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Mast Cells in the Developing Brain Determine Adult Sexual Behavior
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“Mechanistically, mast cells modulate synaptic patterning indirectly through crosstalk with microglia. 120”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [120]
In the citing paper
“Mast cells can also be found in the developing brain of mice 54 and rats, 119 including the pre‐optic area. 120 This brain region is essential for male copulatory behavior, which is marked by a higher synaptic density compared to females. Late fetal and early postnatal stages are critical for sexual differentiation in this region. At these stages, mast cell numbers are higher in the pre‐optic area”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [120]
In the citing paper
“Pharmacological inhibition of mast cells at late fetal stages dampens copulation behavior in adult male offspring, suggesting that masculinization is normally mediated by mast cells. Conversely, perinatal administration of exogenous estradiol or mast cell activation using the compound 48/80 both partially masculinize the copulation behavior of female mice.”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [120]
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Cites
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“schizophrenia, and attention deficit hyperactivity disorder (24-27).”
Induction of PGE2 by estradiol mediates developmental masculinization of sex behavior
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“(K) Mast cells stain positive for histamine in vivo, and treatment of primary cultured mast cells with estradiol increased histamine release [F(2,29)=6.”
BackgroundInfluential
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Cruz-Pereira, J. S., Rea, K., Nolan, Y. M., O'Leary, O. F., Dinan, T. G., & Cryan, J. F. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-122216-011613 · Cited by 320
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Self-citationGoldstein, J. M., Cohen, J. E., Mareckova, K., Holsen, L., Whitfield-Gabrieli, S., Gilman, S. E., Buka, S. L., & Hornig, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2014464118 · Cited by 70
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Metadata
- Authors
- Lenz, K. M., Pickett, L. A., Wright, C. L., Davis, K. T., Joshi, A., & McCarthy, M. M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2018-08-07
- Volume
- 38
- Issue
- 37
- Pages
- 8044-8059
- ISSN
- 0270-6474
- 1529-2401
- Cited by
- 111
- References
- 7
- Language
- en
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