Cited by 415Neuroscience and Neuropharmacology ResearchAmino Acid Enzymes and MetabolismNeuroinflammation and Neurodegeneration Mechanisms

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors

Open access

Schell, Michael J., Brady Jr., Roscoe O., Molliver, Mark E., Snyder, Solomon H.·1997·The Journal of Neuroscience

DOI 10.1523/jneurosci.17-05-01604.1997PMC PMC6573391

Open this paper in CoChat — free account Open PDF

Abstract

d-Serine is localized in mammalian brain to a discrete population of glial cells near NMDA receptors, suggesting that d-serine is an endogenous agonist of the receptor-associated glycine site. To explore this possibility, we have compared the immunohistochemical localizations of d-serine, glycine, and NMDA receptors in rat brain. In the telencephalon,d-serine is concentrated in protoplasmic astrocytes, which are abundant in neuropil in close vicinity to NMDA receptor 2A/B subunits. Ultrastructural examination of the CA1 region of hippocampus reveals d-serine in the cytosolic matrix of astrocytes that ensheath neurons and blood vessels, whereas NR2A/B is concentrated in dendritic spines. By contrast, glycine immunoreactivity in telencephalon is the lowest in brain. During postnatal week 2,d-serine levels in cerebellum are comparable to those in adult cerebral cortex but fall to undetectable levels by day 26. During week 2, we observe parallel ontogeny of d-serine in Bergmann glia and NR2A/B in Purkinje cells, suggesting a role for astrocytic d-serine in NMDA receptor-mediated synaptogenesis.d-Serine in the radial processes of Bergmann glia is also well positioned to regulate NMDA receptor-dependent granule cell migration. In the inner granule layer,d-serine is found transiently in protoplasmic astrocytes surrounding glomeruli, where it could regulate development of the mossy fiber/granule cell synapse.d-Serine seems to be the endogenous ligand of glycine sites in the telencephalon and developing cerebellum, whereas glycine predominates in the adult cerebellum, olfactory bulb, and hindbrain.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.17-05-01604.1997

Cites

0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Molecular cloning and characterization of the rat NMDA receptor
Moriyoshi, K., Masu, M., Ishii, T., Shigemoto, R., Mizuno, N., & Nakanishi, S. (1991) · Nature · doi:10.1038/354031a0 · Cited by 1,771
Comparison of Two Forms of Long-Term Potentiation in Single Hippocampal Neurons
Zalutsky, R. A., & Nicoll, R. A. (1990) · Science · doi:10.1126/science.2114039 · Cited by 759
N-methyl-D-aspartate receptors: different subunit requirements for binding of glutamate antagonists, glycine antagonists, and channel-blocking agents
Lynch, D. R., Anegawa, N. J., Verdoorn, T., & Pritchett, D. B. (1994) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10028-x · Cited by 173

Show all 3 references

Research works printed but not linked: 73

10.1002/cne.901450402 · DOI · Paper page
10.1016/0006-8993(86)90208-8 · DOI
Chouinard, 1993, Presence of the N-methyl-d-aspartate-associated glycine receptor agonist, d-serine, in human temporal cortex: comparison of normal, Parkinson, and Alzheimer tissues., J Neurochem, 61, 1561, 10.1111/j.1471-4159.1993.tb13657.x · DOI
10.1126/science.164.3876.142 · DOI
10.1016/0166-2236(87)90172-X · DOI
10.1113/jphysiol.1982.sp014304 · DOI
10.1016/S0960-9822(95)00168-0 · DOI
10.1111/j.1471-4159.1976.tb01561.x · DOI
10.1016/0306-4522(93)90290-V · DOI
Dupont, 1987, Postnatal development of the chemosensitivity of rat cerebellar Purkinje cells to excitatory amino acids: an in vitro study., Brain Res, 431, 59, 10.1016/0165-3806(87)90195-7 · DOI
10.1097/00001756-199604100-00007 · DOI
10.1038/368335a0 · DOI
10.1016/0304-3940(93)90126-6 · DOI
10.1016/0006-8993(87)90794-3 · DOI
10.1016/0306-4522(89)90067-5 · DOI
10.1146/annurev.ne.10.030187.001545 · DOI
10.1016/0014-5793(92)80397-Y · DOI
10.1016/0378-4347(92)80300-F · DOI
10.1111/j.1471-4159.1993.tb03575.x · DOI
10.1111/j.1471-4159.1993.tb03219.x · DOI
10.1111/j.1460-9568.1995.tb00687.x · DOI
10.1016/0306-4522(94)00597-X · DOI
10.1016/0361-9230(87)90076-1 · DOI
10.1038/325529a0 · DOI
Jursky, 1996, Developmental expression of the glycine transporters GLYT1 and GLYT2 in mouse brain., J Neurochem, 67, 336, 10.1046/j.1471-4159.1996.67010336.x · DOI
10.1016/0165-6147(93)90108-V · DOI
10.1126/science.8096653 · DOI
10.1016/0306-4522(86)90112-0 · DOI
10.1038/358036a0 · DOI
Lahoya, 1980, Glycine metabolism and glycine synthase activity during the postnatal development of rat brain., Dev Neurosci, 3, 75, 10.1159/000112379 · DOI
10.1523/JNEUROSCI.08-10-03822.1988 · DOI
10.1007/BF00494354 · DOI
10.1113/jphysiol.1991.sp018465 · DOI
10.1046/j.1471-4159.1995.65010454.x · DOI
10.1097/00001756-199406020-00011 · DOI
10.1038/357070a0 · DOI
10.1126/science.256.5060.1217 · DOI · Paper page
10.1016/0896-6273(94)90210-0 · DOI · Paper page
10.1007/BF02124295 · DOI
10.1016/0006-8993(94)91932-1 · DOI
10.1016/0006-8993(88)91573-9 · DOI
Palay SL Chan-Palay V (1974) Cerebellar cortex: cytology and organization. (Springer, New York). · DOI
10.1523/JNEUROSCI.14-10-06102.1994 · DOI
10.1523/JNEUROSCI.14-02-00667.1994 · DOI
Portera-Cailliau, 1996, N-methyl-d-aspartate receptor proteins NR2A and NR2B are differentially distributed in the developing rat central nervous system as revealed by subunit-specific antibodies., J Neurochem, 66, 692, 10.1046/j.1471-4159.1996.66020692.x · DOI
10.1016/0306-4522(92)90151-Q · DOI
Priestley, 1995, Pharmacological properties of recombinant human N-methyl-d-aspartate receptors comprising NR1a/NR2A and NR1a/NR2B subunit assemblies expressed in permanently transfected mouse fibroblast cells., Mol Pharmacol, 48, 841, 10.1016/S0026-895X(25)10541-5 · DOI
10.1016/0304-3940(85)90378-7 · DOI
10.1126/science.1352066 · DOI
10.1016/0306-4522(85)90176-9 · DOI
10.1002/glia.440140302 · DOI
10.1073/pnas.84.21.7744 · DOI
10.1002/(SICI)1098-1136(199608)17:4<263::AID-GLIA1>3.0.CO;2-0 · DOI
10.1016/0028-3908(93)90018-X · DOI
10.1016/0006-8993(89)90823-8 · DOI
10.1016/0006-8993(91)91436-5 · DOI
10.1073/pnas.92.9.3948 · DOI · Paper page
10.1016/0304-3940(95)11459-A · DOI
10.1111/j.1476-5381.1990.tb14695.x · DOI
10.1111/j.1471-4159.1991.tb03468.x · DOI
10.1146/annurev.ne.16.030193.002305 · DOI
10.1016/0306-4522(92)90139-S · DOI
Trombley, 1994, Glycine exerts potent inhibitory actions on mammalian olfactory bulb neurons., J Neurophysiol, 71, 761, 10.1152/jn.1994.71.2.761 · DOI
10.1523/JNEUROSCI.16-03-00877.1996 · DOI · Paper page
10.1523/JNEUROSCI.08-02-00472.1988 · DOI
10.1097/00001756-199212000-00027 · DOI
10.1002/cne.903430402 · DOI
10.1111/j.1471-4159.1977.tb07782.x · DOI
10.1111/j.1471-4159.1977.tb10427.x · DOI
10.1016/0006-8993(81)91275-0 · DOI
10.1111/j.1471-4159.1989.tb11803.x · DOI
10.1523/JNEUROSCI.15-05-03952.1995 · DOI
10.1523/JNEUROSCI.16-03-01140.1996 · DOI

