Addictive Nicotine Alters Local Circuit Inhibition during the Induction of In Vivo Hippocampal Synaptic Potentiation
Open accessAbstract
The drug addiction process shares many commonalities with normal learning and memory. Addictive drugs subvert normal synaptic plasticity mechanisms, and the consequent synaptic changes underlie long-lasting modifications in behavior that accrue during the progression from drug use to addiction. Supporting this hypothesis, it was recently shown that nicotine administered to freely moving mice induces long-term synaptic potentiation of the perforant path connection to granule cells of the dentate gyrus. The perforant path carries place and spatial information that links the environment to drug taking. An example of that association is the nicotine-induced synaptic potentiation of the perforant path that was found to underlie nicotine-conditioned place preference. The present study examines the influence of nicotine over local GABAergic inhibition within the dentate gyrus during the drug-induced synaptic potentiation. In vivo recordings from freely moving mice suggested that both feedforward and feedback inhibition onto granules cells were diminished by nicotine during the induction of synaptic potentiation. In vitro brain slice studies indicated that nicotine altered local circuit inhibition within the dentate gyrus leading to disinhibition of granule cells. These changes in local inhibition contributed to nicotine-induced in vivo synaptic potentiation, thus, likely contributed to drug-associated memories. Through this learning process, environmental features become cues that motivate conditioned drug-seeking and drug-taking behaviors.
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Drugs of abuse, such as nicotine and methylphenidate, recruit dopaminergic neurotransmission to influence synaptic plasticity within the hippocampus.
“Also, there is functional evidence that indicates that drugs of abuse, such as nicotine (Tang and Dani, 2009; Zhang et al., 2010) and methylphenidate (Jenson et al., 2015), recruit dopaminergic neurotransmission to influence synaptic plasticity within the hippocampus.”
From Dopamine regulates aversive contextual learning and associated in vivo synaptic plasticity in the Hippocampus (2016) · cites this paper as Zhang et al., 2010
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- Authors
- Zhang, T. A., Tang, J., Pidoplichko, V. I., & Dani, J. A.
- Affiliations
- Baylor College of Medicine (US)
- Corresponding author
- Dani, John A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-05-05
- Volume
- 30
- Issue
- 18
- Pages
- 6443-6453
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2891764
- OpenAlex
- W2079296713
- Cited by
- 33
- References
- 85
- Citations by year
- 2024: 1 · 2023: 2 · 2021: 2 · 2020: 2 · 2018: 4 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 3 · 2013: 6 · 2012: 4
- FWCI
- 1.55
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Diana Helis Henry Medical Research Foundation
- National Institutes of Health (DA09411, NS21229)
- National Institute on Drug Abuse (DA09411, R01DA009411)
- National Institute of Neurological Disorders and Stroke (NS 21229, R37NS021229, R01NS021229)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Keywords
- nicotine, hippocampus, dentate gyrus, granule cells, perforant path, synaptic potentiation, GABAergic inhibition, feedforward inhibition, product inhibition, disinhibition, drug addiction, conditioned place preference, drug-associated memory, synaptic plasticity
- MeSH terms
- Animals, gamma-Aminobutyric Acid, Mice, Inbred C57BL, Neural Inhibition, Neurons, Nicotine, Illicit Drugs, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Receptors, AMPA, Dentate Gyrus, Perforant Pathway, Mice, In Vitro Techniques
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