Cited by 245Neuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental DisordersMemory and Neural Mechanisms

The DOI matches its Crossref record; 77 of the 79 references it cites were found in a registry or an index.

Postsynaptic Scaffolds of Excitatory and Inhibitory Synapses in Hippocampal Neurons: Maintenance of Core Components Independent of Actin Filaments and Microtubules

Open access

Allison, Daniel W., Chervin, Adam S., Gelfand, Vladimir I., Craig, Ann Marie·2000·The Journal of Neuroscience

DOI 10.1523/jneurosci.20-12-04545.2000PMC PMC6772458

Open this paper in CoChat — free account Open PDF

Abstract

The mechanisms responsible for anchoring molecular components of postsynaptic specializations in the mammalian brain are not well understood but are presumed to involve associations with cytoskeletal elements. Here we build on previous studies of neurotransmitter receptors (Allison et al., 1998) to analyze the modes of attachment of scaffolding and signal transducing proteins of both glutamate and GABA postsynaptic sites to either the microtubule or microfilament cytoskeleton. Hippocampal pyramidal neurons in culture were treated with latrunculin A to depolymerize actin, with vincristine to depolymerize microtubules, or with Triton X-100 to extract soluble proteins. The synaptic clustering of PSD-95, a putative NMDA receptor anchoring protein and a core component of the postsynaptic density (PSD), was unaffected by actin depolymerization, microtubule depolymerization, or detergent extraction. The same was largely true for GKAP, a PSD-95-interacting protein. In contrast, the synaptic clustering of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)alpha, another core component of the PSD, was completely dependent on an intact actin cytoskeleton and was partially disrupted by detergent. Drebrin and alpha-actinin-2, actin-binding proteins concentrated in spines, were also dependent on F-actin for synaptic localization but were unaffected by detergent extraction. Surprisingly, the subcellular distributions of the inhibitory synaptic proteins GABA(A)R and gephyrin, which has a tubulin-binding motif, were unaffected by depolymerization of microtubules or actin or by detergent extraction. These studies reveal an unsuspected heterogeneity in the modes of attachment of postsynaptic proteins to the cytoskeleton and support the idea that PSD-95 and gephyrin may be core scaffolding components independent of the actin or tubulin cytoskeleton.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.20-12-04545.2000

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95
Kornau, H., Schenker, L. T., Kennedy, M. B., & Seeburg, P. H. (1995) · Science · doi:10.1126/science.7569905 · Cited by 1,916
Untitled work
(1991) · Medical Entomology and Zoology · Cited by 1,512
Dendritic spine changes associated with hippocampal long-term synaptic plasticity
Engert, F., & Bonhoeffer, T. (1999) · Nature · doi:10.1038/19978 · Cited by 1,412
Rat hippocampal neurons in dispersed cell culture.
Banker, G. A., & Cowan, W. M. (1977) · Brain Research · doi:10.1016/0006-8993(77)90594-7 · Cited by 1,110
Dendritic Spines: Cellular Specializations Imparting Both Stability and Flexibility to Synaptic Function
Harris, K. M., & Kater, S. B. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.002013 · Cited by 1,020
Shank, a Novel Family of Postsynaptic Density Proteins that Binds to the NMDA Receptor/PSD-95/GKAP Complex and Cortactin
Naisbitt, S., Kim, E., Tu, J. C., Xiao, B., Sala, C., Valtschanoff, J., Weinberg, R. J., Worley, P. F., & Sheng, M. (1999) · Neuron · doi:10.1016/s0896-6273(00)80809-0 · Cited by 1,009
Postsynaptic clustering of major GABAA receptor subtypes requires the γ2 subunit and gephyrin
Essrich, C., Lorez, M., Benson, J. A., Fritschy, J., & Lüscher, B. (1998) · Nature Neuroscience · doi:10.1038/2798 · Cited by 856
GABAA-receptor-associated protein links GABAA receptors and the cytoskeleton
Wang, H.-B., Bedford, F., Brandon, N., Moss, S., & Olsen, R. (1999) · Nature · doi:10.1038/16264 · Cited by 754
Dynamic Control of CaMKII Translocation and Localization in Hippocampal Neurons by NMDA Receptor Stimulation
Shen, K., & Meyer, T. (1999) · Science · doi:10.1126/science.284.5411.162 · Cited by 673
Competitive binding of α-actinin and calmodulin to the NMDA receptor
Wyszynski, M., Lin, J., Rao, A., Nigh, E., Beggs, A. H., Craig, A. M., & Sheng, M. (1997) · Nature · doi:10.1038/385439a0 · Cited by 596
Self-citation