Sorted by citations

Items 201–300 of 369

Neonatal Disruption of Serine Racemase Causes Schizophrenia-Like Behavioral Abnormalities in Adulthood: Clinical Rescue by D-Serine
Hagiwara, H., Iyo, M., & Hashimoto, K. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062438 · Cited by 33
Glial–Neuronal Interactions—Implications for Plasticity and Drug Addiction
Vijayaraghavan, S. (2009) · The AAPS Journal · doi:10.1208/s12248-009-9085-4 · Cited by 33
“has led to the idea that the amino acid might be a significant player in the regulation of NMDA receptors by acting as the natural substrate for the glycine binding site on the receptor (103,104).”
High-resolution structure of human phosphoserine phosphatase in open conformation.
Peeraer, Y., Rabijns, A., Verboven, C., Collet, J., Schaftingen, E. V., & de Ranter, C. D. (2003) · Acta Crystallographica Section D: Biological Crystallography · doi:10.1107/s0907444903005407 · Cited by 32
Interactions between GABA and glycine at inhibitory amino acid receptors on rat olfactory bulb neurons.
Trombley, P., Hill, B. J., & Horning, M. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.82.6.3417 · Cited by 32
“Some investigators have reported that glycine immunoreactivity is concentrated in the external plexiform layer (EPL), the neuropil surrounding mitral cell bodies, and in periglomerular cells (Pourcho et al. 1992; Schell et al. 1997; van den Pol and Gorcs 1988).”
Background
D-Amino Acids and Cancer: Friends or Foes?
Murtas, G., & Pollegioni, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24043274 · Cited by 36
Chiral analysis of amino acid neurotransmitters and neuromodulators in mouse brain by CE‐LIF
Jakó, T., Szabó, E., Tábi, T., Zachár, G., Csillag, A., & Szökő, É. (2014) · Electrophoresis · doi:10.1002/elps.201400224 · Cited by 35
Cell-specific Expression of N -Methyl-D-Aspartate Receptor Subunits in Müller Glia and Neurons from the Chick Retina
Lamas, M., Lee-Rivera, I., & López-Colomé, A. M. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.04-1398 · Cited by 31
Effects of N-methyl-D-aspartate, kainate or veratridine on extracellular concentrations of free D-serine and L-glutamate in rat striatum: an in vivo microdialysis study.
Hashimoto, A., Kanda, J., & Oka, T. (2000) · Brain Research Bulletin · doi:10.1016/s0361-9230(00)00357-9 · Cited by 31
The relationship between TGF-β1 and cognitive function in the brain
Su, C., Miao, J., & Guo, J. (2023) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2023.110820 · Cited by 35
“Its synthesis and release play a role in modulating synaptic plasticity within the hippocampus, pre-frontal cortex, and hypothalamus (Schell et al., 1997).”
AMPA receptor mediated d ‐serine release from retinal glial cells
Sullivan, S. J., & Miller, R. F. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.07077.x · Cited by 33
In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter ‐1 ( SLC 7A10)
Brown, J. M., Hunihan, L. W., Prack, M. M., Harden, D., Bronson, J. J., Dzierba, C. D., Gentles, R. G., Hendricson, A. W., Krause, R., Macor, J. E., et al. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12618 · Cited by 30
A Metabolomic Approach to Ionotropic Glutamate Receptor Subtype Function: A Nuclear Magnetic Resonance in vitro Investigation
Rae, C., Moussa, C., Griffin, J., Parekh, S. B., Bubb, W., Hunt, N., & Balcar, V. (2006) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/sj.jcbfm.9600257 · Cited by 29
Serine Racemase Knockout Mice
Mori, H., & Inoue, R. (2010) · Chemistry & Biodiversity · doi:10.1002/cbdv.200900293 · Cited by 33
Measuring D‐serine efflux from mouse cortical brain slices using online microdialysis‐capillary electrophoresis
O'Brien, K. B., & Bowser, M. T. (2006) · Electrophoresis · doi:10.1002/elps.200500770 · Cited by 28
Measuring the effect of glutamate receptor agonists on extracellular D-serine concentrations in the rat striatum using online microdialysis-capillary electrophoresis.
Ciriacks, C. M., & Bowser, M. T. (2006) · Neuroscience Letters · doi:10.1016/j.neulet.2005.09.080 · Cited by 28
The pharmacological stimulation of NMDA receptors via co-agonist site: an fMRI study in the rat brain.
Panizzutti, R., Rausch, M., Zurbrügg, S., Baumann, D., Beckmann, N., & Rudin, M. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.01.062 · Cited by 28
Distribution and MK-801-induced expression of serine racemase mRNA in rat brain by real-time quantitative PCR.
Yoshikawa, M., Kobayashi, T., Oka, T., Kawaguchi, M., & Hashimoto, A. (2004) · Brain Research. Molecular Brain Research · doi:10.1016/j.molbrainres.2004.06.015 · Cited by 28
D-Amino acids from foods and gut microbiota and their effects in health and disease
Roskjær, A. B., Roager, H. M., & Dragsted, L. O. (2024) · Food Reviews International · doi:10.1080/87559129.2024.2347472 · Cited by 35
d-Amino Acids and pLG72 in Alzheimer’s Disease and Schizophrenia
Cheng, Y., Lin, C., & Lane, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222010917 · Cited by 30
“Early studies have indicated that there are concentrations of D-serine and SR in astrocytes [11,13] and that this glia-derived Dserine modulates NMDA receptor activity and synaptic memory [14].”
Background
Homocysteine reduces NMDAR desensitization and differentially modulates peak amplitude of NMDAR currents, depending on GluN2 subunit composition
Bolton, A. D., Phillips, M. A., & Constantine‐Paton, M. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00809.2012 · Cited by 26
“1996), despite the fact that GLY and the other NMDAR coagonist D-serine are both present in some brain regions (Papouin et al. 2012; Rosenberg et al. 2013; Schell et al. 1997).”
