Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

Interplay between Cortical Spreading Depolarization and Seizures

Kramer, D. R., Fujii, T., Ohiorhenuan, I. E., & Liu, C. Y. (2017) · Stereotactic and Functional Neurosurgery · doi:10.1159/000452841 · Cited by 3,718 · see citing works

Glial and neuronal control of brain blood flow

Attwell, D., Buchan, A. M., Charpak, S., Lauritzen, M., MacVicar, B. A., & Newman, E. A. (2010) · Nature · doi:10.1038/nature09613 · Cited by 2,511 · see citing works

Neurovascular regulation in the normal brain and in Alzheimer's disease

Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213 · see citing works

Capillary pericytes regulate cerebral blood flow in health and disease

Hall, C. N., Reynell, C., Gesslein, B., Hamilton, N. B., Mishra, A., Sutherland, B. A., O’Farrell, F. M., Buchan, A. M., Lauritzen, M., & Attwell, D. (2014) · Nature · doi:10.1038/nature13165 · Cited by 1,870 · see citing works

On the Regulation of the Blood‐supply of the Brain

Roy, C., & Sherrington, C. (1890) · The Journal of Physiology · doi:10.1113/jphysiol.1890.sp000321 · Cited by 1,834 · see citing works

Interpreting the BOLD Signal

Logothetis, N. K., & Wandell, B. A. (2004) · Annual Review of Physiology · doi:10.1146/annurev.physiol.66.082602.092845 · Cited by 1,568 · see citing works

Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease

Girouard, H., & Iadecola, C. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00966.2005 · Cited by 1,268 · see citing works

Glial regulation of the cerebral microvasculature

Iadecola, C., & Nedergaard, M. (2007) · Nature Neuroscience · doi:10.1038/nn2003 · Cited by 1,153 · see citing works

Bidirectional control of CNS capillary diameter by pericytes

Peppiatt, C. M., Howarth, C., Mobbs, P., & Attwell, D. (2006) · Nature · doi:10.1038/nature05193 · Cited by 1,150 · see citing works

Astrocyte-mediated control of cerebral blood flow

Takano, T., Tian, G.-F., Peng, W., Lou, N., Libionka, W., Han, X., & Nedergaard, M. (2005) · Nature Neuroscience · doi:10.1038/nn1623 · Cited by 1,137 · see citing works

The neural basis of functional brain imaging signals

Attwell, D., & Iadecola, C. (2002) · Trends in Neurosciences · doi:10.1016/s0166-2236(02)02264-6 · Cited by 957 · see citing works

Astrocyte calcium signaling: the third wave

Bazargani, N., & Attwell, D. (2016) · Nature Neuroscience · doi:10.1038/nn.4201 · Cited by 949 · see citing works

The Müller cell: a functional element of the retina

Newman, E. A., & Reichenbach, A. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10040-0 · Cited by 789 · see citing works

Pericyte contraction induced by oxidative-nitrative stress impairs capillary reflow despite successful opening of an occluded cerebral artery

Yemişçi, M., Özdemir, Y., Vural, A., Can, A., Topalkara, K., & Dalkara, T. (2009) · Nature Medicine · doi:10.1038/nm.2022 · Cited by 780 · see citing works

Brain metabolism dictates the polarity of astrocyte control over arterioles

Gordon, G. R., Choi, H. B., Rungta, R. L., Ellis‐Davies, G. C. R., & MacVicar, B. A. (2008) · Nature · doi:10.1038/nature07525 · Cited by 739 · see citing works

Regional Blood Flow in the Normal and Ischemic Brain Is Controlled by Arteriolar Smooth Muscle Cell Contractility and Not by Capillary Pericytes

Hill, R., Тонг, Л., Yuan, P., Murikinati, S. R., Gupta, S., & Grutzendler, J. (2015) · Neuron · doi:10.1016/j.neuron.2015.06.001 · Cited by 704 · see citing works

Astrocytic Ca2+ signaling evoked by sensory stimulation in vivo

Wang, X., Lou, N., Xu, Q., Tian, G.-F., Peng, W. G., Han, X., Kang, J., Takano, T., & Nedergaard, M. (2006) · Nature Neuroscience · doi:10.1038/nn1703 · Cited by 685 · see citing works

Glial Cells Dilate and Constrict Blood Vessels: A Mechanism of Neurovascular Coupling

Metea, M. R., & Newman, E. A. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.4048-05.2006 · Cited by 637 · see citing works

The cortical angiome: an interconnected vascular network with noncolumnar patterns of blood flow

Blinder, P., Tsai, P. S., Kaufhold, J. P., Knutsen, P. M., Suhl, H., & Kleinfeld, D. (2013) · Nature Neuroscience · doi:10.1038/nn.3426 · Cited by 573 · see citing works

Hypertension and Cerebrovascular Dysfunction

Iadecola, C., & Davisson, R. L. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.03.010 · Cited by 557 · see citing works

Local potassium signaling couples neuronal activity to vasodilation in the brain

Filosa, J. A., Bonev, A. D., Straub, S. V., Meredith, A. L., Wilkerson, M. K., Aldrich, R. W., & Nelson, M. T. (2006) · Nature Neuroscience · doi:10.1038/nn1779 · Cited by 556 · see citing works

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

Paukert, M., Agarwal, A., Cha, J., Doze, V. A., Kang, J. U., & Bergles, D. E. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.038 · Cited by 556 · see citing works

