Impaired Action Potential Initiation in GABAergic Interneurons Causes Hyperexcitable Networks in an Epileptic Mouse Model Carrying a Human NaV1.1 Mutation
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Mutations in SCN1A and other ion channel genes can cause different epileptic phenotypes, but the precise mechanisms underlying the development of hyperexcitable networks are largely unknown. Here, we present a multisystem analysis of an SCN1A mouse model carrying the Na V 1.1-R1648H mutation, which causes febrile seizures and epilepsy in humans. We found a ubiquitous hypoexcitability of interneurons in thalamus, cortex, and hippocampus, without detectable changes in excitatory neurons. Interestingly, somatic Na+channels in interneurons and persistent Na+currents were not significantly changed. Instead, the key mechanism of interneuron dysfunction was a deficit of action potential initiation at the axon initial segment that was identified by analyzing action potential firing. This deficit increased with the duration of firing periods, suggesting that increased slow inactivation, as recorded for recombinant mutated channels, could play an important role. The deficit in interneuron firing caused reduced action potential-driven inhibition of excitatory neurons as revealed by less frequent spontaneous but not miniature IPSCs. Multiple approaches indicated increased spontaneous thalamocortical and hippocampal network activity in mutant mice, as follows: (1) more synchronous and higher-frequency firing was recorded in primary neuronal cultures plated on multielectrode arrays; (2) thalamocortical slices examined by field potential recordings revealed spontaneous activities and pathological high-frequency oscillations; and (3) multineuron Ca 2+imaging in hippocampal slices showed increased spontaneous neuronal activity. Thus, an interneuron-specific generalized defect in action potential initiation causes multisystem disinhibition and network hyperexcitability, which can well explain the occurrence of seizures in the studied mouse model and in patients carrying this mutation.
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Scn1a is a gene that encodes Nav1.1, a sodium channel necessary for PV cell firing.
“Scn1a is a gene that encodes Nav1.1, a sodium channel necessary for PV cell firing (Ogiwara et al., 2007; Hedrich et al., 2014).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Hedrich et al., 2014
Reduced PV cell spike output may contribute to seizures in mice with genetic knock-in of mutated human Scn1a, which results in subtle changes in Nav1.1 functionality.
“Recent studies demonstrate that reduced PV cell spike output may contribute to seizures in mice with genetic knock-in of mutated human Scn1a, which results in subtle changes in Nav1.1 functionality (Ogiwara et al., 2007; Hedrich et al., 2014).”
From The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders (2018) · cites this paper as Hedrich et al., 2014
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Shrestha, S., & Offer, S. M. (2016) · Medical Epigenetics · doi:10.1159/000444713 · Cited by 8,949 · see citing works
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
Cobb, S. R., Buhl, E. H., Halasy, K., Paulsen, O., & Somogyi, P. (1995) · Nature · doi:10.1038/378075a0 · Cited by 1,498 · see citing works
De Novo Mutations in the Sodium-Channel Gene SCN1A Cause Severe Myoclonic Epilepsy of Infancy
Claes, L., Del-Favero, J., Ceulemans, B., Lagae, L., Van Broeckhoven, C., & De Jonghe, P. (2001) · The American Journal of Human Genetics · doi:10.1086/320609 · Cited by 1,292 · see citing works
Tamamaki, N., Yanagawa, Y., Tomioka, R., Miyazaki, J., Obata, K., & Kaneko, T. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10905 · Cited by 1,277 · see citing works
Yu, F. H., Mantegazza, M., Westenbroek, R. E., Robbins, C. A., Kalume, F., Burton, K. A., Spain, W. J., McKnight, G. S., Scheuer, T., & Catterall, W. A. (2006) · Nature Neuroscience · doi:10.1038/nn1754 · Cited by 1,173 · see citing works
Self-citationMutations of SCN1A, encoding a neuronal sodium channel, in two families with GEFS+2
Escayg, A., MacDonald, B. T., Meisler, M. H., Baulac, S., Huberfeld, G., An-Gourfinkel, I., Brice, A., LeGuern, E., Moulard, B., Chaigne, D., et al. (2000) · Nature Genetics · doi:10.1038/74159 · Cited by 996 · see citing works
Self-citationOgiwara, I., Miyamoto, H., Morita, N., Atapour, N., Mazaki, E., Inoue, I., Takeuchi, T., Itohara, S., Yanagawa, Y., Obata, K., et al. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.5270-06.2007 · Cited by 879 · see citing works
Temporal structure in spatially organized neuronal ensembles: a role for interneuronal networks
Buzsáki, G., & Chrobak, J. J. (1995) · Current Opinion in Neurobiology · doi:10.1016/0959-4388(95)80012-3 · Cited by 878 · see citing works
Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine
Dichgans, M., Freilinger, T. M., Eckstein, G., Babini, E., Lorenz‐Depiereux, B., Biskup, S., Ferrari, M. D., Herzog, J., van den Maagdenberg, A. M. J. M., Pusch, M., et al. (2005) · The Lancet · doi:10.1016/s0140-6736(05)66786-4 · Cited by 852 · see citing works
Scheffer, I. E. (1997) · Brain · doi:10.1093/brain/120.3.479 · Cited by 758 · see citing works
Bursting of Thalamic Neurons and States of Vigilance
