Forebrain-Specific Neuronal Inhibition of Nuclear Factor-κB Activity Leads to Loss of Neuroprotection

A simple method for organotypic cultures of nervous tissue

Stoppini, L., Buchs, P., & Muller, D. (1991) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(91)90128-m · Cited by 3,097 · see citing works

NF-κB at the crossroads of life and death

Karin, M., & Lin, A. (2002) · Nature Immunology · doi:10.1038/ni0302-221 · Cited by 2,709 · see citing works

Control of memory formation through regulated expression of a CaMKII transgene

Mayford, M., Bach, M. E., Huang, Y.-Y., Wang, L., Hawkins, R. D., & Kandel, E. R. (1996) · Science · doi:10.1126/science.274.5293.1678 · Cited by 1,550 · see citing works

Nuclear factor-κB: The enemy within

Aggarwal, B. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.09.003 · Cited by 1,289 · see citing works

NF-κB in neuronal plasticity and neurodegenerative disorders

Mattson, M. P., & Camandola, S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11916 · Cited by 877 · see citing works

NF-kB: a crucial transcription factor for glial and neuronal cell function

O'Neill, L. A. J., & Kaltschmidt, C. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)01035-1 · Cited by 849 · see citing works

Doxycycline-mediated quantitative and tissue-specific control of gene expression in transgenic mice.

Kistner, A., Gossen, M., Zimmermann, F., Jerecic, J., Ullmer, C., Lübbert, H., & Bujard, H. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.10933 · Cited by 780 · see citing works

Neuroprotection by Aspirin and Sodium Salicylate Through Blockade of NF-κB Activation

Grilli, M., Pizzi, M., Memo, M., & Spano, P. (1996) · Science · doi:10.1126/science.274.5291.1383 · Cited by 751 · see citing works

NF-κB is activated and promotes cell death in focal cerebral ischemia

Schneider, A., Martín-Villalba, A., Weih, F., Vogel, J., Wirth, T., & Schwaninger, M. (1999) · Nature Medicine · doi:10.1038/8432 · Cited by 642 · see citing works

Genetic determinants of susceptibility to excitotoxic cell death: Implications for gene targeting approaches

Schauwecker, P. E., & Steward, O. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.4103 · Cited by 510 · see citing works

Constitutive NF-kB Activity in Neurons

Kaltschmidt, C., Kaltschmidt, B., Neumann, H., Wekerle, H., & Baeuerle, P. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3981-3992.1994 · Cited by 398 · see citing works

The Encephalomyocarditis Virus Internal Ribosome Entry Site Allows Efficient Coexpression of Two Genes from a Recombinant Provirus in Cultured Cells and in Embryos

Ghattas, I. R., Sanes, J. R., & Majors, J. E. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.12.5848-5859.1991 · Cited by 330 · see citing works

Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival

Bhakar, A. L., Tannis, L.-L., Zeindler, C., Russo, M. P., Jobin, C., Park, D. S., MacPherson, S., & Barker, P. A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08466.2002 · Cited by 310 · see citing works

Constitutive NF-kappa B activity in neurons.

Kaltschmidt, C., Kaltschmidt, B., Neumann, H., Wekerle, H., & Baeuerle, P. A. (1994) · Molecular and Cellular Biology · doi:10.1128/mcb.14.6.3981 · Cited by 304 · see citing works

Inhibition of NF-κB potentiates amyloid β-mediated neuronal apoptosis

Kaltschmidt, B., Uherek, M., Wellmann, H., Volk, B., & Kaltschmidt, C. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9409 · Cited by 280 · see citing works

Chimeric green fluorescent protein-aequorin as bioluminescent Ca 2+ reporters at the single-cell level

Baubet, V., Mouellic, H. L., Campbell, A. K., Lucas-Meunier, E., Fossier, P., & Brûlet, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.13.7260 · Cited by 272 · see citing works

The encephalomyocarditis virus internal ribosome entry site allows efficient coexpression of two genes from a recombinant provirus in cultured cells and in embryos.

Ghattas, I. R., Sanes, J. R., & Majors, J. E. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.12.5848 · Cited by 239 · see citing works

NF-κB activity in transgenic mice: developmental regulation and tissue specificity

Schmidt‐Ullrich, R., Mémet, S., Lilienbaum, A., Feuillard, J., Raphaël, M., & Israël, A. (1996) · Development · doi:10.1242/dev.122.7.2117 · Cited by 227 · see citing works

N- and C-Terminal Sequences Control Degradation of MAD3/IκBα in Response to Inducers of NF-κB Activity

Whiteside, S. T., Ernst, M. K., Bail, O. L., Laurent‐Winter, C., Rice, N. R., & Israël, A. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.10.5339 · Cited by 222 · see citing works

Brain synapses contain inducible forms of the transcription factor NF-κB

Kaltschmidt, C., Kaltschmidt, B., & Baeuerle, P. A. (1993) · Mechanisms of Development · doi:10.1016/0925-4773(93)90031-r · Cited by 220 · see citing works