Pericyte-mediated regulation of capillary diameter: a component of neurovascular coupling in health and disease

Hamilton, N. B. (2010) · Frontiers in Neuroenergetics · doi:10.3389/fnene.2010.00005 · Cited by 513 · see citing works

Ca2+ signaling in astrocytes from Ip3r2−/− mice in brain slices and during startle responses in vivo

Srinivasan, R., Huang, B. S., Venugopal, S., Johnston, A. D., Chai, H., Zeng, H., Golshani, P., & Khakh, B. S. (2015) · Nature Neuroscience · doi:10.1038/nn.4001 · Cited by 499 · see citing works

Calcium signalling in glial cells

Verkhratsky, A., & Kettenmann, H. (1996) · Trends in Neurosciences · doi:10.1016/0166-2236(96)10048-5 · Cited by 498 · see citing works

Propagation of Intercellular Calcium Waves in Retinal Astrocytes and Müller Cells

Newman, E. A. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-07-02215.2001 · Cited by 449 · see citing works

Does the Release of Potassium from Astrocyte Endfeet Regulate Cerebral Blood Flow?

Paulson, O. B., & Newman, E. A. (1987) · Science · doi:10.1126/science.3616619 · Cited by 414 · see citing works

Pericytes in capillaries are contractile in vivo, but arterioles mediate functional hyperemia in the mouse brain

Fernández-Klett, F., Offenhauser, N., Dirnagl, U., Priller, J., & Lindauer, U. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1011321108 · Cited by 399 · see citing works

Imaging calcium microdomains within entire astrocyte territories and endfeet with GCaMPs expressed using adeno-associated viruses

Shigetomi, E., Bushong, E. A., Haustein, M. D., Tong, X., Jackson‐Weaver, O., Kracun, S., Xu, J. P., Sofroniew, M. V., Ellisman, M. H., & Khakh, B. S. (2013) · The Journal of General Physiology · doi:10.1085/jgp.201210949 · Cited by 378 · see citing works

Endothelin-1–Induced Arrhythmogenic Ca 2+ Signaling Is Abolished in Atrial Myocytes of Inositol-1,4,5-Trisphosphate(IP 3 )–Receptor Type 2–Deficient Mice

Li, X., Zima, A. V., Sheikh, F., Blatter, L. A., & Chen, J. (2005) · Circulation Research · doi:10.1161/01.res.0000172556.05576.4c · Cited by 333 · see citing works

Two-photon imaging of capillary blood flow in olfactory bulb glomeruli

Chaigneau, E. M., Oheim, M., Audinat, É., & Charpak, S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2133652100 · Cited by 306 · see citing works

Calcium dynamics in astrocyte processes during neurovascular coupling

Otsu, Y., Couchman, K., Lyons, D. G., Collot, M., Agarwal, A., Mallet, J.-M., Pfrieger, F. W., Bergles, D. E., & Charpak, S. (2015) · Nature Neuroscience · doi:10.1038/nn.3906 · Cited by 286 · see citing works

Visually evoked hemodynamical response and assessment of neurovascular coupling in the optic nerve and retina

Riva, C. E., Logean, E., & Falsini, B. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.07.002 · Cited by 265 · see citing works

Functions of the two glutamate transporters GLAST and GLT-1 in the retina

Harada, T., Harada, C., Watanabe, M., Inoue, Y., Sakagawa, T., Nakayama, N., Sasaki, S., Okuyama, S., Watase, K., Wada, K., et al. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4663 · Cited by 250 · see citing works

Reduced response of retinal vessel diameters to flicker stimulation in patients with diabetes

Garhöfer, G. (2004) · British Journal of Ophthalmology · doi:10.1136/bjo.2003.033548 · Cited by 233 · see citing works

In vivo Stimulus-Induced Vasodilation Occurs without IP 3 Receptor Activation and May Precede Astrocytic Calcium Increase

Nizar, K., Uhlířová, H., Tian, P., Saisan, P. A., Cheng, Q., Reznichenko, L., Weldy, K. L., Steed, T., Sridhar, V. B., MacDonald, C. L., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3285-12.2013 · Cited by 220 · see citing works

Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex

Lindauer, U., Megow, D., Matsuda, H., & Dirnagl, U. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.2.h799 · Cited by 213 · see citing works

Astrocytic Gq-GPCR-Linked IP 3 R-Dependent Ca 2+ Signaling Does Not Mediate Neurovascular Coupling in Mouse Visual Cortex In Vivo

Bonder, D. E., & McCarthy, K. D. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.2591-14.2014 · Cited by 205 · see citing works

Reduced cerebral blood flow response and compensation among patients with untreated hypertension

Jennings, J. R., Muldoon, M. F., Ryan, C., Price, J. C., Greer, P., Sutton-Tyrrell, K., van der Veen, F. M., & Meltzer, C. C. (2005) · Neurology · doi:10.1212/01.wnl.0000158283.28251.3c · Cited by 198 · cited 2× · see citing works

Regulation of Blood Flow in the Retinal Trilaminar Vascular Network

Kornfield, T. E., & Newman, E. A. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1971-14.2014 · Cited by 188 · see citing works

Calcium Increases in Retinal Glial Cells Evoked by Light-Induced Neuronal Activity

Newman, E. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1354-05.2005 · Cited by 178 · see citing works