Llinás, R. R., & Steriade, M. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00166.2006 · Cited by 682 · see citing works
Thalamocortical responses of mouse somatosensory (barrel) cortexin vitro
Agmon, A., & Connors, B. W. (1991) · Neuroscience · doi:10.1016/0306-4522(91)90333-j · Cited by 673 · see citing works
Pathophysiological mechanisms of genetic absence epilepsy in the rat
Danober, L., Deransart, C., Depaulis, A., Vergnes, M., & Marescaux, C. (1998) · Progress in Neurobiology · doi:10.1016/s0301-0082(97)00091-9 · Cited by 583 · see citing works
Statistical Methods for the Analysis of Biomedical Data
Ziegel, E. R., & Woolson, R. F. (1989) · Technometrics · doi:10.2307/1268847 · Cited by 582 · see citing works
High-speed in vivo calcium imaging reveals neuronal network activity with near-millisecond precision
Grewe, B. F., Langer, D., Kasper, H., Kampa, B. M., & Helmchen, F. (2010) · Nature Methods · doi:10.1038/nmeth.1453 · Cited by 525 · see citing works
Sleep, epilepsy and thalamic reticular inhibitory neurons
Steriade, M. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.03.007 · Cited by 443 · see citing works
The axon initial segment and the maintenance of neuronal polarity
Rasband, M. N. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2852 · Cited by 442 · see citing works
Local Generation of Fast Ripples in Epileptic Brain
Bragin, A., Módy, I., Wilson, C. L., & Engel, J. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-05-02012.2002 · Cited by 432 · see citing works
Enhanced tonic GABAA inhibition in typical absence epilepsy
Cope, D. W., Giovanni, G. D., Fyson, S. J., Orbán, G., Errington, A. C., Lörincz, M. L., Gould, T. M., Carter, D., & Crunelli, V. (2009) · Nature Medicine · doi:10.1038/nm.2058 · Cited by 431 · see citing works
GABAergic Interneurons Shape the Functional Maturation of the Cortex
Le Magueresse, C., & Monyer, H. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.011 · Cited by 425 · see citing works
Regulation of neuronal input transformations by tunable dendritic inhibition
Lovett-Barron, M., Turi, G. F., Kaifosh, P., Lee, P. H., Bolze, F., Sun, X.-H., Nicoud, J.-F., Zemelman, B. V., Sternson, S. M., & Losonczy, A. (2012) · Nature Neuroscience · doi:10.1038/nn.3024 · Cited by 417 · see citing works
Cell-type-dependent molecular composition of the axon initial segment
Lorincz, A., & Nusser, Z. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4833-08.2008 · Cited by 382 · see citing works
Distal Initiation and Active Propagation of Action Potentials in Interneuron Dendrites
Martina, M., Vida, I., & Jonas, P. (2000) · Science · doi:10.1126/science.287.5451.295 · Cited by 375 · see citing works
Beenhakker, M. P., & Huguenard, J. R. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.015 · Cited by 374 · see citing works
Molecular Basis of an Inherited Epilepsy
Lossin, C., Wang, D. W., Rhodes, T. H., Vanoye, C. G., & George, A. L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00714-6 · Cited by 361 · see citing works
Reciprocal Inhibitory Connections and Network Synchrony in the Mammalian Thalamus
Huntsman, M. M., Porcello, D. M., Homanics, G. E., DeLorey, T. M., & Huguenard, J. R. (1999) · Science · doi:10.1126/science.283.5401.541 · Cited by 361 · see citing works
Holekamp, T. F., Turaga, D., & Holy, T. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.01.011 · Cited by 337 · see citing works
Site of Action Potential Initiation in Layer 5 Pyramidal Neurons
Palmer, L. M., & Stuart, G. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4812-05.2006 · Cited by 336 · see citing works
Mechanisms of physiological and epileptic HFO generation
Jefferys, J. G. R., de la Prida, L. M., Wendling, F., Bragin, A., Avoli, M., Timofeev, I., & Lopes, F. H. D. S. (2012) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2012.02.005 · Cited by 309 · see citing works
Sequential Generation of Two Distinct Synapse-Driven Network Patterns in Developing Neocortex
Allène, C., Cattani, A., Ackman, J. B., Bonifazi, P., Aniksztejn, L., Ben-Ari, Y., & Cossart, R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3733-08.2008 · Cited by 281 · see citing works
Korn, S. J., Giacchino, J. L., Chamberlin, N. L., & Dingledine, R. J. (1987) · Journal of Neurophysiology · doi:10.1152/jn.1987.57.1.325 · Cited by 266 · see citing works
Genotype–phenotype associations in SCN1A -related epilepsies
Zuberi, S. M., Brunklaus, A., Birch, R. C., Reavey, E., Duncan, J., & FORBES, G. (2011) · Neurology · doi:10.1212/wnl.0b013e31820c309b · Cited by 252 · see citing works
An Extrasynaptic GABAA Receptor Mediates Tonic Inhibition in Thalamic VB Neurons
Jia, F., Pignataro, L., Schofield, C. M., Yue, M. E., Harrison, N. L., & Goldstein, P. A. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00421.2005 · Cited by 242 · see citing works
Martin, M. S., Dutt, K., Papale, L. A., Dubé, C. M., Dutton, S. B. B., de Haan, G., Shankar, A., Tufik, S. B., Meisler, M. H., Baram, T. Z., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.078568 · Cited by 229 · see citing works
Self-citationMartina, M., & Jonas, P. (1997) · The Journal of Physiology · doi:10.1111/j.1469-7793.1997.593ba.x · Cited by 229 · see citing works
Polarized distribution of ion channels within microdomains of the axon initial segment
