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Cited by 124Neurogenesis and neuroplasticity mechanismsVisual perception and processing mechanismsNeuroscience and Neuropharmacology Research

Elimination of neurons from the rhesus monkey's lateral geniculate nucleus during development

Williams, Robert W., Rakic, Pasko·1988·Journal of Comparative Neurology
DOI 10.1002/cne.902720310
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Abstract

The timing, magnitude, and spatial distribution of neuron elimination was studied in the dorsal lateral geniculate nucleus of 57 rhesus monkeys (Macaca mulatta) ranging in age from the 48th day of gestation to maturity. Normal and degenerating cells were counted in Nissl‐stained sections by using video‐enhanced differential interference contrast optics and videooverlay microscopy. Before embryonic day 60 (E60), the geniculate nucleus contains 2,200,000 ± 100,000 neurons. Roughly 800,000 of these neurons are eliminated over a 40‐ to 50‐day period spanning the middle third of gestation. Neurons are lost at an average rate of 300 an hour between E48 and E60, and at an average rate of 800 an hour between E60 and E100. Very few neurons are lost after E100, and as early as E103 the population has fallen to the adult average of 1,400,000 ± 90,000. Degenerating neurons are far more common in the magnocellular part of the nucleus than in the parvicellular part. In 20 of 29 cases, the number of neurons is greater on the right than on the left side. The right‐left asymmetry averages about 8.5% and the difference is statistically significant (X 2 = 38, p< .001). The period of cell death occurs before the emergence of cell layers in the geniculate nucleus, before the establishment of geniculocortical connections, and before the formation of ocular dominance columns (Rakic, 76). Most important, the depletion of neurons in the geniculate nucleus begins long before the depletion of retinal axons. The number of geniculate neurons is probably a key factor controlling the number of the retinal cells that survive to maturity.

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  • In the central nervous system, overproduction of neurons with ensuing neuronal death is a common mechanism employed by the developing brain to ensure that the appropriate balance of projection and receptive neurons is attained.

    “in the central nervous system overproduction of neurons with ensuing neuronal death is a common mechanism employed by the developing brain to ensure that the appropriate balance of projection and receptive neurons is attained.19, 23, 24, 25”

    From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [24]

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Authors
Williams, R. W., & Rakic, P.
Affiliations
Yale University (US)
ORCID
Venue
Journal of Comparative Neurology
Publisher
Wiley
Published
1988-06-15
Volume
272
Issue
3
Pages
424-436
ISSN
  • 0021-9967 (ISSN-L)
  • 1096-9861
DOI
10.1002/cne.902720310
OpenAlex
W2004130336
Cited by
124
References
81
Citations by year
2023: 4 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2014: 2 · 2013: 4 · 2012: 1
FWCI
2.76
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5960 d)
Locations
  • The Journal of Comparative Neurology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Eye Institute (EY02593, EY 06627)
  • National Institute of Neurological Disorders and Stroke (NS-22807)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
neuronal elimination, lateral geniculate nucleus, rhesus monkeys, developmental cell death, magnocellular neurons, parvicellular neurons, left-right asymmetry, ocular dominance columns, embryonic development
MeSH terms
Animals, Cell Count, Embryonic and Fetal Development, Geniculate Bodies, Immunochemistry, Macaca, Macaca mulatta, Nerve Degeneration, Neurons

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