Show all 79 references

Sorted by citations

Items 101–200 of 243

Spinophilin is phosphorylated by Ca2+/calmodulin‐dependent protein kinase II resulting in regulation of its binding to F‐actin
Grossman, S. D., Futter, M., Snyder, G. L., Allen, P. B., Nairn, A. C., Greengard, P., & Hsieh‐Wilson, L. C. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02491.x · Cited by 62
Synaptic structure and diffusion dynamics of synaptic receptors
Triller, A., & Choquet, D. (2003) · Biology of the Cell · doi:10.1016/j.biolcel.2003.07.001 · Cited by 67
Shank–cortactin interactions control actin dynamics to maintain flexibility of neuronal spines and synapses
MacGillavry, H. D., Kerr, J. M., Kassner, J. D., Frost, N. A., & Blanpied, T. A. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13129 · Cited by 63
Two pools of Triton X‐100‐insoluble GABAA receptors are present in the brain, one associated to lipid rafts and another one to the post‐synaptic GABAergic complex
Li, X., Serwanski, D. R., Miralles, C. P., Bahr, B. A., & Blas, A. L. D. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04635.x · Cited by 54
Enhanced Vulnerability to NMDA Toxicity in Sublethal Traumatic Neuronal Injury In Vitro
Arundine, M., Chopra, G. K., Wrong, A., Lei, S., Aarts, M. M., MacDonald, J. F., & Tymianski, M. (2003) · Journal of Neurotrauma · doi:10.1089/089771503322686166 · Cited by 51
Mechanisms of Transport and Exocytosis of Dense-Core Granules Containing Tissue Plasminogen Activator in Developing Hippocampal Neurons
Silverman, M. A., Johnson, S., Gurkins, D., Farmer, M., Lochner, J. E., Rosa, P., & Scalettar, B. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4694-04.2005 · Cited by 52
Glutamate-induced δ-catenin redistribution and dissociation from postsynaptic receptor complexes
Jones, S. B., Lanford, G. W., Chen, Y., Moribito, M., Kim, K., & Lu, Q. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00532-8 · Cited by 50
α-Actinin-2 Mediates Spine Morphology and Assembly of the Post-Synaptic Density in Hippocampal Neurons
Hodges, J., Martín‐Vílchez, S., Asmussen, H., Whitmore, L. A., & Horwitz, A. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101770 · Cited by 50
Cytoskeletal makeup of the synapse: Shaft versus spine
Bucher, M., Fanutza, T., & Mikhaylova, M. (2019) · Cytoskeleton · doi:10.1002/cm.21583 · Cited by 51
Potentiation of GABA A Currents after Mechanical Injury of Cortical Neurons
Kao, C.-Q., Goforth, P. B., Ellis, E. F., & Satin, L. S. (2004) · Journal of Neurotrauma · doi:10.1089/089771504322972059 · Cited by 50
Drebrin particles: components in the ensemble of proteins regulating actin dynamics of lamellipodia and filopodia
Peitsch, W. K., Hofmann, I., Prätzel, S., Gründ, C., Kuhn, C., Moll, I., Langbein, L., & Franke, W. W. (2001) · European Journal of Cell Biology · doi:10.1078/0171-9335-00194 · Cited by 47
The state of the actin cytoskeleton determines its association with gephyrin: Role of ena/VASP family members
Bausen, M., Fuhrmann, J. C., Betz, H., & O’Sullivan, G. A. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.11.004 · Cited by 47
Cellular transport and membrane dynamics of the glycine receptor
Dumoulin, A. (2009) · Frontiers in Molecular Neuroscience · doi:10.3389/neuro.02.028.2009 · Cited by 45
Cdk5 in Neuroskeletal Dynamics
Smith, D. S. (2003) · Neurosignals · doi:10.1159/000074626 · Cited by 45
Substrate-selective and Calcium-independent Activation of CaMKII by α-Actinin
Jalan‐Sakrikar, N., Bartlett, R. K., Baucum, A. J., & Colbran, R. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.351817 · Cited by 47
Chapter 13 Synaptic and extrasynaptic GABAA receptor and gephyrin clusters
Christie, S. B., Li, R.-W., Miralles, C. P., Riquelme, R., Yang, B. Y., Charych, E. I., Yu, W., Daniels, S. B., Cantino, M. E., & Blas, A. L. D. (2002) · Progress in brain research · doi:10.1016/s0079-6123(02)36015-1 · Cited by 43
