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Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism

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Liu, Yan, Young, Kimberly A., Curtis, J. Thomas, Aragona, Brandon J., Wang, Zuoxin·2011·The Journal of Neuroscience

DOI 10.1523/jneurosci.1006-11.2011PMC PMC3114880

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Abstract

Although the protective effects of social bonds on drug use/abuse have been well documented, we know little about the underlying neural mechanisms. Using the prairie vole (Microtus ochrogaster)—a socially monogamous rodent that forms long-term pair bonds after mating—we demonstrate that amphetamine (AMPH) conditioning induced a conditioned place preference (CPP) in sexually naive (SN), but not pair-bonded (PB), males. Although AMPH treatment induced a similar magnitude of dopamine release in the nucleus accumbens (NAcc) of SN and PB males, it had differential effects on NAcc D1 receptor (D1R) binding. Specifically, AMPH treatment increased D1R binding in SN, but decreased D1R binding in PB males. NAcc D1R, but not D2 receptor, antagonism blocked AMPH-induced CPP in SN males and NAcc D1R activation before AMPH conditioning enabled AMPH-induced CPP in PB males. Together, our data demonstrate that pair-bonding experience decreases the rewarding properties of AMPH through a D1R-mediated mechanism.

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Authors: Liu, Y., Young, K. A., Curtis, J. T., Aragona, B. J., & Wang, Z.
Affiliations: Florida State University (US)
Oklahoma State University (US)
Corresponding author: Wang, Zuoxin
ORCID: Liu, Yan
Young, Kimberly A.
Curtis, J. Thomas
Aragona, Brandon J.
Wang, Zuoxin
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2011-06-01
Volume: 31
Issue: 22
Pages: 7960-7966
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1006-11.2011
PMC: PMC3114880
OpenAlex: W2026242391
Cited by: 103
References: 50
Citations by year: 2026: 1 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 12 · 2015: 5 · 2014: 8 · 2013: 16 · 2012: 11
FWCI: 4.90
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
U.S. Public Health Service (HDR01-48462, DAK02-23048, DAR01-19627, MHR01-58616, DAF31-25570)
National Institute of Mental Health (R01MH058616)
National Institute on Drug Abuse (K02DA023048, R01DA019627)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: amphetamine, pair bonding, social monogamy, Microtus ochrogaster, dopamine D1 receptor, conditioned place preference, nucleus accumbens, drug reward, dopamine D2 receptor, dopamine release
MeSH terms: Amphetamine, Animals, Conditioning, Psychological, Arvicolinae, Dopamine, Male, Microinjections, Nucleus Accumbens, Pair Bond, Reward, Sexual Behavior, Animal, Receptors, Dopamine D1, Receptors, Dopamine D2

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Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism

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