Retrograde Regulation of GABA Transmission by the Tonic Release of Oxytocin and Endocannabinoids Governs Postsynaptic Firing
Open accessAbstract
The probability of neurotransmitter release at the nerve terminal is an important determinant of synaptic efficacy. At some central synapses, the postsynaptic, or target, neuron determines neurotransmitter release probability (Pr) at the presynaptic terminal. The mechanisms responsible for this target-cell dependent control of Pr have not been elucidated. Using whole-cell patch-clamp recordings from magnocellular neurosecretory cells in the paraventricular and supraoptic nuclei of the hypothalamus, we demonstrate that inhibitory, GABA synapses specifically onto oxytocin (OT)-producing neurosecretory cells exhibit a low Pr that is relatively uniform at multiple synapses onto the same cell. This low Pr results from a two-step process that requires the tonic release of OT from the postsynaptic cell. The ambient extracellular levels of neuropeptide are sufficient to activate postsynaptic OT receptors and trigger the Ca 2+-dependent production of endocannabinoids, which act in a retrograde manner at presynaptic cannabinoid CB 1 receptors to decrease GABA release. The functional consequence of this tonic inhibition of GABA release is that all inhibitory inputs facilitate uniformly when activated at high rates of activity. This causes inhibition in the postsynaptic cell that is sufficiently powerful to disrupt firing. Blockade of CB 1 receptors increases Pr at these synapses, resulting in a rapid depression of IPSCs at high rates of activity, thereby eliminating the ability of afferent inputs to inhibit postsynaptic firing. By playing a deterministic role in GABA release at the afferent nerve terminal, the postsynaptic OT neuron effectively filters synaptic signals and thereby modulates its own activity patterns.
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Oxytocin signalling controls the probability of presynaptic GABA release through postsynaptic release of endocannabinoids and activation of presynaptic CB1 receptors.
“oxytocin signalling controls the probability of presynaptic GABA release through the postsynaptic release of endocannabinoids and the activation of presynaptic CB1 receptors50.”
From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [50]
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“Activation of some types of Gq-coupled receptors promotes endocannabinoid release from the dendrites of cells throughout the brain (Kim et al., 2002; Hirasawa et al., 2004; Haj-Dahmane and Shen, 2005; Narushima et al., 2007; Oliet et al., 2007; Best and Regehr, 2008; Kola et al., 2008).”
BackgroundStoop, R. (2014) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2014.09.012 · Cited by 84 · see citing works
“Similar to its effects in the hypothalamus [45], it is possible that OT modulates endocannabinoid release and activates presynaptic CB1 receptors.”
Alger, B. E. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.220855 · Cited by 82 · see citing works
Carey, M. R., & Regehr, W. G. (2009) · Neuron · doi:10.1016/j.neuron.2009.02.022 · Cited by 80 · see citing works
“Endocannabinoid release is directly regulated by G q -coupled receptors such as group I metabotropic glutamate receptors, oxytocin receptors, and some types of muscarinic and serotonin receptors (Best and Regehr, 2008; Kim et al., 2002; Maejima et al., 2001; Oliet et al., 2007).”
Russo, R., D’Agostino, G., Mattace Raso, G., Avagliano, C., Cristiano, C., Meli, R., & Calignano, A. (2012) · Peptides · doi:10.1016/j.peptides.2012.08.005 · Cited by 66 · see citing works
Bealer, S. L., Armstrong, W. E., & Crowley, W. R. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00217.2010 · Cited by 76 · see citing works
“The site of oxytocin’s action critical for this effect is not certain, and may involve both pre- and postsynaptic actions (28, 45, 59, 60, 75) and multiple signaling pathways.”
BackgroundAstrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine
Chen, C., Jiang, Z., Fu, X., Yu, D., Huang, H. Y., & Tasker, J. G. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.092 · Cited by 74 · see citing works
Dendritic Transmitter Release: A Comparison of Two Model Systems
Bergquist, F., & Ludwig, M. (2008) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2008.01714.x · Cited by 70 · see citing works
Multiple signalling modalities mediated by dendritic exocytosis of oxytocin and vasopressin
Ludwig, M., & Stern, J. E. (2015) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2014.0182 · Cited by 66 · see citing works
“As 238 presynaptic oxytocin receptors are not found in the SON, this paracrine action was likely to be indirect and 239 indeed has been shown to be mediated by oxytocin-dependent endocannabinoid release from the oxytocin 240 neuron [100, 101].”