Rapid stimulus-evoked astrocyte Ca 2+ elevations and hemodynamic responses in mouse somatosensory cortex in vivo

Lind, B. L., Brazhe, A., Jessen, S. B., Tan, F. C. C., & Lauritzen, M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310065110 · Cited by 175 · see citing works

Neuron-glia signaling in developing retina mediated by neurotransmitter spillover

Rosa, J. M., Bos, R., Sack, G. S., Fortuny, C., Agarwal, A., Bergles, D. E., Flannery, J. G., & Feller, M. B. (2015) · eLife · doi:10.7554/elife.09590 · Cited by 175 · see citing works

Neurovascular function in Alzheimer's disease patients and experimental models

Nicolakakis, N., & Hamel, E. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.43 · Cited by 156 · see citing works

Structural and Hemodynamic Analysis of the Mouse Retinal Microcirculation

Pâques, M., Tadayoni, R., Sercombe, R., Laurent, P., Genevois, O., Gaudric, A., & Vicaut, É. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0738 · Cited by 137 · see citing works

Inhibition of inducible nitric oxide synthase reverses the loss of functional hyperemia in diabetic retinopathy

Mishra, A., & Newman, E. A. (2010) · Glia · doi:10.1002/glia.21068 · Cited by 117 · see citing works

In SituObservation of Living Pericytes in Rat Retinal Capillaries

Schönfelder, U., Hofer, A., Paul, M., & Funk, R. H. W. (1998) · Microvascular Research · doi:10.1006/mvre.1998.2086 · Cited by 110 · see citing works

Imaging Below the Diffraction Limit: A Statistical Analysis

Shahram, M., & Milanfar, P. (2004) · IEEE Transactions on Image Processing · doi:10.1109/tip.2004.826096 · Cited by 103 · see citing works

Mechanisms involved in the cerebrovascular dilator effects of N-methyl-d-aspartate in cerebral cortex

Busija, D. W., Bari, F., Domoki, F., & Louis, T. M. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.05.011 · Cited by 100 · see citing works

Nitric oxide and adenosine mediate vasodilation during functional activation in cerebellar cortex

Li, J., & Iadecola, C. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90049-3 · Cited by 89 · see citing works

Imaging Light Responses of Targeted Neuron Populations in the Rodent Retina

Borghuis, B. G., Tian, L., Xu, Y., Nikonov, S. S., Vardi, N., Zemelman, B. V., & Looger, L. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6064-10.2011 · Cited by 87 · see citing works

Attenuation of activity-induced increases in cerebellar blood flow in mice lacking neuronal nitric oxide synthase

Yang, G., Zhang, Y., Ross, M. E., & Iadecola, C. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00043.2003 · Cited by 74 · see citing works

Striatal dopaminergic afferents concentrate in GDNF-positive patches during development and in developing intrastriatal striatal grafts

L�pez-Mart�n, E., Caruncho, H. J., Rodríguez‐Pallares, J., Guerra, M. J., & Labandeira-García, J. L. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990405)406:2 · Cited by 40 · see citing works

An eyecup preparation for the rat and mouse

Newman, E. A., & Bartosch, R. (1999) · Journal of Neuroscience Methods · doi:10.1016/s0165-0270(99)00138-7 · Cited by 25 · see citing works

Calcium responses mediated by type 2 IP3-receptors are required for osmotic volume regulation of retinal glial cells in mice

Lipp, S., Wurm, A., Pannicke, T., Wiedemann, P., Reichenbach, A., Chen, J., & Bringmann, A. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.04.001 · Cited by 21 · see citing works

Assessment of Glial Function in the In Vivo Retina

Srienc, A. I., Kornfield, T. E., Mishra, A., Burian, M. A., & Newman, E. A. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-452-0_33 · Cited by 12 · see citing works

The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease

Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480 · see citing works

Blood-Brain Barrier: From Physiology to Disease and Back

Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R., & Zlokovic, B. V. (2019) · Physiological Reviews · doi:10.1152/physrev.00050.2017 · Cited by 2,294 · see citing works

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243 · see citing works

The role of brain vasculature in neurodegenerative disorders

Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W., & Zlokovic, B. V. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0234-x · Cited by 998 · see citing works

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

Mishra, A., Reynolds, J. R., Chen, Y., Gourine, A. V., Rusakov, D. A., & Attwell, D. (2016) · Nature Neuroscience · doi:10.1038/nn.4428 · Cited by 535 · see citing works

Capillary pericytes express α-smooth muscle actin, which requires prevention of filamentous-actin depolymerization for detection

Alarcón-Martínez, L., Yilmaz-Ozcan, S., Yemişçi, M., Schallek, J. B., Kılıç, K., Can, A., Polo, A. D., & Dalkara, T. (2018) · eLife · doi:10.7554/elife.34861 · Cited by 273 · see citing works

Neural control of choroidal blood flow

Reiner, A., Fitzgerald, M. E., Mar, N. D., & Li, C. (2017) · Progress in retinal and eye research · doi:10.1016/j.preteyeres.2017.12.001 · Cited by 235 · see citing works

Markers for human brain pericytes and smooth muscle cells

Smyth, L. C. D., Rustenhoven, J., Scotter, E. L., Schweder, P. M., Faull, R. L. M., Park, T., & Dragunow, M. (2018) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2018.06.001 · Cited by 245 · see citing works

