The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex
Open accessAbstract
Little is known about regionally specific signals that control the number of neuronal progenitor cells in vivo. We have previously shown that the germline mutation of the basic fibroblast growth factor (Fgf2) gene results in a reduction in the number of cortical neurons in the adult. We show here that Fgf2 is expressed in the pseudostratified ventricular epithelium (PVE) in a dorsoventral gradient and that Fgf2 and its receptor, Fgfr-1, are downregulated by mid to late stages of neurogenesis. In Fgf2 knockout mice, the volume and cell number of the dorsal PVE (the cerebral cortical anlage) are substantially smaller, whereas the volume of the basal PVE is unchanged. The dorsal PVE of Fgf2 knockout mice has a 50% decrease in founder cells and a reduced expansion of the progenitor pool over the first portion of neurogenesis. Despite this reduction, the degree of apoptosis within the PVE is not changed in the Fgf2 knockouts. Cortical neuron number was decreased by 45% in Fgf2 knockout mice by the end of neurogenesis, whereas the number of neurons in the basal ganglia was unaffected. Microscopically, the frontal cerebral cortex of neonatal Fgf2 null mutant mice lacked large neurons in deep cortical layers. We suggest that Fgf2 is required for the generation of a specific class of cortical neurons arising from the dorsal PVE.
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Cites
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The Fibroblast Growth Factor signaling pathway
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BackgroundInfluentialBiomolecular gradients in cell culture systems
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Microfluidic cell culture systems for drug research
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The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis
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Metadata
- Authors
- Raballo, R., Rhee, J., Lyn-Cook, R., Leckman, J. F., Schwartz, M. L., & Vaccarino, F. M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-07-01
- Volume
- 20
- Issue
- 13
- Pages
- 5012-5023
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2124134886
- Cited by
- 420
- References
- 83
- FWCI
- 4.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Raballo, R., Rhee, J., Lyn-Cook, R., Leckman, J. F., Schwartz, M. L., & Vaccarino, F. M. (2000). Basic Fibroblast Growth Factor (Fgf2) Is Necessary for Cell Proliferation and Neurogenesis in the Developing Cerebral Cortex. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-13-05012.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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