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Cited by 204Gastrointestinal motility and disordersFunctional Brain Connectivity StudiesPsychosomatic Disorders and Their Treatments

Brain imaging approaches to the study of functional GI disorders: A Rome Working Team Report

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Mayer, E. A., Aziz, Q., Coen, S., Kern, M., Labus, J. S., Lane, R., Kuo, B., Naliboff, B. +1 more·2009·Neurogastroenterology & Motility
DOI 10.1111/j.1365-2982.2009.01304.xPMC PMC3829384
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Abstract

Abstract Progresses in the understanding of human brain‐gut interactions in health and disease have been limited by the lack of non‐invasive techniques to study brain activity. The advent of neuroimaging techniques has made it possible not only to study the structure and function of the brain, but also to characterize signaling system underlying brain function. This article gives a brief overview of relevant functional neuroanatomy, and of the most commonly used brain imaging techniques. It summarizes published functional brain imaging studies using acute visceral stimulation of the oesophagus, stomach and colon in healthy control subjects and patients with functional GI disorders, and briefly discusses pertinent findings from these studies. The article concludes with a critical assessment of published studies, and with recommendations for improved study paradigms and analysis strategies.

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  • The advent of human brain imaging techniques such as positron emission tomography in the 1980s allowed conclusive demonstrations that alterations in the gut lead to activation of key brain networks.

    “The advent of human brain imaging techniques such as positron emission tomography in the 1980s allowed for conclusive demonstrations that alterations in the gut (e.g. by distension) lead to activation of key brain networks (Mayer et al., 2009;Van Oudenhove et al., 2007).”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Mayer et al., 2009

    Section 5 reports that imaging studies of esophageal, gastric and rectal stimulation consistently found activation in key brain regions, particularly the insula and anterior cingulate cortex. Section 6.3 also describes PET evidence of brain-network activation during rectal distension. The paper does not establish the claim’s specific chronology—that the advent of PET in the 1980s enabled these demonstrations. (LLM, conf=0.84)

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Authors
Mayer, E. A., Aziz, Q., Coen, S., Kern, M., Labus, J. S., Lane, R., Kuo, B., Naliboff, B., & Tracey, I.
Affiliations
  • University of California, Los Angeles (US)
  • Queen Mary University of London (GB)
  • Medical College of Wisconsin (US)
  • University of Arizona (US)
  • Harvard University (US)
  • John Radcliffe Hospital (GB)
Corresponding author
Mayer, E. A.
ORCID
Venue
Neurogastroenterology & Motility
Publisher
Wiley
Published
2009-05-20
Volume
21
Issue
6
Pages
579-596
ISSN
  • 1350-1925 (ISSN-L)
  • 1365-2982
DOI
10.1111/j.1365-2982.2009.01304.x
PMC
PMC3829384
OpenAlex
W1997428759
Cited by
204
References
15
Citations by year
2026: 8 · 2025: 1 · 2024: 7 · 2023: 7 · 2022: 11 · 2021: 7 · 2020: 12 · 2019: 15 · 2018: 14 · 2017: 7 · 2016: 16 · 2015: 16 · 2014: 19 · 2013: 13 · 2012: 17
FWCI
2.52
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Neurogastroenterology & Motility (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
  • Research Portal (King's College London) (submittedVersion)
Funders
  • National Institute of Nursing Research (R01NR007768, NR007768)
  • National Institute of Diabetes and Digestive and Kidney Diseases (DK-48351, K23DK069614, R01DK048351, P50DK064539, DK 64530)
  • National Center for Complementary and Integrative Health (R24AT002681, AT00268)
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Psychosomatic Disorders and Their Treatments
Keywords
functional gastrointestinal disorders, brain-gut interaction, neuroimaging, functional neuroanatomy, visceral stimulation, esophagus, stomach, colon, brain activity, analytical strategies
MeSH terms
Brain, Brain Mapping, Electric Stimulation, Female, Gastrointestinal Diseases, Humans, Magnetic Resonance Imaging, Male, Sex Characteristics, Positron-Emission Tomography

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