Saccadic target selection deficits after lateral intraparietal area inactivation in monkeys
Open accessAbstract
We investigated the contribution of the lateral intraparietal area (LIP) to the selection of saccadic eye movement targets and to saccade execution using muscimol-induced reversible inactivation and compared those effects with inactivation of the adjacent ventral intraparietal area (VIP) and with sham injections of saline into LIP. Three types of tasks were used: saccades to single visual or memorized targets, saccades to synchronous and asynchronous bilateral targets, and visual search of a target among distractors. LIP inactivation failed to produce deficits in the latency or accuracy of saccades to single targets, but it dramatically reduced the frequency of contralateral saccades in the presence of bilateral targets, and it increased search time for a contralateral target during serial visual search. In the latter task, the observed deficits might reflect either an ispilateral bias in saccadic search strategy or an attentional impairment in locating a target among flanking distractors within the contralateral field. No effects were observed on any of these tasks after VIP inactivation. These results suggest that one important contribution of LIP to oculomotor behavior is the selection of targets for saccades in the context of competing visual stimuli.
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In nonhuman primates, endogenous spatial attention is controlled by a trio of structures: FEF, LIP, and SC.
“For example, in the visual modality, evidence from neurophysiological studies in nonhuman primates indicates that endogenous spatial attention appears to be controlled by a trio of structures including the frontal eye field (FEF) in prefrontal cortex (PFC) (e.g. [26]), the lateral intraparietal area (LIP) in parietal cortex [27], and the superior colliculus (SC) (e.g. [28]).”
From Linking ADHD to the Neural Circuitry of Attention (2017) · cites this paper as [27]
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- Authors
- Wardak, C., Olivier, E., & Duhamel, J.-R.
- Affiliations
- Lyon 1 Université (FR)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-11-15
- Volume
- 22
- Issue
- 22
- Pages
- 9877-9884
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6757813
- OpenAlex
- W2110085884
- Cited by
- 203
- References
- 39
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 5 · 2023: 8 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 14 · 2017: 10 · 2016: 7 · 2015: 13 · 2014: 6 · 2013: 10 · 2012: 13
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Digital Access to Libraries (submittedVersion, other-oa)
- Funders
- Fondation pour la Recherche Médicale
- Centre National de la Recherche Scientifique
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Visual Attention and Saliency Detection
- Keywords
- lateral intraparietal area, saccades, saccade target selection, ventral intraparietal area, muscimol inactivation, oculomotor control, attentional bias
- MeSH terms
- Animals, Behavior, Animal, Fixation, Ocular, Macaca mulatta, Memory, Muscimol, Neurons, Parietal Lobe, Photic Stimulation, Reaction Time, Saccades, GABA Agonists
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