Cited by 107Functional Brain Connectivity StudiesHeart Rate Variability and Autonomic ControlAdvanced MRI Techniques and Applications

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Spontaneous Brain Activity Relates to Autonomic Arousal

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Fan, Jin, Xu, Pengfei, Van Dam, Nicholas T., Eilam-Stock, Tehila, Gu, Xiaosi, Luo, Yue-jia, Hof, Patrick R.·2012·The Journal of Neuroscience

DOI 10.1523/jneurosci.1172-12.2012PMC PMC3435430

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Abstract

Although possible sources and functions of the resting-state networks (RSNs) of the brain have been proposed, most evidence relies on circular logic and reverse inference. We propose that autonomic arousal provides an objective index of psychophysiological states during rest that may also function as a driving source of the activity and connectivity of RSNs. Recording blood oxygenation level-dependent (BOLD) signal using functional magnetic resonance imaging and skin conductance simultaneously during rest in human subjects, we found that the spontaneous fluctuations of BOLD signals in key nodes of RSNs are associated with changes in nonspecific skin conductance response, a sensitive psychophysiological index of autonomic arousal. Our findings provide evidence of an important role for the autonomic nervous system to the spontaneous activity of the brain during “rest.”

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Authors: Fan, J., Xu, P., Van Dam, N. T., Eilam-Stock, T., Gu, X., Luo, Y.-J., & Hof, P. R.
Affiliations: Queens College, CUNY (US)
Beijing Normal University (CN)
Icahn School of Medicine at Mount Sinai (US)
ORCID: Fan, Jin
Xu, Pengfei
Gu, Xiaosi
Hof, Patrick R.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2012-08-15
Volume: 32
Issue: 33
Pages: 11176-11186
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1172-12.2012
PMC: PMC3435430
OpenAlex: W2013020031
Cited by: 107
References: 44
Citations by year: 2026: 2 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 13 · 2015: 13 · 2014: 10 · 2013: 7 · 2012: 2
FWCI: 5.25
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: James S. McDonnell Foundation (22002078)
National Institutes of Health (RR029887)
Queens College, City University of New York
National Key Research and Development Program of China (2011CB711000)
National Institute of Mental Health (R21MH083164, R01MH094305)
National Center for Research Resources (UL1RR029887)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords: resting-state networks, autonomic arousal, spontaneous brain activity, skin conductance, BOLD signal fluctuations, autonomic nervous system, psychophysiological state, resting state, functional connectivity
MeSH terms: Adult, Arousal, Autonomic Nervous System, Brain, Brain Mapping, Galvanic Skin Response, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Oxygen, Psychophysics, Regression Analysis, Rest, Young Adult

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Spontaneous Brain Activity Relates to Autonomic Arousal

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