Vascular Compartmentalization of Functional Hyperemia from the Synapse to the Pia

Rungta, R. L., Chaigneau, E. M., Osmanski, B.-F., & Charpak, S. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.012 · Cited by 247 · see citing works

Targeting pericytes for therapeutic approaches to neurological disorders

Cheng, J., Korte, N., Nortley, R., Sethi, H., Tang, Y., & Attwell, D. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1893-0 · Cited by 242 · see citing works

The “Neuro-Glial-Vascular” Unit: The Role of Glia in Neurovascular Unit Formation and Dysfunction

Kugler, E., Greenwood, J., & MacDonald, R. B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.732820 · Cited by 215 · see citing works

Multiple Lines of Evidence Indicate That Gliotransmission Does Not Occur under Physiological Conditions

Fiacco, T. A., & McCarthy, K. D. (2018) · Journal of Neuroscience · doi:10.1523/jneurosci.0016-17.2017 · Cited by 194 · see citing works

Cells of the Blood–Brain Barrier: An Overview of the Neurovascular Unit in Health and Disease

McConnell, H., & Mishra, A. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-2289-6_1 · Cited by 165 · see citing works

Capillary pericytes mediate coronary no-reflow after myocardial ischaemia

O’Farrell, F. M., Mastitskaya, S., Hammond‐Haley, M., de Freitas, F. S. S., Wah, W. R., & Attwell, D. (2017) · eLife · doi:10.7554/elife.29280 · Cited by 156 · see citing works

Stimulation-induced increases in cerebral blood flow and local capillary vasoconstriction depend on conducted vascular responses

Cai, C., Fordsmann, J. C., Hørlyck, S., Gesslein, B., Lønstrup, M., Hald, B. O., Zambach, S. A., Brodin, B., & Lauritzen, M. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1707702115 · Cited by 151 · see citing works

Microglia at center stage: a comprehensive review about the versatile and unique residential macrophages of the central nervous system

Lannes, N., Eppler, E., Etemad, S., Yotovski, P., & Filgueira, L. (2017) · Oncotarget · doi:10.18632/oncotarget.23106 · Cited by 139 · see citing works

Neurovascular coupling mechanisms in health and neurovascular uncoupling in Alzheimer’s disease

Zhu, W. M., Neuhaus, A. A., Beard, D. J., Sutherland, B. A., & DeLuca, G. C. (2022) · Brain · doi:10.1093/brain/awac174 · Cited by 136 · see citing works

Mechanisms Mediating Functional Hyperemia in the Brain

Nippert, A. R., Biesecker, K. R., & Newman, E. A. (2017) · The Neuroscientist · doi:10.1177/1073858417703033 · Cited by 135 · see citing works

Human Parafoveal Capillary Vascular Anatomy and Connectivity Revealed by Optical Coherence Tomography Angiography

Nesper, P. L., & Fawzi, A. A. (2018) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-24710 · Cited by 132 · see citing works

Astrocytes Integrate Behavioral State and Vascular Signals during Functional Hyperemia

Tran, C. H. T., Peringod, G., & Gordon, G. R. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.045 · Cited by 126 · see citing works

Control of brain energy supply by astrocytes

Nortley, R., & Attwell, D. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.012 · Cited by 125 · see citing works

Neurovascular Coupling in Development and Disease: Focus on Astrocytes

Stackhouse, T. L., & Mishra, A. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.702832 · Cited by 124 · see citing works

Cerebral small vessel disease alters neurovascular unit regulation of microcirculation integrity involved in vascular cognitive impairment

Yang, Q. Z., Wei, X., Deng, B., Chang, Z., Jin, D., Huang, Y., Zhang, J. H., Yenari, M. A., Jin, K., & Wang, Q. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105750 · Cited by 132 · see citing works

Fractalkine-induced microglial vasoregulation occurs within the retina and is altered early in diabetic retinopathy

Mills, S. A., Jobling, A. I., Dixon, M., Bui, B. V., Vessey, K. A., Phipps, J. A., Greferath, U., Venables, G., Wong, V. H. Y., Wong, C. H. Y., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2112561118 · Cited by 121 · see citing works

Pericyte Structural Remodeling in Cerebrovascular Health and Homeostasis

Berthiaume, A., Hartmann, D. A., Majesky, M. W., Bhat, N. R., & Shih, A. Y. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00210 · Cited by 112 · see citing works

Brain-state dependent astrocytic Ca 2+ signals are coupled to both positive and negative BOLD-fMRI signals

Wang, M., He, Y., B, T. J. S. A., & Yu, X. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1711692115 · Cited by 95 · see citing works

A journey into the retina: Müller glia commanding survival and death

Subirada, P. V., Paz, M. C., Ridano, M. E., Lorenc, V. E., Vaglienti, M. V., Barcelona, P. F., Luna, J. D., & Sanchez, M. C. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.13965 · Cited by 99 · see citing works

Active role of capillary pericytes during stimulation-induced activity and spreading depolarization

Khennouf, L., Gesslein, B., Brazhe, A., Octeau, J. C., Kutuzov, N. P., Khakh, B. S., & Lauritzen, M. (2018) · Brain · doi:10.1093/brain/awy143 · Cited by 89 · see citing works

Neurovascular dysfunction in glaucoma

Alarcón-Martínez, L., Shiga, Y., Villafranca‐Baughman, D., Vargas, J. L. C., Vidal-Paredes, I. A., Quintero, H., Fortune, B. A., Danesh-Meyer, H. V., & Polo, A. D. (2023) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2023.101217 · Cited by 88 · see citing works

Pericyte morphology and function.

