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Hippocampal Dysfunction and Cognitive Impairments Provoked by Chronic Early-Life Stress Involve Excessive Activation of CRH Receptors
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Chronic stress impairs learning and memory in humans and rodents and disrupts long-term potentiation (LTP) in animal models. These effects are associated with structural changes in hippocampal neurons, including reduced dendritic arborization. Unlike the generally reversible effects of chronic stress on adult rat hippocampus, we have previously found that the effects of early-life stress endure and worsen during adulthood, yet the mechanisms for these clinically important sequelae are poorly understood. Stress promotes secretion of the neuropeptide corticotropin-releasing hormone (CRH) from hippocampal interneurons, activating receptors (CRF 1 ) located on pyramidal cell dendrites. Additionally, chronic CRF 1 occupancy negatively affects dendritic arborization in mouse organotypic slice cultures, similar to the pattern observed in middle-aged, early-stressed (CES) rats. Here we found that CRH expression is augmented in hippocampus of middle-aged CES rats, and then tested whether the morphological defects and poor memory performance in these animals involve excessive activation of CRF 1 receptors. Central or peripheral administration of a CRF 1 blocker following the stress period improved memory performance of CES rats in novel-object recognition tests and in the Morris water maze. Consonant with these effects, the antagonist also prevented dendritic atrophy and LTP attenuation in CA1 Schaffer collateral synapses. Together, these data suggest that persistently elevated hippocampal CRH–CRF 1 interaction contributes importantly to the structural and cognitive impairments associated with early-life stress. Reducing CRF 1 occupancy post hoc normalized hippocampal function during middle age, thus offering potential mechanism-based therapeutic interventions for children affected by chronic stress.
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“potential threats activate the hypothalamic-pituitary-adrenal (HPA) axis, leading to enhanced expression of corticotropin releasing hormone (CRH) in the hippocampus and damage to hippocampal neurons (Brunson et al., 2001; Ivy et al., 2010).”
From Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience (2014) · cites this paper as Ivy et al., 2010
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Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
Effects of stress throughout the lifespan on the brain, behaviour and cognition
Lupien, S. J., McEwen, B. S., Gunnar, M. R., & Heim, C. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2639 · Cited by 6,256
STRESS AND HIPPOCAMPAL PLASTICITY
McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087
The link between childhood trauma and depression: insights from HPA axis studies in humans
Heim, C., Newport, D. J., Mletzko, T., Miller, A. H., & Nemeroff, C. B. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.008 · Cited by 1,704
Joëls, M., & Baram, T. Z. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2632 · Cited by 1,521
Self-citationDendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Recognition memory and the medial temporal lobe: a new perspective
Squire, L. R., Wixted, J. T., & Clark, R. E. (2007) · Nature reviews. Neuroscience · doi:10.1038/nrn2154 · Cited by 1,059
Shrinkage of dendritic spines associated with long-term depression of hippocampal synapses
Zhou, Q., Homma, K. J., & Poo, M.-M. (2004) · Neuron · doi:10.1016/j.neuron.2004.11.011 · Cited by 1,025
Spatial memory, recognition memory, and the hippocampus
Broadbent, N. J., Squire, L. R., & Clark, R. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406344101 · Cited by 985
Research works printed but not linked: 1
- 10.1210/en.142.1.89 · DOI
Cited by
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McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.012 · Cited by 1,389
Childhood Adversity and Neural Development: A Systematic Review
McLaughlin, K. A., Weissman, D., & Bitrán, D. (2019) · Annual Review of Developmental Psychology · doi:10.1146/annurev-devpsych-121318-084950 · Cited by 892
Sex differences and stress across the lifespan
Bale, T. L., & Epperson, C. N. (2015) · Nature Neuroscience · doi:10.1038/nn.4112 · Cited by 751
Dimensions of early experience and neural development: deprivation and threat
Sheridan, M. A., & McLaughlin, K. A. (2014) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2014.09.001 · Cited by 697
Modulation of the Hypothalamic-Pituitary-Adrenal Axis by Early Life Stress Exposure
van Bodegom, M., Homberg, J. R., & Henckens, M. J. A. G. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00087 · Cited by 606
Epigenetic and transgenerational reprogramming of brain development