Background
High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period
Cleveland, W. L., DeLaPaz, R. L., Fawwaz, R. A., & Challop, R. S. (2009) · Neural Plasticity · doi:10.1155/2009/768398 · Cited by 30
“Studies in rodents suggest that in much of the forebrain, endogenous glycine concentration is substantially lower than that in the hindbrain and spinal cord [126], making the ability of MRS to measure glycine concentrations in small voxels an important advantage.”
Background
Up-regulation of d-serine Might Induce GABAergic Neuronal Degeneration in the Cerebral Cortex and Hippocampus in the Mouse Pilocarpine Model of Epilepsy
Liu, Y.-H., Wang, L., Wei, L., Huang, Y., & Chen, L.-W. (2009) · Neurochemical Research · doi:10.1007/s11064-008-9897-0 · Cited by 27
“D-serine-immunoreactivity was detected in the astrocytes of both control and pilocarpine model, which was basically consistent with previous reports [9, 25 ].”
BackgroundResultInfluential
Method for on-line derivatization and separation of aspartic acid enantiomer in pharmaceuticals application by the coupling of flow injection with micellar electrokinetic chromatography.
Cheng, Y., Fan, L.-Y., Chen, H., Chen, X.-G., & Hu, Z.-D. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.03.019 · Cited by 26
MK-801 upregulates the expression of d-amino acid oxidase mRNA in rat brain.
Yoshikawa, M., Oka, T., Kawaguchi, M., & Hashimoto, A. (2004) · Brain Research. Molecular Brain Research · doi:10.1016/j.molbrainres.2004.08.017 · Cited by 26
Rescue of abnormal phenotypes in δ2 glutamate receptor‐deficient mice by the extracellular N‐terminal and intracellular C‐terminal domains of the δ2 glutamate receptor
Torashima, T., Iizuka, A., Horiuchi, H., Mitsumura, K., Yamasaki, M., Koyama, C., Takayama, K., Iino, M., Watanabe, M., & Hirai, H. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06841.x · Cited by 25
“surrounding cells in the cerebellum because they are contained in Bergmann glia (d-serine, only in the developing period) and basket cells (glycine) (Schell et al., 1997).”
Background
EAAT1 and d-serine expression are early features of human retinal development
Díaz, C., Macnab, L. T., Williams, S. M., Sullivan, R., & Pow, D. V. (2007) · Experimental Eye Research · doi:10.1016/j.exer.2007.01.008 · Cited by 25
Vesicular release mechanisms in astrocytic signalling.
Volknandt, W. (2002) · Neurochemistry International · doi:10.1016/s0197-0186(02)00045-1 · Cited by 25
Increased excitation-inhibition balance due to a loss of GABAergic synapses in the serine racemase knockout model of NMDA receptor hypofunctionPreprint
Jami, S. A., Cameron, S., Wong, J. M., Daly, E., McAllister, A., & Gray, J. A. (2020) · bioRxiv · doi:10.1101/2020.09.18.304170 · Cited by 24
“Early studies suggested that D-serine is exclusively synthesized and released by astrocytes (Schell et al., 1995; Schell et al., 1997; Wolosker et al., 1999) leading to the classification of Dserine as a gliotransmitter (Wolosker et al.”
Background
EphA4 Regulates Hippocampal Neural Precursor Proliferation in the Adult Mouse Brain by d-Serine Modulation of N-Methyl-d-Aspartate Receptor Signaling
Zhao, J., Taylor, C. J., Newcombe, E. A., Spanevello, M., O’Keeffe, I., Cooper, L. T., Jhaveri, D. J., Boyd, A., & Bartlett, P. F. (2018) · Cerebral Cortex · doi:10.1093/cercor/bhy319 · Cited by 29
Epigenetic Activation of ASCT2 in the Hippocampus Contributes to Depression-Like Behavior by Regulating D-Serine in Mice
Wang, J., Zhang, K., Chen, X., Liu, X., Teng, H., Zhao, M., & Sun, Z. S. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00139 · Cited by 27
“, 2006), neuronal migration (Schell et al., 1997; Kim et al., 2005), and excitotoxicity (Katsuki et al.”
Background
DISC 1, astrocytes and neuronal maturation: a possible mechanistic link with implications for mental disorders
Xia, M., Zhu, S., Shevelkin, A. V., Ross, C. A., & Pletnikov, M. V. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13663 · Cited by 23
D‐Serine metabolism in C6 glioma cells: Involvement of alanine‐serine‐cysteine transporter (ASCT2) and serine racemase (SRR) but not D‐amino acid oxidase (DAO)
Sikka, P., Walker, R. M., Cockayne, R., Wood, M. J. A., Harrison, P. J., & Burnet, P. W. J. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22332 · Cited by 23
“In glial cells of the hindbrain, DAO is abundantly expressed and active (Horiike et al., 1994) and is thought to underlie the very low levels of D-serine in the cerebellum (Schell et al., 1997).”
Background
Gliotransmission at central glutamatergic synapses: d-serine on stage
Martineau, M., Baux, G., & Mothet, J. (2006) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2005.12.011 · Cited by 29
Distribution of D-amino acid oxidase (DAO) activity in the medulla and thoracic spinal cord of the rat: implications for a role for D-serine in autonomic function.
Kappor, R., & Kapoor, V. (1997) · Brain Research · doi:10.1016/s0006-8993(97)00886-x · Cited by 24
Tonic NMDA Receptor Currents in the Brain: Regulation and Cognitive Functions
Kim, H., Choi, S., Lee, E., Koh, W., & Lee, C. J. (2024) · Biological Psychiatry · doi:10.1016/j.biopsych.2024.03.009 · Cited by 26
Roles of N-methyl-d-aspartate receptors and d-amino acids in cancer cell viability
Du, S., Sung, Y., Wey, M., Wang, Y., Alatrash, N., Berthod, A., MacDonnell, F. M., & Armstrong, D. W. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05733-8 · Cited by 33
Retinal NMDA receptor function and expression are altered in a mouse lacking d -amino acid oxidase