BackgroundStress disrupts engram ensembles in lateral amygdala to generalize threat memory in mice
Lesuis, S. L., Park, S., Hoorn, A., Rashid, A. J., Mocle, A. J., Salter, E. W., Vislavski, S., Gray, M. T., Torelli, A. M., Cristofaro, A. D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.034 · Cited by 72 · see citing works
“79,80 To determine whether CB1R activation similarly disrupts GABA release from LA PV+ neurons, we examined the effects of the CB1R agonist WIN55,212-2 (WIN55) on PV+ neuron synapses onto LA principal neurons using ex vivo slice electrophysiology.”
Endocannabinoids Gate State-Dependent Plasticity of Synaptic Inhibition in Feeding Circuits
Crosby, K. M., Inoue, W., Pittman, Q. J., & Bains, J. S. (2011) · Neuron · doi:10.1016/j.neuron.2011.06.006 · Cited by 65 · see citing works
“This is consistent with its action elsewhere in the hypothalamus (Hirasawa et al., 2004; Huang et al., 2007; Oliet et al., 2007; Wamsteeker et al., 2010) and throughout the brain (Kano et al., 2009).”
Self-citationMechanisms of endocannabinoid control of synaptic plasticity
Winters, B. L., & Vaughan, C. W. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108736 · Cited by 63 · see citing works
Hashimotodani, Y., Ohno‐Shosaku, T., Tanimura, A., Kita, Y., Sano, Y., Shimizu, T., Marzo, V. D., & Kano, M. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.254474 · Cited by 62 · see citing works
“…tone, at least under certain experimental conditions, depending on the balance between constitutive synthesis and degradation (Wilson & Nicoll, 2001; Hentges et al. 2005; Slanina & Schweitzer, 2005; Hashimotodani et al. 2007b; Neu et al. 2007; Oliet et al. 2007; Pan et al. 2011; Zhong et al. 2011).”
BackgroundDendritic Release of Neurotransmitters
Ludwig, M., Apps, D. K., Menzies, J. R. W., Patel, J. C., & Rice, M. E. (2016) · Comprehensive physiology · doi:10.1002/cphy.c160007 · Cited by 62 · see citing works
Pelkey, K. A., & McBain, C. J. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2007.148635 · Cited by 58 · see citing works
“In particular, recent years have witnessed a flood of publications describing a critical role for endocannabinoids (eCBs) as retrograde mediators of presynaptic LTD throughout the CNS, and some reports suggest a priviledged role for Ca2+ influx through CP-AMPARs in eCB generation (Gerdeman et al. 2002; Chevaleyre & Ca…”
BackgroundRegulation of hypothalamic corticotropin‐releasing hormone neurone excitability by oxytocin
Jamieson, B. B., Nair, B. B., & Iremonger, K. J. (2017) · Journal of Neuroendocrinology · doi:10.1111/jne.12532 · Cited by 55 · see citing works
Blitz, D. M., White, R. S., Saideman, S. R., Cook, A. P., Christie, A. E., Farzan Nadim, A., & Nusbaum, M. P. (2008) · Journal of Experimental Biology · doi:10.1242/jeb.015222 · Cited by 57 · see citing works
“…the ability of the same neurons to release signaling molecules that act both locally, in a paracrine fashion, and as circulating hormones (Mayeri, 1979; Sigvardt et al., 1986; Jung and Scheller, 1991; Loechner and Kaczmarek, 1994; Ludwig and Pittman, 2003; Fort et al., 2004; Oliet et al., 2007).”
BackgroundOxytocin-Induced Postinhibitory Rebound Firing Facilitates Bursting Activity in Oxytocin Neurons
Israël, J.-M., Poulain, D. A., & Oliet, S. H. R. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5198-07.2008 · Cited by 52 · see citing works
“, 2003) and which has been related to the release of endocannabinoids acting on presynaptic CB1 receptors (Oliet et al., 2007).”
