Area Postrema Neurons Are Modulated by the Adipocyte Hormone Adiponectin
Open accessAbstract
Adiponectin is an adipocyte-derived peptide hormone involved in energy homeostasis and the pathogenesis of obesity, including hypertension. Area postrema (AP) lacks a blood–brain barrier and is a critical homeostatic integration center for humoral and neural signals. Here we investigate the role of AP in adiponectin signaling. We show that rat AP expresses AdipoR1 and AdipoR2 adiponectin receptor mRNA. We used current-clamp electrophysiology to investigate whether adiponectin influenced membrane properties of AP neurons and found that ∼60% of rat AP neurons tested were sensitive to adiponectin. Additional electrophysiology experiments coupled with single-cell reverse transcription-PCR indicated that all neurons that expressed both subtypes of receptor were sensitive to adiponectin, whereas neurons expressing only one subtype were predominantly insensitive. Last, microinjection of adiponectin into AP caused significant increases in arterial blood pressure, with no change in heart rate, suggesting that adiponectin acts at AP to provide a possible link between control of energy homeostasis and cardiovascular function.
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Adiponectin can directly act on the area postrema, which lies outside the blood-brain barrier, to ultimately regulate cardiovascular function.
“Ferguson’s group (106) has shown that adiponectin can directly act on the area postrema, which lies out with the blood-brain barrier, to ultimately regulate cardiovascular function (106), and the possibility that adiponectin also controls peripheral effects via the central nervous system was alluded to recently with the demonstration of adiponectin, albeit at lower levels and with a different mult”
From Cardiac remodeling in obesity (2008) · cites this paper as [106]
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Self-citationADIPONECTIN MODULATES EXCITABILITY OF SUBFORNICAL ORGAN NEURONS AT DIFFERENT ENERGY STATES
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- Authors
- Fry, M., Smith, P. M., Hoyda, T. D., Duncan, M., Ahima, R. S., Sharkey, K. A., & Ferguson, A. V.
- Affiliations
- Queen's University (CA)
- University of Calgary (CA)
- University of Pennsylvania (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-09-20
- Volume
- 26
- Issue
- 38
- Pages
- 9695-9702
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6674457
- OpenAlex
- W1978088424
- Cited by
- 100
- References
- 52
- Citations by year
- 2026: 2 · 2024: 1 · 2022: 1 · 2021: 4 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 5 · 2015: 5 · 2014: 8 · 2013: 4 · 2012: 9
- FWCI
- 3.92
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Heart and Stroke Foundation of Canada
- Crohn's and Colitis Foundation
- Crohn's and Colitis Foundation of Canada
- Canadian Association of Gastroenterology
- Fondation pour la Recherche Médicale
- Alberta Heritage Foundation for Medical Research
- National Institutes of Health
- Canadian Institutes of Health Research
- National Institute of Diabetes and Digestive and Kidney Diseases (P01-DK49210, P01DK049210)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Keywords
- adiponectin, area postrema, AdipoR1, AdipoR2, adiponectin receptors, neuronal excitability, blood pressure regulation, energy homeostasis, obesity, hypertension, neuroendocrine regulation, hypothalamic neurons
- MeSH terms
- Animals, Cells, Cultured, Hormones, Male, Neurons, Receptors, Cell Surface, RNA, Messenger, Rats, Sprague-Dawley, Adipocytes, Area Postrema, Rats, Adiponectin, Receptors, Adiponectin
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