Gustafson, E. C., Morgans, C. W., Tekmen, M., Sullivan, S. J., Esguerra, M., Konno, R., & Miller, R. F. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00310.2013 · Cited by 22
Mutant Mice and Rats Lacking D ‐Amino Acid Oxidase
Konno, R., Hamase, K., Maruyama, R., & Zaitsu, K. (2010) · Chemistry & Biodiversity · doi:10.1002/cbdv.200900303 · Cited by 25
d‐Serine enhancement of NMDA receptor‐mediated calcium increases in rat retinal ganglion cells
Daniels, B. A., & Baldridge, W. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06532.x · Cited by 23
“…glycine is an endogenous coagonist for NMDAR activation, however within the past 15 years D-serine has emerged as an alternative (Matsui et al. 1995; Schell et al. 1997; Wolosker et al. 1999; Mothet et al. 2000) particularly in regions of the CNS where glycine is absent or present at low levels.”
Background
Confirmation of peak assignments in capillary electrophoresis using immunoprecipitation. Application to D-aspartate measurements in neurons.
Miao, H., Rubakhin, S., & Sweedler, J. (2006) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.09.037 · Cited by 23
Impact of Aging in Microglia-Mediated D-Serine Balance in the CNS
Beltrán-Castillo, S., Eugenín, J. L., & Rommy von Bernhardi, M. (2018) · Mediators of Inflammation · doi:10.1155/2018/7219732 · Cited by 50
“Serine racemase is expressed by many CNS cells, including pyramidal neurons in the cerebral cortex, gammaaminobutyric acid (GABA) ergic medium-spiny neurons in the striatum, cerebellar GABAergic Purkinje cells [28], vestibular nuclei neurons [29], astrocytes from the caudal medulla oblongata [11], telencephalon, and t…”
Background
D-Serine in Neuropsychiatric Disorders: New Advances
Durrant, A. R., & Heresco‐Levy, U. (2014) · Advances in Psychiatry · doi:10.1155/2014/859735 · Cited by 21
“NMDAR activation requires the binding of either GLY or DSR at the GMS on the NR1 subunit [45, 46].”
Background
Enantiomeric resolution of amino acids by thin-layer chromatography
Nagata, Y., Iida, T., & Sakai, M. (2001) · doi:10.1016/s1381-1177(00)00209-5 · Cited by 22
Novel phosphoserine phosphatase inhibitors.
Hawkinson, J. E., Acosta-Burruel, M., Ta, N., & Wood, P. L. (1997) · European Journal of Pharmacology · doi:10.1016/s0014-2999(97)01304-6 · Cited by 22
Glia as Active Participants in the Development and Function of Synapses
Eroğlu, Ç., Barres, B. A., & Stevens, B. (2008) · Springer eBooks · doi:10.1007/978-0-387-77232-5_23 · Cited by 17
“trigger responses in microglial cells ( 99 ).”
Background
d-Cycloserine enhances the bidirectional range of NMDAR-dependent hippocampal synaptic plasticity
Vestring, S., Dorner, A., Scholliers, J., Ehrenberger, K., Kiss, A., Arenz, L., Theiß, A., Rossner, P., Frase, S., du Vinage, C., et al. (2024) · Translational Psychiatry · doi:10.1038/s41398-023-02725-7 · Cited by 24
“A signi ﬁ cant level of LTP was rescued by the addition of 100 µM D -serine in the bath solution (158.7 ± 25.4% of the baseline, p < 0.0426, n = 12; p = 0.2139 vs. control LTP; Fig.”
BackgroundInfluential
Aging-Associated Cognitive Decline is Reversed by D-Serine Supplementation
Nava-Gomez, L. J., Calero-Vargas, I., Higinio-Rodríguez, F., Vázquez-Prieto, B., Olivares-Moreno, R., Ortíz-Retana, J. J., Aranda, P., Hernández‐Chan, N. G., Rojas‐Piloni, G., Alcauter, S., et al. (2022) · eNeuro · doi:10.1523/eneuro.0176-22.2022 · Cited by 21
“Chronic supplementation of D-serine fully restored the aging-associated reductions in the functional connectivity of this aging network, in concordance with the high expression of NMDAR and the location of D-serine in frontal areas and the cingulate and retrosplenial cortices (Schell et al., 1997).”
Result
Serine Racemase Deletion Affects the Excitatory/Inhibitory Balance of the Hippocampal CA1 Network
Ploux, E., Bouët, V., Radzishevsky, I. S., Wolosker, H., Fréret, T., & Billard, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21249447 · Cited by 19
A combined spectroscopic and molecular dynamic analysis of the inclusion behaviour of l-serine and β-cyclodextrin
Chakraborty, S., Karmakar, A., Goswami, T., Ghosh, P., & Mandal, A. (2020) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2020.114447 · Cited by 21
Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude
Gerhold, K. J., Drdla-Schutting, R., Honsek, S. D., Forsthuber, L., & Sandkühler, J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0731-14.2015 · Cited by 23
“D-serine acts as coagonist on NMDARs (Schell et al., 1995; Schell et al., 1997; Mothet et al., 2000), which have been linked previously to ultra-low-dose buprenorphine-induced hyperalgesia (Wala and Holtman, 2011).”
Background
Serine racemase deletion abolishes light‐evoked NMDA receptor currents in retinal ganglion cells
Sullivan, S. J., Esguerra, M., Wickham, R. J., Romero, G. E., Coyle, J. T., & Miller, R. F. (2011) · The Journal of Physiology · doi:10.1113/jphysiol.2011.217059 · Cited by 24
“SR was thought to be predominantly expressed by astrocytes (Wolosker et al. 1999a) possessing high levels of D-serine (Schell et al. 1997).”
Background
Behavioral characterization of a mutant mouse strain lacking d-amino acid oxidase activity
Zhang, M., Ballard, M. E., Basso, A. M., Bratcher, N. A., Browman, K. E., Curzon, P., Konno, R., Meyer, A. H., & Rueter, L. E. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.09.030 · Cited by 21
An Active Role for Astrocytes in Synaptic Plasticity?
Wenker, I. C. (2010) · Journal of Neurophysiology · doi:10.1152/jn.00429.2010 · Cited by 22
