctive electrophysiological and structural properties depending upon their precursor cell type of origin. These data indicate that individual precursor subclasses synchronously produce functionally different neurons, even within the same lamina, and identify a primary mechanism leading to cortical neuronal diversity.
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Multiple classes of NPCs exist that result in numerous subtypes of neurons.
“Recent studies have identified multiple classes of NPCs that result in numerous subtypes of neurons even within a small defined region of the cortex (Tyler et al., 2015; Guillamon-Vivancos et al., 2019).”
From Neurodevelopment in Down syndrome: Concordance in humans and models (2022) · cites this paper as Tyler et al., 2015
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Cites
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Self-citationCortical and Clonal Contribution of Tbr2 Expressing Progenitors in the Developing Mouse Brain
Vasistha, N. A., García-Moreno, F., Arora, S., Cheung, A. F. P., Arnold, S. J., Robertson, E. J., & Molnár, Z. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhu125 · Cited by 177 · cited 3× · see citing works
“In agreement with previous work (Vasistha et al., 2014), these cells, the majority of which were located close to the ventricular surface (Fig.”
BackgroundResultInfluentialAberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome.
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“Empirical evidence from mouse models of fragile X syndrome, which exhibit a significant expansion in bIPCs (Tervonen et al., 2009), and Down syndrome, which show a specific deficit in aIPC production (Tyler and Haydar, 2013), support this hypothesis.”
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Neurodevelopment in Down syndrome: Concordance in humans and models
Klein, J. A., & Haydar, T. F. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.941855 · Cited by 47 · see citing works
“Recent studies have identified multiple classes of NPCs that result in numerous subtypes of neurons even within a small defined region of the cortex (Tyler et al., 2015; Guillamon-Vivancos et al., 2019).”
BackgroundSelf-citation
- Authors
- Tyler, W. A., Medalla, M., Guillamon-Vivancos, T., Luebke, J. I., & Haydar, T. F.
- Affiliations
- Boston University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-04-15
- Volume
- 35
- Issue
- 15
- Pages
- 6142-6152
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4397608
- OpenAlex
- W2043093018
- Cited by
- 60
- References
- 7
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 9 · 2015: 2
- FWCI
- 2.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fundación Rafael del Pino
- National Institutes of Health
- National Institute of Mental Health (K99MH101234, MH101234, R00MH101234)
- National Institute of Neurological Disorders and Stroke (R21NS089340, NS089340, NS051582)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- intermediate progenitor cells, neocortical pyramidal neurons, layer 2/3 neurons, genetic fate mapping, excitatory neurons, dorsal telencephalon, mouse brain development
- MeSH terms
- Animals, Embryo, Mammalian, Luminescent Proteins, Lysine, Membrane Potentials, Mice, Transgenic, Nerve Net, Pyramidal Cells, Electroporation, Patch-Clamp Techniques, Cell Lineage, Neocortex, Excitatory Postsynaptic Potentials, T-Box Domain Proteins, Mice, Neural Stem Cells
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