Neurons: The Interplay between Cytoskeleton, Ion Channels/Transporters and Mitochondria
Alberti, P., Semperboni, S., Cavaletti, G., & Scuteri, A. (2022) · Cells · doi:10.3390/cells11162499 · Cited by 42
Accelerators, Brakes, and Gears of Actin Dynamics in Dendritic Spines
Pontrello, C. G., & Ethell, I. M. (2009) · The Open Neuroscience Journal · doi:10.2174/1874082000903020067 · Cited by 45
Cell Biological and Biochemical Characterization of Drebrin Complexes in Mesangial Cells and Podocytes of Renal Glomeruli
Peitsch, W. K., Hofmann, I., Endlich, N., Prätzel, S., Kuhn, C., Spring, H., Gröne, H., Kriz, W., & Franke, W. W. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000069222.63700.de · Cited by 42
Actin and Actin-Binding Proteins: Masters of Dendritic Spine Formation, Morphology, and Function
Lin, W., & Webb, D. J. (2009) · The Open Neuroscience Journal · doi:10.2174/1874082000903020054 · Cited by 42
Depolarization-induced translocation of the RNA-binding protein Sam68 to the dendrites of hippocampal neurons
Fredj, N. B., Grange, J., Sadoul, R., Richard, S., Goldberg, Y., & Boyer, V. (2004) · Journal of Cell Science · doi:10.1242/jcs.00927 · Cited by 40
Stress-Induced Thermoprotection of Neuromuscular Transmission
Klose, M. K. (2004) · Integrative and Comparative Biology · doi:10.1093/icb/44.1.14 · Cited by 40
Developmentally regulated changes in cellular compartmentation and synaptic distribution of actin in hippocampal neurons
Zhang, W., & Benson, D. L. (2002) · Journal of Neuroscience Research · doi:10.1002/jnr.10313 · Cited by 38
Modification of AMPA receptor clustering regulates cerebellar synaptic plasticity
Hirai, H. (2001) · Neuroscience Research · doi:10.1016/s0168-0102(00)00237-6 · Cited by 40
EPHB receptor signaling in dendritic spine development
Irie, F. (2004) · Frontiers in bioscience · doi:10.2741/1325 · Cited by 40
Developmental-Dependent Action of Microtubule Depolymerization on the Function and Structure of Synaptic Glycine Receptor Clusters in Spinal Neurons
van Zundert, B., Álvarez, F. J., Tapia, J. C., Yeh, H. H., Diaz, E., & Aguayo, L. G. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00364.2003 · Cited by 38
A Pictorial History of the Neuronal Cytoskeleton
Leterrier, C. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.2872-20.2020 · Cited by 31
Photodynamic sensitizers modulate cytoskeleton structural dynamics in neuronal cells
Dubey, T., & Chinnathambi, S. (2021) · Cytoskeleton · doi:10.1002/cm.21655 · Cited by 36
Seizures Induced by in Vivo Latrunculin A and Jasplakinolide Microperfusion in the Rat Hippocampus
Sierra‐Paredes, G., Oreiro-García, T., Núñez-Rodriguez, A., Vázquez-López, A., & Sierra‐Marcuño, G. (2006) · Journal of Molecular Neuroscience · doi:10.1385/jmn:28:2:151 · Cited by 38
Potentiation of the osmosensitive taurine release and cell volume regulation by cytosolic Ca 2+ rise in cultured cerebellar astrocytes
Cardin, V., Lezama, R. A., Torres-Márquez, M. E., & Pasantes‐Morales, H. (2003) · Glia · doi:10.1002/glia.10271 · Cited by 36
NCAM/Spectrin Complex Disassembly Results in PSD Perforation and Postsynaptic Endocytic Zone Formation
Puchkov, D., Leshchyns’ka, I., Nikonenko, A. G., Schachner, M., & Sytnyk, V. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq283 · Cited by 35
Hyperthermic seizure induces persistent alteration in excitability of the dentate gyrus in immature rats
Kwak, S., Kim, J., Kim, S. C., Kwon, O., Choi, S., & Kang, T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.04.026 · Cited by 35
Regulation of synapse composition by protein acetylation: the role of acetylated cortactin
Catarino, T., Ribeiro, L. F., Santos, S. D., & Carvalho, A. L. (2012) · Journal of Cell Science · doi:10.1242/jcs.110742 · Cited by 36
Synaptogenesis in the cerebellar cortex: Differential regulation of gephyrin and GABAA receptors at somatic and dendritic synapses of Purkinje cells