Development of derivatization reagents bearing chiral 4-imidazolidinone for distinguishing primary amines from other amino acids and application to the liquid chromatography-tandem mass spectrometric analysis of miso.
Sakamoto, T., Onozato, M., Uekusa, S., Ichiba, H., Umino, M., Shirao, M., & Fukushima, T. (2021) · Journal of Chromatography A · doi:10.1016/j.chroma.2021.462341 · Cited by 20
Succinimidyl (3-[(benzyloxy)carbonyl]-5-oxo-1,3-oxazolidin-4-yl)acetate on a triazole-bonded phase for the separation of dl-amino-acid enantiomers and the mass-spectrometric determination of chiral amino acids in rat plasma.
Sakamoto, T., Furukawa, S., Nishizawa, T., Fukuda, M., Sasaki, M., Onozato, M., Uekusa, S., Ichiba, H., & Fukushima, T. (2019) · Journal of Chromatography A · doi:10.1016/j.chroma.2018.11.061 · Cited by 20
Changes in Serine Racemase-Dependent Modulation of NMDA Receptor: Impact on Physiological and Pathological Brain Aging
Billard, J. (2018) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2018.00106 · Cited by 28
“Attributed initially to glycine (Johnson and Ascher, 1987, 1992; Kleckner and Dingledine, 1988), this role of co-agonist in much brain area and particularly in those involved in cognitive functions, is now devoted to D-serine (Schell et al., 1997; Mothet et al., 2000; Snyder and Kim, 2000; Shleper et al., 2005; Billar…”
Background
Functional Characterization and In Silico Docking of Full and Partial GluK2 Kainate Receptor Agonists
Fay, A.-M. L., Corbeil, C. R., Brown, P., Moitessier, N., & Bowie, D. (2009) · Molecular Pharmacology · doi:10.1124/mol.108.054254 · Cited by 20
“Because D-serine is expressed in discrete populations of glial cells opposed to NMDARs ( Schell et al., 1997a ), it has been categorized as a gliotransmitter (Mothet et al., 2000; Panatier et al., 2006).”
Influential
Immunohistochemical demonstration of l-serine distribution in the rat brain
Yasuda, E., Ma, N., & Semba, R. (2001) · NeuroReport · doi:10.1097/00001756-200104170-00032 · Cited by 20
Glutamate and Depression
Rı́o, J. D., & Frechilla, D. (2005) · Humana Press eBooks · doi:10.1007/978-1-59259-852-6_10 · Cited by 11
Enantioselectivity Effects in Clinical Metabolomics and Lipidomics
Oliveira, R. V., Simionato, A. V. C., & Cass, Q. B. (2021) · Molecules · doi:10.3390/molecules26175231 · Cited by 23
“More specifically, D-Asp has been described as an important mammals’ neuromodulator or neurotransmitter [83] and has been already reported in elevated levels in the cerebrospinal fluid of Alzheimer’s patients [84], while diminished in brain tissues, contributing to a lower N-methyl-D-aspartate (NMDA) receptor function…”
Background
D-amino acids in normal ageing and pathogenesis of neurodegenerative diseases
Chervyakov, A. V., Gulyaeva, N. V., & Zakharova, M. N. (2011) · Neurochemical Journal · doi:10.1134/s1819712411020036 · Cited by 22
Effects of endogenous agonists, glycine and D‐serine, on in vivo specific binding of [11C]L‐703,717, a PET radioligand for the glycine‐binding site of NMDA receptors
Haradahira, T., Okauchi, T., Maeda, J., Zhang, M.-R., Nishikawa, T., Konno, R., Suzuki, K., & Suhara, T. (2003) · Synapse · doi:10.1002/syn.10254 · Cited by 19
“GlyT1 plays a critical role in the control of extracellular glycine concentrations at the NMDA receptors (Supplisson and Bergman, 1997), and recently a novel GlyT1-selective inhibitor, NFPS, was developed (Aubrey and Vandenberg, 2001; Bergeron et al., 1998).”
ASC Transporters Mediate D-Serine Transport into Astrocytes Adjacent to Synapses in the Mouse Brain
Krishnan, K. S., & Billups, B. (2023) · Biomolecules · doi:10.3390/biom13050819 · Cited by 23
“Early research revolved around the assumption that glycine was the preferred co-agonist in the central nervous system [6], although D-serine localisation is more highly correlated than glycine to the NMDAR position [7].”
Background
Increased burst‐firing of ventral tegmental area dopaminergic neurons in d ‐amino acid oxidase knockout micein vivo
Schweimer, J. V., Coullon, G. S. L., Betts, J. F., Burnet, P. W. J., Engle, S. J., Brandon, N. J., Harrison, P. J., & Sharp, T. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12667 · Cited by 16
“…(NMDA) receptors (Schell et al., 1995; Mothet et al., 2000; Oliet & Mothet, 2009; Papouin et al., 2012), and DAO is one determinant of synaptic D-serine availability and hence NMDA receptor functioning (Schell et al., 1997; Mothet et al., 2000; Almond et al., 2006; Panatier et al., 2006).”
The serine racemase mRNA is expressed in both neurons and glial cells of the rat retina.
Takayasu, N., Yoshikawa, M., Watanabe, M., Tsukamoto, H., Suzuki, T., Kobayashi, H., & Noda, S. (2008) · Archives of histology and cytology · doi:10.1679/aohc.71.123 · Cited by 18
“This is consistent with results of previous studies showing that D-serine and Srr were localized in glial cells (Schell et al., 1997; Wolosker et al., 1999; Stevens et al., 2003; Mustafa et al., 2004; O'Brien et al., 2005).”
BackgroundResult
d-Serine regulates CREB phosphorylation induced by NMDA receptor activation in Müller glia from the retina
Lamas, M., Lee-Rivera, I., Ramı́rez, M., & López-Colomé, A. M. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.009 · Cited by 18
Effects of MK-801 on the expression of serine racemase and d-amino acid oxidase mRNAs and on the D-serine levels in rat brain.
Hashimoto, A., Yoshikawa, M., Andoh, H., Yano, H., Matsumoto, H., Kawaguchi, M., Oka, T., & Kobayashi, H. (2007) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.09.062 · Cited by 18
Capillary electrophoresis-electrospray ionization mass spectrometry of amino acids, peptides, and proteins.