Lack of the p50 Subunit of Nuclear Factor-κB Increases the Vulnerability of Hippocampal Neurons to Excitotoxic Injury

Yu, Z., Zhou, D., Bruce‐Keller, A. J., Kindy, M. S., & Mattson, M. P. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-20-08856.1999 · Cited by 213 · see citing works

Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulationPreprint

Li, Q., Estepa, G., Mémet, S., Israël, A., & Verma, I. M. (2000) · Genes & Development · doi:10.1101/gad.14.14.1729 · Cited by 203 · see citing works

Progressive incorporation of propidium iodide in cultured mouse neurons correlates with declining electrophysiological status: a fluorescence scale of membrane integrity

Macklis, J. D., & Madison, R. D. (1990) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(90)90007-3 · Cited by 198 · see citing works

p75-Mediated NF-κB Activation Enhances the Survival Response of Developing Sensory Neurons to Nerve Growth Factor

Hamanoue, M., Middleton, G., Wyatt, S. L., Jaffray, E., Hay, R. T., & Davies, A. M. (1999) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.1999.0770 · Cited by 197 · see citing works

Basic FGF, NGF, and IGFs Protect Hippocampal and Cortical Neurons against Iron-Induced Degeneration

Zhang, Y., Tatsuno, T., Carney, J. M., & Mattson, M. P. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.51 · Cited by 195 · see citing works

Induction of NF-κB Activity during Haloperidol-Induced Oxidative Toxicity in Clonal Hippocampal Cells: Suppression of NF-κB and Neuroprotection by Antioxidants

Post, A., Holsboer, F., & Behl, C. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-20-08236.1998 · Cited by 146 · see citing works

NF-κB transcription factors: critical regulators of hematopoiesis and neuronal survival

Denk, A., Wirth, T., & Baumann, B. (2000) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(00)00009-5 · Cited by 126 · see citing works

Kainic Acid‐Induced Apoptosis in Rat Striatum Is Associated with Nuclear Factor‐κB Activation

Nakai, M., Qin, Z., Chen, J., Wang, Y., & Chase, T. N. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740647.x · Cited by 104 · see citing works

Lack of NF-κB p50 Exacerbates Degeneration of Hippocampal Neurons after Chemical Exposure and Impairs Learning

Kassed, C. A., Willing, A. E., Garbuzova-Davis, S., Sanberg, P. R., & Pennypacker, K. R. (2002) · Experimental Neurology · doi:10.1006/exnr.2002.7967 · Cited by 103 · see citing works

Cortical neurons containing somatostatin‐ or parvalbumin‐like immunoreactivity are atypically vulnerable to excitotoxic injury in vitro

Weiss, J. H., Koh, J., Baimbridge, K. G., & Choi, D. W. (1990) · Neurology · doi:10.1212/wnl.40.8.1288 · Cited by 81 · see citing works

A DEVD‐Inhibited Caspase Other than CPP32 Is Involved in the Commitment of Cerebellar Granule Neurons to Apoptosis Induced by K+ Deprivation

D’Mello, S. R., Aglieco, F., Roberts, M. R., Borodezt, K., & Haycock, J. W. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70051809.x · Cited by 74 · see citing works

Neuronal κB-binding Factors Consist of Sp1-related Proteins

Mao, X. R., Moerman-Herzog, A. M., & Barger, S. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204292200 · Cited by 34 · see citing works

Macrophage colony stimulating factor prevents NMDA‐induced neuronal death in hippocampal organotypic cultures

Vincent, V. A. M., Robinson, C. C., Simsek, D., & Murphy, G. M. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.01087.x · Cited by 29 · see citing works

Tryptophan hydroxylase mRNAs analysis by RT-PCR: Preliminary report on the effect of noradrenaline in the neonatal rat pineal gland

Besan�on, R., Reboul, A., Claustrat, B., Jouvet, A., Belin, M.-F., & Fèvre‐Montange, M. (1997) · Journal of Neuroscience Research · doi:10.1002/(sici)1097-4547(19970915)49:6 · Cited by 7 · see citing works

Hydrogen peroxide sensing, signaling and regulation of transcription factors

Marinho, H. S., Real, C., Cyrne, L., Soares, H., & Antunes, F. (2014) · Redox Biology · doi:10.1016/j.redox.2014.02.006 · Cited by 851 · see citing works

SIRT1 Protects against Microglia-dependent Amyloid-β Toxicity through Inhibiting NF-κB Signaling

Chen, J., Zhou, Y., Mueller-Steiner, S., Chen, L.-F., Kwon, H., Yi, S., Mucke, L., & Gan, L. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509329200 · Cited by 740 · see citing works

Roles for NF-κB in nerve cell survival, plasticity, and disease

Mattson, M. P., & Meffert, M. K. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401837 · Cited by 597 · see citing works

Tumor Necrosis Factor (TNF)-mediated Neuroprotection against Glutamate-induced Excitotoxicity Is Enhanced by N-Methyl-D-aspartate Receptor Activation

