GABAergic innervation of corticotropin-releasing hormone (CRH)-secreting parvocellular neurons and its plasticity as demonstrated by quantitative immunoelectron microscopy
Abstract
GABA has been identified as an important neurotransmitter in stress-related circuitry mediating inhibitory effects on neurosecretory neurons that comprise the central limb of the hypothalamo-pituitary-adrenocortical axis. Using combinations of pre-embedding immunostaining and postembedding immunogold methods at the ultrastructural level, direct synaptic contacts were revealed between GABA-containing terminals and neurosecretory cells that were immunoreactive for corticotropin-releasing hormone (CRH) in the hypothalamic paraventricular nucleus (PVN). The vast majority of axo-dendritic GABA synapses was symmetric (inhibitory) type, and 46% of all synaptic boutons in the medial parvocellular subdivision of the PVN were immunoreactive to GABA. Using the disector method, an unbiased stereological method on serial ultrathin sections, the total calculated number of synaptic contacts within the medial parvocellular subdivision of the PVN was 55.4 x 10(6)/mm(3). On CRH-positive profiles 20.1 x 10(6) GABAergic synaptic boutons were detected per mm(3) in control, colchicine-treated rats. In the medial parvocellular subdivision, 79% of GABAergic boutons terminated on CRH neurons. Following adrenalectomy, which increases the synthetic and secretory activities of CRH neurons, the number of GABAergic synapses that terminate on CRH-positive profiles was increased by 55%. GABA-containing boutons appeared to be swollen, while the contact surfaces of cellular membranes between GABAergic boutons and CRH-positive profiles were shorter in adrenalectomized animals than in controls. Our data provide ultrastructural evidence for direct inhibitory GABAergic control of stress-related CRH neurons and suggest a pivotal role of GABA-containing inputs in the functional plasticity of parvocellular neurosecretory neurons seen in response to adrenalectomy.
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The HPA axis is regulated by GABAergic signaling at the level of CRH, and nearly 50% of synapses in the PVN are GABAergic.
“The HPA axis is also regulated by GABAergic signaling at the level of CRH, and nearly 50% of all synapses in the PVN are GABAergic (233).”
From Signalling cognition: The gut microbiota and hypothalamic-pituitary-adrenal axis (2023) · cites this paper as [233]
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- Authors
- Miklós, I. H., & Kovács, K. J.
- Affiliations
- HUN-REN Institute of Experimental Medicine (HU)
- Corresponding author
- Kovács, K.J
- Venue
- Neuroscience
- Publisher
- Elsevier BV
- Published
- 2002-09
- Volume
- 113
- Issue
- 3
- Pages
- 581-592
- ISSN
- 0306-4522 (ISSN-L)
- OpenAlex
- W2091326035
- Cited by
- 182
- References
- 62
- Citations by year
- 2026: 6 · 2025: 4 · 2024: 4 · 2023: 8 · 2022: 5 · 2021: 7 · 2020: 8 · 2019: 9 · 2018: 11 · 2017: 3 · 2016: 5 · 2015: 10 · 2014: 9 · 2013: 12 · 2012: 7
- FWCI
- 2.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- GABAergic innervation, corticotropin-releasing factor, parvocellular neurons, paraventricular nucleus, hypothalamic-pituitary-adrenal axis, GABAergic synapses, synaptic plasticity, adrenalectomy, stress response, neurosecretory cells, colchicine
- MeSH terms
- Adrenalectomy, Animals, Corticotropin-Releasing Hormone, gamma-Aminobutyric Acid, Immunohistochemistry, Male, Neuronal Plasticity, Neurons, Paraventricular Hypothalamic Nucleus, Synapses, Microscopy, Immunoelectron, Rats, Wistar, Presynaptic Terminals, Rats
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