Wart, A. V., Trimmer, J. S., & Matthews, G. (2006) · The Journal of Comparative Neurology · doi:10.1002/cne.21173 · Cited by 222 · see citing works
Baulac, S., Gourfinkel‐An, I., Picard, F., Rosenberg‐Bourgin, M., Prud’homme, J.-F., Baulac, M., Brice, A., & Leguern, É. (1999) · The American Journal of Human Genetics · doi:10.1086/302593 · Cited by 208 · see citing works
Mechanisms of human inherited epilepsies
Reid, C. A., Berkovic, S. F., & Petrou, S. (2008) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2008.09.016 · Cited by 207 · see citing works
Role of Axonal NaV1.6 Sodium Channels in Action Potential Initiation of CA1 Pyramidal Neurons
Royeck, M., Horstmann, M., Remy, S., Reitze, M., Yaari, Y., & Beck, H. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90332.2008 · Cited by 204 · see citing works
Self-citationThe voltage-gated sodium channel Scn8a is a genetic modifier of severe myoclonic epilepsy of infancy
Martin, M. S., Tang, B., Papale, L. A., Yu, F. H., Catterall, W. A., & Escayg, A. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm248 · Cited by 202 · see citing works
Self-citationDendritic Mechanisms Underlying Rapid Synaptic Activation of Fast-Spiking Hippocampal Interneurons
Hu, H., Martina, M., & Jonas, P. (2010) · Science · doi:10.1126/science.1177876 · Cited by 202 · see citing works
Spampanato, J. G., Escayg, A., Meisler, M. H., & Goldin, A. L. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-19-07481.2001 · Cited by 191 · see citing works
Self-citationAction Potential Initiation and Propagation in CA3 Pyramidal Axons
Meeks, J. P., & Mennerick, S. J. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01288.2006 · Cited by 189 · see citing works
Ogiwara, I., Iwasato, T., Miyamoto, H., Iwata, R., Yamagata, T., Mazaki, E., Yanagawa, Y., Tamamaki, N., Hensch, T. K., Itohara, S., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt331 · Cited by 183 · see citing works
A supercritical density of Na+ channels ensures fast signaling in GABAergic interneuron axons
Hu, H., & Jonas, P. (2014) · Nature Neuroscience · doi:10.1038/nn.3678 · Cited by 179 · see citing works
Mistry, A. M., Thompson, C. H., Miller, A. R., Vanoye, C. G., George, A. L., & Kearney, J. A. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.01.006 · Cited by 177 · see citing works
Masking epilepsy by combining two epilepsy genes
Glasscock, E., Qian, J., Yoo, J. W., & Noebels, J. L. (2007) · Nature Neuroscience · doi:10.1038/nn1999 · Cited by 175 · see citing works
Dopamine Increases Excitability of Pyramidal Neurons in Primate Prefrontal Cortex
Henze, D. A., González‐Burgos, G., Urban, N. N., Lewis, D. A., & Barrionuevo, G. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.6.2799 · Cited by 171 · see citing works
Liao, Y., Anttonen, A.-K., Liukkonen, E., Gaily, E., Maljevic, S., Schubert, S., Bellan-Koch, A., Petrou, S., Ahonen, V. E., Lerche, H., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181f8812e · Cited by 170 · see citing works
Self-citationRedecker, C., Luhmann, H. J., Hagemann, G., Fritschy, J., & Witte, O. W. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-13-05045.2000 · Cited by 140 · see citing works
Cestèle, S., Scalmani, P., Rusconi, R., Terragni, B., Franceschetti, S., & Mantegazza, M. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.4453-07.2008 · Cited by 132 · see citing works
Self-citationGenetic mechanisms in idiopathic epilepsies
Weber, Y. G., & Lerche, H. (2008) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2008.03058.x · Cited by 130 · see citing works
Self-citationPreferential inactivation of Scn1a in parvalbumin interneurons increases seizure susceptibility
Dutton, S. B., Makinson, C. D., Papale, L. A., Shankar, A., Balakrishnan, B., Nakazawa, K., & Escayg, A. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.08.012 · Cited by 128 · see citing works
Self-citationModulatory Proteins Can Rescue a Trafficking Defective Epileptogenic Nav1.1 Na+Channel Mutant
Rusconi, R., Scalmani, P., Cassulini, R. R., Giunti, G., Gambardella, A., Franceschetti, S., Annesi, G., Wanke, E., & Mantegazza, M. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3515-07.2007 · Cited by 120 · see citing works
Self-citationTang, B., Dutt, K., Papale, L. A., Rusconi, R., Shankar, A., Hunter, J. E., Tufik, S., Yu, F. H., Catterall, W. A., Mantegazza, M., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.04.007 · Cited by 100 · see citing works
Self-citationStatistical Methods for the Analysis of Biomedical Data
Woolson, R. F., & Clarke, W. R. (2002) · Wiley series in probability and statistics · doi:10.1002/9781118033050 · Cited by 95 · see citing works
Alekov, A. K., Rahman, M. M., Mitrović, N., Lehmann‐Horn, F., & Lerche, H. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.00533.x · Cited by 92 · see citing works
Self-citationEndogenous Positive Allosteric Modulation of GABAA Receptors by Diazepam binding inhibitor
Christian, C. A., Herbert, A. G., Holt, R. L., Peng, K. K., Sherwood, K. D., Pangratz-Fuehrer, S., Rudolph, U., & Huguenard, J. R. (2013) · Neuron · doi:10.1016/j.neuron.2013.04.026 · Cited by 90 · see citing works
Axon initial segment dysfunction in a mouse model of genetic epilepsy with febrile seizures plus
