Properties of horizontal and vertical inputs to pyramidal cells in the superficial layers of the cat visual cortex.
Open accessAbstract
The purpose of this study is to elucidate the integrative input mechanisms of pyramidal cells receiving horizontally projecting axon collaterals (horizontal projection) and vertical input from layer IV. We performed whole-cell recordings from pyramidal cells in layer II/III and focally activated other single pyramidal cells monosynaptically connected via long-distance horizontal (LH) projections (the distance between presynaptic and postsynaptic cells was 350-1200 micrometer) in slice preparations of the kitten primary visual cortex. In addition, presynaptic single fibers in layer IV (vertical input) and/or short-distance horizontal (SH) inputs from neighboring single pyramidal cells (distance within 100 micrometer) in layer II/III were activated. Unitary EPSPs evoked by the activation of LH and SH connections had smaller amplitude and larger coefficient of variation than those evoked by stimulating the vertical input. Paired-pulse stimulation of the LH and SH inputs caused the depression of the second EPSP, whereas that of vertical inputs caused either facilitation or depression of the second EPSP. The EPSPs evoked by simultaneous activation of LH and vertical inputs summated linearly at the resting membrane potential. However, the EPSPs evoked by stimulation of the two inputs were nonlinearly (supralinearly) summated when the postsynaptic membrane was depolarized to a certain level. Similar EPSP interaction was observed in response to simultaneous activation of the LH and SH inputs.
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Long distance horizontal connections to pyramidal cells in layer 2/3 exhibit different properties than those from vertical connections.
“Yoshimura et al [49] report that long distance horizontal connections to pyramidal cells in layer 2/3 exhibit different properties than those from vertical connections.”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [49]
Neurons in layer 2/3 are capable of approximating a computation similar to a weighted sum of lateral connections multiplied by a bottom-up input.
“We found several data points suggesting that neurons in layer 2/3 are capable of approximating a similar computation.”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [49]
Under depolarized conditions, the EPSP evoked by activation of an individual input pathway (either horizontal or vertical, but not both) was smaller than that evoked without depolarization.
“They found that, under depolarized conditions, the EPSP evoked by the activation of an individual input pathway (either horizontal or vertical, but not both) was smaller than that evoked without the depolarization.”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [49]
The observed nonlinear summation is attributable to intrinsic membrane properties of the pyramidal cells or synaptic properties of the inputs, rather than properties of the global neuronal circuitry.
“They concluded that this indicated multiplicative supralinear summation of EPSPs caused by simultaneous activation of long range horizontal and vertical inputs under depolarized conditions, and suggested that the observed nonlinear summation is attributable to the intrinsic membrane properties of the pyramidal cells or the synaptic properties of the inputs, rather than the properties of the global”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [49]
When both vertical and horizontal inputs were driven simultaneously, the evoked EPSP was larger than the mathematical summation of the individual EPSPs.
“They also found that when both the vertical and horizontal inputs were driven simultaneously, the evoked EPSP was larger than the mathematical summation of the individual EPSPs.”
From Towards a mathematical theory of cortical micro-circuits (2009) · cites this paper as [49]
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Towards a mathematical theory of cortical micro-circuits
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- Authors
- Yoshimura, Y., Sato, H., Imamura, K., & Watanabe, Y.
- Affiliations
- Research Institute of Environmental Medicine, Nagoya University (JP)
- The University of Osaka (JP)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-03-01
- Volume
- 20
- Issue
- 5
- Pages
- 1931-1940
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6772908
- OpenAlex
- W2105085528
- Cited by
- 67
- References
- 45
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 3 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 1 · 2016: 1 · 2015: 2 · 2014: 7 · 2013: 2 · 2012: 3
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science (98L00201)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- pyramidal neurons, primary visual cortex, horizontal connections, layer 4, synaptic integration, paired-pulse depression, paired-pulse facilitation
- MeSH terms
- Animals, Axons, Cats, Membrane Potentials, Synapses, Visual Cortex, Visual Pathways, Pyramidal Cells, Patch-Clamp Techniques, Excitatory Postsynaptic Potentials, Cell Size, In Vitro Techniques
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