Viltono, L., Patrizi, A., Fritschy, J., & Sassoé‐Pognetto, M. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21713 · Cited by 33
Compatibility between itinerant synaptic receptors and stable postsynaptic structure
Sekimoto, K., & Triller, A. (2009) · Physical Review E · doi:10.1103/physreve.79.031905 · Cited by 37
Colocalization of -actinin and Synaptopodin in the Pyramidal Cell Axon Initial Segment
Sánchez-Ponce, D., Blázquez‐Llorca, L., DeFelipe, J., Garrido, J. J., & Muñoz, A. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhr251 · Cited by 34
Gephyrin Palmitoylation in Basolateral Amygdala Mediates the Anxiolytic Action of Benzodiazepine
Shen, Z., Wu, P., Wang, F., Xia, Z., Deng, Q., Nie, T., Zhang, S.-Q., Zheng, H., Liu, W., Lu, J.-J., et al. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.09.024 · Cited by 32
Synaptic and Nuclear Localization of Brain-Enriched Guanylate Kinase-Associated Protein
Yao, I., Iida, J., Nishimura, W., & Hata, Y. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-13-05354.2002 · Cited by 32
Regulation of postsynaptic gephyrin cluster size by protein phosphatase 1
Bausen, M., Weltzien, F., Betz, H., & O’Sullivan, G. A. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.02.007 · Cited by 30
Glutamate‐induced declustering of post‐synaptic adaptor protein Cupidin (Homer 2/vesl‐2) in cultured cerebellar granule cells
Shiraishi, Y., Mizutani, A., Yuasa, S., Mikoshiba, K., & Furuichi, T. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.02003.x · Cited by 30
Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid β-Derived Neurotoxins
Lambert, M., Velasco, P., Viola, K., & Klein, W. (2009) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152709787601876 · Cited by 29
Role of Ca2+ and calmodulin‐dependent enzymes in the regulation of glycine transport in Müller glia
Gadea, A., López, E., Hernández‐Cruz, A., & López-Colomé, A. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.0022-3042.2001.00735.x · Cited by 27
In vivo, competitive blockade of N-methyl-d-aspartate receptors induces rapid changes in filamentous actin and drebrin A distributions within dendritic spines of adult rat cortex
Fujisawa, S., Shirao, T., & Aoki, C. J. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.03.009 · Cited by 27
Mitigation of synaptic and memory impairments via F-actin stabilization in Alzheimer’s disease
Haseena, P. A., Basavaraju, N., Chandran, M., Jaleel, A., Bennett, D. A., & Kommaddi, R. P. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01558-w · Cited by 26
General Introduction to Drebrin
Shirao, T., & Sekino, Y. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-4-431-56550-5_1 · Cited by 25
SIPA1L1/SPAR1 Interacts with the Neurabin Family of Proteins and is Involved in GPCR Signaling
Matsuura, K., Kobayashi, S., Konno, K., Yamasaki, M., Horiuchi, T., Senda, T., Hayashi, T., Satoh, K., Arima-Yoshida, F., Iwasaki, K., et al. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.0569-21.2022 · Cited by 25
Essential Contribution of the Ligand-Binding βB/βC Loop of PDZ1 and PDZ2 in the Regulation of Postsynaptic Clustering, Scaffolding, and Localization of Postsynaptic Density-95
Nonaka, M., Doi, T., Fujiyoshi, Y., Takemoto‐Kimura, S., & Bito, H. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2489-05.2006 · Cited by 25
Glycine Receptors Involved in Synaptic Transmission Are Selectively Regulated by the Cytoskeleton in Mouse Spinal Neurons
van Zundert, B., Álvarez, F. J., Yévenes, G. E., Cárcamo, J. G., Vera, J. C., & Aguayo, L. G. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00455.2001 · Cited by 25
Fast interaction between AMPA and NMDA receptors by intracellular calcium
Rozov, A. V., & Burnashev, N. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.09.005 · Cited by 24
Lethal weapon: amyloid β-peptide, role in the oxidative stress and neurodegeneration of Alzheimer’s disease
Lahiri, D. K., & Greig, N. H. (2004) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2004.02.002 · Cited by 26