Wimmer, V. C., Reid, C. A., Mitchell, S., Richards, K., Scaf, B. B., Leaw, B., Hill‐Yardin, E. L., Royeck, M., Horstmann, M., Cromer, B. A., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42219 · Cited by 88 · see citing works
Self-citationBursting and tonic discharges in two classes of reticular thalamic neurons
Contreras, D., Dossi, R. C., & Steriade, M. (1992) · Journal of Neurophysiology · doi:10.1152/jn.1992.68.3.973 · Cited by 88 · see citing works
Behrens, C., van den Boom, L., & Heinemann, U. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05462.x · Cited by 84 · see citing works
Heterogeneity of firing properties among rat thalamic reticular nucleus neurons
Lee, S.-H., Govindaiah, G., & Cox, C. L. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.134254 · Cited by 82 · see citing works
Jones, M. S., & Barth, D. S. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.2.1016 · Cited by 81 · see citing works
Ben‐Ari, Y., & Dudek, F. E. (2010) · Epiliepsy currents/Epilepsy currents · doi:10.1111/j.1535-7511.2010.01376.x · Cited by 77 · see citing works
Liautard, C., Scalmani, P., Carriero, G., de Curtis, M., Franceschetti, S., & Mantegazza, M. (2013) · Epilepsia · doi:10.1111/epi.12213 · Cited by 76 · see citing works
Self-citationIlles, S., Theiss, S., Hartung, H., Siebler, M., & Dihné, M. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-93 · Cited by 59 · see citing works
Self-citationGeneralized Epilepsy with Febrile Seizures Plus
Tatum, W. O. (2013) · Springer eBooks · doi:10.1007/978-3-319-01366-4_9 · Cited by 52 · see citing works
Lauxmann, S., Boutry‐Kryza, N., Rivier, C., Mueller, S., Hedrich, U. B. S., Maljevic, S., Szepetowski, P., Lerche, H., & Lesca, G. (2013) · Epilepsia · doi:10.1111/epi.12241 · Cited by 43 · see citing works
Self-citationNa+channelopathies and epilepsy: recent advances and new perspectives
Marini, C., & Mantegazza, M. (2010) · Expert Review of Clinical Pharmacology · doi:10.1586/ecp.10.20 · Cited by 26 · see citing works
Self-citationDevelopment of dissociated cryopreserved rat cortical neurons in vitro
Schock, S., Jolin‐Dahel, K., Schock, P. C., Theiss, S., Arbuthnott, G. W., Garcia-Munoz, M., & Staines, W. A. (2012) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2012.01.016 · Cited by 17 · see citing works
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Oyrer, J., Maljevic, S., Scheffer, I. E., Berkovic, S. F., Petrou, S., & Reid, C. A. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014456 · Cited by 315 · see citing works
SCN1A‐related phenotypes: Epilepsy and beyond
Scheffer, I. E., & Nabbout, R. (2019) · Epilepsia · doi:10.1111/epi.16386 · Cited by 245 · see citing works
Colasante, G., Lignani, G., Brusco, S., Berardino, C. D., Carpenter, J. C., Giannelli, S. G., Valassina, N., Bido, S., Ricci, R., Castoldi, V., et al. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.08.018 · Cited by 236 · see citing works
Developmental and epileptic encephalopathies: from genetic heterogeneity to phenotypic continuum
Guerrini, R., Conti, V., Mantegazza, M., Balestrini, S., Galanopoulou, A. S., & Benfenati, F. (2023) · Physiological Reviews · doi:10.1152/physrev.00063.2021 · Cited by 196 · see citing works
Self-citationStructural basis of α-scorpion toxin action on Na v channels
Clairfeuille, T., Cloake, A., Infield, D. T., Llongueras, J. P., Arthur, C. P., Li, Z. R., Jian, Y., Martin‐Eauclaire, M., Bougis, P. E., Ciferri, C., et al. (2019) · Science · doi:10.1126/science.aav8573 · Cited by 183 · see citing works
The Perineuronal ‘Safety’ Net? Perineuronal Net Abnormalities in Neurological Disorders
Wen, T. H., Binder, D. K., Ethell, I. M., & Razak, K. A. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00270 · Cited by 170 · see citing works
Favero, M., Sotuyo, N. P., Lopez, E., Kearney, J. A., & Goldberg, E. M. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.0193-18.2018 · Cited by 163 · see citing works
Brunklaus, A., Brünger, T., Feng, T., Fons, C., Lehikoinen, A., Panagiotakaki, E., Vintan, M.-A., Symonds, J., Andrew, J., Arzimanoglou, A., et al. (2022) · Brain · doi:10.1093/brain/awac210 · Cited by 167 · see citing works
Self-citationSodium channelopathies of skeletal muscle and brain
Mantegazza, M., Cestèle, S., & Catterall, W. A. (2021) · Physiological Reviews · doi:10.1152/physrev.00025.2020 · Cited by 133 · see citing works
Self-citationAberrant epilepsy-associated mutant Nav1.6 sodium channel activity can be targeted with cannabidiol
Patel, R. R., Barbosa, C., Brustovetsky, T., Brustovetsky, N., & Cummins, T. (2016) · Brain · doi:10.1093/brain/aww129 · Cited by 122 · see citing works
Neuronal mechanisms of mutations in SCN8A causing epilepsy or intellectual disability
Liu, Y., Schubert, J., Sonnenberg, L., Helbig, K. L., Hoei‐Hansen, C. E., Koko, M., Rannap, M., Lauxmann, S., Huq, M., Schneider, M. C., et al. (2018) · Brain · doi:10.1093/brain/awy326 · Cited by 118 · see citing works
Self-citationModulation of apoptosis controls inhibitory interneuron number in the cortex
Denaxa, M., Neves, G., Rabinowitz, A., Kemlo, S., Liodis, P., Burrone, J., & Pachnis, V. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.01.064 · Cited by 112 · see citing works
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Griffin, A., Hamling, K. R., Hong, S., Anvar, M., Lee, L. P., & Baraban, S. C. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00573 · Cited by 103 · see citing works