Alarcón-Martínez, L., Yemişçi, M., & Dalkara, T. (2021) · PubMed · doi:10.14670/hh-18-314 · Cited by 79 · see citing works

The microcirculation, the blood-brain barrier, and the neurovascular unit in health and Alzheimer disease: The aberrant pericyte is a central player

Divecha, Y. A., Rampes, S., Tromp, S., Boyanova, S., Fleckney, A. L., Fidanboylu, M., & Thomas, S. A. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100052 · Cited by 79 · see citing works

How Energy Metabolism Supports Cerebral Function: Insights from 13C Magnetic Resonance Studies In vivo

Sonnay, S., Gruetter, R., & Duarte, J. M. N. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00288 · Cited by 74 · see citing works

Fast Ca2+ responses in astrocyte end‐feet and neurovascular coupling in mice

Lind, B. L., Jessen, S. B., Lønstrup, M., Joséphine, C., Bonvento, G., & Lauritzen, M. (2017) · Glia · doi:10.1002/glia.23246 · Cited by 70 · see citing works

Channelrhodopsin Excitation Contracts Brain Pericytes and Reduces Blood Flow in the Aging Mouse Brain in vivo

Nelson, A. R., Sagare, M. A., Wang, Y., Kisler, K., Zhao, Z., & Zlokovic, B. V. (2020) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2020.00108 · Cited by 73 · see citing works

Astrocyte dysfunction and neurovascular impairment in neurological disorders: Correlation or causation?

McConnell, H., Li, Z., Woltjer, R. L., & Mishra, A. (2019) · Neurochemistry International · doi:10.1016/j.neuint.2019.04.005 · Cited by 72 · see citing works

More than just summed neuronal activity: how multiple cell types shape the BOLD response

Howarth, C., Mishra, A., & Hall, C. N. (2020) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2019.0630 · Cited by 78 · see citing works

Acute Ablation of Cortical Pericytes Leads to Rapid Neurovascular Uncoupling

Kisler, K., Nikolakopoulou, A. M., Sweeney, M. D., Lazić, D., Zhao, Z., & Zloković, B. V. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00027 · Cited by 73 · see citing works

GLP-1 Receptor Agonists in Neurodegeneration: Neurovascular Unit in the Spotlight

Monti, G., Moreira, D. G., Richner, M., Mutsaers, H. A. M., Ferreira, N., & Jan, A. (2022) · Cells · doi:10.3390/cells11132023 · Cited by 69 · see citing works

Astrocytes regulate ultra-slow arteriole oscillations via stretch-mediated TRPV4-COX-1 feedback

Haidey, J. N., Peringod, G., Institóris, Á., Gorzo, K. A., Nicola, W., Vandal, M., Ito, K., Liu, S., Fielding, C., Visser, F., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109405 · Cited by 66 · see citing works

Cellular Control of Brain Capillary Blood Flow: In Vivo Imaging Veritas

Grutzendler, J., & Nedergaard, M. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.05.009 · Cited by 66 · see citing works

Low-level blast exposure induces chronic vascular remodeling, perivascular astrocytic degeneration and vascular-associated neuroinflammation

Sosa, M. A. G., Gasperi, R. D., Pryor, D., Garcia, G. S. P., Perez, G. M., Abutarboush, R., Kawoos, U., Hogg, S., Ache, B., Janssen, W. G. M., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01269-5 · Cited by 62 · see citing works

Two decades of astrocytes in neurovascular coupling

Lia, A., Spiezio, A. D., Speggiorin, M., & Zonta, M. (2023) · Frontiers in Network Physiology · doi:10.3389/fnetp.2023.1162757 · Cited by 62 · see citing works

A Self-Regulating Gap Junction Network of Amacrine Cells Controls Nitric Oxide Release in the Retina

Jacoby, J., Nath, A., Jessen, Z. F., & Schwartz, G. W. (2018) · Neuron · doi:10.1016/j.neuron.2018.09.047 · Cited by 63 · see citing works

Microglia: The breakthrough to treat neovascularization and repair blood-retinal barrier in retinopathy

Fu, X., Feng, S., Qin, H., Yan, L., Zheng, C., & Yao, K. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1100254 · Cited by 58 · see citing works

Redefining our vision: an updated guide to the ocular immune system

Wu, M., Fletcher, E. L., Chinnery, H. R., Downie, L. E., & Mueller, S. N. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-01064-y · Cited by 57 · see citing works

In vivo imaging and analysis of cerebrovascular hemodynamic responses and tissue oxygenation in the mouse brain

Kisler, K., Lazić, D., Sweeney, M. D., Plunkett, S., Khatib, M. E., Vinogradov, S. A., Boas, D. A., Sakadžić, S., & Zloković, B. V. (2018) · Nature Protocols · doi:10.1038/nprot.2018.034 · Cited by 52 · see citing works

Astrocyte‐mediated mechanisms contribute to traumatic brain injury pathology

Muñoz‐Ballester, C., & Robel, S. (2023) · WIREs Mechanisms of Disease · doi:10.1002/wsbm.1622 · Cited by 53 · see citing works

Diversity of neurovascular coupling dynamics along vascular arbors in layer II/III somatosensory cortex