Bale, T. L. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3818 · Cited by 505
Toward understanding how early-life stress reprograms cognitive and emotional brain networks
Chen, Y., & Baram, T. Z. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.181 · Cited by 474
Self-citationEarly life stress and development: potential mechanisms for adverse outcomes
Smith, K. E., & Pollak, S. D. (2020) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-020-09337-y · Cited by 500
Environmental influences on the pace of brain development
Tooley, U. A., Bassett, D. S., & Mackey, A. P. (2021) · Nature reviews. Neuroscience · doi:10.1038/s41583-021-00457-5 · Cited by 488
Joëls, M., Sarabdjitsingh, R. A., & Karst, H. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005892 · Cited by 445
Sex Differences in Vulnerability and Resilience to Stress Across the Life Span
Hodes, G. E., & Epperson, C. N. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.04.028 · Cited by 417
Walker, C., Bath, K. G., Joëls, M., Kőrösi, A., Larauche, M. H., Lucassen, P. J., Morris, M. J., Raineki, C., Roth, T. L., Sullivan, R. M., et al. (2017) · Stress · doi:10.1080/10253890.2017.1343296 · Cited by 432
Self-citationThe Consequences of Early‐Life Adversity: Neurobiological, Behavioural and Epigenetic Adaptations
Maccari, S., Krugers, H. J., Morley‐Fletcher, S., Szyf, M., & Brunton, P. J. (2014) · Journal of Neuroendocrinology · doi:10.1111/jne.12175 · Cited by 367
Smith, K. E., & Pollak, S. D. (2020) · Perspectives on Psychological Science · doi:10.1177/1745691620920725 · Cited by 379
Morgan, C. P., & Bale, T. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.1887-11.2011 · Cited by 346
Cortisol and depression: three questions for psychiatry
Herbert, J. (2013) · Psychological Medicine · doi:10.1017/s0033291712000955 · Cited by 301
The neurodevelopmental origins of suicidal behavior
Turecki, G., Ernst, C., Jollant, F., Labonté, B., & Mechawar, N. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.008 · Cited by 299
Naninck, E. F. G., Hoeijmakers, L., Kakava-Georgiadou, N., Meesters, A., Lazic, S. E., Lucassen, P. J., & Kőrösi, A. (2014) · Hippocampus · doi:10.1002/hipo.22374 · Cited by 300
Food for thought: how nutrition impacts cognition and emotion
Spencer, S. J., Kőrösi, A., Layé, S., Shukitt‐Hale, B., & Barrientos, R. M. (2017) · npj Science of Food · doi:10.1038/s41538-017-0008-y · Cited by 304
Fragmentation and Unpredictability of Early-Life Experience in Mental Disorders
Baram, T. Z., Davis, E. P., Obenaus, A., Sandman, C. A., Small, S. L., Solodkin, A., & Stern, H. S. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.11091347 · Cited by 292
Self-citationNaturalistic rodent models of chronic early‐life stress
Molet, J., Maras, P. M., Avishai‐Eliner, S., & Baram, T. Z. (2014) · Developmental Psychobiology · doi:10.1002/dev.21230 · Cited by 282
Self-citationThe Corticotropin-Releasing Factor Family: Physiology of the Stress Response
Deussing, J. M., & Chen, A. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2017 · Cited by 271
Region-specific roles of the corticotropin-releasing factor–urocortin system in stress
Henckens, M. J. A. G., Deussing, J. M., & Chen, A. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.94 · Cited by 248
Sex differences in prenatal epigenetic programing of stress pathways
Bale, T. L. (2011) · Stress · doi:10.3109/10253890.2011.586447 · Cited by 249
Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome
Molet, J., Heins, K., Zhuo, X., Mei, Y., Regev, L., Baram, T. Z., & Stern, H. S. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.200 · Cited by 230
Self-citationRaineki, C., Cortés, M. R., Belnoue, L., & Sullivan, R. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.5843-11.2012 · Cited by 217
Bolton, J. L., Molet, J., Regev, L., Chen, Y., Rismanchi, N., Haddad, E., Yang, D. Z., Obenaus, A., & Baram, T. Z. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.08.023 · Cited by 222
Self-citationEarly life stress accelerates behavioral and neural maturation of the hippocampus in male mice
Bath, K. G., Manzano-Nieves, G., & Goodwill, H. L. (2016) · Hormones and Behavior · doi:10.1016/j.yhbeh.2016.04.010 · Cited by 219
Suri, D., Veenit, V., Sarkar, A., Thiagarajan, D., Kumar, A., Nestler, E. J., Galande, S., & Vaidya, V. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.10.023 · Cited by 208
Early-life stress mediated modulation of adult neurogenesis and behavior
Korosi, A., Naninck, E. F. G., Oomen, C. A., Schouten, M., Krugers, H., Fitzsimons, C., & Lucassen, P. J. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.07.037 · Cited by 194
Early life stress perturbs the maturation of microglia in the developing hippocampus
Delpech, J.-C., Wei, L., Hao, J., Yu, X., Madore, C., Butovsky, O., & Kaffman, A. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.06.006 · Cited by 193
Neuropeptide receptor ligands as drugs for psychiatric diseases: the end of the beginning?