Delahaye‐Duriez, A., Srivastava, P. K., Shkura, K., Langley, S. R., Laaniste, L., Moreno‐Moral, A., Danis, B., Mazzuferi, M., Foerch, P., Gazina, E. V., et al. (2016) · Genome biology · doi:10.1186/s13059-016-1097-7 · Cited by 87 · see citing works
Hedrich, U. B. S., Lauxmann, S., Wolff, M., Synofzik, M., Bast, T., Binelli, A., Serratosa, J. M., Martínez-Ulloa, P., Allen, N. M., King, M. D., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz4957 · Cited by 87 · see citing works
Self-citationMay, P., Girard, S., Harrer, M., Bobbili, D. R., Schubert, J., Wolking, S., Becker, F., Lachance‐Touchette, P., Meloche, C., Gravel, M., et al. (2018) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30215-1 · Cited by 84 · see citing works
Self-citationInterneuronopathies and their role in early life epilepsies and neurodevelopmental disorders
Katsarou, A., Moshé, S. L., & Galanopoulou, A. S. (2017) · Epilepsia Open · doi:10.1002/epi4.12062 · Cited by 82 · see citing works
Pathophysiological mechanisms of migraine and epilepsy: Similarities and differences
Mantegazza, M., & Cestèle, S. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.11.025 · Cited by 82 · see citing works
Self-citationNew insights into the early mechanisms of epileptogenesis in a zebrafish model of Dravet syndrome
Tiraboschi, E., Martina, S., van der Ent, W., Grzyb, K., Gaweł, K., Cordero-Maldonado, M. L., Poovathingal, S. K., Heintz, S., Satheesh, S. V., Brattespe, J., et al. (2020) · Epilepsia · doi:10.1111/epi.16456 · Cited by 74 · see citing works
Mantegazza, M., & Broccoli, V. (2019) · Epilepsia · doi:10.1111/epi.14700 · Cited by 71 · see citing works
Self-citationHyperexcitable interneurons trigger cortical spreading depression in an Scn1a migraine model
Auffenberg, E., Hedrich, U. B. S., Barbieri, R., Miely, D., Groschup, B., Wuttke, T. V., Vogel, N., Lührs, P., Zanardi, I., Bertelli, S., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142202 · Cited by 70 · see citing works
Self-citationStasi, A. M. D., Farisello, P., Marcon, I., Cavallari, S., Forli, A., Vecchia, D., Losi, G., Mantegazza, M., Panzeri, S., Carmignoto, G., et al. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhw002 · Cited by 67 · see citing works
Self-citationStein, R. E., Kaplan, J. S., Li, J., & Catterall, W. A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1906833116 · Cited by 68 · see citing works
Disordered breathing in a mouse model of Dravet syndrome
Kuo, F., Cleary, C. M., LoTurco, J. J., Chen, X., & Mulkey, D. K. (2019) · eLife · doi:10.7554/elife.43387 · Cited by 67 · see citing works
Pereira, A. R. S., Duprat, F., Pousinha, P. A., Loucif, A., Douchamps, V., Regondi, M. C., Ayrault, M., Eugie, M., Stunault, M. I., Escayg, A., et al. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.01.006 · Cited by 63 · see citing works
Self-citationSCN1A variants from bench to bedside—improved clinical prediction from functional characterization
Brunklaus, A., Schorge, S., Smith, A. D., Ghanty, I., Stewart, K., Gardiner, S., Du, J., Pérez‐Palma, E., Symonds, J. D., Collier, A. C., et al. (2019) · Human Mutation · doi:10.1002/humu.23943 · Cited by 63 · see citing works
Augmented Reticular Thalamic Bursting and Seizures in Scn1a-Dravet Syndrome
Makinson, S. R., Clemente-Perez, A., Higashikubo, B. T., Cho, F. S., Holden, S. S., Bennett, E., Chkhaidze, A., Rooda, O. H. J. E., Cornet, M., Hoebeek, F. E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.018 · Cited by 57 · see citing works
Ye, H., & Kaszuba, S. V. (2017) · Journal of Biomedical Science · doi:10.1186/s12929-017-0399-8 · Cited by 56 · see citing works
Chever, O., Zerimech, S., Scalmani, P., Lemaire, L., Pizzamiglio, L., Loucif, A., Ayrault, M., Крупа, М. М., Desroches, M., Duprat, F., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci142203 · Cited by 55 · see citing works
Self-citationLemaire, L., Desroches, M., Крупа, М. М., Pizzamiglio, L., Scalmani, P., & Mantegazza, M. (2021) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1009239 · Cited by 50 · see citing works
Self-citationGenetic mouse models of migraine
Pietrobon, D., & Brennan, K. C. (2019) · The Journal of Headache and Pain · doi:10.1186/s10194-019-1029-5 · Cited by 50 · see citing works
SCN 2A channelopathies: Mechanisms and models
Hedrich, U. B. S., Lauxmann, S., & Lerche, H. (2019) · Epilepsia · doi:10.1111/epi.14731 · Cited by 49 · see citing works
Self-citationCorticohippocampal circuit dysfunction in a mouse model of Dravet syndrome
Mattis, J., Somarowthu, A., Goff, K. M., Jiang, E., Yom, J., Sotuyo, N. P., McGarry, L. M., Feng, H., Kaneko, K., & Goldberg, E. M. (2022) · eLife · doi:10.7554/elife.69293 · Cited by 49 · see citing works
Bechi, G., Rusconi, R., Cestèle, S., Striano, P., Franceschetti, S., & Mantegazza, M. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.12.028 · Cited by 47 · see citing works
Self-citationModels for discovery of targeted therapy in genetic epileptic encephalopathies
Maljevic, S., Reid, C. A., & Petrou, S. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14134 · Cited by 47 · see citing works
Wolfart, J., & Laker, D. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00168 · Cited by 46 · see citing works
Early-onset familial hemiplegic migraine due to a novel SCN1A mutation
