Cited by 402Stress Responses and CortisolMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

The DOI matches its Crossref record; 68 of the 70 references it cites were found in a registry or an index.

Hippocampal Dysfunction and Cognitive Impairments Provoked by Chronic Early-Life Stress Involve Excessive Activation of CRH Receptors

Open access

Ivy, Autumn S., Rex, Christopher S., Chen, Yuncai, Dubé, Céline, Maras, Pamela M., Grigoriadis, Dimitri E., Gall, Christine M., Lynch, Gary, Baram, Tallie Z.·2010·The Journal of Neuroscience

DOI 10.1523/jneurosci.1784-10.2010PMC PMC2991143

Open this paper in CoChat — free account Open PDF

Abstract

Chronic stress impairs learning and memory in humans and rodents and disrupts long-term potentiation (LTP) in animal models. These effects are associated with structural changes in hippocampal neurons, including reduced dendritic arborization. Unlike the generally reversible effects of chronic stress on adult rat hippocampus, we have previously found that the effects of early-life stress endure and worsen during adulthood, yet the mechanisms for these clinically important sequelae are poorly understood. Stress promotes secretion of the neuropeptide corticotropin-releasing hormone (CRH) from hippocampal interneurons, activating receptors (CRF 1 ) located on pyramidal cell dendrites. Additionally, chronic CRF 1 occupancy negatively affects dendritic arborization in mouse organotypic slice cultures, similar to the pattern observed in middle-aged, early-stressed (CES) rats. Here we found that CRH expression is augmented in hippocampus of middle-aged CES rats, and then tested whether the morphological defects and poor memory performance in these animals involve excessive activation of CRF 1 receptors. Central or peripheral administration of a CRF 1 blocker following the stress period improved memory performance of CES rats in novel-object recognition tests and in the Morris water maze. Consonant with these effects, the antagonist also prevented dendritic atrophy and LTP attenuation in CA1 Schaffer collateral synapses. Together, these data suggest that persistently elevated hippocampal CRH–CRF 1 interaction contributes importantly to the structural and cognitive impairments associated with early-life stress. Reducing CRF 1 occupancy post hoc normalized hippocampal function during middle age, thus offering potential mechanism-based therapeutic interventions for children affected by chronic stress.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.1784-10.2010

Cites

68 of 68 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
The neuro-symphony of stress
Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521
Self-citation
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Recognition memory and the medial temporal lobe: a new perspective
Squire, L. R., Wixted, J. T., & Clark, R. E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2154 · Cited by 1,059
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025
Spatial memory, recognition memory, and the hippocampus
Broadbent, N. J., Squire, L. R., & Clark, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406344101 · Cited by 985