Self-citationOxytocin and excitation/inhibition balance in social recognition
Lopatina, O. L., Komleva, Y. K., Gorina, Y. V., Olovyannikova, R. Y., Труфанова, Л. В., Hashimoto, T., Takahashi, T., Kikuchi, M., Minabe, Y., Higashida, H., et al. (2018) · Neuropeptides · doi:10.1016/j.npep.2018.09.003 · Cited by 51 · see citing works
Neuron–glia interactions in the rat supraoptic nucleus
Oliet, S. H. R., Panatier, A., Piet, R., Mothet, J., POULAIN, D., & Theodosis, D. T. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00410-x · Cited by 49 · see citing works
Self-citationRieger, N. S., Varela, J. A., Ng, A. J., Granata, L. E., Djerdjaj, A., Brenhouse, H. C., & Christianson, J. P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-022-01292-7 · Cited by 47 · see citing works
“Similarly, oxytocin can also trigger endocannabinoid release increasing postsynaptic excitability [45].”
BackgroundDi, S., Popescu, I., & Tasker, J. G. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2971-12.2013 · Cited by 46 · see citing works
“Previous reports described a tonic presynaptic suppression of GABA release onto magnocellular neurons by basal endocannabinoid actions under normal conditions (Oliet et al., 2007; Di et al., 2009; Wang and Armstrong, 2012), which seem to contradict our current observations of GABA synapse modulation by endocannabinoid…”
ResultEndocannabinoids and the Endocrine System in Health and Disease
Hillard, C. J. (2015) · Handbook of experimental pharmacology · doi:10.1007/978-3-319-20825-1_11 · Cited by 45 · see citing works
“CB1Rs are also present on GABA terminals in the hypothalamus (Wittmann et al., 2007) and several studies support a role for ECS in the suppression of tonic GABA release onto magnocellular neurons (Oliet et al., 2007, Di et al., 2009, Wang and Armstrong, 2012).”
BackgroundColangeli, R., Morena, M., Pittman, Q. J., Hill, M. N., & Teskey, G. C. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0068-20.2020 · Cited by 43 · see citing works
“This finding presents a new potential mechanism driving comorbid anxiety in seizure related disorders. eCB signaling exerts presynaptic tonic control of both glutamate and GABA release shaping the synaptic strength of neuronal networks (Zhu and Lovinger, 2005; Oliet et al., 2007).”
BackgroundChanging the tune: plasticity and adaptation of retrograde signals
Iremonger, K. J., Cusulin, J. I. W., & Bains, J. S. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.04.007 · Cited by 42 · see citing works
Self-citationOxytocin knockout mice: a model for studying stress-related and ingestive behaviours
Amico, J. A., Miedlar, J. A., CAI, H., & Vollmer, R. R. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00405-6 · Cited by 41 · see citing works
“In addition, cannabinoid and OXT pathways are known to interact (Di et al., 2003; Oliet et al., 2007).”
BackgroundMethodEndocannabinoid Regulation of Neuroendocrine Systems
Tasker, J. G., Chen, C., Fisher, M. O., Fu, X., Rainville, J. R., & Weiss, G. L. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.09.003 · Cited by 41 · see citing works
Glia-Dependent Switch of Kainate Receptor Presynaptic Action
Bonfardin, V. D. J., Fossat, P., Theodosis, D. T., & Oliet, S. H. R. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3389-09.2010 · Cited by 39 · see citing works
“For instance, activation of KARs on SON neurons or on dopaminergic afferent inputs could trigger the release of endocannabinoids or dopamine, which in turn could activate presynaptic CB1 and D4 receptors, thereby inhibiting GABA release (Azdad et al., 2003; Oliet et al., 2007).”