Marchetti, L., Klein, M., Schlett, K., Pfizenmaier, K., & Eisel, U. L. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311766200 · Cited by 424 · see citing works

Current insights into the regulation of programmed cell death by NF-κB

Dutta, J., Fan, Y., Gupta, N., Fan, G., & Gélinas, C. (2006) · Oncogene · doi:10.1038/sj.onc.1209938 · Cited by 408 · see citing works

NF- B in the Nervous System

Kaltschmidt, B., & Kaltschmidt, C. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001271 · Cited by 392 · see citing works

Cellular Specificity of NF-κB Function in the Nervous System

Dresselhaus, E. C., & Meffert, M. K. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01043 · Cited by 345 · see citing works

Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy

Wang, C., Fan, L., Khawaja, R. R., Liu, B., Zhan, L., Kodama, L., Chin, M., Li, Y., Le, D., Zhou, Y., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-29552-6 · Cited by 333 · see citing works

Unravelling the complexities of the NF-κB signalling pathway using mouse knockout and transgenic models

Gerondakis, S., Grumont, R. J., Gugasyan, R., Wong, W. W.-L., Isomura, I., Ho, W. C., & Banerjee, A. (2006) · Oncogene · doi:10.1038/sj.onc.1209944 · Cited by 304 · see citing works

Strong Evidence That KIAA0319 on Chromosome 6p Is a Susceptibility Gene for Developmental Dyslexia

Cope, N. A., Harold, D. H., Hill, G., Moskvina, V., Stevenson, J., Holmans, P., Owen, M. J., O’Donovan, M. C., & Williams, J. H. (2005) · The American Journal of Human Genetics · doi:10.1086/429131 · Cited by 293 · see citing works

Physiological functions for brain NF-κB

Meffert, M. K., & Baltimore, D. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.11.002 · Cited by 292 · see citing works

NF-κB in the Survival and Plasticity of Neurons

Mattson, M. P. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6961-x · Cited by 255 · see citing works

A 77-Kilobase Region of Chromosome 6p22.2 Is Associated with Dyslexia in Families From the United Kingdom and From the United States

Francks, C., Paracchini, S., Smith, S. D., Richardson, A. J., Scerri, T. S., Cardon, L. R., Marlow, A. J., MacPhie, I. L., Walter, J., Pennington, B. F., et al. (2004) · The American Journal of Human Genetics · doi:10.1086/426404 · Cited by 233 · see citing works

NF-κB as an Inducible Regulator of Inflammation in the Central Nervous System

Anilkumar, S., & Wright-Jin, E. C. (2024) · Cells · doi:10.3390/cells13060485 · Cited by 244 · see citing works

NF-κB Regulates Spatial Memory Formation and Synaptic Plasticity through Protein Kinase A/CREB Signaling

Kaltschmidt, B., Ndiaye‐Lobry, D., Körte, M., Pothion, S., Arbibe, L., Prüllage, M., Pfeiffer, J., Lindecke, A., Staiger, V., Israël, A., et al. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.8.2936-2946.2006 · Cited by 229 · see citing works

Tumor necrosis factor α triggers proliferation of adult neural stem cells via IKK/NF-κB signaling

Widera, D., Mikenberg, I., Elvers, M., Kaltschmidt, C., & Kaltschmidt, B. (2006) · BMC Neuroscience · doi:10.1186/1471-2202-7-64 · Cited by 216 · see citing works

Neuronal Activation of NF-κB Contributes to Cell Death in Cerebral Ischemia

Zhang, W., Potrovita, I., Tarabin, V., Herrmann, O., Beer, V. K., Weih, F., Schneider, A., & Schwaninger, M. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600004 · Cited by 210 · see citing works

NF-κB functions in the nervous system: From development to disease

Mémet, S. (2006) · Biochemical Pharmacology · doi:10.1016/j.bcp.2006.09.003 · Cited by 200 · see citing works

Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice

Akundi, R. S., Huang, Z., Eason, J., Pandya, J. D., Zhi, L., Cass, W. A., Sullivan, P. G., & Büeler, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016038 · Cited by 187 · see citing works

NF-κB as a therapeutic target in neurodegenerative diseases

Camandola, S., & Mattson, M. P. (2007) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.11.2.123 · Cited by 184 · see citing works

Dissection of the NF-κB signalling cascade in transgenic and knockout mice

Pasparakis, M., Luedde, T., & Schmidt-Supprian, M. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401870 · Cited by 172 · see citing works

NF-κB signalling regulates the growth of neural processes in the developing PNS and CNS

Gutiérrez, H., Hale, V. A., Dolcet, X., & Davies, A. M. (2005) · Development · doi:10.1242/dev.01702 · Cited by 167 · see citing works

Nuclear factor kappa B (NF-κB) in multiple sclerosis pathology

Guire, C. M., Prinz, M., Beyaert, R., & Loo, G. (2013) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2013.08.001 · Cited by 154 · see citing works

