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Measures of Cortical Plasticity after Transcranial Paired Associative Stimulation Predict Changes in Electroencephalogram Slow-Wave Activity during Subsequent Sleep
Open accessAbstract
Sleep slow-wave activity (SWA) is thought to reflect sleep need, increasing in proportion to the previous time awake and decreasing during sleep, although the underlying mechanisms are unclear. Recent studies have shown that procedures presumably leading to local plastic changes in the cerebral cortex can lead to local changes in SWA during subsequent sleep. To further investigate the connection between cortical plasticity and sleep SWA, in this study we used a paired associative stimulation (PAS) protocol, in which median nerve stimuli were followed at different intervals (25 or 10 ms) by transcranial magnetic stimulation (TMS) pulses to the contralateral cortical hand area. As expected, such a protocol led to a sustained increase (long-term potentiation-like) or decrease (long-term depression-like) of cortical excitability as measured by motor evoked potentials. By using a TMS-compatible high-density electroencephalographic (EEG) system, we also found that, in individual subjects, TMS-evoked cortical responses over sensorimotor cortex changed with different interstimulus intervals. Moreover, during subsequent sleep, SWA increased locally in subjects whose TMS-evoked cortical responses had increased after PAS, and decreased in subjects whose cortical responses had decreased. Changes in TMS-evoked cortical EEG response and change in sleep SWA were localized to similar cortical regions and were positively correlated. Together, these results suggest that changes in cortical excitability in opposite directions lead to corresponding changes in local sleep regulation, as reflected by SWA, providing evidence for a tight relationship between cortical plasticity and sleep intensity.
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“Paired associative TMS stimulation (PAS) before sleep produced increases or decreases in subsequent SWS, depending on whether the protocol successfully induced long-term potentiation-like increases or long-term depression-like decreases in cortical excitability as measured by motor evoked potentials (583).”
From About Sleep's Role in Memory (2013) · cites this paper as [583]
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Cites
Delorme, A., & Makeig, S. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2003.10.009 · Cited by 24,371
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Nonparametric permutation tests for functional neuroimaging: A primer with examples
Nichols, T. E., & Holmes, A. P. (2002) · Human Brain Mapping · doi:10.1002/hbm.1058 · Cited by 6,256
Regulation of Synaptic Efficacy by Coincidence of Postsynaptic APs and EPSPs
Markram, H., Lübke, J., Frotscher, M., & Sakmann, B. (1997) · Science · doi:10.1126/science.275.5297.213 · Cited by 3,832
Thalamocortical oscillations in the sleeping and aroused brain
Steriade, M., McCormick, D. A., & Sejnowski, T. J. (1993) · Science · doi:10.1126/science.8235588 · Cited by 3,564
Standardized low-resolution brain electromagnetic tomography (sLORETA): technical details.
Pascual-Marqui, R. D. (2002) · PubMed · Cited by 3,329
Rossini, P. M., Barker, A. T., Berardelli, A., Caramia, M. D., Caruso, G., Cracco, R. Q., Dimitrijević, M. R., Hallett, M., Katayama, Y., Lücking, C. H., et al. (1994) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(94)90029-9 · Cited by 3,030
Synaptic plasticity: taming the beast
Abbott, L. F., & Nelson, S. B. (2000) · Nature Neuroscience · doi:10.1038/81453 · Cited by 2,263 · cited 1×
“The PAS paradigm was developed based on the principles of spike time-dependent plasticity (Abbott and Nelson, 2000), according to which presynaptic activity that precedes postsynaptic firing should induce potentiation, whereas reversing the order should cause depression.”
MethodSleep function and synaptic homeostasis
Tononi, G., & Cirelli, C. (2006) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2005.05.002 · Cited by 2,151
Self-citationSleep-dependent memory consolidation
Stickgold, R. (2005) · Nature · doi:10.1038/nature04286 · Cited by 1,857
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Electroencephalographic and neurophysiological changes
Gorgoni, M., Salfi, F., Gennaro, L. D., & Ferrara, M. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822963-7.00038-4 · Cited by 1
The role of napping on memory consolidation in preschool children
Kurdziel, L. B. F. (2020) · Scholarworks (University of Massachusetts Amherst) · doi:10.7275/6053550.0
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Halász, P., & Bódizs, R. (2012) · Springer eBooks · doi:10.1007/978-1-4471-4333-8_5
Guerra, A., Ferreri, F., Ponzo, D., Vollero, L., Pino, G. D., Petrichella, S., Benvenuto, A., Tombini, M., Rossini, L., Denaro, L., et al. (2014) · Clinical Neurophysiology · doi:10.1016/s1388-2457(14)50327-6
Self-citationModulation of plasticity of the soleus area of the motor cortex using paired associative stimulation
Kumpulainen, S. (2015) · Jyväskylä University Digital Archive (University of Jyväskylä)
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Hung, C., Sarasso, S., Ferrarelli, F., Riedner, B. A., Cirelli, C., & Tononi, G. (2013)
Self-citationWu, S. W., & Pedapati, E. V. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802001-2.00003-5
Seigneur, J. (2013) · Corpus Université Laval (Université Laval)
Johnson, N. (2016) · University of Minnesota Digital Conservancy (University of Minnesota)
TMS and TMS-EEG studies on the excitability, connectivity and plasticity of the human motor cortex
Ferreri, F. (2011) · UEF eRepo (University of Eastern Finland)
Self-citationZulkifly, M. F. M. (2020) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-8364
Niknazar, H., Malerba, P., & Mednick, S. C. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.03.462961
Ringli, M., & Huber, R. (2020) · Springer Reference Medizin · doi:10.1007/978-3-642-54672-3_957-1
Self-citationRingli, M., & Huber, R. (2025) · Springer Reference Medizin · doi:10.1007/978-3-662-65186-5_957
Self-citationMorozova, M., Yakovlev, L., Syrov, N., Lebedev, M. D., & Kaplan, A. (2026) · Journal of Visualized Experiments · doi:10.3791/69508
Classifying Sleep Slow Oscillations in Low Density EEG
Gaither, J., White, P., Mednick, S. C., & Malerba, P. (2026) · Neuroinformatics · doi:10.1007/s12021-026-09776-3
Hung, C. (2008) · Loughborough University Institutional Repository (Loughborough University)
Neural Correlates of Human Sleep and Sleep-Dependent Memory Processing
Meyer, C., Muto, V., Jaspar, M., Kussé, C., Foret, A., Mascetti, L., & Maquet, P. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-384995-3.00008-3
Metadata
- Authors
- Huber, R., Määttä, S., Esser, S. K., Sarasso, S., Ferrarelli, F., Watson, A., Ferreri, F., Peterson, M. J., & Tononi, G.
- Affiliations
- University of Wisconsin–Madison (US)
- Università Campus Bio-Medico (IT)
- Corresponding author
- Tononi, Giulio
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-07-30
- Volume
- 28
- Issue
- 31
- Pages
- 7911-7918
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2809373
- OpenAlex
- W2042816111
- Cited by
- 147
- References
- 55
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 13 · 2014: 14 · 2013: 16 · 2012: 16
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Padua Research Archive (University of Padova) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS055185)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- cortical plasticity, paired associative stimulation, long-term potentiation, long-term depression, cortical excitability, motor evoked potentials, sensorimotor cortex, sleep regulation, sleep need, interstimulus interval
- MeSH terms
- Adult, Cerebral Cortex, Electric Stimulation, Electroencephalography, Humans, Male, Neuronal Plasticity, Predictive Value of Tests, Sleep, Transcranial Magnetic Stimulation
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