Show all 70 references

Research works printed but not linked: 1

10.1210/en.142.1.89 · DOI

Sorted by citations

Items 301–400 of 401

The role of the dorsal hippocampus in resistance to the development of posttraumatic stress disorder-like behaviours
Wisłowska-Stanek, A., Lehner, M., Tomczuk, F., Kołosowska, K., Krząśnik, P., Turzyńska, D., & Skórzewska, A. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114185 · Cited by 7
Maternal and affective behaviors of lactating rats reared in overlapping litters
Uriarte, N., Fernández, M. V., Agrati, D., Zuluaga, M. J., Ferreño, M., & Ferreira, A. (2014) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2014.04.001 · Cited by 9
Influence of postnatal glucocorticoids on hippocampal-dependent learning varies with elevation patterns and administration methods
Claflin, D. I., Schmidt, K. D., Vallandingham, Z. D., Kraszpulski, M., & Hennessy, M. B. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.05.010 · Cited by 8
Poria cocos Regulates Cell Migration and Actin Filament Aggregation in B35 and C6 Cells by Modulating the RhoA, CDC42, and Rho Signaling Pathways
Lee, C.-Y., Lee, C.-T., Tzeng, I., Kuo, C., Tsai, F., & Chen, M. (2021) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2021/6854860 · Cited by 8
Inhibition of adult neurogenesis reduces avoidance behavior in male, but not female, mice subjected to early life adversity
Waters, R. C., Worth, H. M., Vasquez, B., & Gould, E. (2022) · Neurobiology of Stress · doi:10.1016/j.ynstr.2022.100436 · Cited by 8
Acoustic Stress Induces Opposite Proliferative/Transformative Effects in Hippocampal Glia
Cruz-Mendoza, F., Luquı́n, S., Garcı́a‐Estrada, J., Fernández-Quezada, D., & Jáuregui-Huerta, F. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065520 · Cited by 7
Two Adverse Early Life Events Induce Differential Changes in Brain CRH and Serotonin Systems in Rats along with Hyperphagia and Depression
Alcántara‐Alonso, V., García-Luna, C., Soberanes-Chávez, P., Estrada-Camarena, E. M., & de Gortari, P. (2024) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2302041 · Cited by 9
Early-life stress does not alter spatial memory performance, hippocampal neurogenesis, neuroinflammation, or telomere length in 20-month-old male mice
Kotah, J. M., Hoeijmakers, L., Nutma, E., Lucassen, P. J., & Kőrösi, A. (2021) · Neurobiology of Stress · doi:10.1016/j.ynstr.2021.100379 · Cited by 7
Correlations Between Endocrine Hormones and Cognitive Function in Patients with Obesity: a Cross-sectional Study
Zhang, Y., Huang, B., Yang, W., Zhong, S., Lai, S., Zhao, H., He, J.-L., Cai, S., Lv, S., Wang, C., et al. (2022) · Obesity Surgery · doi:10.1007/s11695-022-06076-y · Cited by 7
Origins of Addiction Predictably Embedded in Childhood Trauma: A Neurobiological Review
Wiet, S. (2017) · Journal of korean Academy of Child and Adolescent Psychiatry · doi:10.5765/jkacap.2017.28.1.4 · Cited by 7
Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses
Hokenson, R. E., Rodríguez-Acevedo, K. L., Chen, Y., Short, A. K., Samrari, S. A., Devireddy, B., Jensen, B. J., Winter, J., Gall, C. M., Soma, K. K., et al. (2026) · Neuron · doi:10.1016/j.neuron.2025.12.037 · Cited by 6
Self-citation
Early life adversities, psychopathologies and novel pharmacological strategies
Cattaneo, A., Begni, V., Zonca, V., & Riva, M. A. (2024) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2024.108686 · Cited by 8
Examining the relationship between psychosocial adversity and inhibitory control: A functional magnetic resonance imaging study of children growing up in extreme poverty
Surani, Z., Turesky, T. K., Sullivan, E., Shama, T., Haque, R., Islam, N., Kakon, S. H., Yu, X., Petri, W. A., Nelson, C. A., et al. (2024) · Journal of Experimental Child Psychology · doi:10.1016/j.jecp.2024.106072 · Cited by 7
FAAH Inhibition Reverses Depressive-like Behavior and Sex-Specific Neuroinflammatory Alterations Induced by Early Life Stress
Portugalov, A., & Akirav, I. (2024) · Cells · doi:10.3390/cells13221881 · Cited by 7
A pilot study showing that repeated exposure to stress produces alterations in subsequent responses to anesthetics in rats
Wang, L., Holland, L. S., Fong, R., Khokhar, S., Fox, A. P., & Xie, Z. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214093 · Cited by 6