White matter disturbances in phenylketonuria: Possible underlying mechanisms
Ferreira, B. K., Rodrigues, M. T., STRECK, E. L., Ferreira, G. C., & Schuck, P. F. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24598 · Cited by 25
Molecules that Disrupt Memory Circuits in Alzheimer’s Disease: The Attack on Synapses by Aβ Oligomers (ADDLs)
Klein, W. L., Lacor, P. N., Felice, F. G. D., & Ferreira, S. T. (2007) · Research and perspectives in neurosciences · doi:10.1007/978-3-540-45702-2_11 · Cited by 23
"MEMORY BYTES" — MOLECULAR MATCH FOR CaMKII PHOSPHORYLATION ENCODING OF MICROTUBULE LATTICES
Hameroff, S. R., Craddock, T. J. A., & Tuszyński, J. A. (2010) · Journal of Integrative Neuroscience · doi:10.1142/s0219635210002482 · Cited by 23
Exercise intensities modulate cognitive function in spontaneously hypertensive rats through oxidative mediated synaptic plasticity in hippocampus
Lee, C., Wu, D., Chen, S., Lin, Y., & Lee, T. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16816 · Cited by 21
Involvement of the Snk-SPAR pathway in glutamate-induced excitotoxicity in cultured hippocampal neurons
Wu, L., Sun, C., Zhang, Y., Fan, M., Xu, J., Ma, H., & Jian, Z. (2007) · Brain Research · doi:10.1016/j.brainres.2007.06.082 · Cited by 21
A role for the cytoskeleton in heat‐shock–mediated thermoprotection of locust neuromuscular junctions
Klose, M. K., Armstrong, G. A. B., & Robertson, R. M. (2004) · Journal of Neurobiology · doi:10.1002/neu.20058 · Cited by 21
Modulation of the NMDA Receptor Through Secreted Soluble Factors
Cerpa, W. F., Ramos‐Fernández, E., & Inestrosa, N. C. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-9009-x · Cited by 20
PLPP/CIN regulates bidirectional synaptic plasticity via GluN2A interaction with postsynaptic proteins
Kim, J., Kim, Y.-J., Lee, D.-S., Kim, J. Y., Ko, A.-R., Hyun, H.-W., Kim, M. J., & Kang, T. (2016) · Scientific Reports · doi:10.1038/srep26576 · Cited by 21
Acute reorganization of postsynaptic GABAA receptors reveals the functional impact of molecular nanoarchitecture at inhibitory synapses
Olah, S. S., Kareemo, D. J., Buchta, W. C., Sinnen, B. L., Miller, C. N., Actor-Engel, H. S., Gookin, S. E., Winborn, C. S., Kleinjan, M. S., Crosby, K. C., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113331 · Cited by 19
LIS1-dependent retrograde translocation of excitatory synapses in developing interneuron dendrites
Kawabata, I., Kashiwagi, Y., Obashi, K., Ohkura, M., Nakai, J., Wynshaw-Boris, A. J., Yanagawa, Y., & Okabe, S. (2012) · Nature Communications · doi:10.1038/ncomms1736 · Cited by 19
Synaptic activity and F-actin coordinately regulate CaMKIIα localization to dendritic postsynaptic sites in developing hippocampal slices
Ahmed, R., Zha, X., Green, S. H., & Dailey, M. E. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.08.020 · Cited by 18
Late‐phase, protein synthesis‐dependent long‐term potentiation in hippocampal CA1 pyramidal neurones with destabilized microtubule networks
Vickers, C. A., & Wyllie, D. J. A. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707314 · Cited by 18
The Calcineurin Inhibitor Ascomicin Interferes with the Early Stage of the Epileptogenic Process Induced by Latrunculin A Microperfusion in Rat Hippocampus
Freire‐Cobo, C., Sierra‐Paredes, G., Freire, M., & Sierra‐Marcuño, G. (2014) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-014-9558-9 · Cited by 17
Linking the synapse to the cytoskeleton: a breath-taking role for microfilaments
Jockusch, B. M., Rothkegel, M., & Schwarz, G. (2004) · Neuroreport · doi:10.1097/01.wnr.0000131673.92694.58 · Cited by 14
Seizures induced by microperfusion of glutamate and glycine in the hippocampus of rats pretreated with latrunculin A
Vázquez-López, A., Sierra‐Paredes, G., & Sierra‐Marcuño, G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.06.063 · Cited by 14