NF‐κB pathway: a target for preventing β‐amyloid (Aβ)‐induced neuronal damage and Aβ42 production

Valerio, A., Boroni, F., Benarese, M., Sarnico, I., Ghisi, V., Bresciani, L. G., Ferrario, M., Borsani, G., Spano, P., & Pizzi, M. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04722.x · Cited by 148 · see citing works

Inactivation of astroglial NF‐κB promotes survival of retinal neurons following ischemic injury

Dvoriantchikova, G., Barakat, D. J., Brambilla, R., Agudelo, C., Hernandez, E., Bethea, J. R., Shestopalov, V. I., & Ivanov, D. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06814.x · Cited by 146 · see citing works

Bim and Noxa Are Candidates to Mediate the Deleterious Effect of the NF-κB Subunit RelA in Cerebral Ischemia

Inta, I. M., Paxian, S. A., Maegele, I., Zhang, W., Pizzi, M., Spano, P., Sarnico, I., Muhammad, S., Herrmann, O., Inta, D., et al. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3670-06.2006 · Cited by 137 · see citing works

IκB Kinase/Nuclear Factor κB-Dependent Insulin-Like Growth Factor 2 (Igf2) Expression Regulates Synapse Formation and Spine Maturation via Igf2 Receptor Signaling

Schmeißer, M. J., Baumann, B., Johannsen, S., Vindedal, G. F., Jensen, V., Hvalby, Ø., Sprengel, R., Seither, J., Maqbool, A., Magnutzki, A., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0111-12.2012 · Cited by 137 · see citing works

NF-κB Signaling Pathways

Mincheva-Tasheva, S., & Soler, R. M. (2012) · The Neuroscientist · doi:10.1177/1073858412444007 · Cited by 133 · see citing works

Tumor Necrosis Factor-Like Weak Inducer of Apoptosis-Induced Neurodegeneration

Potrovita, I., Zhang, W., Burkly, L. C., Hahm, K., Lincecum, J. M., Wang, M. Z., Maurer, M. H., Rossner, M. J., Schneider, A., & Schwaninger, M. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.1089-04.2004 · Cited by 131 · see citing works

Mechanisms of DNA damage-mediated neurotoxicity in neurodegenerative disease

Welch, G., & Tsai, L. (2022) · The EMBO Reports · doi:10.15252/embr.202154217 · Cited by 129 · see citing works

Role of brain-derived neurotrophic factor and NF-kappaB in neuronal plasticity and survival: From genes to phenotype.

Marini, A. M., Jiang, X., Wu, X., Tian, F., Zhu, D., Okagaki, P., & Lipsky, R. H. (2004) · PubMed · Cited by 129 · see citing works

TLR4 and CD14 receptors expressed in rat pineal gland trigger NFKB pathway

Cruz‐Machado, S. D. S., Carvalho‐Sousa, C. E., Tamura, E. K., Pinato, L., Cecon, E., Fernandes, P. A. C. M., Avellar, M. C. W., Ferreira, Z. S., & Markus, R. P. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00785.x · Cited by 126 · see citing works

Strong Neuroprotection by Inhibition of NF-κB After Neonatal Hypoxia-Ischemia Involves Apoptotic Mechanisms but Is Independent of Cytokines

Nijboer, C. H. A., Heijnen, C. J., Groenendaal, F., May, M. J., van Bel, F., & Kavelaars, A. (2008) · Stroke · doi:10.1161/strokeaha.107.504175 · Cited by 117 · see citing works

Sp1 Is Up-regulated in Cellular and Transgenic Models of Huntington Disease, and Its Reduction Is Neuroprotective

Qiu, Z., Norflus, F., Singh, B., Swindell, M. K., Buzescu, R., Bejarano, M., Chopra, R., Zucker, B., Benn, C., DiRocco, D. P., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511648200 · Cited by 117 · see citing works

NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain

Kaltschmidt, B., & Kaltschmidt, C. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00069 · Cited by 117 · see citing works

NF-κB/Rel Regulates Inhibitory and Excitatory Neuronal Function and Synaptic Plasticity

O'Mahony, A., Raber, J., Montano, M., Foehr, E., Han, V., Lu, S.-M., Kwon, H., LeFevour, A., Chakraborty-Sett, S., & Greene, W. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.00510-06 · Cited by 110 · see citing works

Lentiviral-mediated Targeted NF-κB Blockade in Dorsal Spinal Cord Glia Attenuates Sciatic Nerve Injury–induced Neuropathic Pain in the Rat

Meunier, A., Latrémolière, A., Dominguez, E., Mauborgne, A., Philippe, S., Hamon, M., Mallet, J. J., Benoliel, J. J., & Pohl, M. (2007) · Molecular Therapy · doi:10.1038/sj.mt.6300107 · Cited by 105 · see citing works

NF-κB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid β-peptide toxicity

Pizzi, M., Sarnico, I., Boroni, F., Benarese, M., Steimberg, N., Mazzoleni, G., Dietz, G. P. H., Bähr, M., Liou, H.-C., & Spano, P. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401598 · Cited by 100 · see citing works

