Cited by 556Neuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration MechanismsNeural dynamics and brain function

Norepinephrine Controls Astroglial Responsiveness to Local Circuit Activity

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Paukert, Martin, Agarwal, Amit, Cha, Jaepyeong, Doze, Van A., Kang, Jin U., Bergles, Dwight E.·2014·Neuron

Abstract

Astrocytes perform crucial supportive functions, including neurotransmitter clearance, ion buffering, and metabolite delivery. They can also influence blood flow and neuronal activity by releasing gliotransmitters in response to intracellular Ca(2+) transients. However, little is known about how astrocytes are engaged during different behaviors in vivo. Here we demonstrate that norepinephrine primes astrocytes to detect changes in cortical network activity. We show in mice that locomotion triggers simultaneous activation of astrocyte networks in multiple brain regions. This global stimulation of astrocytes was inhibited by alpha-adrenoceptor antagonists and abolished by depletion of norepinephrine from the brain. Although astrocytes in visual cortex of awake mice were rarely engaged when neurons were activated by light stimulation alone, pairing norepinephrine release with light stimulation markedly enhanced astrocyte Ca(2+) signaling. Our findings indicate that norepinephrine shifts the gain of astrocyte networks according to behavioral state, enabling astrocytes to respond to local changes in neuronal activity.

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Crossref · 10.1016/j.neuron.2014.04.038

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  • Arousal increases the responsiveness of astrocyte networks to local cortical activity, suggesting that arousal increases the gain of such networks to perceive external stimuli and modulate neuronal function.

    “This increases the responsiveness of astrocyte networks to local cortical activity 64 , suggesting that arousal increases the gain of such networks to perceive external stimuli and modulate neuronal function.”

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Authors
Paukert, M., Agarwal, A., Cha, J., Doze, V. A., Kang, J. U., & Bergles, D. E.
Affiliations
  • Johns Hopkins University (US)
  • University of North Dakota (US)
Corresponding author
  • Paukert, Martin
  • Bergles, Dwight E.
Venue
Neuron
Publisher
Elsevier BV
Published
2014-06
Volume
82
Issue
6
Pages
1263-1270
ISSN
0896-6273 (ISSN-L)
OpenAlex
W2079574859
Cited by
556
References
35
Citations by year
2026: 36 · 2025: 39 · 2024: 44 · 2023: 54 · 2022: 52 · 2021: 53 · 2020: 55 · 2019: 41 · 2018: 51 · 2017: 43 · 2016: 33 · 2015: 44 · 2014: 11
FWCI
19.95
Type
journal article
Language
en
Open access
Locations
  • Neuron (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Multiple Sclerosis Society
  • Johns Hopkins University
  • Science of Learning Institute, Johns Hopkins University
  • National Institute on Alcohol Abuse and Alcoholism (R03AA022239, AA022239)
  • National Institute of Mental Health (P50MH100024, P50MH084020, MH-084020)
  • National Institute of Neurological Disorders and Stroke (P30NS050274)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
norepinephrine, astrocytes, astrocyte activation, locomotion, alpha-adrenergic receptors, calcium signaling, cortical network activity, visual cortex, photostimulation, behavioral state, astrocyte-neuron interaction
MeSH terms
Action Potentials, Animals, Astrocytes, Mice, Transgenic, Nerve Net, Norepinephrine, Photic Stimulation, Visual Cortex, Mice

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