Network, Cellular, and Molecular Mechanisms Underlying Long-Term Memory Formation
Carasatorre, M., & Ramı́rez-Amaya, V. (2012) · Current topics in behavioral neurosciences · doi:10.1007/7854_2012_229 · Cited by 14
Intramyocardial injection of human adipose-derived stem cells ameliorates cognitive deficit by regulating oxidative stress–mediated hippocampal damage after myocardial infarction
Lee, T., Lee, C.-C., Harn, H., Chiou, T., Chuang, M., Chen, C., Chuang, C., Lin, P., & Lin, S. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02135-6 · Cited by 12
Immobilized Pool of NCAM180 in the Postsynaptic Membrane Is Homeostatically Replenished by the Flux of NCAM180 from Extrasynaptic Regions
Leshchyns’ka, I., Tanaka, M. M., Schachner, M., & Sytnyk, V. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.252098 · Cited by 11
PLPP/CIN-mediated NF2-serine 10 dephosphorylation regulates F-actin stability and Mdm2 degradation in an activity-dependent manner
Kim, J., Lee, D.-S., Kim, T. H., Park, H., Kim, M.-J., & Kang, T. (2021) · Cell Death and Disease · doi:10.1038/s41419-020-03325-9 · Cited by 11
Cytotoxic Intermediates in the Fibrillation Pathway: Aβ Oligomers in Alzheimer’s Disease as a Case Study
Klein, W. L. (2007) · Springer eBooks · doi:10.1007/0-387-25919-8_4 · Cited by 11
Subcellular localization and regulation of GABAA receptors and associated proteins
Lüscher, B., & Fritschy, J. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)48013-5 · Cited by 10
Binding of gephyrin to microtubules is regulated by its phosphorylation at Ser270
Zhou, L., Kiss, É., Demmig, R., Kirsch, J., Nawrotzki, R., & Kuhse, J. (2021) · Histochemistry and Cell Biology · doi:10.1007/s00418-021-01973-2 · Cited by 10
Drebrin and Spine Formation
Takahashi, H., & Naito, Y. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-4-431-56550-5_10 · Cited by 10
Changes in cytoskeletal gene expression linked to MPTP-treatment in Mice
Cuadrado‐Tejedor, M., Sesma, M. T., Giménez‐Amaya, J. M., & Ortíz, L. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.05.014 · Cited by 9
The actin binding protein α-actinin-2 expression is associated with dendritic spine plasticity and migrating granule cells in the rat dentate gyrus following pilocarpine-induced seizures
Sbai, O., Soussi, R., Bôle, A., Khrestchatisky, M., Esclapez, M., & Ferhat, L. (2020) · Experimental Neurology · doi:10.1016/j.expneurol.2020.113512 · Cited by 8
Septin 6 localizes to microtubules in neuronal dendrites
Moon, I. S., Lee, H., & Walikonis, R. S. (2012) · Cytotechnology · doi:10.1007/s10616-012-9477-7 · Cited by 8
Actin Cytoskeleton at the Synapse: An Alzheimer's Disease Perspective
Haseena, P. A., Basavaraju, N., Gupta, A., & Kommaddi, R. P. (2025) · Cytoskeleton · doi:10.1002/cm.21993 · Cited by 9
The role of selected postsynaptic scaffolding proteins at glutamatergic synapses in autism-related animal models
Melišková, V., Havránek, T., Bačová, Z., & Bakoš, J. (2021) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2004106 · Cited by 7
Single-cell reconstruction reveals input patterns and pathways into corticotropin-releasing factor neurons in the central amygdala in mice
Huang, C., Wang, Y., Chen, P., Shan, Q., Wang, H., Ding, L., Bi, G., & Zhou, J. (2022) · Communications Biology · doi:10.1038/s42003-022-03260-9 · Cited by 7
Imbalance of synaptic and extrasynaptic NMDA receptors induced by the deletion of CRMP1 accelerates age-related cognitive decline in mice
Tsai, Y.-C., Huang, S., Peng, H., Lin, S., Lin, S., Chin, T., & Huang, S. (2023) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2023.12.006 · Cited by 7
Drebrin expression is increased in spinal motoneurons of rats after axotomy
Kobayashi, S., Shirao, T., & Sasaki, T. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02155-3 · Cited by 7
Network features and pathway analyses of a signal transduction cascade
Yamashima, R. (2009) · Frontiers in Neuroinformatics · doi:10.3389/neuro.11.013.2009 · Cited by 7
