The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus
Open accessAbstract
Activity-dependent synaptic plasticity and neurogenesis are two forms of brain plasticity that can participate in functional remodeling of neural networks during the formation of memories. We examined whether long-term potentiation (LTP) of excitatory synaptic transmission, a well characterized form of synaptic plasticity believed to play a critical role in memory formation, can regulate the rate of neurogenesis in the adult rat dentate gyrus in vivo. We first show that induction of LTP at medial perforant path–granule cell synapses stimulates the proliferation of progenitor cells in the dentate gyrus with a consequential long-term persistence of a larger population of surviving newborn cells. Using protocols to examine the effect of LTP on survival, we next show that LTP induction promotes survival of 1- to 2-week-old dentate granule cells. In no case did LTP appear to affect neuronal differentiation. Finally, we show that LTP induces expression of the plasticity-related transcription factor Zif268 in a substantial fraction of 2-week-old but not 1-week-old neurons, suggesting the prosurvival effect of LTP can be observed in the absence of LTP-mediated Zif268 induction in newborn cells. Our results indicate that electrically induced LTP in the dentate gyrus in vivo provides a cellular/molecular environment that favors both proliferation and survival of adult-generated neurons.
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Cites
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Long-Term Potentiation and Memory
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Wnt signalling regulates adult hippocampal neurogenesis
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Cited by
New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?
Deng, W., Aimone, J. B., & Gage, F. H. (2010) · Nature reviews. Neuroscience · doi:10.1038/nrn2822 · Cited by 2,120
(2009) · Cited by 2,013
Kee, N., Teixeira, C. M., Wang, A. H., & Frankland, P. W. (2007) · Nature Neuroscience · doi:10.1038/nn1847 · Cited by 875
Evidence for a cytokine model of cognitive function
McAfoose, J., & Baune, B. T. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.10.005 · Cited by 760
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Metadata
- Authors
- Bruel-Jungerman, E., Davis, S., Rampon, C., & Laroche, S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-05-31
- Volume
- 26
- Issue
- 22
- Pages
- 5888-5893
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1984056362
- Cited by
- 296
- References
- 37
- FWCI
- 4.78
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Bruel-Jungerman, E., Davis, S., Rampon, C., & Laroche, S. (2006). Long-Term Potentiation Enhances Neurogenesis in the Adult Dentate Gyrus. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.0782-06.2006
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