Chronic corticosterone administration in adolescence enhances dorsolateral striatum-dependent learning in adulthood
Gadberry, T. M., Goodman, J., & Packard, M. G. (2022) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2022.970304 · Cited by 6
Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior – a TPH2 imaging genetics approachPreprint
Liu, C., Xu, L., Li, J., Zhou, F., Yang, X., Zheng, X., Fu, M., Li, K., Sindermann, C., Montag, C., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/685099 · Cited by 7
Predictability Can Reduce the Burden of Adverse Childhood Experiences: Policies to Promote It
Glynn, L. M. (2024) · Policy Insights from the Behavioral and Brain Sciences · doi:10.1177/23727322241304354 · Cited by 5
High-fat diet impairs the dendritic morphology of hippocampal CA1 pyramidal neurons in male but not female mice
Teng, S.-F., Lee, M. T., Lee, L., Hwang, L.-L., Chen, C.-P., Lee, H., Chen, C., & Chiou, L. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1687060 · Cited by 5
Adverse health effects and stresses on offspring due to paternal exposure to harmful substances
Sun, J., Teng, M., Wu, F., Zhao, X., Li, Y., Zhao, L., Zhao, W., Lai, K. P., Leung, K., & Giesy, J. P. (2022) · Critical Reviews in Environmental Science and Technology · doi:10.1080/10643389.2022.2129941 · Cited by 5
Early life adversity impaired dorsal striatal synaptic transmission and behavioral adaptability to appropriate action selection in a sex-dependent manner
de Carvalho, G., Khoja, S., Haile, M. T., & Chen, L. Y. (2023) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2023.1128640 · Cited by 5
Early life stress lastingly alters the function and AMPA ‐receptor composition of glutamatergic synapses in the hippocampus of male mice
Brosens, N., Simon, C., Kessels, H. W. H. G., Lucassen, P. J., & Krugers, H. J. (2023) · Journal of Neuroendocrinology · doi:10.1111/jne.13346 · Cited by 5
Role of corticotropin-releasing hormone in the impact of chronic stress during pregnancy on inducing depression in male offspring mice
Lv, Y., Chen, P., Kuang, L., Han, Z., Solanki, B., Zhou, W., Tao, F., Chen, R., & Yao, Y. (2020) · Brain Research · doi:10.1016/j.brainres.2020.147029 · Cited by 5
Early life stress facilitates synapse premature unsilencing to enhance AMPA receptor function in the developing hippocampus
Al‐Chami, A., Ross, A., Hayley, S. P., & Sun, H. (2020) · Journal of Neurophysiology · doi:10.1152/jn.00339.2020 · Cited by 5
Preclinical neuroimaging of gene–environment interactions in psychiatric disease
Yi, S. Y., Barnett, B. R., & Yu, J. J. (2019) · British Journal of Radiology · doi:10.1259/bjr.20180885 · Cited by 5
Novel molecular insights into the role of CRH type 1 receptor in the pathophysiology of depression
Rakeshkumar, P. P., ‬‬‬‬‬‬‬Bommaraju, S., Datusalia, A. K., & Nayak, P. K. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117430 · Cited by 4
Coping with the experience of frustration throughout life: Sex- and age-specific effects of early life stress on the susceptibility to reward devaluation
Alves, J., dos Santos, A. P. B., Vieira, A. D. S., Martini, A. P. R., de Lima, R. M. S., Smaniotto, T. Â., de Moraes, R. O., Gomes, R. F., Acerbi, G. C. D. A., de Assis, E. Z. B., et al. (2024) · Neuroscience · doi:10.1016/j.neuroscience.2024.06.020 · Cited by 4
Early-life stress affects Mongolian gerbil interactions with conspecific vocalizations in a sex-specific manner
Hardy, K. A., Hart, D. M., & Rosen, M. J. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1128586 · Cited by 4
Animal Models of Environmental Manipulations Resulting in Epigenetic Modifications That Increase Risk for Affective Disorders
Schoenrock, S. A., & Tarantino, L. M. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-417114-5.00009-7 · Cited by 4
Childhood abuse and EEG source localization in crack cocaine dependence
Alper, K., Shah, J., Howard, B., John, E. R., & Prichep, L. S. (2013) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2013.01.008 · Cited by 6
Early-life adversity alters adult nucleus incertus neurons: implications for neuronal mechanisms of increased stress and compulsive behavior vulnerability