Why Alzheimer’s is a Disease of Memory: Synaptic Targeting by Pathogenic Aβ Oligomers (ADDLs)
Klein, W. L., Felice, F. G. D., Lacor, P. N., Lambert, M. P., & Zhao, W.-Q. (2008) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-540-76330-7_9 · Cited by 7
Repeated carbenoxolone injections during late pregnancy alter Snk-SPAR and PSD-95 expression in the hippocampus of rat pups
Surakul, P., Weerachatyanukul, W., & Chutabhakdikul, N. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.02.060 · Cited by 7
PTBP-dependent PSD-95 and CamKIIα alternative splicing in the lens.
Frederikse, P. H., Nandanoor, A., & Kasinathan, C. (2014) · Europe PMC (PubMed Central) · Cited by 6
An investigation into the role of calcium in the modulation of rat synaptosomal d-[3H]aspartate transport by docosahexaenoic acid
Berry, C. B., & McBean, G. J. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02565-4 · Cited by 6
NMDA Receptors
Petralia, R. S., & Wenthold, R. J. (2008) · Humana Press eBooks · doi:10.1007/978-1-59745-055-3_2 · Cited by 7
Mobility of acetylcholine receptors in command Helix lucorum neurons in a cellular analog of habituation
Pivovarov, A. S., Murzina, G. B., Makhnovsky, D. A., Tret’yakova, M. S., & Vasil’yeva, N. A. (2013) · Invertebrate Neuroscience · doi:10.1007/s10158-013-0155-z · Cited by 4
Subunit-Specific NMDA Receptor Trafficking to Synapses
Barría, A. (2007) · Elsevier eBooks · doi:10.1016/b978-012369437-9/50015-3 · Cited by 4
The Role of Actin Microfilaments in Depression of Acetylcholine-Induced Currents in Common Snail Neurons in a Cellular Analog of Habituation
Pivovarov, A. S., Васильева, Н. А., Murzina, G. B., & Makhnovsky, D. A. (2013) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-013-9771-7 · Cited by 3
Role of microtubules in late-associative plasticity of hippocampal Schaffer collateral-CA1 synapses in mice
Jing, D., Li, D., Cheng, P., Chen, Y., & Behnisch, T. (2019) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2019.107038 · Cited by 3
Effect Alkaloid and aqueous extraction of Convolvulus Scammonia on microtubules of CHO cell line(china hamster)
Hade, I., & Zenia, T. A. (2011) · Diyala Journal for Pure Science · Cited by 3
The combined disruption of microfilaments and microtubules affects the distribution and function of GABAA receptors in rat cerebellum granule cells in culture
Luccardini, C., Casagrande, S., Cupello, A., Pellistri, F., Ramoino, P., & Robello, M. (2004) · Neuroscience Letters · doi:10.1016/j.neulet.2004.01.067 · Cited by 3
A novel approach reveals temporal patterns of synaptogenesis between the isolated growth cones of Lymnaea neurons
Luk, C., Schmold, N., Lee, T. K. M., & Syed, N. I. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07428.x · Cited by 3
The Role of the Postsynaptic Density and the Spine Cytoskeleton in Synaptic Plasticity
Marcora, E. M., Carlisle, H. J., & Kennedy, M. B. (2008) · Elsevier eBooks · doi:10.1016/b978-012370509-9.00036-x · Cited by 4
Antibodies in Stiff-Person Spectrum Disorders and Their Correlations with Clinical Phenotypes
Termsarasab, P., Thammongkolchai, T., & Katirji, B. (2020) · Springer eBooks · doi:10.1007/978-3-030-43059-7_8 · Cited by 2
Disrupting Protein-Protein Interaction: Therapeutic Tools Against Brain Damage
Aarts, M. M., & Tymianski, M. (2005) · Springer eBooks · doi:10.1007/0-387-24532-4_12 · Cited by 2
Partial seizures induced by latrunculin A microperfusion in the mouse hippocampus: Role of extracellular glutamate and NMDA receptors
(2015) · Molecular & Cellular Epilepsy · doi:10.14800/mce.608 · Cited by 2
Peptide action in stroke therapy
Aarts, M. M., & Tymianski, M. (2003) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.3.7.1093 · Cited by 2
Influence of receptor lateral diffusion on depression of neuronal cholinosensitivity
Murzina, G. B. (2013) · BIOPHYSICS · doi:10.1134/s000635091303010x · Cited by 2