Rungta, R. L., Zuend, M., Aydin, A.-K., Martineau, É., Boido, D., Weber, B., & Charpak, S. (2021) · Communications Biology · doi:10.1038/s42003-021-02382-w · Cited by 49 · see citing works

Mechanism and potential treatment of the “no reflow” phenomenon after acute myocardial infarction: role of pericytes and GPR39

Methner, C., Cao, Z., Mishra, A., & Kaul, S. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00312.2021 · Cited by 49 · see citing works

The renin-angiotensin system and the retinal neurovascular unit: A role in vascular regulation and disease

Phipps, J. A., Dixon, M. A., Jobling, A. I., Wang, A. Y., Greferath, U., Vessey, K. A., & Fletcher, E. L. (2019) · Experimental Eye Research · doi:10.1016/j.exer.2019.107753 · Cited by 48 · see citing works

Pericytes Make Spinal Cord Breathless after Injury

de Almeida, V. M., Paiva, A. E., Sena, I. F. G., Mintz, A., Magno, L. A. V., & Birbrair, A. (2017) · The Neuroscientist · doi:10.1177/1073858417731522 · Cited by 47 · see citing works

Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?

Staurenghi, E., Giannelli, S., Testa, G., Sottero, B., Leonarduzzi, G., & Gamba, P. (2021) · Antioxidants · doi:10.3390/antiox10121890 · Cited by 44 · see citing works

Targeting gliovascular connexins prevents inflammatory blood-brain barrier leakage and astrogliosis

Bock, M. D., Smet, M. A. J. D., Verwaerde, S., Tahiri, H., Schumacher, S., Haver, V. V., Witschas, K., Steinhäuser, C., Rouach, N., Vandenbroucke, R. E., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.135263 · Cited by 43 · see citing works

Microglia have a grip on brain microvasculature

Kisler, K., Nikolakopoulou, A. M., & Zloković, B. V. (2021) · Nature Communications · doi:10.1038/s41467-021-25595-3 · Cited by 42 · see citing works

Pericytes

Dalkara, T. (2019) · Stroke · doi:10.1161/strokeaha.118.023590 · Cited by 40 · see citing works

Capillary flow disturbances after experimental subarachnoid hemorrhage: A contributor to delayed cerebral ischemia?

Anzabi, M., Angleys, H., Aamand, R., Ardalan, M., Mouridsen, K., Rasmussen, P. M., Sørensen, J. C. H., Plesnila, N., Østergaard, L., & Iversen, N. (2018) · Microcirculation · doi:10.1111/micc.12516 · Cited by 39 · see citing works

Pericytes in Ischemic Stroke

Dalkara, T., Alarcón-Martínez, L., & Yemişçi, M. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-16908-4_9 · Cited by 38 · see citing works

Exendin‐4, a GLP‐1 receptor agonist regulates retinal capillary tone and restores microvascular patency after ischaemia–reperfusion injury

Zhai, R., Xu, H., Hu, F., Wu, J., Kong, X., & Sun, X. (2020) · British Journal of Pharmacology · doi:10.1111/bph.15059 · Cited by 38 · see citing works

Regulation of blood flow in diabetic retinopathy

Nippert, A. R., & Newman, E. A. (2020) · Visual Neuroscience · doi:10.1017/s0952523820000036 · Cited by 38 · see citing works

Steady-State Free Ca2+ in Astrocytes Is Decreased by Experience and Impacts Arteriole Tone

Mehina, E. M. F., Murphy‐Royal, C., & Gordon, G. R. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0239-17.2017 · Cited by 36 · see citing works

Origins of the Resting-State Functional MRI Signal: Potential Limitations of the “Neurocentric” Model

Lu, H., Jaime, S., & Yang, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.01136 · Cited by 39 · see citing works

Toward three-dimensional in vitro models to study neurovascular unit functions in health and disease

Robert, J., Caffrey, T. M., & Button, E. B. (2021) · Neural Regeneration Research · doi:10.4103/1673-5374.310671 · Cited by 37 · see citing works

Dilation of cortical capillaries is not related to astrocyte calcium signaling

Franco, A. P. D., Chiang, P., & Newman, E. A. (2021) · Glia · doi:10.1002/glia.24119 · Cited by 39 · see citing works

Layer-specific anatomical and physiological features of the retina’s neurovascular unit

Grimes, W. N., Berson, D. M., Sabnis, A., Hoon, M., Sinha, R., Tian, H., & Diamond, J. S. (2024) · Current Biology · doi:10.1016/j.cub.2024.11.023 · Cited by 44 · see citing works

The role of neurovascular coupling dysfunction in cognitive decline of diabetes patients

Feng, L., & Gao, L. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1375908 · Cited by 37 · see citing works

In vivo Two-Photon Imaging Reveals Acute Cerebral Vascular Spasm and Microthrombosis After Mild Traumatic Brain Injury in Mice

Han, X., Chai, Z., Ping, X., Song, L.-J., Ma, C., Ruan, Y., & Jin, X. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00210 · Cited by 34 · see citing works

Anomalies in neurovascular coupling during early diabetes: A review

Fletcher, E. L., Dixon, M., Mills, S. A., & Jobling, A. I. (2022) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.14190 · Cited by 33 · see citing works