BackgroundSelf-citationRoles of phospholipase Cβ and NMDA receptor in activity‐dependent endocannabinoid release
Hashimotodani, Y., Ohno‐Shosaku, T., Watanabe, M., & Kano, M. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.137497 · Cited by 37 · see citing works
“…al. 2002; Galante & Diana, 2004; Kushmerick et al. 2004; Narushima et al. 2006), M1 and/or M3 muscarinic acetylcholine receptors (Kim et al. 2002; Fukudome et al. 2004; Narushima et al. 2007; Newman et al. 2007), orexin receptor (Haj-Dahmane & Shen, 2005) and oxytocin receptor (Oliet et al. 2007).”
BackgroundLaurentiis, A. D., Fernández‐Solari, J., Mohn, C. E., Burdet, B., Zubilete, M. A. Z., & Rettori, V. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.02.006 · Cited by 36 · see citing works
“In this case the activation of eCBs synthesis and release leads to downregulation of GABA release (Oliet et al., 2007).”
BackgroundResultMetaplasticity of Hypothalamic Synapses following In Vivo Challenge
Kuzmiski, J. B., Pittman, Q. J., & Bains, J. S. (2009) · Neuron · doi:10.1016/j.neuron.2009.05.027 · Cited by 34 · see citing works
“Previous studies in the hypothalamus have shown that eCBs can modulate synaptic transmission transiently following either presynaptic HFS or postsynaptic depolarization (Di et al., 2005a; Hirasawa et al., 2004), via oxytocin receptor (Hirasawa et al., 2004; Oliet et al., 2007 ) or glucocorticoid receptor (Di et al., 2…”
Self-citationMultiple cannabinoid signaling cascades powerfully suppress recurrent excitation in the hippocampus
Jensen, K. R., Berthoux, C., Nasrallah, K., & Castillo, P. E. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2017590118 · Cited by 33 · see citing works
Endocannabinoid-serotonin systems interaction in health and disease
Colangeli, R., Teskey, G. C., & Giovanni, G. D. (2021) · Progress in brain research · doi:10.1016/bs.pbr.2021.01.003 · Cited by 30 · see citing works
Melis, M., Greco, B., & Tonini, R. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12501 · Cited by 30 · see citing works
“In addition to canonical activity-dependent eCB mobilisation, under some experimental conditions tonic eCB signaling can regulate basal neurotransmission (Hentges et al., 2005; Neu et al., 2007; Oleson et al., 2012a,b; Oliet et al., 2007).”
BackgroundZampronio, A. R., Kuzmiski, J. B., Florence, C. M., Mulligan, S. J., & Pittman, Q. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5079-10.2010 · Cited by 27 · see citing works
“The differential response is in line with previous findings (Oliet et al., 2007) that eCBs act within a limited diffusion distance as the eCBs emanating from VP neurons do not appear to affect synapses impinging upon OT neuFigure 6.”
BackgroundResultEndocannabinoid signaling in neural plasticity.
Alger, B. (2009) · Current topics in behavioral neurosciences · doi:10.1007/978-3-540-88955-7_6 · Cited by 29 · see citing works
Harris, C., Weiss, G. L., Di, S., & Tasker, J. G. (2019) · Neurobiology of Stress · doi:10.1016/j.ynstr.2019.100158 · Cited by 27 · see citing works
“Previous findings in magnocellular neurons indicate that AEA is released tonically at GABA synapses (Oliet et al., 2007) and 2-AG release is induced at glutamate synapses in response to glucocorticoid and depolarization (Di et al.”
Ohbuchi, T., Yokoyama, T., Saito, T., Hashimoto, H., Suzuki, H., Otsubo, H., Fujihara, H., Suzuki, H., & Ueta, Y. (2009) · Brain Research · doi:10.1016/j.brainres.2008.12.057 · Cited by 26 · see citing works
Ruginsk, S. G., Uchôa, E. T., Elias, L. L. K., & Antunes‐Rodrigues, J. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.03.001 · Cited by 23 · see citing works
Freestone, P. S., Guatteo, E., Piscitelli, F., Marzo, V. D., Lipski, J., & Mercuri, N. B. (2013) · Neuropharmacology · doi:10.1016/j.neuropharm.2013.12.007 · Cited by 23 · see citing works
“1D), indicating a presynaptic effect of the drug (Oliet et al., 2007).”