Guguła, A., Sambak, P., Trenk, A., Drabik, S., Nogaj, A., Sołtys, Z., Gundlach, A. L., & Błasiak, A. (2025) · Neuropsychopharmacology · doi:10.1038/s41386-025-02089-0 · Cited by 3
Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress
Shobe, J. L., Ghanbarian, E., Bain, R., Saxena, R., Chandrasekaran, M., & McNaughton, B. L. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1646883 · Cited by 3
Cognitive reserve, frailty status, and risk of neurodegenerative diseases: a prospective cohort study
Huang, X., Ling, Y., Tan, S., Bai, Z., Shen, S., Wang, H., & Lyu, J. (2025) · npj Parkinson s Disease · doi:10.1038/s41531-025-01231-5 · Cited by 4
Radioprotective effects of asiaticoside and asiatic acid in neural stem cells derived from human stem cells from apical papilla through increasing dose-reduction factor and their lowering effects on SH-SY5Y cell viability
Tangrodchanapong, T., Jiso, A., Changkaew, P., Khachonkham, S., Thongsuk, A., Chodchavanchai, T., Khemawoot, P., Ruangsawasdi, N., Dharmasaroja, P., & Songsaad, A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0325480 · Cited by 3
Treatment of Mitochondrial Disturbances due to Early Life Adversity in Mice Results in Restoration of Complex I Activity and Normal Reward Behavior
Eagleson, K. L., & Levitt, P. R. (2025) · eNeuro · doi:10.1523/eneuro.0172-25.2025 · Cited by 4
Epigenetics: A New Frontier for Post-Traumatic Stress Disorder?
Schafe, G. E. (2014) · Epigenomics · doi:10.2217/epi.14.6 · Cited by 3
Modeling early-life adversity in the laboratory: animal models, their advantages, and future directions in extrapolating findings to humans
Campbell, T. S., & Roth, T. L. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-821785-6.00013-x · Cited by 3
Improving behavioral deficits induced by perinatal ethanol and stress exposure in adolescent male rat progeny via maternal melatonin treatment
Bagheri, F., Goudarzi, I., Lashkarbolouki, T., Salmani, M. E., Goudarzi, A., & Morley‐Fletcher, S. (2023) · Psychopharmacology · doi:10.1007/s00213-023-06470-z · Cited by 4
Corticotropin releasing factor modulates excitatory synaptic transmission
Joshi, N., McAree, M., & Chandler, D. J. (2020) · Vitamins and hormones · doi:10.1016/bs.vh.2020.04.003 · Cited by 3
Opposing actions of CRF-R1 and CB1 receptor on facial stimulation-induced MLI-PC plasticity in mouse cerebellar cortex
Li, G.-G., Piao, C.-J., Wan, P., Li, S., Wei, Y.-X., Zhao, G.-J., Wu, W., Hong, L., Chu, C., & Qiu, D. (2022) · BMC Neuroscience · doi:10.1186/s12868-022-00726-8 · Cited by 3
Greater avoidance of a saccharin cue paired with passive delivery of heroin is associated with a select increase in expression of CRFR2 and CRFbp in the hippocampus in rats
McFalls, A. J., Jenney, C., Stanford, R. S., Woodward, E., Hajnal, A. S., Grigson, P. S., & Vrana, K. E. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.10.009 · Cited by 3
Blocking NRSF Function Rescues Spatial Memory Impaired by Early-Life Adversity and Reveals Unexpected Underlying Transcriptional ProgramsPreprint
Schulmann, A., Bolton, J. L., Curran, M. M., Regev, L., Kamei, N., Singh-Taylor, A., Jiang, S., Molet, J., Mortazavi, A., & Baram, T. Z. (2018) · SSRN Electronic Journal · doi:10.2139/ssrn.3284454 · Cited by 3
Self-citation
Targeting corticotropin-releasing hormone receptor type 1 (Crhr1) neurons: validating the specificity of a novel transgenic Crhr1-FlpO mouse
Hardy, M., Chen, Y., Baram, T. Z., & Justice, N. J. (2024) · Brain Structure and Function · doi:10.1007/s00429-024-02879-0 · Cited by 3
Self-citation
Early-life stress of limited bedding/nesting material induced recognition memory loss and decreased hippocampal VGluT1 and nectin3 levels in aged male mice
He, Z.-C., Yu, Y., Wang, T., Yin, H., Sun, Y., Liu, X., Xie, X., Wang, H., Su, Y., Li, J., et al. (2025) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2025.173980 · Cited by 2
The multimodal neuroimaging signatures and gene expression profiles for adverse childhood experiences
Yu, T., Zhao, G., Sun, Y., Lu, Z., Liao, Y., Yuan, R., Kang, Z., Feng, X., Zhu, Y., Guo, J., et al. (2025) · BMC Medicine · doi:10.1186/s12916-025-04387-2 · Cited by 3
PTSD and appetite dysregulation: mTOR-dependent modulation of fear memory and satiety circuits
Krattli, S. N., Li, A. S., & McLachlan, C. S. (2025) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2025.106495 · Cited by 2
