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Measures of Cortical Plasticity after Transcranial Paired Associative Stimulation Predict Changes in Electroencephalogram Slow-Wave Activity during Subsequent Sleep
Open accessAbstract
Sleep slow-wave activity (SWA) is thought to reflect sleep need, increasing in proportion to the previous time awake and decreasing during sleep, although the underlying mechanisms are unclear. Recent studies have shown that procedures presumably leading to local plastic changes in the cerebral cortex can lead to local changes in SWA during subsequent sleep. To further investigate the connection between cortical plasticity and sleep SWA, in this study we used a paired associative stimulation (PAS) protocol, in which median nerve stimuli were followed at different intervals (25 or 10 ms) by transcranial magnetic stimulation (TMS) pulses to the contralateral cortical hand area. As expected, such a protocol led to a sustained increase (long-term potentiation-like) or decrease (long-term depression-like) of cortical excitability as measured by motor evoked potentials. By using a TMS-compatible high-density electroencephalographic (EEG) system, we also found that, in individual subjects, TMS-evoked cortical responses over sensorimotor cortex changed with different interstimulus intervals. Moreover, during subsequent sleep, SWA increased locally in subjects whose TMS-evoked cortical responses had increased after PAS, and decreased in subjects whose cortical responses had decreased. Changes in TMS-evoked cortical EEG response and change in sleep SWA were localized to similar cortical regions and were positively correlated. Together, these results suggest that changes in cortical excitability in opposite directions lead to corresponding changes in local sleep regulation, as reflected by SWA, providing evidence for a tight relationship between cortical plasticity and sleep intensity.
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“Paired associative TMS stimulation (PAS) before sleep produced increases or decreases in subsequent SWS, depending on whether the protocol successfully induced long-term potentiation-like increases or long-term depression-like decreases in cortical excitability as measured by motor evoked potentials (583).”
From About Sleep's Role in Memory (2013) · cites this paper as [583]
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Metadata
- Authors
- Huber, R., Määttä, S., Esser, S. K., Sarasso, S., Ferrarelli, F., Watson, A., Ferreri, F., Peterson, M. J., & Tononi, G.
- Affiliations
- University of Wisconsin–Madison (US)
- Università Campus Bio-Medico (IT)
- Corresponding author
- Tononi, Giulio
- ORCID
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-07-30
- Volume
- 28
- Issue
- 31
- Pages
- 7911-7918
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2809373
- OpenAlex
- W2042816111
- Cited by
- 147
- References
- 55
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 8 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 7 · 2015: 13 · 2014: 14 · 2013: 16 · 2012: 16
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Padua Research Archive (University of Padova) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- James S. McDonnell Foundation
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS055185)
- Topics
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- cortical plasticity, paired associative stimulation, long-term potentiation, long-term depression, cortical excitability, motor evoked potentials, sensorimotor cortex, sleep regulation, sleep need, interstimulus interval
- MeSH terms
- Adult, Cerebral Cortex, Electric Stimulation, Electroencephalography, Humans, Male, Neuronal Plasticity, Predictive Value of Tests, Sleep, Transcranial Magnetic Stimulation
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