Cited by 315Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCancer-related Molecular Pathways

G1 Phase Regulation, Area-Specific Cell Cycle Control, and Cytoarchitectonics in the Primate Cortex

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Lukaszewicz, Agnès, Savatier, Pierre, Cortay, Véronique, Giroud, Pascale, Huissoud, Cyril, Berland, Michel, Kennedy, Henry, Dehay, Colette·2005·Neuron

Abstract

We have investigated the cell cycle-related mechanisms that lead to the emergence of primate areas 17 and 18. These areas are characterized by striking differences in cytoarchitectonics and neuron number. We show in vivo that (1) area 17 precursors of supragranular neurons exhibit a shorter cell cycle duration, a reduced G1 phase, and a higher rate of cell cycle reentry than area 18 precursors; (2) area 17 and area 18 precursors show contrasting and specific levels of expression of cyclin E (high in area 17, low in area 18) and p27Kip1 (low in area 17, high in area 18); (3) ex vivo up- and downmodulation of cyclin E and p27Kip1 show that both regulators influence cell cycle kinetics by modifying rates of cell cycle progression and cell cycle reentry; (4) modeling the areal differences in cell cycle parameters suggests that they contribute to areal differences in numbers of precursors and neuron production.

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Crossref · 10.1016/j.neuron.2005.06.032

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  • oRGs are present in large numbers in gyrencephalic primates and are considered pivotal to the evolutionary increase in human cortex size and complexity.

    “oRGs are present in large numbers in gyrencephalic primates22,23,40–44 and are considered pivotal to the evolutionary increase in human cortex size and complexity45,46.”

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Authors
Lukaszewicz, A., Savatier, P., Cortay, V., Giroud, P., Huissoud, C., Berland, M., Kennedy, H., & Dehay, C.
Affiliations
Lyon 1 Université (FR)
Corresponding author
Dehay, Colette
Venue
Neuron
Publisher
Elsevier BV
Published
2005-08
Volume
47
Issue
3
Pages
353-364
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2124843892
Cited by
315
References
73
Citations by year
2026: 5 · 2025: 9 · 2024: 5 · 2023: 13 · 2022: 13 · 2021: 17 · 2020: 17 · 2019: 18 · 2018: 12 · 2017: 11 · 2016: 22 · 2015: 19 · 2014: 23 · 2013: 16 · 2012: 14
FWCI
4.31
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion, other-oa)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
  • Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords
cell cycle re-entry, primate visual cortex, area 17, area 18, cyclin E, p27, neuronal precursors, neuron number, cell cycle kinetics, cortical development
MeSH terms
Animals, Cell Cycle, Cerebral Cortex, Fetus, Kinetics, Macaca fascicularis, Models, Neurological, Neurons, Time Factors, Down-Regulation, Up-Regulation, G1 Phase, Cell Cycle Proteins, Cyclin E, Tumor Suppressor Proteins, Fetal Development, Cyclin-Dependent Kinase Inhibitor p27, In Vitro Techniques

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