Cited by 179Memory and Neural MechanismsNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

The NMDA antagonist MK-801 blocks the extinction of Pavlovian fear conditioning.

Baker, Jeffrey D., Azorlosa, Julian L.·1996·Behavioral Neuroscience

Abstract

Five groups of rats were given Pavlovian fear conditioning. Four groups were then given extinction training. Prior to extinction these groups received an injection of either the noncompetitive NMDA antagonist MK-801 (0.025, 0.05, or 0.1 mg/kg) or saline. The 5th group received saline but no extinction. During testing, the extinction groups given saline or 0.025 mg/kg of MK-801 showed reduced fear, but the groups that had received the higher doses exhibited as much conditioned fear as the saline group, which had not received extinction. This study showed that MK-801 blocked extinction in a dose-dependent manner. The design of the study ruled out the possibility that the effect was due to state-dependency or to MK-801 interfering with the processing of the conditioned stimulus.

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Crossref · 10.1037/0735-7044.110.3.618

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Authors
Baker, J. D., & Azorlosa, J. L.
Affiliations
Southeastern Louisiana University (US)
Venue
Behavioral Neuroscience
Published
1996-06
Volume
110
Issue
3
Pages
618-620
ISSN
  • 0735-7044 (ISSN-L)
  • 1939-0084
OpenAlex
W2007266319
Cited by
179
References
0
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 10 · 2017: 12 · 2016: 5 · 2015: 8 · 2014: 9 · 2013: 6 · 2012: 8
FWCI
0.71
Type
journal article
Language
en
Open access
closed
Locations
  • Behavioral Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
MK-801, NMDA receptor antagonists, fear conditioning, fear extinction, dose-dependent effects, state dependence
MeSH terms
Animals, Avoidance Learning, Conditioning, Classical, Extinction, Psychological, Fear, Male, N-Methylaspartate, Dizocilpine Maleate, Rats, Sprague-Dawley, Rats

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