Mathematical methods for modeling the microcirculation

Arciero, J. C., Causin, P., & Malgaroli, F. (2017) · AIMS Biophysics · doi:10.3934/biophy.2017.3.362 · Cited by 32 · see citing works

Central Nervous System Pericytes Contribute to Health and Disease

Girolamo, F., Errede, M., Bizzoca, A., Virgintino, D., & Ribatti, D. (2022) · Cells · doi:10.3390/cells11101707 · Cited by 32 · see citing works

Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction

Kaul, S., Methner, C., Cao, Z., & Mishra, A. (2022) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2022.06.008 · Cited by 33 · see citing works

Role of capillary pericytes in the integration of spontaneous Ca2+ transients in the suburothelial microvasculature in situ of the mouse bladder

Hashitani, H., Mitsui, R., Miwa‐Nishimura, K., & Lam, M. (2018) · The Journal of Physiology · doi:10.1113/jp275845 · Cited by 30 · see citing works

Contractile apparatus in CNS capillary pericytes

Erdener, Ş. E., Küreli, G., & Dalkara, T. (2022) · Neurophotonics · doi:10.1117/1.nph.9.2.021904 · Cited by 30 · see citing works

Microglial regulation of the retinal vasculature in health and during the pathology associated with diabetes

Jobling, A. I., Greferath, U., Dixon, M., Quiriconi, P., Eyar, B., van Koeverden, A. K., Mills, S. A., Vessey, K. A., Bui, B. V., & Fletcher, E. L. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101349 · Cited by 31 · see citing works

Functional optical coherence tomography of neurovascular coupling interactions in the retina

Son, T., Alam, M. N., Toslak, D., Wang, B., Lu, Y., & Yao, X. (2018) · Journal of Biophotonics · doi:10.1002/jbio.201800089 · Cited by 29 · see citing works

Comparison of GCaMP3 and GCaMP6f for studying astrocyte Ca2+ dynamics in the awake mouse brain

Ye, L., Haroon, M. A., Salinas, A., & Paukert, M. (2017) · PLoS ONE · doi:10.1371/journal.pone.0181113 · Cited by 28 · see citing works

Elucidating glial responses to products of diabetes-associated systemic dyshomeostasis

Padovani-Claudio, D. A., Ramos, C. J., Capozzi, M. E., & Penn, J. S. (2023) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2022.101151 · Cited by 26 · see citing works

Functional OCT angiography reveals early retinal neurovascular dysfunction in diabetes with capillary resolution

Liu, K., Zhu, T., Gao, M., Yin, X., Zheng, R., Yan, Y., Gao, L., Ding, Z., Ye, J., & Li, P. (2023) · Biomedical Optics Express · doi:10.1364/boe.485940 · Cited by 25 · see citing works

PV interneurons evoke astrocytic C a 2+ responses in awake mice, which contributes to neurovascular coupling

Krogsgaard, A., Sperling, L., Dahlqvist, M., Thomsen, K., Kulkovienė, G., Li, F., Thunemann, M., Lauritzen, M., & Lind, B. L. (2023) · Glia · doi:10.1002/glia.24370 · Cited by 24 · see citing works

Methods to measure blood flow and vascular reactivity in the retina

Böhm, E. W., Pfeiffer, N., Wagner, F. M., & Gericke, A. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2022.1069449 · Cited by 23 · see citing works

The Neurovascular Unit as a Locus of Injury in Low-Level Blast-Induced Neurotrauma

Elder, G. A., Sosa, M. A. G., Gasperi, R. D., Garcia, G. S. P., Perez, G. M., Abutarboush, R., Kawoos, U., Zhu, C. W., Janssen, W. G. M., Stone, J. R., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021150 · Cited by 24 · see citing works

Neuronally Derived Soluble Abeta Evokes Cell-Wide Astrocytic Calcium Dysregulation in Absence of Amyloid Plaquesin Vivo

Kelly, P., Sanchez-Mico, M. V., Hou, S. S., Whiteman, S. T., Russ, A., Hudry, E., Arbel‐Ornath, M., Greenberg, S. M., & Bacskai, B. J. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.1988-22.2023 · Cited by 22 · see citing works

The role of microglia in the development of diabetic retinopathy

Quiriconi, P., Hristov, V., Aburaya, M., Greferath, U., Jobling, A. I., & Fletcher, E. L. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00009-2 · Cited by 22 · see citing works

Astrocyte regulation of cerebral blood flow during hypoglycemia

Nippert, A. R., Chiang, P.-P., Franco, A. P. D., & Newman, E. A. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221089091 · Cited by 21 · see citing works

Evidence of vascular involvement in myopia: a review

Benavente-Pérez, A. (2023) · Frontiers in Medicine · doi:10.3389/fmed.2023.1112996 · Cited by 19 · see citing works

Potential and Realized Impact of Astroglia Ca2 + Dynamics on Circuit Function and Behavior

Lim, E. Y., Ye, L., & Paukert, M. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.682888 · Cited by 19 · see citing works

Hypothalamic neuronal cellular and subcellular abnormalities in experimental obesity

Razolli, D. S., Moura‐Assis, A., Bombassaro, B., & Velloso, L. A. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0451-8 · Cited by 18 · see citing works

An in vitro bioengineered model of the human arterial neurovascular unit to study neurodegenerative diseases

Robert, J., Weilinger, N. L., Cao, L., Cataldi, S., Button, E. B., Stukas, S. K., Martin, E. M., Seibler, P., Gilmour, M., Caffrey, T. M., et al. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00418-z · Cited by 17 · see citing works

