The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke
Open accessAbstract
Evaluation of infarct volumes and infiltrating immune cell populations in mice after middle cerebral artery occlusion (MCAO) strongly implicates a mixture of both pathogenic and regulatory immune cell subsets in stroke pathogenesis and recovery. Our goal was to evaluate the contribution of B cells to the development of MCAO by comparing infarct volumes and functional outcomes in wild-type (WT) versus B-cell-deficient μMT(-/-) mice. The results clearly demonstrate larger infarct volumes, higher mortality, more severe functional deficits, and increased numbers of activated T cells, macrophages, microglial cells, and neutrophils in the affected brain hemisphere of MCAO-treated μMT(-/-) versus WT mice. These MCAO-induced changes were completely prevented in B-cell-restored μMT(-/-) mice after transfer of highly purified WT GFP(+) B cells that were detected in the periphery, but not the CNS. In contrast, transfer of B cells from IL-10(-/-) mice had no effect on infarct volume when transferred into μMT(-/-) mice. These findings strongly support a previously unrecognized activity of IL-10-secreting WT B cells to limit infarct volume, mortality rate, recruitment of inflammatory cells, and functional neurological deficits 48 h after MCAO. Our novel observations are the first to implicate IL-10-secreting B cells as a major regulatory cell type in stroke and suggest that enhancement of regulatory B cells might have application as a novel therapy for this devastating neurologic condition.
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Citations
Cites
Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice
Kim, J. M., Rasmussen, J. P., & Rudensky, A. Y. (2007) · Nature Immunology · doi:10.1038/ni1428 · Cited by 1,820
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The inflammatory response in stroke
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Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
Liesz, A., Suri-Payer, E., Veltkamp, C., Doerr, H., Sommer, C., Rivest, S., Giese, T., & Veltkamp, R. (2009) · Nature Medicine · doi:10.1038/nm.1927 · Cited by 1,115
Role of T Lymphocytes and Interferon-γ in Ischemic Stroke
Yilmaz, G., Arumugam, T. V., Stokes, K. Y., & Granger, D. N. (2006) · Circulation · doi:10.1161/circulationaha.105.593046 · Cited by 722
Cytokine-producing B lymphocytes-key regulators of immunity
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Experimental Stroke Induces Massive, Rapid Activation of the Peripheral Immune System
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Self-citationCarter, N. A., Vasconcellos, R., Rosser, E. C., Tulone, C., Muñoz-Suano, A., Kamanaka, M., Ehrenstein, M. R., Flavell, R. A., & Mauri, C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100284 · Cited by 476
Cited by
Inflammation and Stroke: An Overview
Anrather, J., & Iadecola, C. (2016) · Neurotherapeutics · doi:10.1007/s13311-016-0483-x · Cited by 958
Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke
Yang, C., Hawkins, K. E., Doré, S., & Candelario-Jalil, E. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00136.2018 · Cited by 871
Immune responses to stroke: mechanisms, modulation, and therapeutic potential.
Iadecola, C., Buckwalter, M. S., & Anrather, J. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135530 · Cited by 853
The immunology of acute stroke
Chamorro, Á., Meisel, A., Planas, A. M., Urra, X., van de Beek, D., & Veltkamp, R. (2012) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.98 · Cited by 707
The role of peripheral immune cells in the CNS in steady state and disease
Prinz, M., & Priller, J. (2017) · Nature Neuroscience · doi:10.1038/nn.4475 · Cited by 657
Metadata
- Authors
- Ren, X., Akiyoshi, K., Dziennis, S., Vandenbark, A. A., Herson, P. S., Hurn, P. D., & Offner, H.
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2011-06-08
- Volume
- 31
- Issue
- 23
- Pages
- 8556-8563
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2112094579
- Cited by
- 300
- References
- 32
- FWCI
- 8.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ren, X., Akiyoshi, K., Dziennis, S., Vandenbark, A. A., Herson, P. S., Hurn, P. D., & Offner, H. (2011). Regulatory B Cells Limit CNS Inflammation and Neurologic Deficits in Murine Experimental Stroke. Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1623-11.2011
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