Cited by 108Olfactory and Sensory Function StudiesNeuroendocrine regulation and behaviorHypothalamic control of reproductive hormones

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Sex Difference and Steroid Modulation of Pheromone-Induced Immediate Early Genes in the Two Zones of the Mouse Accessory Olfactory System

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Halem, Heather A., Baum, Michael J., Cherry, James A.·2001·The Journal of Neuroscience

DOI 10.1523/jneurosci.21-07-02474.2001PMC PMC6762392

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Abstract

Two anatomically and neurochemically distinct zones within the vomeronasal organ (VNO) and accessory olfactory bulb (AOB) have been identified that are responsible for the detection of pheromones. Using markers to distinguish between apical and basal neurons of the VNO neuroepithelium and rostral versus caudal AOB glomeruli, we examined immediate early gene immunoreactivity (IEG-IR) in gonadectomized, steroid-treated mice in response to pheromones of male and female conspecifics. After exposure of estradiol-treated females to soiled male bedding, more VNO neurons in the basal than the apical layer exhibited IEG-IR compared with VNO neurons of estradiol-treated males. Conversely, whereas soiled female bedding failed to induce IEG-IR in VNO neurons of estradiol-treated males or females, both apical and basal neurons were activated in testosterone-treated males. Male and female pheromones also activated mitral and granule cells in the AOBs of all subjects, but responses to different pheromones were distributed across the boundary of the rostral and caudal regions. These data show that differences in the response of males and females to the same pheromonal stimulus are found in the sensory neurons of the VNO. We propose that centrifugal, noradrenergic inputs to VNO neurons, which may differ in the two sexes and respond differently to adult sex steroids, modulate sensitivity to pheromonal stimulation.

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Authors: Halem, H. A., Baum, M. J., & Cherry, J. A.
Affiliations: Boston University (US)
ORCID: Halem, Heather A.
Baum, Michael J.
Cherry, James A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2001-04-01
Volume: 21
Issue: 7
Pages: 2474-2480
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.21-07-02474.2001
PMC: PMC6762392
OpenAlex: W2168851853
Cited by: 108
References: 44
Citations by year: 2026: 1 · 2025: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 3 · 2016: 4 · 2015: 6 · 2014: 6 · 2013: 6 · 2012: 7
FWCI: 3.77
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neuroscience (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r29dc003019-05)
National Institute of Mental Health (R01MH059200, MH 59200)
National Institute on Deafness and Other Communication Disorders (DC03019)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007387, T32 HD07387)
Topics: Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords: vomeronasal organ, accessory olfactory bulb, pheromone detection, sex differences, immediate early genes, estradiol, testosterone, gonadectomy, noradrenergic input
MeSH terms: Animals, Estradiol, Female, Male, Neurons, Olfactory Bulb, Pheromones, Sex Characteristics, Genes, Immediate-Early, Mice

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Sex Difference and Steroid Modulation of Pheromone-Induced Immediate Early Genes in the Two Zones of the Mouse Accessory Olfactory System

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