Fan, C., Wolking, S., Lehmann‐Horn, F., Hedrich, U. B. S., Freilinger, T. M., Lerche, H., Borck, G., Kubisch, C., & Jurkat‐Rott, K. (2016) · Cephalalgia · doi:10.1177/0333102415608360 · Cited by 45 · see citing works
Self-citationActivity of NaV1.2 promotes neurodegeneration in an animal model of multiple sclerosis
Schattling, B., Fazeli, W., Engeland, B., Liu, Y., Lerche, H., Isbrandt, D., & Friese, M. A. (2016) · JCI Insight · doi:10.1172/jci.insight.89810 · Cited by 41 · see citing works
Self-citationGain of Function for the SCN1A/hNav1.1-L1670W Mutation Responsible for Familial Hemiplegic Migraine
Dhifallah, S., Lancaster, E., Merrill, S. L., Leroudier, N., Mantegazza, M., & Cestèle, S. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00232 · Cited by 42 · see citing works
Self-citationParvalbumin Role in Epilepsy and Psychiatric Comorbidities: From Mechanism to Intervention
Godoy, L. D., Prizon, T., Rossignoli, M. T., Leite, J. P., & Liberato, J. L. (2022) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2022.765324 · Cited by 44 · see citing works
Ye, H., Hendee, J., Ruan, J., Zhirova, A., Ye, J., & Dima, M. (2022) · Journal of NeuroEngineering and Rehabilitation · doi:10.1186/s12984-022-01094-4 · Cited by 46 · see citing works
Modeling cortical spreading depression induced by the hyperactivity of interneurons
Desroches, M., Faugeras, O. D., Крупа, М. М., & Mantegazza, M. (2019) · Journal of Computational Neuroscience · doi:10.1007/s10827-019-00730-8 · Cited by 41 · see citing works
Self-citationIzsák, J., Seth, H., Andersson, M. X., Vizlin‐Hodzic, D., Theiss, S., Hanse, E., Ågren, H., Funa, K., & Illes, S. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00351 · Cited by 39 · see citing works
Self-citationChen, W., Luo, B., Gao, N., Li, H., Wang, H., Li, L., Cui, W., Zhang, L., Sun, D., Liu, F., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci136956 · Cited by 39 · see citing works
Voltage‐gated sodium channels in genetic epilepsy: up and down of excitability
Rusina, E., Simonti, M., Duprat, F., Cestèle, S., & Mantegazza, M. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15947 · Cited by 36 · see citing works
Self-citationModel systems for studying cellular mechanisms of SCN1A -related epilepsy
Schutte, S. S., Schutte, R. J., Barragan, E. V., & O’Dowd, D. K. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00824.2015 · Cited by 39 · see citing works
Current Opinions and Consensus for Studying Tremor in Animal Models
Kuo, S., Louis, E. D., Faust, P. L., Handforth, A., Chang, S.-Y., Avlar, B., Lang, E. J., Pan, M., Miterko, L. N., Brown, A. M., et al. (2019) · The Cerebellum · doi:10.1007/s12311-019-01037-1 · Cited by 38 · see citing works
Fadila, S., Beucher, B., Dopeso‐Reyes, I. G., Mavashov, A., Brusel, M., Anderson, K., Ismeurt, C., Goldberg, E. M., Ricobaraza, A., Hernández-Alcoceba, R., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci159316 · Cited by 37 · see citing works
NaV1.1 haploinsufficiency impairs glutamatergic and GABAergic neuron function in the thalamus
Studtmann, C., Ladislav, M., Topolski, M. A., Safari, M., & Swanger, S. A. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105672 · Cited by 39 · see citing works
Ion Channel Dysfunction and Neuroinflammation in Migraine and Depression
Eren‐Koçak, E., & Dalkara, T. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.777607 · Cited by 39 · see citing works
Wu, J., Quraishi, I. H., Zhang, Y., Bromwich, M., & Kaczmarek, L. K. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.113904 · Cited by 36 · see citing works
Xie, Y., Ng, N. N., Safrina, O., Ramos, C. M., Ess, K. C., Schwartz, P. H., Smith, M. A., & O’Dowd, D. K. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104627 · Cited by 35 · see citing works
SCN1A channelopathies: Navigating from genotype to neural circuit dysfunction
Bryson, A., & Petrou, S. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1173460 · Cited by 35 · see citing works
Focal epilepsy in SCN1A ‐mutation carrying patients: is there a role for epilepsy surgery?
Vezyroglou, A., Varadkar, S., Bast, T., Hirsch, É., Strobl, K., Harvey, A. S., Epilepsy Surgery in SCN1A Study Group, Scheffer, I. E., Sisodiya, S. M., & Cross, J. H. (2020) · Developmental Medicine & Child Neurology · doi:10.1111/dmcn.14588 · Cited by 34 · see citing works
Voskobiynyk, Y., Battu, G., Felker, S. A., Cochran, J. N., Newton, M. P., Lambert, L. J., Kesterson, R. A., Myers, R., Cooper, G. M., Roberson, E. D., et al. (2021) · PLoS Genetics · doi:10.1371/journal.pgen.1009195 · Cited by 34 · see citing works
Precision physiology and rescue of brain ion channel disorders
Noebels, J. L. (2017) · The Journal of General Physiology · doi:10.1085/jgp.201711759 · Cited by 32 · see citing works
Rare genetic brain disorders with overlapping neurological and psychiatric phenotypes
Peall, K. J., Owen, M. J., & Hall, J. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00896-x · Cited by 32 · see citing works
Application of induced pluripotent stem cells in epilepsy
Hirose, S., Tanaka, Y., Shibata, M., Kimura, Y., Ishikawa, M., Higurashi, N., Yamamoto, T., Ichise, E., Chiyonobu, T., & Ishii, A. (2020) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2020.103535 · Cited by 30 · see citing works
Epilepsy and migraine—Are they comorbidity?