Corticotropin releasing hormone-expressing inputs to the thalamic paraventricular nucleus: pathways from mother to memory?
Mendoza, J. M., Floriou‐Servou, A., Chen, Y., Kooiker, C. L., Hardy, M., & Baram, T. Z. (2026) · Neurobiology of Stress · doi:10.1016/j.ynstr.2026.100794 · Cited by 2
Self-citation
Bridging the gap: The endocannabinoid system as a functional fulcrum for benzodiazepines in a novel frontier of anxiety pharmacotherapy
Pakkhesal, S., Shakouri, M., Mosaddeghi-Heris, R., Kiani-Nasab, S., Salehi, N., Sharafi, A., & Ahmadalipour, A. (2025) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2025.108799 · Cited by 3
Dependence of psychopharmacological drug effects on early social stress experience: An analysis aligned with the research domain criteria framework
Moreno, M., Martín-González, E., & Dalley, J. W. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103710 · Cited by 2
ForebrainCRF 1 ModulatesEarly-LifeStress-Programmed CognitiveDeficits
Scharf, S. H., & Baram, T. Z. (2011) · Cited by 2
Self-citation
Mechanisms by which early-life experiences promote enduring stress resilience or vulnerability
Short, A. K., Bolton, J. L., & Baram, T. Z. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00012-4 · Cited by 4
Self-citation
Associations of maternal emotion regulation with child white matter connectivity in Black American mother–child dyads
Wang, C., Barrie, D. L. L., Powers, A. D., Stenson, A. F., van Rooij, S. J. H., Stevens, J. S., Jovanović, T., Bradley, B., McGee, R. E., & Fani, N. (2022) · Developmental Psychobiology · doi:10.1002/dev.22303 · Cited by 5
The Impact of Early Life Stress on the Genetic Influence on Brain and Cognitive Development in ChildrenPreprint
Wang, H., Moon, S., Kim, H., Kim, K., Ahn, W., Joo, Y. Y., & Cha, J. (2021) · medRxiv · doi:10.1101/2021.12.27.21268445 · Cited by 2
Socially induced plasticity of the posterior tuberculum and motor behavior in zebrafish (Danio rerio)
Heagy, F. K., Clements, K. N., Adams, C. L., Blain, E., & Issa, F. A. (2024) · Journal of Experimental Biology · doi:10.1242/jeb.248148 · Cited by 2
Infant Maltreatment Induces Early Alterations in Adrenal Glands and Stress Response in Juvenile Rat Offspring
Colapietro, A. A., Balboa, J. G., Retamal, M. N. C., Regueira, E., Hermida, G. N., Cantarelli, V. I., Ponzio, M. F., Pallarés, M. E., Antonelli, M. C., & Diaz, S. L. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04363-5 · Cited by 1
Probing the roles of developmentally active neurons, in early-life adversity induced disruptions of adult behaviors
Weber, R., Mortazavi, A., Baram, T. Z., & Floriou‐Servou, A. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1671495 · Cited by 1
Self-citation
The effects of early life pain and juvenile fear conditioning on CRF-receptor expression in the amygdala and hypothalamus of the juvenile rat
Burman, M. A., & Zuke, J. T. (2026) · PLoS ONE · doi:10.1371/journal.pone.0326300 · Cited by 1
Experience-dependent development of vagal circuitry in rodents and humans
Panvini, S., Kamitakahara, A. K., Rinaman, L., & Levitt, P. R. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106728 · Cited by 2
Promoting healthy aging in occupational settings: satisfaction with life as a strategic target in the Semmelweis–EUniWell framework
Zábó, V., Ceglédi, A., Buda, A., Varga, P., Fekete, M., Fazekas‐Pongor, V., Csípő, T., Adonicsné-Püski, K., Giovannetti, G., Loscalzo, Y., et al. (2026) · GeroScience · doi:10.1007/s11357-026-02339-z · Cited by 1
A Cross-Sectional Study: Structural and Related Functional Connectivity Changes in the Brain: Stigmata of Adverse Parenting in Patients with Major Depressive Disorder?
Nie, Z., Xie, X., Kang, L., Wang, W., Xu, S., Chen, M., Yao, L., Gong, Q., Zhou, E., Li, M., et al. (2023) · Brain Sciences · doi:10.3390/brainsci13040694 · Cited by 1
Children exposed to ACE
Rokach, A., & Clayton, S. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85853-3.00019-7 · Cited by 2
Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained changes in behavioral plasticity and the transcriptomic profile of the amygdala
Martz, J., Shelton, M. A., Langen, T. J., Srinivasan, S., Seney, M. L., & Kentner, A. C. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.01.007 · Cited by 1