Gonzalez-Islas, C. E., García-Bereguiain, M. A., & Wenner, P. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1229-12.2012 · Cited by 27 · see citing works
“…several other studies have demonstrated a tonic endocannabinoid inhibition of presynaptic release of GABAergic transmission (Losonczy et al., 2004; Oliet et al., 2007; Zhu and Lovinger, 2010; Inada et al., 2010; Neu et al., 2007; Hentges et al., 2005; Farkas et al., 2010; Kim and Alger, 2010),…”
Endogenous modulators of synaptic transmission: cannabinoid regulation in the supraoptic nucleus
MCDONALD, N., Kuzmiski, J. B., Naderi, N., Schwab, Y., & Pittman, Q. J. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00412-3 · Cited by 23 · see citing works
“applied CB agonists also presynaptically inhibit neurotransmission in the SON (Hirasawa et al., 2004; Soya et al., 2005; Oliet et al., 2007).”
BackgroundMethodInfluentialJoëls, M., Karst, H., & Tasker, J. G. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101146 · Cited by 23 · see citing works
“…baseline conditions, this corticosteroid-induced stimulation of 2-AG release is specific to glutamate synapses on neuro-endocrine cells, however, magnocellular neuroendocrine cells are also subject to a tonic endocannabinoid suppression of GABA release at inhibitory synapses (Oliet et al., 2007).”
BackgroundMapping and signaling of neural pathways involved in the regulation of hydromineral homeostasis
Antunes‐Rodrigues, J., Ruginsk, S. G., Mecawi, A. S., Margatho, L. O., Cruz, J. C., Vilhena‐Franco, T., Reis, W. L., Ventura, R. R., Reis, L. C., Vivas, L., et al. (2013) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20132788 · Cited by 22 · see citing works
“Consequently, OT is released from somatodendrites of SON magnocellular neurons and acts on presynaptic autoreceptors to facilitate the release of endocannabinoids (ECBs) and GABA, which in turn inhibit neuronal activity (46).”
BackgroundState-Dependent, Bidirectional Modulation of Neural Network Activity by Endocannabinoids
Piet, R., Garenne, A., Farrugia, F., Masson, G. L., Marsicano, G., Chavis, P., & Manzoni, O. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4297-11.2011 · Cited by 22 · see citing works
“, 1998), including that mediated by CB1Rs (Oliet et al., 2007), may enhance the efficacy of synaptic transmission during bursts of presynaptic activity, it is possible that activation of CB1Rs in fast bursting networks sets the release of neurotransmitters, in particular glutamate, to limit synaptic depression and to…”
BackgroundSelf-citationExperience Salience Gates Endocannabinoid Signaling at Hypothalamic Synapses
Cusulin, J. I. W., Senst, L., Teskey, G. C., & Bains, J. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0163-14.2014 · Cited by 21 · see citing works
“CB1Rs also show tonic activation (Oliet et al., 2007), raising the possibility that loss and recovery of eCB signaling reflects changes in the proportion of basally activated CB1Rs.”
BackgroundSelf-citationMetabotropic Glutamate Receptors: Gatekeepers of Homeostasis
Kuzmiski, J. B., & Bains, J. S. (2010) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2010.02020.x · Cited by 20 · see citing works
Self-citationCrosby, K. M., Baimoukhametova, D. V., Bains, J. S., & Pittman, Q. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3123-14.2015 · Cited by 21 · see citing works
“For example, somatodendritic release of oxytocin from hypothalamic neurons suppresses GABA transmission in an eCB-dependent manner (Oliet et al., 2007).”
BackgroundSelf-citationIremonger, K. J., Benediktsson, A. M., & Bains, J. S. (2010) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2010.03.002 · Cited by 20 · see citing works
“In addition, at least at GABA synapses onto MNCs, there is a tonic eCB inhibition of transmitter release that is also mediated by tonic OT receptor activation in these neurons [100].”