Liao, J., Tian, X., Wang, H., & Xiao, Z. (2018) · Genes & Diseases · doi:10.1016/j.gendis.2018.04.007 · Cited by 29 · see citing works
Epilepsy and Migraine Shared Genetic and Molecular Mechanisms: Focus on Therapeutic Strategies
Gotra, P., Bhardwaj, N., Ludhiadch, A., Singh, G., & Munshi, A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02386-x · Cited by 28 · see citing works
Clinical and electrophysiological features of SCN8A variants causing episodic or chronic ataxia
Lyu, H., Boßelmann, C. M., Johannesen, K. M., Koko, M., Ortigoza‐Escobar, J. D., Aguilera, S., García‐Navas, D., Linnankivi, T., Gaily, E. K., van Ruiten, H. J. A., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104855 · Cited by 28 · see citing works
Self-citationMigraine genetics: current findings and future lines of research
Persico, A. M., Verdecchia, M., Pinzone, V., & Guidetti, V. (2015) · neurogenetics · doi:10.1007/s10048-014-0433-x · Cited by 25 · see citing works
The Revolution in Migraine Genetics: From Aching Channels Disorders to a Next-Generation Medicine
Pellacani, S., Sicca, F., Lorenzo, C. D., Grieco, G. S., Valvo, G., Cereda, C., Rubegni, A., & Santorelli, F. M. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00156 · Cited by 25 · see citing works
Catastrophic Epilepsies of Childhood
Howard, M. A., & Baraban, S. C. (2017) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-072116-031250 · Cited by 24 · see citing works
Are we there yet? A critical evaluation of sudden and unexpected death in epilepsy models
Smith, J., Richerson, G. B., Kouchi, H., Duprat, F., Mantegazza, M., Bezin, L., & Rheims, S. (2023) · Epilepsia · doi:10.1111/epi.17812 · Cited by 23 · see citing works
Self-citationLeaders and followers: quantifying consistency in spatio-temporal propagation patterns
Kreuz, T., Satuvuori, E., Pofahl, M., & Mulansky, M. (2017) · New Journal of Physics · doi:10.1088/1367-2630/aa68c3 · Cited by 23 · see citing works
Self-citationScalise, S., Zannino, C., Lucchino, V., Conte, M. L., Scaramuzzino, L., Cifelli, P., D’Andrea, T., Martinello, K., Fucile, S., Palma, E., et al. (2022) · Biomedicines · doi:10.3390/biomedicines10051075 · Cited by 22 · see citing works
Ion channels in migraine disorders
Pietrobon, D. (2018) · Current Opinion in Physiology · doi:10.1016/j.cophys.2018.02.001 · Cited by 21 · see citing works
Ahnaou, A., & Drinkenburg, W. H. I. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.039 · Cited by 23 · see citing works
Merseburg, A., Kasemir, J., Buss, E. W., Leroy, F., Bock, T., Porro, A., Barnett, A., Tröder, S. E., Engeland, B., Stockebrand, M. C., et al. (2022) · eLife · doi:10.7554/elife.70826 · Cited by 21 · see citing works
Interneuron Dysfunction in a New Mouse Model of SCN1A GEFS+
Das, A., Zhu, B., Xie, Y., Zeng, L., Pham, A. T., Neumann, J. C., Safrina, O., Benavides, D. R., MacGregor, G. R., Schutte, S. S., et al. (2021) · eNeuro · doi:10.1523/eneuro.0394-20.2021 · Cited by 20 · see citing works
Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels
Miceli, F., Soldovieri, M. V., Ambrosino, P., Maria, M. D., Manocchio, L., Medoro, A., & Taglialatela, M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00259 · Cited by 20 · see citing works
Beretta, S., Gritti, L., Ponzoni, L., Scalmani, P., Mantegazza, M., Sala, M., Verpelli, C., & Sala, C. (2022) · Molecular Autism · doi:10.1186/s13229-021-00484-0 · Cited by 18 · see citing works
Self-citationStudtmann, C., Ladislav, M., Safari, M., Khondaker, R., Chen, Y., Vaughan, G. A., Topolski, M. A., Tomović, E., Balík, A., & Swanger, S. A. (2023) · Journal of Neurophysiology · doi:10.1152/jn.00525.2022 · Cited by 19 · see citing works
Zerimech, S., Chever, O., Scalmani, P., Pizzamiglio, L., Duprat, F., & Mantegazza, M. (2020) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.107951 · Cited by 19 · see citing works
Self-citationThe genetic relationship between epilepsy and hemiplegic migraine
Huang, Y., Xiao, H., Qin, X., Nong, Y., Zou, D., & Wu, Y. (2017) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s132451 · Cited by 19 · see citing works
Izsák, J., Seth, H., Iljin, M., Theiss, S., Ågren, H., Funa, K., Aigner, L., Hanse, E., & Illes, S. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01399-3 · Cited by 18 · see citing works
Self-citationDravet Variant SCN1AA1783V Impairs Interneuron Firing Predominantly by Altered Channel Activation
Layer, N., Sonnenberg, L., González, E. P., Benda, J., Hedrich, U. B. S., Lerche, H., Koch, H., & Wuttke, T. V. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.754530 · Cited by 17 · see citing works
Self-citationIzsák, J., Seth, H., Theiss, S., Hanse, E., & Illes, S. (2020) · Stem Cell Reports · doi:10.1016/j.stemcr.2020.05.006 · Cited by 18 · see citing works
Self-citationNeurons with Multiple Axons Have Functional Axon Initial Segments
Guo, Y., Liu, Z., Chen, Y., Chai, Z., Zhou, C. Y., & Zhang, Y. (2017) · Neuroscience Bulletin · doi:10.1007/s12264-017-0169-3 · Cited by 17 · see citing works
Almog, Y., Mavashov, A., Brusel, M., & Rubinstein, M. (2022) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.823640 · Cited by 16 · see citing works
Uchino, K., Kawano, H., Tanaka, Y., Adaniya, Y., Asahara, A., Deshimaru, M., Kubota, K., Watanabe, T., Katsurabayashi, S., Iwasaki, K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-90224-4 · Cited by 15 · see citing works
Pérez-Alcázar, M., Culley, G. R., Lyckenvik, T., Mobarrez, K., Björefeldt, A., Wasling, P., Seth, H., Asztély, F., Harrer, A., Iglseder, B., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00054 · Cited by 15 · see citing works