Mediation on the association between HPA axis hyperactivity and cognitive impairment by abnormal hippocampal function in people who lost their only child
Pan, C., Cao, Y., Ge, J., Li, Y., Feng, W., Yan, J., Wu, L., Lan, Q., Lu, G., Qi, R., et al. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.04.055 · Cited by 1
The role of the CRF-urocortin system in stress resilience
Henckens, M. J. A. G., Deussing, J. M., & Chen, A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813983-7.00016-1 · Cited by 1
The Effects of Poria cocos on Rho Signaling-Induced Regulation of Mobility and F-Actin Aggregation in MK-801-Treated B35 and C6 Cells
Chen, Y.-C., Lee, C.-T., Tsai, F., & Chen, M. (2022) · Behavioural Neurology · doi:10.1155/2022/8225499 · Cited by 1
Self-citation
Early Life Stress
Harms, M. B., & Pollak, S. D. (2020) · Wiley eBooks · doi:10.1002/9781119057840.ch42 · Cited by 1
Antipoverty programs mitigate socioeconomic disparities in hippocampal volume and internalizing problems among U.S. youthsPreprint
Weissman, D. G., Hatzenbuehler, M. L., Cikara, M., Barch, D. M., & McLaughlin, K. A. (2021) · doi:10.31234/osf.io/8nhej · Cited by 1
Examining the relationship between psychosocial adversity and inhibitory control: an fMRI study of children growing up in extreme povertyPreprint
Surani, Z., Turesky, T. K., Sullivan, E., Shama, T., Haque, R., Islam, N., Kakon, S. H., Yu, X., Petri, W. A., Nelson, C. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.05.578942 · Cited by 1
The impact of early life adversity on cortical structure in adolescent twins followed since birth
Ismaylova, E. (2013) · doi:10.71781/30178
A novel molecular mechanism of stress peptide action in neurons.
Stern, C. M. (2010) · University of Minnesota Digital Conservancy (University of Minnesota)
The Polycomb complex: a key regulator in altered neurogenesis resulting from early-life stress?
Willemse, E. A. J. (2012) · Utrecht University Repository (Utrecht University)
Early‐Life Stress: Rodent Models, Lessons and Challenges
Maras, P. M., & Baram, T. Z. (2015) · doi:10.1002/9781118921692.ch12
Self-citation
Dissection of Forebrain Corticotropin-Releasing Hormone Receptor 1 Signaling in Stress-Induced Cognitive Deficits –– The Role of Synaptic Cell Adhesion Molecules
Wang, X. (2011) · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München) · doi:10.5282/edoc.13447
Hippocampal Circuitry Dysfunction in the 5-HT1A Knockout Mouse
Metzger, K. L. (2012) · ScholarlyCommons (University of Pennsylvania)
Modelling Stress‐Related Mood Disorders in Animals
Schmidt, M. V., Wagner, K. V., Wang, X., & Balsevich, G. (2015) · Wiley eBooks · doi:10.1002/9781118921692.ch8
Assesment of Caregiver Experiences and Their Influence on Global DNA Methylation within the Adolescent Hippocampus and Amygdala
Forster, A. (2015) · Library, Museums and Press - UDSpace (University of Delaware)
L-THEANINE’S EFFECTS ON LEARNING AND MEMORY IN COLLEGE STUDENTS
Nickel, M. M. (2017)
An in vitro model system for studying the stress-induced memory disorder
Ogura, A., Saito, S., Kimura, S., & Tominaga‐Yoshino, K. (2017) · Folia Pharmacologica Japonica · doi:10.1254/fpj.150.223
The Biological and Behavioural Effects of Electroconvulsive Stimulus in Rodents: Investigation and Translational Implications of a Genetic Animal Model of Depression
Kyeremanteng, C. (2012) · uO Research (University of Ottawa) · doi:10.20381/ruor-5452
Early life rearing of stressed animals in complex housing environment drives stress resilience in physiology, behavior and brain plasticity during adulthood
Nagarajan, A. H. (2018) · DR-NTU (Nanyang Technological University) · doi:10.32657/10356/75560
Psychoneuroendocrinology of Resilience: An Overview
Sousa, A. D., Shrivastava, A., & Nemeroff, C. B. (2018) · Springer eBooks · doi:10.1007/978-3-319-70554-5_28
Pain and Stress
Eiland, L. R. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4377-3611-3.00013-4
Do cognitive processes mediate the relationship between adverse childhood experiences and health related outcomes
Trossman, R. (2019) · UWSpace (University of Waterloo)
Function of the Endocannabinoid System in Neurodegenerative Diseases and Cancers
