Cited by 243Neural and Behavioral Psychology StudiesTreatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

The DOI matches its Crossref record; 56 of the 58 references it cites were found in a registry or an index.

Distinct Regions of Prefrontal Cortex Mediate Resistance and Vulnerability to Depression

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Abstract

The neuroanatomical correlates of depression remain unclear. Functional imaging data have associated depression with abnormal patterns of activity in prefrontal cortex (PFC), including the ventromedial (vmPFC) and dorsolateral (dlPFC) sectors. If vmPFC and dlPFC are critical neural substrates for the pathogenesis of depression, then damage to either area should affect the expression of depressive symptoms. Using patients with brain lesions we show that, relative to nonfrontal lesions, bilateral vmPFC lesions are associated with markedly low levels of depression, whereas bilateral dorsal PFC lesions (involving dorsomedial and dorsolateral areas in both hemispheres) are associated with substantially higher levels of depression. These findings demonstrate that vmPFC and dorsal PFC are critically and causally involved in depression, although with very different roles: vmPFC damage confers resistance to depression, whereas dorsal PFC damage confers vulnerability.

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Crossref · 10.1523/jneurosci.2324-08.2008

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Research works printed but not linked: 2

  1. Damasio H Damasio AR (1989) Lesion analysis in neurospychology (Oxford UP, New York).
  2. First MB Spitzer RL Gibbon M Williams JBW (2002) Structured clinical interview for DSM-IV-TR axis I disorders, research version (Biometrics Research, New York State Psychiatric Institute, (SCID-I/P) New York) patient edition.

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Metadata

Authors
Koenigs, M., Huey, E. D., Calamia, M., Raymont, V., Tranel, D., & Grafman, J.
Affiliations
  • University of Wisconsin–Madison (US)
  • National Institutes of Health (US)
  • University of Iowa (US)
  • Henry M. Jackson Foundation (US)
Venue
The Journal of Neuroscience
Published
2008-11-19
Volume
28
Issue
47
Pages
12341-12348
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2128478192
Cited by
243
References
58
Citations by year
2026: 6 · 2025: 10 · 2024: 13 · 2023: 11 · 2022: 15 · 2021: 11 · 2020: 17 · 2019: 16 · 2018: 6 · 2017: 19 · 2016: 13 · 2015: 13 · 2014: 18 · 2013: 18 · 2012: 17
FWCI
6.89
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Civil War Book Review (submittedVersion)
Funders
  • National Institutes of Health (Z99 NS999999)
  • National Institute on Drug Abuse (R01DA022549)
  • National Institute of Neurological Disorders and Stroke (P01 NS19632, P01NS019632, NS-19632, Z01NS002792)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
depression, prefrontal cortex, ventromedial prefrontal cortex, dorsolateral prefrontal cortex, dorsomedial prefrontal cortex, brain lesions, lesion studies, depression vulnerability
MeSH terms
Adult, Brain Injuries, Brain Mapping, Cognition Disorders, Depression, Female, Humans, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Movement Disorders, Severity of Illness Index, Tomography, X-Ray Computed, Veterans, Prefrontal Cortex

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