Moini, M. (2004) · Methods in molecular biology · doi:10.1385/1-59259-798-x:253 · Cited by 18
Psychostimulant Drugs and Neuroplasticity
Fernández‐Espejo, E., & Rodriguez-Espinosa, N. (2011) · Pharmaceuticals · doi:10.3390/ph4070976 · Cited by 25
“D-serine modulates NMDA receptor activity in the central nervous system [33-35], and it acts through binding to NMDA receptors at the glycine site, thereby facilitating their activation [25].”
Background
Mutant rat strain lacking d-amino-acid oxidase
Konno, R., Okamura, T., Kasai, N., Summer, K., & Niwa, A. (2009) · Amino Acids · doi:10.1007/s00726-008-0163-1 · Cited by 17
“Later, Schell et al. (1997) showed that the distribution pattern of D-serine closely resembles that of the NR2A/B subunits of NMDA receptors.”
Background
D-Aspartic acid in bovine dentine non-collagenous phosphoprotein.
Masuda, W., Nouso, C., Kitamura, C., Terashita, M., & Noguchi, T. (2002) · Archives of Oral Biology · doi:10.1016/s0003-9969(02)00064-x · Cited by 17
Racemization in Post-Translational Modifications Relevance to Protein Aging, Aggregation and Neurodegeneration: Tip of the Iceberg
Dyakin, V. V., Wısnıewskı, T., & Lajtha, Á. (2021) · Symmetry · doi:10.3390/sym13030455 · Cited by 20
“These cells enclose nerve terminals and are enriched in specific regions of the gray matter including cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdala [98,228,458,459].”
Background
D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine
Betts, J. F., Schweimer, J. V., Burnham, K. E., Burnet, P. W. J., Sharp, T., & Harrison, P. J. (2014) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2014.00011 · Cited by 17
“ORIGINAL RESEARCH ARTICLE published: 02 May 2014 doi: 10.3389/fnsyn.2014.00011 D-amino acid oxidase is expressed in the ventral tegmental area and modulates cortical dopamine”
BackgroundInfluential
Tonic and phasic alteration in amygdala 5-HT, glutamate and GABA transmission after prefrontal cortex damage in rats
Gonzalez, L. E., M., B. J. Q., Rangel, A., Pino, S., & Hernandez, L. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.048 · Cited by 14
“It is believed that D-serine, an endogenous agonist at the glycine site of N-methyl-D-aspartate (NMDA) receptors, modulates excitatory neurotransmission [55].”
Background
Determination of d-serine in human serum by LC-MS/MS using a triazole-bonded column after pre-column derivatization with (S)-4-(3-isothiocyanatopyrrolidin-1-yl)-7- (N, N-dimethylaminosulfonyl)-2,1,3-benzoxadiazole
Sakamoto, T., Kuwabara, R., Takahashi, S., Onozato, M., Ichiba, H., Iizuka, H., & Fukushima, T. (2015) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-015-9119-y · Cited by 16
D-aspartate dysregulation in Ddo−/− mice modulates phencyclidine-induced gene expression changes of postsynaptic density molecules in cortex and striatum
de Bartolomeis, A., Errico, F., Aceto, G., Tomasetti, C., Usiello, A., & Iasevoli, F. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.05.003 · Cited by 16
“Brain D-aspartate concentration is high during embryonic stages and strongly decreases after birth (Hashimoto et al., 1993a; Sakai et al., 1998; Schell et al., 1997a; Wolosker et al., 2000), due to concomitant rise in the expression of the catabolic Abbreviations:ANOVA, one-way analysis of…”
Background
Roles of quaternary structure and cysteine residues in the activity of human serine racemase
Wang, W., & Barger, S. W. (2011) · BMC Biochemistry · doi:10.1186/1471-2091-12-63 · Cited by 14
“There is considerable evidence that the dominant agonist for the NR1 site in most parts of brain is not glycine but D-serine [3,4].”
Background
Role of the glycine site of the N‐methyl‐d‐aspartate receptor in synaptic plasticity induced by pairing
Krasteniakov, N., Martina, M., & Bergeron, R. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04099.x · Cited by 15
“that d-serine and glycine are present in the mammalian CNS, including human CNS (Westergren et al., 1994; Matsui et al., 1995; Schell et al., 1995; Hashimoto & Oka, 1997; Schell et al., 1997).”
BackgroundInfluential
Serine Racemase and D-Serine Transport in Human Placenta and Evidence for a Transplacental Gradient for D-Serine in Humans
Chen, Z., Huang, W., Srinivas, S. R., Jones, C. R., Ganapathy, V., & Prasad, P. (2004) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2004.02.003 · Cited by 15
Distribution of D-amino-acid oxidase and D-serine in vertebrate brains
Horiike, K., Ishida, T., Tanaka, H., & Arai, R. (2001) · doi:10.1016/s1381-1177(00)00201-0 · Cited by 15
Regulation of GABAergic neurotransmission by purinergic receptors in brain physiology and disease
Juvenal, G. D. A., Higa, G. S. V., Marques, L. B., Zampieri, T. T., Viana, F. J. C., Britto, L. R. G., Tang, Y. C., Illés, P., Virgilio, F. D., Ulrich, H., et al. (2024) · Purinergic Signalling · doi:10.1007/s11302-024-10034-x · Cited by 16
The Postnatal Development of d-Serine in the Retinas of Two Mouse Strains, Including a Mutant Mouse with a Deficiency in d-Amino Acid Oxidase and a Serine Racemase Knockout Mouse
Romero, G. E., Lockridge, A., Morgans, C., Bandyopadhyay, D., & Miller, R. F. (2014) · ACS Chemical Neuroscience · doi:10.1021/cn5000106 · Cited by 14
Role for D-Serine within the Ventral Tegmental Area in the Development of Cocaine's Sensitization
Fernández-Espejo, E., Ramiro-Fuentes, S., Portavella, M., & Moreno‐Paublete, R. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301495 · Cited by 14
“…efespejo@us.es Neuropsychopharmacology (2008) 33, 995–1003 & 2008 Nature Publishing Group All rights reserved 0893-133X/08 $30.00 www.neuropsychopharmacology.org D-serine that facilitates activation of NMDA receptors in developing cerebellum and hippocampus (Schell et al, 1997; Yang et al, 2003).”