NF-κB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety

Kassed, C. A., & Herkenham, M. A. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.03.026 · Cited by 99 · see citing works

The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-κB from the synapse to the nucleus

Marcora, E. M., & Kennedy, M. B. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq358 · Cited by 99 · see citing works

Chapter 24 NF‐KappaB Dimers in the Regulation of Neuronal Survival

Sarnico, I., Lanzillotta, A., Benarese, M., Alghisi, M., Baiguera, C., Battistin, L., Spano, P., & Pizzi, M. (2009) · International review of neurobiology · doi:10.1016/s0074-7742(09)85024-1 · Cited by 97 · see citing works

Minimal NF-κB activity in neurons

LISTWAK, S. J., Rathore, P., & Herkenham, M. A. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.013 · Cited by 95 · see citing works

Association of NFKB1, which encodes a subunit of the transcription factor NF- B, with alcohol dependence

Edenberg, H. J., Xuei, X., Wetherill, L. F., Bierut, L., Bucholz, K., Dick, D. M., Hesselbrock, V., Kuperman, S., Porjesz, B., Schuckit, M. A., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm368 · Cited by 89 · see citing works

Huntingtin and the Synapse

Barron, J. C., Hurley, E. P., & Parsons, M. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.689332 · Cited by 85 · see citing works

Pyrrolidine dithiocarbamate inhibits translocation of nuclear factor kappa‐B in neurons and protects against brain ischaemia with a wide therapeutic time window

Nurmi, A., Vartiainen, N. E., Pihlaja, R., Goldsteins, G., Yrjänheikki, J., & Koıstınaho, J. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02756.x · Cited by 85 · see citing works

Neurons burdened by DNA double-strand breaks incite microglia activation through antiviral-like signaling in neurodegeneration

Welch, G. M., Boix, C. A., Schmauch, E., Davila-Velderrain, J., Victor, M. B., Dileep, V., Bozzelli, P. L., Su, Q., Cheng, J. D., Lee, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abo4662 · Cited by 84 · see citing works

Transcriptional control of maladaptive and protective responses in alcoholics: A role of the NF-κB system

Yakovleva, T., Bazov, I., Watanabe, H., Hauser, K. F., & Bakalkin, G. Y. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.12.019 · Cited by 78 · see citing works

Oxidative Stress Activates Transcription Factor NF-kB-Mediated Protective Signaling in Primary Rat Neuronal Cultures

Kratsovnik, E., Bromberg, Y., Sperling, O., & Zoref‐Shani, E. (2005) · Journal of Molecular Neuroscience · doi:10.1385/jmn:26:1:027 · Cited by 76 · see citing works

Distinct roles of diverse nuclear factor-κB complexes in neuropathological mechanisms

Pizzi, M., & Spano, P. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.027 · Cited by 77 · see citing works

Astroglial Inhibition of NF-κB Does Not Ameliorate Disease Onset and Progression in a Mouse Model for Amyotrophic Lateral Sclerosis (ALS)

Crosio, C., Valle, C., Casciati, A., Iaccarino, C., & Carrı̀, M. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017187 · Cited by 72 · see citing works

DAILY VARIATION OF CONSTITUTIVELY ACTIVATED NUCLEAR FACTOR KAPPA B (NFKB) IN RAT PINEAL GLAND

Cecon, E., Fernandes, P. A. C. M., Pinato, L., Ferreira, Z. S., & Markus, R. P. (2010) · Chronobiology International · doi:10.3109/07420521003661615 · Cited by 70 · see citing works

The Role of NF-κB Triggered Inflammation in Cerebral Ischemia

Jover‐Mengual, T., Hwang, J.-Y., Byun, H.-R., Court-Vazquez, B. L., Centeno, J. M., Burguete, M. C., & Zukin, R. S. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.633610 · Cited by 69 · see citing works

Regrowing the Adult Brain: NF-κB Controls Functional Circuit Formation and Tissue Homeostasis in the Dentate Gyrus

Imielski, Y., Schwamborn, J. C., Lüningschrör, P., Heimann, P., Holzberg, M., Werner, H., Leske, O., Püschel, A. W., Mémet, S., Heumann, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030838 · Cited by 66 · see citing works

Functional mechanism of neuroprotection by inhibitors of type B monoamine oxidase in Parkinson’s disease

Naoi, M., & Maruyama, W. (2009) · Expert Review of Neurotherapeutics · doi:10.1586/ern.09.68 · Cited by 68 · see citing works

FLIPL Protects Neurons against In Vivo Ischemia and In Vitro Glucose Deprivation-Induced Cell Death

Taoufik, E., Valable, S., Muller, G. J., Roberts, M. L., Divoux, D., Tinel, A., Voulgari-Kokota, A., Tseveleki, V., Altruda, F., Lassmann, H., et al. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1091-07.2007 · Cited by 66 · see citing works