Chancey, J. H., & Howard, M. A. (2022) · eNeuro · doi:10.1523/eneuro.0080-22.2022 · Cited by 14 · see citing works
Astrocytic Glutamate Transporters and Migraine
Conti, F., & Pietrobon, D. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03849-w · Cited by 14 · see citing works
Koch, N. A., Sonnenberg, L., Hedrich, U. B. S., Lauxmann, S., & Benda, J. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1194811 · Cited by 14 · see citing works
Self-citationHoltkamp, D., Opitz, T., Hebeisen, S., Soares-da-Silva, P., & Beck, H. (2018) · Epilepsia · doi:10.1111/epi.14504 · Cited by 14 · see citing works
Self-citationAutonomic dysfunction in epilepsy mouse models with implications for SUDEP research
Bauer, J., Devinsky, O., Rothermel, M., & Koch, H. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2022.1040648 · Cited by 13 · see citing works
Capitano, F., Kuchenbuch, M., Lavigne, J., Chaptoukaev, H., Zuluaga, M. A., Lorenzi, M., Nabbout, R., & Mantegazza, M. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2316364121 · Cited by 10 · see citing works
Self-citationMechanisms underlying CSD initiation implicated by genetic mouse models of migraine
Pietrobon, D., & Brennan, K. C. (2025) · The Journal of Headache and Pain · doi:10.1186/s10194-025-01948-x · Cited by 11 · see citing works
Binini, N., Sancini, G., Villa, C., Magro, R. D., Sansoni, V., Rusconi, R., Mantegazza, M., Grioni, D., Talpo, F., Toselli, M., et al. (2017) · Brain Research · doi:10.1016/j.brainres.2017.09.023 · Cited by 11 · see citing works
Self-citationMembrane Resonance in Pyramidal and GABAergic Neurons of the Mouse Perirhinal Cortex
Binini, N., Talpo, F., Spaiardi, P., Maniezzi, C., Pedrazzoli, M., Raffin, F., Mattiello, N., Castagno, A. N., Masetto, S., Yanagawa, Y., et al. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.703407 · Cited by 10 · see citing works
Synaptic or ion channel modifier? PRRT2 is a chameleon-like regulator of neuronal excitability
Lerche, H. (2018) · Brain · doi:10.1093/brain/awy073 · Cited by 10 · see citing works
Self-citationAnimal Models of Febrile Seizures: Limitations and Recent Advances in the Field
Griflyuk, A. V., Postnikova, T. Y., & Zaitsev, A. V. (2024) · Cells · doi:10.3390/cells13221895 · Cited by 9 · see citing works
Koch, H., Niturad, C. E., Theiss, S., Bien, C. G., Elger, C. E., Wandinger, K., Vincent, A. C., Malter, M. P., Körtvélyessy, P., Lerche, H., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-41849-z · Cited by 9 · see citing works
Self-citationMcCabe, M. P., Shore, A. N., Frankel, W. N., & Weston, M. C. (2020) · eNeuro · doi:10.1523/eneuro.0269-20.2020 · Cited by 8 · see citing works
Channelopathy of Dravet Syndrome and Potential Neuroprotective Effects of Cannabidiol
Xu, C., Zhang, Y., Gozal, D., & Carney, P. R. (2021) · Journal of Central Nervous System Disease · doi:10.1177/11795735211048045 · Cited by 8 · see citing works
Bayraktar, E., Liu, Y., Sonnenberg, L., Hedrich, U. B. S., Sara, Y., Eltokhi, A., Lyu, H., Lerche, H., Wuttke, T. V., & Lauxmann, S. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15981 · Cited by 8 · see citing works
Self-citationThe effect of sodium channels on neurological/neuronal disorders: A systematic review
Bagheri, S., Haddadi, R., Saki, S., Kourosh‐Arami, M., & Komaki, A. (2021) · International Journal of Developmental Neuroscience · doi:10.1002/jdn.10153 · Cited by 8 · see citing works
In vitro human ion channel assays predictive of drug-induced seizure
Cohen, J. D., You, D., Sharma, A. K., Takai, T., Hara, H., Sales, V. T., Yukawa, T., & Cai, B. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae148 · Cited by 7 · see citing works
- Authors
- Hedrich, U. B. S., Liautard, C., Kirschenbaum, D., Pofahl, M., Lavigne, J., Liu, Y., Theiss, S., Slotta, J., Escayg, A., Dihné, M., Beck, H., Mantegazza, M., & Lerche, H.
- Affiliations
- Hertie Institute for Clinical Brain Research (DE)
- Centre National de la Recherche Scientifique (FR)
- University of Bonn (DE)
- Heinrich Heine University Düsseldorf (DE)
- Emory University (US)
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2014-11-05
- Volume
- 34
- Issue
- 45
- Pages
- 14874-14889
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4220023
- OpenAlex
- W1964533239
- Cited by
- 164
- References
- 70
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 15 · 2023: 16 · 2022: 19 · 2021: 20 · 2020: 9 · 2019: 21 · 2018: 13 · 2017: 16 · 2016: 9 · 2015: 6 · 2014: 1
- FWCI
- 8.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DZNE Pub (submittedVersion)
- Journal of Neuroscience Nursing
- Funders
- Danish Cancer Society Research Center
- European Commission
- Deutsche Forschungsgemeinschaft (SFB1089)
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS072221)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- SCN1A, Nav1.1, GABAergic interneurons, action potential generation, axon initial segment, slow inactivation, disinhibition, network hyperexcitability, febrile seizures, epilepsy, thalamocortical network, hippocampal network activity, inhibitory postsynaptic currents, sodium channel mutations
- MeSH terms
- Action Potentials, Animals, Axons, Brain, Calcium, Cells, Cultured, Epilepsy, Humans, Interneurons, Mice, Inbred C57BL, Mutation, Nerve Net, Mice, Inhibitory Postsynaptic Potentials, GABAergic Neurons, NAV1.1 Voltage-Gated Sodium Channel
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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