BackgroundSelf-citationSex-Specific Vasopressin Signaling Buffers Stress-Dependent Synaptic Changes in Female Mice
Loewen, S. P., Baimoukhametova, D. V., & Bains, J. S. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.1026-20.2020 · Cited by 20 · see citing works
Self-citationMaternal Brain Adaptations in Pregnancy
Brunton, P. J., & Russell, J. A. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00044-2 · Cited by 18 · see citing works
Endogenous cannabinoids are required for MC4R-mediated control of energy homeostasis
Yong, Y., Çakır, I., Pan, P. L., Biddinger, J. E., Bluett, R. J., Mackie, K., Bingham, N. C., Patel, S. H., & Ghamari‐Langroudi, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2015990118 · Cited by 18 · see citing works
Borie, A. M., Young, L. J., & Liu, R. C. (2022) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2021.0057 · Cited by 17 · see citing works
“ECBs then retrogradely act on presynaptic GABAergic neurons to inhibit the release of GABA back onto oxytocinergic neurons [83].”
BackgroundCentral Nervous System Control of Oxytocin Secretion during Lactation
Armstrong, W. E. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00013-2 · Cited by 16 · see citing works
Tonic Regulation of GABAergic Synaptic Activity on Vasopressin Neurones by Cannabinoids
Wang, L., & Armstrong, W. E. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02239.x · Cited by 13 · see citing works
Hierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pair
Aoki, I., Golinelli, L., Dunkel, E., Bhat, S., Bassam, E., Beets, I., & GOTTSCHALK, A. R. (2024) · Nature Communications · doi:10.1038/s41467-024-53899-7 · Cited by 13 · see citing works
Rajamanickam, S., & Justice, N. J. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100400 · Cited by 13 · see citing works
Wu, N., & Tasker, J. G. (2017) · eNeuro · doi:10.1523/eneuro.0216-17.2017 · Cited by 13 · see citing works
“Endocannabinoid synthesis is elicited in magnocellular neuroendocrine cells of the hypothalamus by depolarization (Hirasawa et al., 2004; Di et al., 2005b) and in response to oxytocin (Oliet et al., 2007), as well as in response to rapid glucocorticoid actions (Di et al., 2003, 2005a).”
BackgroundVilela, F. C., Ruginsk, S. G., de Melo, C. M., & Giusti‐Paiva, A. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1238-8 · Cited by 12 · see citing works
“[36], as well as by McDonald et al.”
Endocannabinoids at the Synapse: Retrograde Signaling and Presynaptic Plasticity in the Brain
Gerdeman, G. L. (2007) · Springer eBooks · doi:10.1007/978-0-387-74349-3_11 · Cited by 11 · see citing works
Molecular Mechanisms Involved in the Control of Neurohypophyseal Hormones Secretion
Iovino, M., Guastamacchia, E., Giagulli, V. A., Licchelli, B., Iovino, E., & Triggiani, V. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140905150730 · Cited by 11 · see citing works
“Indeed, ECBs act on pre-synaptic CB1R to inhibit GABA release, and consequently induce inhibition of post-synaptic firing, thus showing that OT acts at the presynaptic receptors to inhibit its own release and at the post-synaptic receptors to govern its own activity [166].”
BackgroundMultiplexed membrane signaling by glucocorticoids
Harrison, L. M., & Tasker, J. G. (2022) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2022.100390 · Cited by 11 · see citing works
The Cell Biology of Oxytocin and Vasopressin Cells
Tasker, J. G., Voisin, D. L., & Armstrong, W. E. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-803592-4.00058-4 · Cited by 7 · see citing works
Gómora‐Arrati, P., Dominguez, G., & Ågmo, A. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12434 · Cited by 5 · see citing works
Dendritic Release of Neurotransmitters
Ludwig, M., Apps, D. K., Menzies, J. R. W., Patel, J. C., & Rice, M. E. (2017) · Comprehensive physiology · doi:10.1002/j.2040-4603.2017.tb00742.x · Cited by 4 · see citing works
Ferrari, M. S. G., Bain, A. A., & Narváez, S. C. D. (2023) · Social and ecological interactions in the Galapagos Islands · doi:10.1007/978-3-031-28089-4_31 · Cited by 4 · see citing works
Dynamic synapses in the hypothalamic-neurohypophyseal system
Iremonger, K. J., & Bains, J. S. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00411-1 · Cited by 4 · see citing works
“This is an important consideration since release probability at inhibitory GABA synapses onto MNCs is regulated by the target cell itself (Oliet et al., 2007).”