Soliman, M., Potlakayala, S. D., Desai, D. H., Weeden, H., Husain, R., Lookfong, N. A., Trite, T., Spagnola, J., Amin, S., & Rudrabhatla, S. L. (2019) · American Journal of Plant Sciences · doi:10.4236/ajps.2019.1010130
DTI-identified microstructural changes in the gray matter of mice overexpressing CRF in the forebrain
Deslauriers, J., Tóth, M., Scadeng, M., McKenna, B. S., Bussell, R., Gresack, J. E., Rissman, R. A., Risbrough, V. B., & Brown, G. G. (2020) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2020.111137 · Cited by 1
Animal models of environmental manipulations causing epigenetic modifications that increase risk for major depressive disorder and anxiety disorders
Peedicayil, J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823577-5.00024-6
Faculty Opinions recommendation of Reduced hippocampal and amygdala volume as a mechanism underlying stress sensitization to depression following childhood trauma.
Sullivan, R. M., & Opendak, M. M. (2020) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.738202304.793579786
Experiences Shape Hippocampal Neuron Morphology and the Balance of CRHR1 and OTRPreprint
Wei, F., Deng, X. Y., Ma, B., Li, W., Chen, Y., Zhao, L., Zhang, Y., Zheng, T., Xian, D., He, Y., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-1207767/v1
Self-citation
Resource Scarcity But Not Maternal Separation Provokes Unpredictable Maternal Care Sequences in Mice and Both Upregulate Crh-Associated Gene Expression in the AmygdalaPreprint
Demaestri, C., Gallo, M. E., Mazenod, E., Hong, A. T., Arora, H., Short, A. K., Stern, H. S., Baram, T. Z., & Bath, K. G. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4158328
Self-citation
The causal involvement of the BDNF-TrkB pathway in dentate gyrus in early-life stress-induced cognitive deficitsPreprint
Li, J., Sun, Y., Su, Y., Wang, Q., Wang, T., Zheng, J.-Y., Zhang, C., Liu, X., Ma, Y., Li, X., et al. (2022) · Research Square · doi:10.21203/rs.3.rs-2291445/v1
The Relationship between Unpredictability in Childhood and Depression Among College Students: The Mediating Role of Coping Style and ResiliencePreprint
Ye, C., Ye, B., & Zhang, Z. (2023) · Research Square · doi:10.21203/rs.3.rs-3280857/v1
The Effects of Early Life Pain and Juvenile Fear Conditioning on CRF-Receptor Expression in the Amygdala and HypothalamusPreprint
Burman, M. A., & Zuke, J. T. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.29.656935
Prenatal maternal mood instability and child externalizing problems: An ecological momentary assessment study
Srivastava, S. G., Sandman, C. A., Davis, E. P., & Glynn, L. M. (2025) · Journal of Affective Disorders · doi:10.1016/j.jad.2025.119947
Early adversity promotes adolescent avoidance behavior by enhancing prefrontal–amygdala communication through CRH⁺ glutamatergic neuronsPreprint
Goodpaster, C. M., Zeidler, Z., Gongwer, M. W., Bland, C. J., Shari, M., Klune, C. B., Jones, N. S., Ramirez, M., Batul-Alturki, M., Hundley, R., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.23.696229
Characterizing behavioral effects of early-life stress in an animal model of auditory processing
Hardy, K. A., Rybolt, S., Patel, B., Dye, R., & Rosen, M. J. (2026) · Physiology & Behavior · doi:10.1016/j.physbeh.2026.115278
BioGraphX-RNA: a universal physicochemical graph encoding for interpretable RNA subcellular localization prediction
Saeed, A., & Abbas, W. (2026) · BMC Bioinformatics · doi:10.1186/s12859-026-06619-5
The role of astrocytes in the social transmission of stress
Gómez-Sotres, P. (2024) · theses.fr (ABES) · doi:10.70675/1d3b266aze7c4z4968z98c6za5ffe9fe383a
Early resource scarcity drives persistent transcriptional changes and vascular remodeling in the female prefrontal cortexPreprint
Andrews, E. R., Crist, R. C., Silva, A. I., Chehimi, S. N., Miranda, G., Shuey, J., Berhane, L., Hoot, L., Harris, E., Cuarenta, A., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.06.11.731696
Unveiling the mechanisms of comorbidity of aging and depression: a perspective based on early life stress (ELS)
Lin, C., Zhang, S., Li, Q., Qi, Z., & Liu, W. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.07.053
Maternal Predictability and Child Biobehavioral Outcomes
Han, D. (2026) · Digital Commons - DU (University of Denver) · doi:10.56902/etdcrp.2026.90