Griebel, G., & Holsboer, F. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3702 · Cited by 194
Early-life adversity and neurological disease: age-old questions and novel answers
Short, A. K., & Baram, T. Z. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0246-5 · Cited by 187
Self-citationThe CRF Family of Neuropeptides and their Receptors - Mediators of the Central Stress Response
Dedic, N., Chen, A., & Deussing, J. M. (2017) · Current Molecular Pharmacology · doi:10.2174/1874467210666170302104053 · Cited by 187
Joëls, M. (2018) · Journal of Endocrinology · doi:10.1530/joe-18-0226 · Cited by 195
Early life adversity shapes neural circuit function during sensitive postnatal developmental periods
Malave, L., van Dijk, M. T., & Anacker, C. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02092-9 · Cited by 177
Early life stress paradigms in rodents: potential animal models of depression?
Schmidt, M. V., Wang, X., & Meijer, O. C. (2010) · Psychopharmacology · doi:10.1007/s00213-010-2096-0 · Cited by 179
Sculpting the hippocampus from within: stress, spines, and CRH
Maras, P. M., & Baram, T. Z. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2012.01.005 · Cited by 183
Self-citationLucassen, P. J., Naninck, E. F. G., van Goudoever, J. B., Fitzsimons, C. P., Joëls, M., & Kőrösi, A. (2013) · Trends in Neurosciences · doi:10.1016/j.tins.2013.08.002 · Cited by 180
Early life stress in fathers improves behavioural flexibility in their offspring
Gapp, K., Soldado-Magraner, S., Álvarez-Sánchez, M., Bohacek, J., Vernaz, G., Shu, H., Franklin, T. B., Wolfer, D. P., & Mansuy, I. M. (2014) · Nature Communications · doi:10.1038/ncomms6466 · Cited by 170
Lucassen, P. J., Oomen, C. A., Naninck, E. F. G., Fitzsimons, C. P., van Dam, A.-M., Czeh, B., & Korosi, A. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a021303 · Cited by 166
Kumar, A. (2011) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2011.00007 · Cited by 175
Sex as a Biological Variable: Who, What, When, Why, and How
Bale, T. L., & Epperson, C. N. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.215 · Cited by 175
Forebrain CRF1Modulates Early-Life Stress-Programmed Cognitive Deficits
Wang, X., Rammes, G., Kraev, I., Wolf, M., Liebl, C., Scharf, S. H., Rice, C. J., Wurst, W., Holsboer, F., Deussing, J. M., et al. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.2259-11.2011 · Cited by 163
Self-citationTochitani, S., Ikeno, T., Ito, T., Sakurai, A., Yamauchi, T., & Matsuzaki, H. (2016) · PLOS ONE · doi:10.1371/journal.pone.0138293 · Cited by 157
Chocyk, A., Bobula, B., Dudys, D., Przyborowska, A., Majcher-Maślanka, I., Hess, G., & Wędzony, K. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12208 · Cited by 153
GABAA receptor-acting neurosteroids: a role in the development and regulation of the stress response
Gunn, B. G., Cunningham, L., Mitchell, S. G., Swinny, J. D., Lambert, J. J., & Belelli, D. (2015) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.06.001 · Cited by 149
Bolton, J. L., Short, A. K., Othy, S., Kooiker, C. L., Shao, M., Gunn, B. G., Beck, J., Bai, X., Law, S. M., Savage, J. C., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110600 · Cited by 158
Self-citationNectin-3 links CRHR1 signaling to stress-induced memory deficits and spine loss
Wang, X., Su, Y., Wagner, K. V., Avrabos, C., Scharf, S. H., Hartmann, J., Wolf, M., Liebl, C., Kühne, C., Wurst, W., et al. (2013) · Nature Neuroscience · doi:10.1038/nn.3395 · Cited by 141
The influence of unpredictable, fragmented parental signals on the developing brain
Glynn, L. M., & Baram, T. Z. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.01.002 · Cited by 146
Self-citationRincón‐Cortés, M., & Sullivan, R. M. (2014) · Frontiers in Endocrinology · doi:10.3389/fendo.2014.00033 · Cited by 147