BackgroundSelf-citationHierarchical regulation of functionally antagonistic neuropeptides expressed in a single neuron pairPreprint
Aoki, I., Golinelli, L., Dunkel, E., Bhat, S., Bassam, E., Beets, I., & GOTTSCHALK, A. R. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.23.568473 · Cited by 4 · see citing works
Rein, J. L., Mackie, K., Kleyman, T. R., & Satlin, L. M. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00320.2022 · Cited by 3 · see citing works
Dendritic Release of the Neuropeptides Vasopressin and Oxytocin
Ludwig, M. (2014) · doi:10.1002/9781118606803.ch9 · Cited by 3 · see citing works
Salinas-Abarca, A. B., Martı́nez-Lorenzana, G., Condés‐Lara, M., & González‐Hernández, A. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114383 · Cited by 2 · see citing works
SNAP-47 mediates somatic oxytocin dynamics in hypothalamic neurons
Aznar-Escolano, B., Royo, M. V. V., Madrigal, M. P., Portalés, A., Villanueva, J., Gutiérrez, L. M., & Jurado, S. (2026) · Communications Biology · doi:10.1038/s42003-025-09442-5 · Cited by 1 · see citing works
“…the functional implications of basal OT are not yet completely understood, OT somatic release is believed to contribute to activity patterns that enhance neuropeptide secretion 42,62,64,65 , sustain basal hypo-thalamic activity 69 , and support critical functions like social homeostasis 32 .”
Sarmad, S., Alexander, S. P. H., Barrett, D. A., Marsden, C. A., & Kendall, D. A. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07235.x · Cited by 1 · see citing works
Novel Aspects of Glucocorticoids Actions on Energy Homeostasis and Hydromineral Balance
Ruginsk, S. G., Cesar, R., Borges, B. C., Torres, E., Elias, L. L. K., & Antunes‐Rodrigues, J. (2012) · InTech eBooks · doi:10.5772/53266
“…that the endocannabinoid system can mediate not only the central effects of glucocorticoids but also independently modulate the excitability of postsynaptic terminals after the dendritic-mediated release of neuropeptides like OT (Hirasawa et al., 2004; McDonald et al., 2008; Oliet et al., 2007).”
Endocannabinoid Modulation of Synaptic Inputs to Magnocellular Neurons
Popescu, I., Di, S., & Tasker, J. G. (2014) · doi:10.1002/9781118606803.ch10
Control of Neurotransmitter Release Properties by Presynaptic Calcium
Thanawala, M. S. (2014) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
- Authors
- Oliet, S. H. R., Baimoukhametova, D. V., Piet, R., & Bains, J. S.
- Affiliations
- Inserm (FR)
- University of Calgary (CA)
- Université Bordeaux Segalen (FR)
- Corresponding author
- Bains, Jaideep S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-02-07
- Volume
- 27
- Issue
- 6
- Pages
- 1325-1333
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673587
- OpenAlex
- W2091992063
- Cited by
- 107
- References
- 64
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 5 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 9 · 2013: 7 · 2012: 8
- FWCI
- 4.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Fondation pour la Recherche Médicale
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- retrograde regulation, oxytocin, endocannabinoids, CB1 receptor, postsynaptic inhibition, presynaptic inhibition, magnocellular neurosecretory cells, paraventricular nucleus, supraoptic nucleus, hypothalamus, inhibitory synapses
- MeSH terms
- Animals, Calcium, Egtazic Acid, Female, gamma-Aminobutyric Acid, Hypothalamus, Anterior, Male, Morpholines, Naphthalenes, Oxytocin, Paraventricular Hypothalamic Nucleus, Piperidines, Pyrazoles, Rats, Sprague-Dawley, Rats, Wistar, Presynaptic Terminals, Patch-Clamp Techniques, 6-Cyano-7-nitroquinoxaline-2,3-dione, Receptor, Cannabinoid, CB1, Extracellular Fluid, Benzoxazines, Rats, Cannabinoid Receptor Modulators, Endocannabinoids
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