Dopamine and opioid systems interact within the nucleus accumbens to maintain monogamous pair bonds
Open accessAbstract
Prairie vole breeder pairs form monogamous pair bonds, which are maintained through the expression of selective aggression toward novel conspecifics. Here, we utilize behavioral and anatomical techniques to extend the current understanding of neural mechanisms that mediate pair bond maintenance. For both sexes, we show that pair bonding up-regulates mRNA expression for genes encoding D1-like dopamine (DA) receptors and dynorphin as well as enhances stimulated DA release within the nucleus accumbens (NAc). We next show that D1-like receptor regulation of selective aggression is mediated through downstream activation of kappa-opioid receptors (KORs) and that activation of these receptors mediates social avoidance. Finally, we also identified sex-specific alterations in KOR binding density within the NAc shell of paired males and demonstrate that this alteration contributes to the neuroprotective effect of pair bonding against drug reward. Together, these findings suggest motivational and valence processing systems interact to mediate the maintenance of social bonds.
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Opioid signaling at KORs occurs downstream of NAc shell DA activation of D1Rs to generate selective aggression, whereas affiliative behavior remains unchanged following manipulations to NAc D1Rs and KORs.
“Opioid signaling at KORs occurs downstream of NAc shell DA activation of D1Rs to generate selective aggression, whereas affiliative behavior remains unchanged following manipulations to NAc D1Rs and KORs [156,157].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [157]
The dopamine and opioid systems interact to underpin social bonding behaviors, with the nucleus accumbens providing an area of convergence for neural pathways.
“However, the dopamine and opioid systems are also known to interact to underpin social bonding behaviors (166), with the nucleus accumbens providing an area of convergence for neural pathways (167).”
From A transdiagnostic perspective on social anhedonia (2019) · cites this paper as [166]
Both the dopamine and opioid systems have been shown to interact to maintain monogamous pair bonds in prairie voles.
“For instance, both the dopamine and opioid systems have been shown to interact to maintain monogamous pair bonds in prairie voles (15, 38).”
From Variation in the β-endorphin, oxytocin, and dopamine receptor genes is associated with different dimensions of human sociality (2017) · cites this paper as [38]
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- Authors
- Resendez, S. L., Keyes, P. C., Day, J. J., Hambro, C., Austin, C. J., Maina, F. K., Eidson, L. N., Porter-Stransky, K. A., Nevárez, N., McLean, J. W., Kuhnmuench, M. A., Murphy, A. Z., Mathews, T. A., & Aragona, B. J.
- Affiliations
- University of North Carolina at Chapel Hill (US)
- University of Michigan (US)
- University of Alabama at Birmingham (US)
- Wayne State University (US)
- Georgia State University (US)
- Department of Psychology, University of Michigan-Ann Arbor, Ann Arbor, United States
- Corresponding author
- Resendez, Shanna L
- Aragona, Brandon J
- Venue
- eLife
- Publisher
- eLife Sciences Publications, Ltd
- Published
- 2016-07-02
- Volume
- 5
- ISSN
- 2050-084X (ISSN-L)
- PMC
- PMC4972541
- OpenAlex
- W2471484281
- Cited by
- 88
- References
- 101
- Citations by year
- 2026: 2 · 2025: 14 · 2024: 7 · 2023: 11 · 2022: 11 · 2021: 6 · 2020: 9 · 2019: 8 · 2018: 10 · 2017: 8 · 2016: 2
- FWCI
- 14.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- eLife (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- UNC Libraries
- Funders
- National Science Foundation (0953106)
- National Institute of Child Health and Human Development (T32HD040127)
- National Institute on Drug Abuse (DA034681)
- University of Michigan (Office of Vice President Research Grant)
- National Institute of Mental Health (5R21MH096216-02)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- pair bond maintenance, monogamy, Microtus ochrogaster, nucleus accumbens, D1-like receptors, kappa opioid receptor, dynorphin, social avoidance, sex differences, drug reward, social motivation
- MeSH terms
- Animals, Arvicolinae, Dopamine, Dynorphins, Nucleus Accumbens, Pair Bond, Receptors, Dopamine D1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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