CoChat
Sign Up
Cited by 144Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Theta-Frequency Synaptic Potentiation in CA1 In Vitro Distinguishes Cognitively Impaired from Unimpaired Aged Fischer 344 Rats

Open access
Tombaugh, Geoffrey C., Rowe, Wayne B., Chow, Ana R., Michael, Timothy H., Rose, Gregory M.·2002·The Journal of Neuroscience
DOI 10.1523/jneurosci.22-22-09932.2002PMC PMC6757825
Open this paper in CoChat — free accountOpen PDF

Abstract

Hippocampal-dependent learning and memory deficits have been well documented in aging rodents. The results of several recent studies have suggested that these deficits arise from weakened synaptic plasticity within the hippocampus. In the present study, we examined the relationship between hippocampal long-term potentiation (LTP) in vitro and spatial learning in aged (24-26 months) Fischer 344 rats. We found that LTP induced in the CA1 region using theta-frequency stimulation (5 Hz) is selectively impaired in slices from a subpopulation of aged rats that had shown poor spatial learning in the Morris water maze. LTP at 5 Hz in aged rats that did not show learning deficits was similar to that seen in young (4-6 months) controls. We also found that 5 Hz LTP amplitude strongly correlated with individual learning performance among aged rats. The difference in 5 Hz LTP magnitude among aged rats was not attributable to an altered response to 5 Hz stimulation or to differences in the NMDA receptor-mediated field EPSP. In addition, no performance-related differences in LTP were seen when LTP was induced with 30 or 70 Hz stimulation protocols. Finally, both 5 Hz LTP and spatial learning in learning-impaired rats were enhanced with the selective muscarinic M2 antagonist BIBN-99 (5,11-dihydro-8-chloro-11-[[4-[3-[(2,2-dimethyl-1-oxopentyl)ethylamino]propyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one). These findings reinforce the idea that distinct types of hippocampal LTP offer mechanistic insight into age-associated cognitive decline.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1523/jneurosci.22-22-09932.2002

Cites

86 of 86 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The hippocampus is important in learning and memory and in Alzheimer's disease neuropathogenesis.

    “Given the importance of the hippocampus in learning and memory and AD neuropathogenesis (Tombaugh et al., 2002)”

    From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Tombaugh et al., 2002

    The paper’s opening discussion states that spatial learning in rodents is strongly hippocampus-dependent and that the hippocampus plays a key role in spatial memory formation. It does not address the hippocampus’s role in Alzheimer’s disease neuropathogenesis; Alzheimer’s disease appears only in the title of a work listed in the References. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • Abnormalities in hippocampal pathology have been linked to AD and other neurodegenerative disorders.

    “Notably, abnormalities in hippocampal pathology have been linked to AD and other neurodegenerative disorders (Tombaugh et al., 2002).”

    From Arbovirus infection increases the risk for the development of neurodegenerative disease pathology in the murine model (2024) · cites this paper as Tombaugh et al., 2002

    The Discussion describes hippocampal synaptic changes and learning in aged rats, but does not link hippocampal pathology to Alzheimer’s disease or other neurodegenerative disorders. Searches for Alzheimer’s disease and neurodegenerative disorders found only a reference title mentioning Alzheimer’s disease, not a statement of the claimed link. (LLM, conf=0.72)

    Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Related

Authors
Tombaugh, G. C., Rowe, W. B., Chow, A. R., Michael, T. H., & Rose, G. M.
ORCID
Rose, Gregory M.
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2002-11-15
Volume
22
Issue
22
Pages
9932-9940
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.22-22-09932.2002
PMC
PMC6757825
OpenAlex
W1597519089
Cited by
144
References
86
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 4 · 2022: 4 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 5 · 2015: 7 · 2014: 5 · 2013: 13 · 2012: 9
FWCI
2.10
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
long-term potentiation, hippocampal CA1, aging, age-related cognitive decline, spatial learning, Morris water maze, M2 muscarinic receptor, NMDA receptor, synaptic plasticity, hippocampal slices
MeSH terms
Age Factors, Animals, Behavior, Animal, Cognition Disorders, Dibenzazepines, Electric Stimulation, Hippocampus, Male, Synaptic Transmission, Pyridines, Rats, Inbred F344, Reaction Time, Receptors, Muscarinic, Theta Rhythm, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Muscarinic Antagonists, Maze Learning, Excitatory Postsynaptic Potentials, Receptor, Muscarinic M2, Rats, In Vitro Techniques

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review