The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Sex Difference and Steroid Modulation of Pheromone-Induced Immediate Early Genes in the Two Zones of the Mouse Accessory Olfactory System
Open accessAbstract
Two anatomically and neurochemically distinct zones within the vomeronasal organ (VNO) and accessory olfactory bulb (AOB) have been identified that are responsible for the detection of pheromones. Using markers to distinguish between apical and basal neurons of the VNO neuroepithelium and rostral versus caudal AOB glomeruli, we examined immediate early gene immunoreactivity (IEG-IR) in gonadectomized, steroid-treated mice in response to pheromones of male and female conspecifics. After exposure of estradiol-treated females to soiled male bedding, more VNO neurons in the basal than the apical layer exhibited IEG-IR compared with VNO neurons of estradiol-treated males. Conversely, whereas soiled female bedding failed to induce IEG-IR in VNO neurons of estradiol-treated males or females, both apical and basal neurons were activated in testosterone-treated males. Male and female pheromones also activated mitral and granule cells in the AOBs of all subjects, but responses to different pheromones were distributed across the boundary of the rostral and caudal regions. These data show that differences in the response of males and females to the same pheromonal stimulus are found in the sensory neurons of the VNO. We propose that centrifugal, noradrenergic inputs to VNO neurons, which may differ in the two sexes and respond differently to adult sex steroids, modulate sensitivity to pheromonal stimulation.
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“Indeed, a number of studies have shown that responses of VNO sensory neurons can be modulated by hormones, internal status, and sensory experience in a sex-specific manner (Dey et al., 2015; Halem et al., 2001; Tachikawa et al., 2013; Xu et al., 2016).”
From Neuronal Representation of Social Information in the Medial Amygdala of Awake Behaving Mice (2017) · cites this paper as Halem et al., 2001
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A novel family of genes encoding putative pheromone receptors in mammals
Dulac, C., & Axel, R. (1995) · Cell · doi:10.1016/0092-8674(95)90161-2 · Cited by 1,001
An Exteroceptive Block to Pregnancy in the Mouse
Bruce, H. M. (1959) · Nature · doi:10.1038/184105a0 · Cited by 746
A Multigene Family Encoding a Diverse Array of Putative Pheromone Receptors in Mammals
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A New Multigene Family of Putative Pheromone Receptors
Ryba, N. J. P., & Tirindelli, R. (1997) · Neuron · doi:10.1016/s0896-6273(00)80946-0 · Cited by 598
Sexual selection for sensory exploitation in the frog Physalaemus pustulosus
Ryan, M. J., Fox, J. H., Wilczynski, W., & Rand, A. S. (1990) · Nature · doi:10.1038/343066a0 · Cited by 584
Ultrasensitive pheromone detection by mammalian vomeronasal neurons
Leinders-Zufall, T., Lane, A. P., Puche, A. C., Ma, W., Novotny, M. V., Shipley, M. T., & Zufall, F. (2000) · Nature · doi:10.1038/35015572 · Cited by 576
Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system
Rodriguez, I., Feinstein, P., & Mombaerts, P. (1999) · Cell · doi:10.1016/s0092-8674(00)80730-8 · Cited by 402
OCCURRENCE OF ANOESTRUS IN MICE CAGED IN GROUPS
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A map of pheromone receptor activation in the mammalian brain
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Structure and function of the vomeronasal system: an update
Halpern, M. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00103-5 · Cited by 639
Transgenerational epigenetic imprints on mate preference
Crews, D., Gore, A. C., Hsu, T. S., Dangleben, N. L., Spinetta, M., Schallert, T., Anway, M. D., & Skinner, M. K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610410104 · Cited by 418
Sex-specific peptides from exocrine glands stimulate mouse vomeronasal sensory neurons
Kimoto, H., Haga‐Yamanaka, S., Sato, K., & Touhara, K. (2005) · Nature · doi:10.1038/nature04033 · Cited by 378
Tirindelli, R., Dibattista, M., Pifferi, S., & Menini, A. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2008 · Cited by 393
Pheromone-mediated gene expression in the honey bee brain
Grozinger, C. M., Sharabash, N. M., Whitfield, C. W., & Robinson, G. E. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2335884100 · Cited by 332
Metadata
- Authors
- Halem, H. A., Baum, M. J., & Cherry, J. A.
- Affiliations
- Boston University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-04-01
- Volume
- 21
- Issue
- 7
- Pages
- 2474-2480
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762392
- OpenAlex
- W2168851853
- Cited by
- 108
- References
- 44
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 7
- FWCI
- 3.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r29dc003019-05)
- National Institute of Mental Health (R01MH059200, MH 59200)
- National Institute on Deafness and Other Communication Disorders (DC03019)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007387, T32 HD07387)
- Topics
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- vomeronasal organ, accessory olfactory bulb, pheromone detection, sex differences, immediate early genes, estradiol, testosterone, gonadectomy, noradrenergic input
- MeSH terms
- Animals, Estradiol, Female, Male, Neurons, Olfactory Bulb, Pheromones, Sex Characteristics, Genes, Immediate-Early, Mice
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