NFκB signaling regulates embryonic and adult neurogenesis

Zhang, Y., & Hu, W. (2012) · Frontiers in Biology · doi:10.1007/s11515-012-1233-z · Cited by 63 · see citing works

The Role of NF-κB in Neuroinflammation

Babkina, I., Sergeeva, S. P., & Горбачева, Л. Р. (2021) · Neurochemical Journal · doi:10.1134/s1819712421020045 · Cited by 64 · see citing works

Post‐ischemic brain damage: NF‐κB dimer heterogeneity as a molecular determinant of neuron vulnerability

Pizzi, M., Sarnico, I., Lanzillotta, A., Battistin, L., & Spano, P. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06767.x · Cited by 63 · see citing works

Estrogen Action in Mood and Neurodegenerative Disorders: Estrogenic Compounds with Selective Properties–The Next Generation of Therapeutics

Österlund, M. K., Witt, M., & Gustafsson, J.-Α. (2005) · Endocrine · doi:10.1385/endo:28:3:235 · Cited by 63 · see citing works

Selectively increased sensitivity of cerebellar granule cells to AMPA receptor-mediated excitotoxicity in a mouse model of Batten disease

Kovács, A., Weimer, J. M., & Pearce, D. A. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.12.018 · Cited by 63 · see citing works

Intrahippocampal injection of Aβ 1-42 inhibits neurogenesis and down-regulates IFN-γ and NF-κB expression in hippocampus of adult mouse brain

Zheng, M., Liu, J., Ruan, Z., Tian, S., Ma, Y., Zhu, J., & Li, G. (2013) · Amyloid · doi:10.3109/13506129.2012.755122 · Cited by 62 · see citing works

Activation of Nuclear Factor-κB in the Brain after Experimental Subarachnoid Hemorrhage and Its Potential Role in Delayed Brain Injury

You, W., Wang, C.-X., Pan, Y., Zhang, X., Zhou, X., Zhang, X., Shi, J., & Zhou, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060290 · Cited by 61 · see citing works

Perinatal brain injury and regulation of transcription

Chang, Y., & Huang, C. (2006) · Current Opinion in Neurology · doi:10.1097/01.wco.0000218229.73678.a8 · Cited by 57 · see citing works

Translational and transcriptional control of Sp1 against ischaemia through a hydrogen peroxide-activated internal ribosomal entry site pathway

Yeh, S.-H., Yang, W., Gean, P. W., Hsu, C. Y., Tseng, J. T.-C., Su, T. P., Chang, W.-C., & Hung, J. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr161 · Cited by 56 · see citing works

Unique aspects of transcriptional regulation in neurons - nuances in NFkappaB and Sp1-related factors

Mao, X. R., Moerman-Herzog, A. M., Chen, Y., & Barger, S. W. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-16 · Cited by 54 · see citing works

NFκB in neurons? The Uncertainty Principle in neurobiology

Massa, P. T., Aleyasin, H., Park, D. S., Mao, X. R., & Barger, S. W. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03810.x · Cited by 53 · see citing works

Coincident enrichment of phosphorylated IκBα, activated IKK, and phosphorylated p65 in the axon initial segment of neurons

Schultz, C., König, H., Turco, D. D., Politi, C., Eckert, G. P., Ghebremedhin, E., Prehn, J. H. M., Kögel, D., & Deller, T. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2006.06.008 · Cited by 52 · see citing works

Nuclear Factor-κB Activation in Axons and Schwann Cells in Experimental Sciatic Nerve Injury and Its Role in Modulating Axon Regeneration: Studies With Etanercept

Smith, D. R., Tweed, C. W., Fernyhough, P., & Glazner, G. W. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181a7c14e · Cited by 50 · see citing works

Receptor for advanced glycation end products (RAGE) mediates neuronal differentiation and neurite outgrowth

Wang, L., Li, S., & Jungalwala, F. B. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21578 · Cited by 50 · see citing works

Estrogen Neuroprotection Against the Neurotoxic Effects of Ethanol Withdrawal: Potential Mechanisms

Jung, M. E., Gatch, M. B., & Simpkins, J. W. (2005) · Experimental Biology and Medicine · doi:10.1177/153537020523000102 · Cited by 49 · see citing works

Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats

Lv, Q., Lan, W., Sun, W., Ye, R., Fan, X., Ma, M., Yin, Q., Jiang, Y., Xu, G., Dai, J., et al. (2014) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2014.06.037 · Cited by 49 · see citing works

The Characteristic Long-Term Upregulation of Hippocampal NF-κB Complex in PTSD-Like Behavioral Stress Response Is Normalized by High-Dose Corticosterone and Pyrrolidine Dithiocarbamate Administered Immediately after Exposure

Cohen, H., Kozlovsky, N., Matar, M. A., Zohar, J., & Kaplan, Z. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2011.118 · Cited by 49 · see citing works

Prolyl 4-hydroxylase activity-responsive transcription factors: From hydroxylation to gene expression and neuroprotection

Siddiq, A. (2007) · Frontiers in bioscience · doi:10.2741/2892 · Cited by 47 · see citing works

