The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Social Bonding Decreases the Rewarding Properties of Amphetamine through a Dopamine D1 Receptor-Mediated Mechanism
Open accessAbstract
Although the protective effects of social bonds on drug use/abuse have been well documented, we know little about the underlying neural mechanisms. Using the prairie vole (Microtus ochrogaster)—a socially monogamous rodent that forms long-term pair bonds after mating—we demonstrate that amphetamine (AMPH) conditioning induced a conditioned place preference (CPP) in sexually naive (SN), but not pair-bonded (PB), males. Although AMPH treatment induced a similar magnitude of dopamine release in the nucleus accumbens (NAcc) of SN and PB males, it had differential effects on NAcc D1 receptor (D1R) binding. Specifically, AMPH treatment increased D1R binding in SN, but decreased D1R binding in PB males. NAcc D1R, but not D2 receptor, antagonism blocked AMPH-induced CPP in SN males and NAcc D1R activation before AMPH conditioning enabled AMPH-induced CPP in PB males. Together, our data demonstrate that pair-bonding experience decreases the rewarding properties of AMPH through a D1R-mediated mechanism.
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“when amphetamine or a selective D1 receptor agonist was administered systemically to male voles, this interfered with mating-induced pair bonding, and this disruption seems dependent on D1 receptor activation [542-544].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [544]
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“Furthermore, the changes in D1R signaling that occur during pair bonding act directly to decrease the reinforcing effects of amphetamines (Liu et al 2011).”
From The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction (2012) · cites this paper as Liu et al 2011
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Di Chiara, G., & Imperato, A. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5274 · Cited by 4,733
Robinson, T. G., & BECKER, J. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80193-7 · Cited by 2,108
Berridge, K. C., & Robinson, T. E. (2003) · Trends in Neurosciences · doi:10.1016/s0166-2236(03)00233-9 · Cited by 1,869
Is there a common molecular pathway for addiction?
Nestler, E. J. (2005) · Nature Neuroscience · doi:10.1038/nn1578 · Cited by 1,388
Dimensions of Adult Attachment, Affect Regulation, and Romantic Relationship Functioning
Brennan, K. A., & Shaver, P. R. (1995) · Personality and Social Psychology Bulletin · doi:10.1177/0146167295213008 · Cited by 915
Robinson, T. E., & Kolb, B. E. (1999) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.1999.00576.x · Cited by 726
Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria
Drevets, W. C., Gautier, C., Price, J. C., Kupfer, D. J., Kinahan, P. E., Grace, A. A., Price, J. L., & Mathis, C. A. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01038-6 · Cited by 706 · cited 2×
“Levels of released DA have been closely correlated with the positive subjective effects of drugs of abuse (Volkow et al., 1999; Drevets et al., 2001; Leyton, 2010) and psychostimulant-induced NAcc DA release has been altered by social experience in some cases [e.”
BackgroundMechanisms of Amphetamine Action Revealed in Mice Lacking the Dopamine Transporter
Jones, S. R., Gainetdinov, R. R., Wightman, R. M., & Caron, M. G. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-06-01979.1998 · Cited by 626
The neurobiology of drug addiction
Koob, G. F., & Nestler, E. J. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.3.482 · Cited by 581
Yokel, R. A., & Wise, R. A. (1975) · Science · doi:10.1126/science.1114313 · Cited by 540
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The neural mechanisms and circuitry of the pair bond
Walum, H., & Young, L. J. (2018) · Nature Reviews Neuroscience · doi:10.1038/s41583-018-0072-6 · Cited by 353
Burkett, J. P., & Young, L. J. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2794-x · Cited by 307
“Furthermore, the changes in D1R signaling that occur during pair bonding act directly to decrease the reinforcing effects of amphetamines (Liu et al. 2011).”
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299
Breaking the loop: Oxytocin as a potential treatment for drug addiction
McGregor, I. S., & Bowen, M. T. (2012) · Hormones and Behavior · doi:10.1016/j.yhbeh.2011.12.001 · Cited by 268
Fisher, H. E., Xu, X., Aron, A. P., & Brown, L. L. (2016) · Frontiers in Psychology · doi:10.3389/fpsyg.2016.00687 · Cited by 241
Metadata
- Authors
- Liu, Y., Young, K. A., Curtis, J. T., Aragona, B. J., & Wang, Z.
- Affiliations
- Florida State University (US)
- Oklahoma State University (US)
- Corresponding author
- Wang, Zuoxin
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-06-01
- Volume
- 31
- Issue
- 22
- Pages
- 7960-7966
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3114880
- OpenAlex
- W2026242391
- Cited by
- 103
- References
- 50
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 3 · 2023: 10 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 12 · 2015: 5 · 2014: 8 · 2013: 16 · 2012: 11
- FWCI
- 4.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- U.S. Public Health Service (HDR01-48462, DAK02-23048, DAR01-19627, MHR01-58616, DAF31-25570)
- National Institute of Mental Health (R01MH058616)
- National Institute on Drug Abuse (K02DA023048, R01DA019627)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- amphetamine, pair bonding, social monogamy, Microtus ochrogaster, dopamine D1 receptor, conditioned place preference, nucleus accumbens, drug reward, dopamine D2 receptor, dopamine release
- MeSH terms
- Amphetamine, Animals, Conditioning, Psychological, Arvicolinae, Dopamine, Male, Microinjections, Nucleus Accumbens, Pair Bond, Reward, Sexual Behavior, Animal, Receptors, Dopamine D1, Receptors, Dopamine D2
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