Astrocytes of the eye and optic nerve: heterogeneous populations with unique functions mediate axonal resilience and vulnerability to glaucoma

Cullen, P., & Sun, D. (2023) · Frontiers in Ophthalmology · doi:10.3389/fopht.2023.1217137 · Cited by 17 · see citing works

Excitatory neurotransmission activates compartmentalized calcium transients in Müller glia without affecting lateral process motility

Tworig, J. M., Coate, C. J., & Feller, M. B. (2021) · eLife · doi:10.7554/elife.73202 · Cited by 15 · see citing works

Topographic Distribution of Contractile Protein in the Human Macular Microvasculature

Yu, P. K., An, D., Balaratnasingam, C., Cringle, S. J., & Yu, D. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-26986 · Cited by 16 · see citing works

Development of perivascular astrocyte processes

Cohen‐Salmon, M., Guille, N., & Boulay, A.-C. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1585340 · Cited by 15 · see citing works

A High-Density Narrow-Field Inhibitory Retinal Interneuron with Direct Coupling to Müller Glia

Grimes, W. N., Aytürk, D. G., Hoon, M., Yoshimatsu, T., Gamlin, C. R., Carrera, D., Nath, A., Nadal-Nicolás, F. M., Ahlquist, R. M., Sabnis, A., et al. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0199-20.2021 · Cited by 15 · see citing works

Peroxisome Proliferator-Activated Receptor α Activation Protects Retinal Ganglion Cells in Ischemia-Reperfusion Retinas

Yao, F., Zhang, X., Yao, X., Ren, X., Xia, X., Jiang, J., & Ding, L. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.788663 · Cited by 14 · see citing works

Glia Regulate the Development, Function, and Plasticity of the Visual System From Retina to Cortex

Benfey, N. J., Foubert, D., & Ruthazer, E. S. (2022) · Frontiers in Neural Circuits · doi:10.3389/fncir.2022.826664 · Cited by 13 · see citing works

Stimulation of μ-opioid receptors dilates retinal arterioles by neuronal nitric oxide synthase-derived nitric oxide in rats

Someya, E., Mori, A., Sakamoto, K., Ishii, K., & Nakahara, T. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.03.043 · Cited by 13 · see citing works

Role of Neuron–Glia Signaling in Regulation of Retinal Vascular Tone in Rats

Someya, E., Akagawa, M., Mori, A., Morita, A., Yui, N., Asano, D., Sakamoto, K., & Nakahara, T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20081952 · Cited by 12 · see citing works

The function of astrocytes in cerebral infarction and potential therapeutic approaches

Beylerli, O., Фанилевич, Г. И., Beilerli, A., Ilyasova, T., Shi, H., & Sufianov, A. A. (2024) · Brain Hemorrhages · doi:10.1016/j.hest.2024.03.003 · Cited by 11 · see citing works

Revealing neurovascular coupling at a high spatial and temporal resolution in the living human retina

Senée, P., Krafft, L., Loukili, I., Farias, D. C., Thouvenin, O., Atlan, M., Pâques, M., Meimon, S. C., & Mecê, P. (2025) · Science Advances · doi:10.1126/sciadv.adx2941 · Cited by 11 · see citing works

A New Approach for the Segmentation of Three Distinct Retinal Capillary Plexuses Using Optical Coherence Tomography Angiography

Zhu, Q., Xing, X., Zhu, M., Xiao, H.-X., Ma, L., Chen, L., Liang, J., Yuan, Y., & Song, E. (2019) · Translational Vision Science & Technology · doi:10.1167/tvst.8.3.57 · Cited by 11 · see citing works

Persistent Coronary Vasomotor Tone During Myocardial Ischemia Occurs at the Capillary Level and May Involve Pericytes

Le, D. E., Zhao, Y. Q., & Kaul, S. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.930492 · Cited by 11 · see citing works

Mechanisms of Blood Flow Regulation in the Retina: Glial Calcium Signaling Regulates Capillary, but Not Arteriole Diameter

Biesecker, K. R. (2016) · University of Minnesota Digital Conservancy (University of Minnesota)

Dilation of cortical capillaries is not related to astrocyte calcium signaling

Franco, A. P. D., Chiang, P., & Newman, E. A. (2021) · Glia · doi:10.1002/glia.24119 · Cited by 39 · see citing works

Endothelial Ca 2+ signals in Penetrating Arterioles Control Local Blood Flow in the Brain.

Mughal, A., Longden, T. A., Hennig, G. W., & Nelson, M. T. (2020) · The FASEB Journal · doi:10.1096/fasebj.2020.34.s1.04433

Neural activity drives dynamic Ca2+ signals in capillary endothelial cells that shape local brain blood flow

Longden, T. A., Harraz, O. F., Hennig, G. W., Shui, B., Lee, F., Lee, J., Reining, S., Kotlikoff, M. I., Kostensis, E., König, G. M., et al. (2019) · The FASEB Journal · doi:10.1096/fasebj.2019.33.1_supplement.688.8 · Cited by 3 · see citing works

Assessment of Glial Function in the In Vivo Retina

Srienc, A. I., Kornfield, T. E., Mishra, A., Burian, M. A., & Newman, E. A. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-452-0_33 · Cited by 12 · see citing works