Authors: Allison, D. W., Chervin, A. S., Gelfand, V. I., & Craig, A. M.
Affiliations: University of Illinois Urbana-Champaign (US)
ORCID: Chervin, Adam S.
Gelfand, Vladimir I.
Craig, Ann Marie
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2000-06-15
Volume: 20
Issue: 12
Pages: 4545-4554
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.20-12-04545.2000
PMC: PMC6772458
OpenAlex: W2148256023
Cited by: 245
References: 79
Citations by year: 2025: 5 · 2024: 3 · 2023: 2 · 2022: 4 · 2021: 10 · 2020: 4 · 2019: 3 · 2018: 4 · 2017: 5 · 2016: 2 · 2015: 5 · 2014: 12 · 2013: 8 · 2012: 7
FWCI: 8.28
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
National Institutes of Health (GM-52111)
National Institute of General Medical Sciences (R01GM052111, GM52111-01)
National Institute of Neurological Disorders and Stroke (NS33184, R01NS033184)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: postsynaptic scaffolds, postsynaptic density, actin cytoskeleton, microtubules, PSD-95, GKAP, CaMKIIα, drebrin, ACTN2, GABAA receptor, gephyrin, glutamatergic synapses, inhibitory synapses, hippocampal pyramidal neurons, latrunculin A, vincristine, detergent extraction, dendritic spines
MeSH terms: Disks Large Homolog 4 Protein, Actins, Animals, Cells, Cultured, Evoked Potentials, Hippocampus, Marine Toxins, Membrane Proteins, Microtubules, Nerve Tissue Proteins, Neurons, Synapses, Thiazoles, Vincristine, Octoxynol, Bridged Bicyclo Compounds, Heterocyclic, Excitatory Postsynaptic Potentials, Intracellular Signaling Peptides and Proteins, Rats, Thiazolidines

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Postsynaptic Scaffolds of Excitatory and Inhibitory Synapses in Hippocampal Neurons: Maintenance of Core Components Independent of Actin Filaments and Microtubules

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks