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Spontaneous Brain Activity Relates to Autonomic Arousal
Open accessAbstract
Although possible sources and functions of the resting-state networks (RSNs) of the brain have been proposed, most evidence relies on circular logic and reverse inference. We propose that autonomic arousal provides an objective index of psychophysiological states during rest that may also function as a driving source of the activity and connectivity of RSNs. Recording blood oxygenation level-dependent (BOLD) signal using functional magnetic resonance imaging and skin conductance simultaneously during rest in human subjects, we found that the spontaneous fluctuations of BOLD signals in key nodes of RSNs are associated with changes in nonspecific skin conductance response, a sensitive psychophysiological index of autonomic arousal. Our findings provide evidence of an important role for the autonomic nervous system to the spontaneous activity of the brain during “rest.”
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“This perspective on the AIC as an integral part of hierarchical predictive coding in the brain explains the involvement of AIC across low-level autonomic and sensorimotor (Craig et al., 2000; Sterzer and Kleinschmidt, 2010; Fan et al., 2012) to high-level cognitive and social (Montague and Lohrenz, 2007; King-Casas et al., 2008; Bossaerts, 2010; Kirk et al., 2011) domains.”
From Anterior insular cortex and emotional awareness (2013) · cites this paper as Fan et al., 2012
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Metadata
- Authors
- Fan, J., Xu, P., Van Dam, N. T., Eilam-Stock, T., Gu, X., Luo, Y.-J., & Hof, P. R.
- Affiliations
- Queens College, CUNY (US)
- Beijing Normal University (CN)
- Icahn School of Medicine at Mount Sinai (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-08-15
- Volume
- 32
- Issue
- 33
- Pages
- 11176-11186
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3435430
- OpenAlex
- W2013020031
- Cited by
- 107
- References
- 44
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 8 · 2018: 5 · 2017: 7 · 2016: 13 · 2015: 13 · 2014: 10 · 2013: 7 · 2012: 2
- FWCI
- 5.25
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- James S. McDonnell Foundation (22002078)
- National Institutes of Health (RR029887)
- Queens College, City University of New York
- National Key Research and Development Program of China (2011CB711000)
- National Institute of Mental Health (R21MH083164, R01MH094305)
- National Center for Research Resources (UL1RR029887)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- resting-state networks, autonomic arousal, spontaneous brain activity, skin conductance, BOLD signal fluctuations, autonomic nervous system, psychophysiological state, resting state, functional connectivity
- MeSH terms
- Adult, Arousal, Autonomic Nervous System, Brain, Brain Mapping, Galvanic Skin Response, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Neural Pathways, Oxygen, Psychophysics, Regression Analysis, Rest, Young Adult
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