BackgroundInfluential
d -Serine inhibits AMPA receptor-mediated current in rat hippocampal neurons
Gong, X., Zabek, R. L., & Bai, D. (2007) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/y07-040 · Cited by 13
Cellular distribution of D-serine, serine racemase and D-amino acid oxidase in the rat vestibular sensory epithelia.
Demêmes, D., Mothet, J., & Nicolas, M. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.09.020 · Cited by 14
Physiological relevance of endogenous free D-serine in the mammalian brain: are scientists on a royal road for the treatment of glutamatergic-related brain disorders?
Mothet, J. (2001) · Pathologie et biologie · doi:10.1016/s0369-8114(01)00227-9 · Cited by 14
Amino acid analyses of the exosome-eluted fractions from human serum by HPLC with fluorescence detection
Onozato, M., Tanaka, Y., Arita, M., Sakamoto, T., Ichiba, H., Sadamoto, K., Kondo, M., & Fukushima, T. (2018) · Practical Laboratory Medicine · doi:10.1016/j.plabm.2018.e00099 · Cited by 20
“Because the glutamate hypothesis proposes that the main symptoms of schizophrenia are caused by a hypofunction of the NMDA receptor in the central nervous system [14,15], D-Ser deficiency may underlie the pathogenesis of this disease.”
Background
Metabolomics in Schizophrenia and Major Depressive Disorder
Petrovchich, I., Sosinsky, A. Z., Konde, A. S., Archibald, A. R., Henderson, D. C., Maletić‐Savatić, M., & Milanovic, S. M. (2016) · Frontiers in Biology · doi:10.1007/s11515-016-1400-8 · Cited by 12
“The glutamate hypothesis of schizophrenia etiology suggests that endogenous D-serine is a crucial factor related to the hypofunction of the N -methyl-D- aspartate (NMDA) receptor (Schell et al., 1997; Hashimoto et al., 2003).”
Pharmacological characterization of NMDA-like receptors in the single-celled organism Paramecium primaurelia
Ramoino, P., Candiani, S., Pittaluga, A., Usai, C., Gallus, L., Ferrando, S., Milanese, M., Faimali, M., & Bonanno, G. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.093914 · Cited by 13
“D-Serine, a glialderived endogenous ligand for the glycine-binding site of NMDA receptors in mammals (Mothet et al., 2000; Oliet and Mothet, 2009; Schell et al., 1997), behaved similar to glycine thus strengthening the role of this binding site in the machinery of the NMDA-like receptors in…”
Background
Cross‐linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species
Wang, W., & Barger, S. W. (2012) · Journal of Neuroscience Research · doi:10.1002/jnr.22832 · Cited by 14
“Highly expressed in forebrain (Xia et al., 2004), SR is localized to neurons (Kartvelishvily et al., 2006) and protoplasmic astrocytes (Schell et al., 1997), with some expression by quiescent and activated microglia (Wu et al., 2004; Williams et al., 2006).”
Amperometric Self-Referencing Ceramic Based Microelectrode Arrays for D-Serine Detection
Campos-Beltrán, D., Konradsson‐Geuken, Å., Quintero, J. E., & Marshall, L. (2018) · Biosensors · doi:10.3390/bios8010020 · Cited by 18
VTA dopamine neuron plasticity – the unusual suspects
Xin, W., Edwards, N., & Bonci, A. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13425 · Cited by 17
Amperometric microbiosensor as an alternative tool for investigation of d-serine in brain
Zain, Z. M., Ghani, S. A., & O'Neill, R. (2012) · Amino Acids · doi:10.1007/s00726-012-1365-0 · Cited by 12
“D-Serine staining (Schell et al. 1997) using antibodies to highlight D-serine localization has revealed that D-serine is mostly associated with astrocytes that ensheathe synapses and is particularly enriched in gray matter.”
BackgroundInfluential
Contributions of Glutamate and GABA Systems to the Neurobiology and Treatment of Schizophrenia
Krystal, J. H., & Moghaddam, B. (2010) · Wiley eBooks · doi:10.1002/9781444327298.ch21 · Cited by 17
Distinct effects of D-serine on spinal nociceptive responses in normal and carrageenan-injected rats.
Guo, J.-D., Wang, H., Zhang, Y.-Q., & Zhao, Z.-Q. (2006) · Biochemical and Biophysical Research Communications - BBRC · doi:10.1016/j.bbrc.2006.02.156 · Cited by 12
Mass spectrometrical analysis of human serine racemase in foetal brain
Hepner, F., Pollak, A., Ulfig, N., Yae-Kyung, M., & Lubec, G. (2005) · Journal of neural transmission · doi:10.1007/s00702-005-0304-6 · Cited by 12
“, 2004) and its ontogenic role in brain development (Schell et al., 1997).”
BackgroundInfluential
Effect of D-serine on a delayed match-to-place task for the water maze.
Stouffer, E. M., Petri, H. L., & Devan, B. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2003.10.008 · Cited by 12
“Because of its co-localization with NMDA receptors, and the fact that d-serine has a greater affinity to the glycine modulatory site of the NMDA receptor complex than does glycine, several researchers have proposed that the ‘glycine’ binding site is actually a d-serine binding site [19,31–34].”
Background
D-Serine alleviates retrograde amnesia of a visual discrimination task in rats with a lesion of the perirhinal cortex.
Andersen, J. M., Fonnum, F., & Myhrer, T. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02894-4 · Cited by 12
Effect of the glycine modulatory site of the N-methyl-D-aspartate receptor on synaptic responses in kitten visual cortex.
Ito, K., & Hicks, T. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)01709-8 · Cited by 12
Flavins and Flavoproteins: Applications in Medicine
Jortzik, E., Wang, L., Ma, J., & Becker, K. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-0452-5_7 · Cited by 13