IKKβ Deficiency in Myeloid Cells Ameliorates Alzheimer's Disease-Related Symptoms and Pathology

Liu, Y., Liu, X., Hao, W., Decker, Y., Schomburg, R., Fülöp, L., Pasparakis, M., Menger, M. D., & Fassbender, K. C. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.1348-14.2014 · Cited by 44 · see citing works

IκBα deficiency in brain leads to elevated basal neuroinflammation and attenuated response following traumatic brain injury: implications for functional recovery

Lian, H., Shim, D. J., Gaddam, S. S. K., Rodriguez-Rivera, J., Bitner, B. R., Pautler, R. G., Robertson, C. S., & Zheng, H. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-47 · Cited by 45 · see citing works

NF-kB/NOS cross-talk induced by mitochondrial complex II inhibition: Implications for Huntington's disease

Napolitano, M., Zei, D., Centonze, D., Palermo, R., Bernardi, G., Vacca, A., Calabresi, P., & Gulino, A. (2007) · Neuroscience Letters · doi:10.1016/j.neulet.2007.09.056 · Cited by 46 · see citing works

Involvement of Nuclear Factor-κB in Inflammation and Neuronal Plasticity Associated with Post-Traumatic Stress Disorder

Gupta, S., & Guleria, R. S. (2022) · Cells · doi:10.3390/cells11132034 · Cited by 48 · see citing works

The regulating effect of curcumin on NF-κB pathway in neurodegenerative diseases: a review of the underlying mechanisms

Esmaealzadeh, N., Miri, M. S., Mavaddat, H., Peyrovinasab, A., Zargar, S. G., Kabiri, S. S., Razavi, S. M., & Abdolghaffari, A. H. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01492-1 · Cited by 45 · see citing works

Human Umbilical Cord Blood Cells Protect Oligodendrocytes from Brain Ischemia through Akt Signal Transduction

Rowe, D. D., Leonardo, C. C., Recio, J. A., Collier, L. A., Willing, A. E., & Pennypacker, K. R. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.296434 · Cited by 44 · see citing works

Protective effect of pioglitazone, a PPARγ ligand, in a 3 nitropropionic acid model of Huntington's disease

Napolitano, M., Costa, L., Palermo, R., Giovenco, A., Vacca, A., & Gulino, A. (2011) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.03.011 · Cited by 43 · see citing works

The power of reversibility regulating gene activities via tetracycline-controlled transcription.

Schönig, K., Bujard, H., & Gossen, M. (2010) · Methods in Enzymology · doi:10.1016/s0076-6879(10)77022-1 · Cited by 45 · see citing works

Roles of HIF-1α, VEGF, and NF-κB in Ischemic Preconditioning-Mediated Neuroprotection of Hippocampal CA1 Pyramidal Neurons Against a Subsequent Transient Cerebral Ischemia

Lee, J., Tae, H., Kim, I. H., Cho, J.-H., Lee, T.-K., Park, J. H., Ahn, J. H., Choi, S. Y., Bai, H. C., Shin, B.-N., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0219-2 · Cited by 41 · see citing works

Activation of NF-κB in the mouse spinal cord following sciatic nerve transection

Pollock, G. A., Pennypacker, K. R., Mémet, S., Israël, A., & Saporta, S. (2005) · Experimental Brain Research · doi:10.1007/s00221-005-2318-6 · Cited by 42 · see citing works

Differential contributions of microglial and neuronal IKKβ to synaptic plasticity and associative learning in alert behaving mice

Kyrargyri, V., Vega‐Flores, G., Gruart, A., Delgado-Garcia, J. M., & Probert, L. (2014) · Glia · doi:10.1002/glia.22756 · Cited by 41 · see citing works

Neuronal IκB Kinase β Protects Mice from Autoimmune Encephalomyelitis by Mediating Neuroprotective and Immunosuppressive Effects in the Central Nervous System

Emmanouil, M., Taoufik, E., Tseveleki, V., Vamvakas, S. M., Tselios, T. V., Karin, M., Lassmann, H., & Probert, L. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900834 · Cited by 39 · see citing works

Hormesis: A promising strategy to sustain endogenous neuronal survival pathways against neurodegenerative disorders

Marini, A. M., Jiang, H., Pan, H., Wu, X., & Lipsky, R. H. (2007) · Ageing Research Reviews · doi:10.1016/j.arr.2007.07.003 · Cited by 38 · see citing works

Differential expression of BDNF mRNA splice variants in mouse brain and immune cells

Kruse, N., Cetin, S., Chan, A., Gold, R., & Lühder, F. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.09.001 · Cited by 38 · see citing works

Defensive effect of natrium diethyldithiocarbamate trihydrate (NDDCT) and lisinopril in DOCA–salt hypertension-induced vascular dementia in rats

Sharma, B., & Singh, N. (2012) · Psychopharmacology · doi:10.1007/s00213-012-2718-9 · Cited by 36 · see citing works