Mechanisms of Shared Vulnerability to Post-traumatic Stress Disorder and Substance Use Disorders
Maria-Rios, C. E., & Morrow, J. D. (2020) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2020.00006 · Cited by 164
Early life manipulations alter learning and memory in rats
Kosten, T. A., Kim, J. J., & Lee, H. J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.003 · Cited by 136
Tuning synaptic transmission in the hippocampus by stress: the CRH system
Chen, Y., Andres, A. L., Frotscher, M., & Baram, T. Z. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00013 · Cited by 136
Self-citationPrenatal maternal mood patterns predict child temperament and adolescent mental health
Glynn, L. M., Howland, M. A., Sandman, C. A., Davis, E. P., Phelan, M. J., Baram, T. Z., & Stern, H. S. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.11.065 · Cited by 131
Self-citationWeissman, D. G., Lambert, H. K., Rodman, A. M., Peverill, M., Sheridan, M. A., & McLaughlin, K. A. (2020) · Depression and Anxiety · doi:10.1002/da.23062 · Cited by 130
Effects of Early-Life Adversity on Hippocampal Structures and Associated HPA Axis Functions
Dahmen, B., Puetz, V. B., Scharke, W., von Polier, G. G., Herpertz-Dahlmann, B., & Konrad, K. (2018) · Developmental Neuroscience · doi:10.1159/000484238 · Cited by 121
Blaze, J., Scheuing, L., & Roth, T. L. (2013) · Developmental Neuroscience · doi:10.1159/000350716 · Cited by 123
Chen, Y., Kramár, E. A., Chen, L. Y., Babayan, A. H., Andres, A. L., Gall, C. M., Lynch, G., & Baram, T. Z. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.17 · Cited by 115
Self-citationStress and excitatory synapses: From health to disease
Timmermans, W., Xiong, H., Hoogenraad, C. C., & Krugers, H. J. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.05.043 · Cited by 120
Lesuis, S. L., Hoeijmakers, L., Kőrösi, A., de Rooij, S. R., Swaab, D. F., Kessels, H. W. H. G., Lucassen, P. J., & Krugers, H. J. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0422-7 · Cited by 128
Measuring novel antecedents of mental illness: the Questionnaire of Unpredictability in Childhood
Glynn, L. M., Stern, H. S., Howland, M. A., Risbrough, V. B., Baker, D. G., Nievergelt, C. M., Baram, T. Z., & Davis, E. P. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0280-9 · Cited by 117
Self-citationBohacek, J., Farinelli, M., Mirante, O., Steiner, G., Gapp, K., Coiret, G., Ebeling, M., Durán-Pacheco, G., Iniguez, A. L., Manuella, F., et al. (2014) · Molecular Psychiatry · doi:10.1038/mp.2014.80 · Cited by 111
Single prolonged stress impairs social and object novelty recognition in rats
Eagle, A. L., Fitzpatrick, C. J., & Perrine, S. A. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.09.014 · Cited by 117
New insights into early-life stress and behavioral outcomes
Bolton, J. L., Molet, J., Ivy, A. S., & Baram, T. Z. (2017) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2016.12.012 · Cited by 118
Self-citationPlasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance
Birnie, M. T., Kooiker, C. L., Short, A. K., Bolton, J. L., Chen, Y., & Baram, T. Z. (2019) · Biological Psychiatry · doi:10.1016/j.biopsych.2019.12.018 · Cited by 123
Self-citationMolet, J., Maras, P. M., Kinney‐Lang, E., Harris, N. G., Rashid, F. M., Ivy, A. S., Solodkin, A., Obenaus, A., & Baram, T. Z. (2016) · Hippocampus · doi:10.1002/hipo.22661 · Cited by 119
Self-citationKoe, A. S., Ashokan, A., & Mitra, R. (2016) · Translational Psychiatry · doi:10.1038/tp.2015.217 · Cited by 109
Wang, X., Labermaier, C., Holsboer, F., Wurst, W., Deussing, J. M., Müller, M. B., & Schmidt, M. V. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08148.x · Cited by 108
Weissman, D. G., Hatzenbuehler, M. L., Cikara, M., Barch, D. M., & McLaughlin, K. A. (2023) · Nature Communications · doi:10.1038/s41467-023-37778-1 · Cited by 107
Smaller Hippocampal Volume Among Black and Latinx Youth Living in High-Stigma Contexts
Hatzenbuehler, M. L., Weissman, D. G., McKetta, S. C., Lattanner, M. R., Ford, J. V., Barch, D. M., & McLaughlin, K. A. (2021) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2021.08.017 · Cited by 101
Progressive alterations of hippocampal CA3-CA1 synapses in an animal model of depression
Qiao, H., An, S.-C., Ren, W., & Ma, X. (2014) · Behavioural Brain Research · doi:10.1016/j.bbr.2014.08.040 · Cited by 110
A Novel, Noninvasive, Predictive Epilepsy Biomarker with Clinical Potential
Choy, M., Dubé, C. M., Patterson, K. E., Barnes, S. R., Maras, P. M., Blood, A. B., Hasso, A. N., Obenaus, A., & Baram, T. Z. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4806-13.2014 · Cited by 101
Self-citationMcClelland, S., Kőrösi, A., Cope, J. L., Ivy, A. S., & Baram, T. Z. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.008 · Cited by 101
Self-citationO’Keane, V., Lightman, S. L., Patrick, K. L., Marsh, M., Papadopoulos, A. S., Pawlby, S. J., Seneviratne, G., Taylor, A., & Moore, R. G. (2011) · Journal of Neuroendocrinology · doi:10.1111/j.1365-2826.2011.02139.x · Cited by 94
Yang, X.-D., Liao, X.-M., Uribe-Mariño, A., Liu, R., Xie, X.-M., Jia, J., Su, Y.-A., Li, J.-T., Schmidt, M. V., Wang, X.-D., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2014.304 · Cited by 93
Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐ AD mice
Baglietto‐Vargas, D., Chen, Y., Suh, D., Ager, R. R., Rodríguez‐Ortiz, C. J., Medeiros, R., Myczek, K., Green, K. N., Baram, T. Z., & LaFerla, F. M. (2015) · Journal of Neurochemistry · doi:10.1111/jnc.13195 · Cited by 97
Self-citationThe behavioral phenotype of early life adversity: A 3-level meta-analysis of rodent studies
Bonapersona, V., Kentrop, J., Lissa, C. J. V., van der Veen, R., Joëls, M., & Sarabdjitsingh, R. A. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.04.021 · Cited by 95
Hoeijmakers, L., Lucassen, P. J., & Kőrösi, A. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00103 · Cited by 98
Chen, Y., Molet, J., Gunn, B. G., Ressler, K. J., & Baram, T. Z. (2015) · Endocrinology · doi:10.1210/en.2015-1673 · Cited by 87
Self-citationArp, J. M., ter Horst, J. P., Loi, M., den Blaauwen, J. L., Bangert, E., Fernández, G., Joëls, M., Oitzl, M. S., & Krugers, H. J. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.05.009 · Cited by 95
Memory and executive functioning in 12‐year‐old children with a history of institutional rearing
Bick, J., Zeanah, C. H., Fox, N. A., & Nelson, C. A. (2018) · Child Development · doi:10.1111/cdev.12952 · Cited by 90
Pavlakis, A. E., Noble, K. G., Pavlakis, S. G., Ali, N., & Frank, Y. (2014) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2014.11.005 · Cited by 88
Experience-dependent plasticity in an innate social behavior is mediated by hypothalamic LTP
Stagkourakis, S., Spigolon, G., Liu, G., & Anderson, D. J. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2011782117 · Cited by 91
Targeted Overexpression of Mitochondrial Catalase Prevents Radiation-Induced Cognitive Dysfunction
Parihar, V. K., Allen, B. D., Tran, K. K., Chmielewski, N. N., Craver, B. M., Martirosian, V., Morganti, J. M., Rosi, S., Vlkolinský, R., Acharya, M. M., et al. (2014) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.5929 · Cited by 89
Programming the Brain and Behaviour by Early‐Life Stress: A Focus on Neuroactive Steroids
Brunton, P. J. (2015) · Journal of Neuroendocrinology · doi:10.1111/jne.12265 · Cited by 88
Early life adversity as a risk factor for cognitive impairment and Alzheimer’s disease
Huang, Z., Jordan, J. D., & Zhang, Q. (2023) · Translational Neurodegeneration · doi:10.1186/s40035-023-00355-z · Cited by 98
Wang, A., Nie, W., Li, H., Hou, Y.-H., Yu, Z., Fan, Q., & Sun, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094394 · Cited by 85