Authors: Schell, M. J., Brady Jr., R. O., Molliver, M. E., & Snyder, S. H.
Affiliations: Johns Hopkins University (US)
ORCID: Schell, Michael J.
Snyder, Solomon H.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1997-03-01
Volume: 17
Issue: 5
Pages: 1604-1615
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.17-05-01604.1997
PMC: PMC6573391
OpenAlex: W1793612468
Cited by: 415
References: 80
Citations by year: 2026: 1 · 2025: 6 · 2024: 8 · 2023: 13 · 2022: 11 · 2021: 14 · 2020: 12 · 2019: 12 · 2018: 12 · 2017: 8 · 2016: 14 · 2015: 12 · 2014: 18 · 2013: 17 · 2012: 15
FWCI: 4.46
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 184 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01da004431-08)
U.S. Public Health Service
National Institute of Mental Health (R01MH018501, R37MH018501, MH-18501)
National Institute on Drug Abuse (DA 00074, 5RO1DA04431, K05DA000074)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Amino Acid Enzymes and Metabolism
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: D-serine, NMDA receptor, glycine site, neuromodulation, astrocytes, Bergmann glia, glycine, cerebellar development, hippocampal CA1, synaptogenesis, granule cell migration, mossy fiber synapses, telencephalon, postnatal development, rat brain
MeSH terms: Animals, Brain Chemistry, Cerebellum, Glycine, Hippocampus, Ligands, Models, Neurological, Neuroglia, Olfactory Bulb, Organ Specificity, Rabbits, Rhombencephalon, Serine, Stereoisomerism, Telencephalon, Receptors, N-Methyl-D-Aspartate, Rats, Sprague-Dawley, Receptors, Glycine, Neurotransmitter Agents, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

d-Serine as a Neuromodulator: Regional and Developmental Localizations in Rat Brain Glia Resemble NMDA Receptors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Metadata

Record

About these checks