Transcriptional Dysregulation in Huntington’s Disease: The Role in Pathogenesis and Potency for Pharmacological Targeting

Pogoda-Wesołowska, A., Chmielewska, N., Maciejak, P., & Szyndler, J. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200705225821 · Cited by 36 · see citing works

GAL4–NF-κB Fusion Protein Augments Transgene Expression from Neuronal Promoters in the Rat Brain

Liu, B. H., Yang, Y., Paton, J. F. R., Li, F., Boulaire, J., Kasparov, S., & Wang, S. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2006.05.020 · Cited by 36 · see citing works

NF-kappaB activation is associated with homocysteine-induced injury in Neuro2a cells

Ferlazzo, N., Condello, S., Currò, M., Parisi, G., Ientile, R., & Caccamo, D. (2008) · BMC Neuroscience · doi:10.1186/1471-2202-9-62 · Cited by 37 · see citing works

Regional, cellular and species difference of two key neuroinflammatory genes implicated in schizophrenia

Murphy, C. E., Kondo, Y., Walker, A. K., Rothmond, D. A., Matsumoto, M., & Weickert, C. S. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.05.055 · Cited by 35 · see citing works

The involvement of NF-κB p65/p52 in the effects of GDNF on DA neurons in early PD rats

Cao, J. P., Wang, H. J., Yu, J., Liu, H. M., & Gao, D. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.03.007 · Cited by 35 · see citing works

Fibroblast growth factor homologous factor 1 interacts with NEMO to regulate NF-&kgr;B signaling in neurons

König, H.-G., Fenner, B., Byrne, J., Schwamborn, R. F., Bernaś, T., Jefferies, C., & Prehn, J. (2012) · Journal of Cell Science · doi:10.1242/jcs.111880 · Cited by 35 · see citing works

Mechanism of NF‐κB inactivation induced by survival signal withdrawal in cerebellar granule neurons

D. Kovács, A., Chakraborty‐Sett, S., Ramirez, S. H., Sniderhan, L. F., Williamson, A. L., & Maggirwar, S. B. (2004) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2004.03493.x · Cited by 32 · see citing works

Decoding signaling pathways involved in prolactin-induced neuroprotection: A review

Molina-Salinas, G., Rivero-Segura, N. A., Cabrera-Reyes, E. A., Rodríguez-Chávez, V., Langley, E., & Cerbón, M. (2021) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2021.100913 · Cited by 31 · see citing works

ROS-Production–Mediated Activation of AP-1 but Not NFκB Inhibits Glutamate-Induced HT4 Neuronal Cell Death

Aharoni-Simon, M., Reifen, R. M., & Tirosh, O. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2006.8.1339 · Cited by 31 · see citing works

Nuclear factor‐κb activation is associated with glutamate‐evoked tissue transglutaminase up‐regulation in primary astrocyte cultures

Caccamo, D., Campisi, A., Currò, M., Aguennouz, M., Volti, G. L., Avola, R., & Ientile, R. (2005) · Journal of Neuroscience Research · doi:10.1002/jnr.20683 · Cited by 30 · see citing works

Upregulation of CX3CL1 mediated by NF-κB activation in dorsal root ganglion contributes to peripheral sensitization and chronic pain induced by oxaliplatin administration

Wang, J., Zhang, X., Tao, R., Zhang, J., Liu, L., Jiang, Y., Ma, S.-H., Lin-xia, S., & Xia, L. (2017) · Molecular Pain · doi:10.1177/1744806917726256 · Cited by 30 · see citing works

Low K + Promotes NF-κB/DNA Binding in Neuronal Apoptosis Induced by K + Loss

Tao, Y., Yan, D., Yang, Q., Zeng, R., & Wang, Y. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.3.1038-1050.2006 · Cited by 30 · see citing works

Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival

Bhakar, A. L., Tannis, L.-L., Zeindler, C., Russo, M. P., Jobin, C., Park, D. S., MacPherson, S., & Barker, P. A. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-19-08466.2002 · Cited by 310 · see citing works

NFκB‐inducing kinase inhibits NFκB activity specifically in neurons of the CNS

Mao, X. R., Phanavanh, B., Hamdan, H., Moerman-Herzog, A. M., & Barger, S. W. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13526 · Cited by 15 · see citing works

Role of nuclear factor kappaB in the central nervous system.

Małek, R., Borowicz, K. K., Jargiello, M., & Czuczwar, S. J. (2007) · PubMed · Cited by 82 · see citing works

Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection

Fridmacher, V., Kaltschmidt, B., Goudeau, B., Ndiaye, D., Rossi, F. M., Pfeiffer, J., Kaltschmidt, C., Israël, A., & Memet, S. (2003) · PUB – Publications at Bielefeld University (Bielefeld University) · Cited by 5 · see citing works

Specific Deficiency in Nuclear Factor-κB Activation in Neurons of the Central Nervous System

Jarosinski, K. W., Whitney, L. W., & Massa, P. T. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780341 · Cited by 22 · see citing works