Authors: Ivy, A. S., Rex, C. S., Chen, Y., Dubé, C., Maras, P. M., Grigoriadis, D. E., Gall, C. M., Lynch, G., & Baram, T. Z.
Affiliations: University of California, Irvine (US)
Neurocrine Biosciences (United States) (US)
ORCID: Ivy, Autumn S.
Chen, Yuncai
Maras, Pamela M.
Gall, Christine M.
Lynch, Gary
Baram, Tallie Z.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2010-09-29
Volume: 30
Issue: 39
Pages: 13005-13015
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1784-10.2010
PMC: PMC2991143
OpenAlex: W2080496806
Cited by: 402
References: 70
Citations by year: 2026: 11 · 2025: 21 · 2024: 27 · 2023: 25 · 2022: 34 · 2021: 21 · 2020: 26 · 2019: 31 · 2018: 20 · 2017: 29 · 2016: 24 · 2015: 26 · 2014: 39 · 2013: 18 · 2012: 28
FWCI: 9.37
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: National Institutes of Health (NS045260)
National Institute on Aging (AG00358)
National Institute of Mental Health (MH087467, F31MH087467, MH73136, R01MH073136)
National Institute of Neurological Disorders and Stroke (P01NS045260, NS 28912, NS045260, R01NS028912, NS051823, R01NS051823, T32NS045540)
Topics: Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: hippocampal dysfunction, corticotropin-releasing factor, CRF1 receptor, dendritic atrophy, long-term potentiation, learning and memory impairment, novel object recognition, Morris water maze, CRF1 receptor antagonist, hippocampal interneurons, middle-aged rats, organotypic slice cultures
MeSH terms: CRF Receptor, Type 1, Animals, Animals, Newborn, Chronic Disease, Cognition Disorders, Corticotropin-Releasing Hormone, Disease Models, Animal, Female, Hippocampus, Humans, Male, Mice, Transgenic, Neurons, Organ Culture Techniques, Stress, Psychological, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Mice, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Hippocampal Dysfunction and Cognitive Impairments Provoked by Chronic Early-Life Stress Involve Excessive Activation of CRH Receptors

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks