The DOI matches its Crossref record; 50 of the 50 references it cites were found in a registry or an index.
The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus
Open accessAbstract
Activation of the mitogen-activated protein kinase (MAPK) cascade recently was discovered to play an important role in synaptic plasticity in area CA1 of rat hippocampus. However, the upstream mechanisms regulating MAPK activity and the downstream effectors of MAPK in the hippocampus are uncharacterized. In the present studies we observed that hippocampal MAPK activation is regulated by both the PKA and PKC systems; moreover, we found that a wide variety of neuromodulatory neurotransmitter receptors (metabotropic glutamate receptors, muscarinic acetylcholine receptors, dopamine receptors, and β-adrenergic receptors) couple to MAPK activation via these two cascades. In additional studies we observed that PKC is a powerful regulator of CREB phosphorylation in area CA1. MAPK plays a critical role in transcriptional regulation by PKC, because MAPK activation is a necessary component for increased CREB phosphorylation in response to the activation of this kinase. Surprisingly, we also observed that MAPK activation is necessary for PKA coupling to CREB phosphorylation in area CA1. Overall, these studies indicate an unexpected richness of diversity in the regulation of MAPK in the hippocampus and suggest the possibility of a broad role for the MAPK cascade in regulating gene expression in long-term forms of hippocampal synaptic plasticity.
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Cites
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Self-citationcAMP Activates MAP Kinase and Elk-1 through a B-Raf- and Rap1-Dependent Pathway
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Cited by
Function and regulation of CREB family transcription factors in the nervous system
Lonze, B. E., & Ginty, D. D. (2002) · Neuron · doi:10.1016/s0896-6273(02)00828-0 · Cited by 2,127
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Self-citationRole of adrenal stress hormones in forming lasting memories in the brain
McGaugh, J. L., & Roozendaal, B. (2002) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(02)00306-9 · Cited by 818
Ji, R.-R., & Woolf, C. J. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2000.0360 · Cited by 733
Schafe, G. E., Atkins, C. M., Swank, M. W., Bauer, E. P., Sweatt, J. D., & LeDoux, J. E. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-21-08177.2000 · Cited by 674
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Metadata
- Authors
- Roberson, E. D., English, J. D., Adams, J. P., Selcher, J. C., Kondratick, C., & Sweatt, J. D.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-06-01
- Volume
- 19
- Issue
- 11
- Pages
- 4337-4348
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1937085587
- Cited by
- 542
- References
- 50
- FWCI
- 15.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Roberson, E. D., English, J. D., Adams, J. P., Selcher, J. C., Kondratick, C., & Sweatt, J. D. (1999). The Mitogen-Activated Protein Kinase Cascade Couples PKA and PKC to cAMP Response Element Binding Protein Phosphorylation in Area CA1 of Hippocampus. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-11-04337.1999
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