Sousa, V. C., Vital, J., Costenla, A. R., Batalha, V. L., Sebastião, A. M., Ribeiro, J. A., & Lopes, L. V. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.024 · Cited by 98
Early secure attachment as a protective factor against later cognitive decline and dementia
Walsh, E., Blake, Y., Donati, A., Stoop, R., & von Gunten, A. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00161 · Cited by 84
Lauková, M., Alaluf, L. G., Serova, L. I., Arango, V., & Sabban, E. L. (2014) · Endocrinology · doi:10.1210/en.2014-1192 · Cited by 84
Huang, L. (2014) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2014.00008 · Cited by 85
The aged brain: genesis and fate of residual progenitor cells in the subventricular zone
Capilla‐González, V., Herranz‐Pérez, V., & García‐Verdugo, J. M. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00365 · Cited by 82
Lambert, H. K., Sheridan, M. A., Sambrook, K., Rosen, M. L., Askren, M. K., & McLaughlin, K. A. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2618-16.2017 · Cited by 87
Reincke, S. A. J., & Hanganu‐Opatz, I. L. (2017) · Scientific Reports · doi:10.1038/srep42042 · Cited by 81
Sandman, C. A., Curran, M. M., Davis, E. P., Glynn, L. M., Head, K., & Baram, T. Z. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2017.16121433 · Cited by 84
Self-citationAndres, A. L., Regev, L., Phi, L., Seese, R. R., Chen, Y., Gall, C. M., & Baram, T. Z. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.1445-13.2013 · Cited by 79
Self-citationEarly life stress impairs synaptic pruning in the developing hippocampus
Dayananda, K. K., Ahmed, S., Wang, D., Polis, B., Islam, R., & Kaffman, A. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.09.014 · Cited by 85
Reemst, K., Kracht, L., Kotah, J. M., Rahimian, R., van Irsen, A. A. S., Sotomayor, G. C., Verboon, L. N., Brouwer, N., Simard, S., Turecki, G., et al. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02265-6 · Cited by 80
Liao, X., Yang, X., Jia, J., Li, J., Xie, X., Su, Y., Schmidt, M. V., Si, T., & Wang, X. (2014) · Hippocampus · doi:10.1002/hipo.22254 · Cited by 78
Metadata
- Authors
- Ivy, A. S., Rex, C. S., Chen, Y., Dubé, C., Maras, P. M., Grigoriadis, D. E., Gall, C. M., Lynch, G., & Baram, T. Z.
- Affiliations
- University of California, Irvine (US)
- Neurocrine Biosciences (United States) (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2010-09-29
- Volume
- 30
- Issue
- 39
- Pages
- 13005-13015
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2991143
- OpenAlex
- W2080496806
- Cited by
- 402
- References
- 70
- Citations by year
- 2026: 11 · 2025: 21 · 2024: 27 · 2023: 25 · 2022: 34 · 2021: 21 · 2020: 26 · 2019: 31 · 2018: 20 · 2017: 29 · 2016: 24 · 2015: 26 · 2014: 39 · 2013: 18 · 2012: 28
- FWCI
- 9.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- National Institutes of Health (NS045260)
- National Institute on Aging (AG00358)
- National Institute of Mental Health (MH087467, F31MH087467, MH73136, R01MH073136)
- National Institute of Neurological Disorders and Stroke (P01NS045260, NS 28912, NS045260, R01NS028912, NS051823, R01NS051823, T32NS045540)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal dysfunction, corticotropin-releasing factor, CRF1 receptor, dendritic atrophy, long-term potentiation, learning and memory impairment, novel object recognition, Morris water maze, CRF1 receptor antagonist, hippocampal interneurons, middle-aged rats, organotypic slice cultures
- MeSH terms
- CRF Receptor, Type 1, Animals, Animals, Newborn, Chronic Disease, Cognition Disorders, Corticotropin-Releasing Hormone, Disease Models, Animal, Female, Hippocampus, Humans, Male, Mice, Transgenic, Neurons, Organ Culture Techniques, Stress, Psychological, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Mice, Rats
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